T Cell Differentiation in Tissue Microenvironments (J7)
February 2-5, 2025
| Fairmont Hotel Vancouver, Vancouver, BC, Canada
Greg M Delgoffe, Amanda Lund, Nikhil S Joshi and Laura K. Mackay
Scholarship Deadline: Nov. 6, 2024 | Abstract Deadline: Jan. 10, 2025 | Early Registration Deadline: Dec. 13, 2024
| 4:00–8:00 PM |
Registration |
British/Columbia Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
British/Columbia Foyer |
| 7:30–8:30 AM |
Breakfast |
Pacific Ballroom, Vancouver Island Room |
| 8:00–8:30 AM |
Poster Setup |
Pacific Ballroom, Vancouver Island Room |
| 8:00–5:00 PM |
Poster Viewing |
Pacific Ballroom, Vancouver Island Room |
| 8:30–9:30 AM |
Welcome and Keynote Address (Joint) |
Columbia Ballroom |
| |
* Nikhil S Joshi, Yale University School of Medicine
Session Chair |
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* Shruti Naik, Icahn School of Medicine at Mount Sinai
Session Chair |
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Yasmine Belkaid, Pasteur Institut
Inflammatory Memory and Heterologous Protection |
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| 9:30–11:30 AM |
Vaccines and Anti-Pathogen Responses (Joint) |
Columbia Ballroom |
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* Amanda Lund, New York University
Session Chair |
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* Renato Ostuni, Ospedale San Raffaele S.r.l.
Session Chair |
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Bana Jabri, University of Chicago
Exploring the Drivers of Viral Pathogenicity |
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David B Masopust, University of Minnesota
Resident Memory in Infection and Vaccination |
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Mihai G. Netea, Radboud University
Trained Immunity in Infection |
|
| 10:00–10:20 AM |
Coffee Break |
British/Columbia Foyer |
| 10:20–10:25 AM |
Award Recipient Acknowledgement |
Columbia Ballroom |
| 11:30–12:30 PM |
Lunch |
Pacific Ballroom, Vancouver Island Room |
| 12:00–2:30 PM |
Poster Session 1 |
Pacific Ballroom, Vancouver Island Room |
| 2:30–4:30 PM |
Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions |
Columbia Ballroom |
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* Pamela Rosato, Dartmouth College
Session Chair |
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Derek Bangs, University of Washington
Tertiary Lymphoid Structures Provide a Tissue Niche for Lung-Resident TCF1+ CD4+ Progenitors During Allergic Asthma |
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Aybuke Garipcan, CSHL
Epithelial YAP orchestrates epithelial – immune crosstalk to facilitate intestinal immune surveillance |
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Elliot Akama-Garren, Harvard Medical School
Stromal Cell PD-L1 Limits T Follicular Regulatory Cell Differentiation |
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Erica Culberson, Cincinnati Children's Hospital Medical Center
Intestinal microbiota program protective CD8+ T cell responses against influenza infection in newborns |
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Mark A. Travis, University of Manchester
A Subset of CD4+ Effector Memory T Cells Limit Immunity to Pulmonary Viral Infection and Prevent Tissue Pathology Via Activation of Latent TGF-Beta |
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Daniel Campbell, Benaroya Research Institute
An IL-2 Mutein Increases Regulatory T Cell Suppression of Dendritic Cells Via IL-10 and CTLA-4 to Promote T Cell Anergy |
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Laure Le Corre, Université de Montréal
Notch-Driven BATF Activity Promotes the Differentiation of Terminal Effector CD8 T Cells |
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Michel DuPage, University of California, Berkeley
H3k27me3 Chromatin Modifications Act as a Rheostat for Treg Function in Inflamed Tissues |
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| 4:30–5:00 PM |
Coffee Available |
British/Columbia Foyer |
| 5:00–7:00 PM |
Metabolic Control of T Cell Differentiation in Tissues |
Columbia Ballroom |
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* Robert L Eil, Oregon Health & Science University
Session Chair |
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Diane Mathis, Harvard Medical School
T Cell Differentiation in Metabolic Tissues |
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* Greg M Delgoffe, University of Pittsburgh
Metabolic Regulation of T Cell Differentiation |
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Roberta Zappasodi, Weill Cornell Medical College of Cornell University
Metabolic Control of Tissue-Infiltrating Regulatory T Cells |
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Will Bailis, University of Pennsylvania
Coordinating T Cell Adaptation During Nutrient Stress |
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| 7:00–8:00 PM |
On Own for Dinner |
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Tuesday, February 4, 2025
| 7:30–8:30 AM |
Breakfast |
Pacific Ballroom, Vancouver Island Room |
| 7:35–8:25 AM |
Meet the Editors (Joint) |
Pacific Ballroom, Vancouver Island Room |
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* Montserrat Cols Vidal, Journal of Experimental Medicine
Senior Scientific Editor |
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* Ursula Weiss, Nature
Senior Editor |
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* Laurie A. Dempsey, Springer Nature
Senior Editor, Nature Immunology |
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* Lucy A Bird, Springer Nature
Senior Editor, Nature Reviews Immunology |
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* Cheri Sirois, Cell Press
Senior Scientific Editor, Cell |
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* Jodi Gullicksrud, Cell Press
Scientific Editor, Immunity |
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* Claire Olingy, American Association for the Advancement of Science (AAAS)
Senior Editor, Science Immunology |
|
| 8:30–11:30 AM |
T Cell Trafficking In, Around, and Out of Tissues |
Columbia Ballroom |
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* Tessa Bergsbaken, Rutgers New Jersey Medical School
Session Chair |
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* Amanda Lund, New York University
Lymphatics and T Cell Tissue Egress in Health and Disease |
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Pilar Alcaide, Tufts University School of Medicine
T Cell Migration and Function in Cardiac Tissue |
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Judith N. Mandl, McGill University
Migration of T Cells Through Challenging Microenvironments |
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Donna L Farber, Columbia University Medical Center
Resident Memory T Cells Across Human Tissues |
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Roham Parsa, Chan Zuckerberg Biohub New York
Short Talk: Tracking Polyclonal CD4+ T Cells Reveals Organ-Specific Selection and Function During Infection |
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Valentina Venzin, Vita-Salute San Raffaele University
Short Talk: CD4+T Cells License Kupffer Cells to Revert the CD8+T Cell Dysfunction Induced by Hepatocellular Priming |
|
| 9:30–9:50 AM |
Coffee Break |
British/Columbia Foyer |
| 11:30–1:00 PM |
Poster Setup |
Pacific Ballroom, Vancouver Island Room |
| 11:30–1:30 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Pacific Ballroom, Vancouver Island Room |
| 1:30–3:30 PM |
Symposia Spotlight 2: Emerging Technologies (Joint) |
Columbia Ballroom |
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* Priyadharshini Devarajan, Stony Brook University School of Medicine
Session Chair |
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Zoltan Maliga, Harvard Medical School
Single Cell Spatial Atlas of T-Cell Phenotypes in Patient Tumors, Inflamed Tissues and Neoadjuvant Response |
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Whitney Harrington, University of Washington
The Impact of Age on T Cell Phenotype in the Lower Female Genital Tract |
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Jia Zhu, University of Washington
Spatial Immune Profiling Reveals T-cell Landscape and Local Interactions Associated with Disease Expression in Human Herpesvirus Infection |
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Kelli A McCord, Baylor College of Medicine
Phenotypic Analysis and Spatial Profiling of Antigen-Specific T Cells in Head and Neck Cancer |
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Iain D Fraser, NIAID, National Institutes of Health
Endogenous Cytokine Reporter Macrophages Facilitate Identification of Novel Innate Immune Training Compounds that can Reactivate Latent HIV |
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* Hannah R Knight, University of Chicago
High-Throughput Screen Identifies Non-Inflammatory Small Molecule Inducers of Trained Immunity |
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Zoe Schaefer, University of Florida
Multi-Level Proteomics Reveals Epigenetic Signatures in BCG-mediated Macrophage Activation |
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| 3:30–4:30 PM |
Career Roundtable (Joint) |
British Ballroom |
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Megan K. MacLeod, Glasgow University
Associate Professor |
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Charles E. Whitehurst, Boehringer Ingelheim Pharmaceuticals, Inc.
Distinguished Research Fellow, Immunology & Respiratory Discovery Sciences |
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Ai Ing Lim, Princeton University
Assistant Professor |
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Maximilian Heeg, Allen Institute
Assistant Investigator |
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| 4:30–5:00 PM |
Coffee Available |
British/Columbia Foyer |
| 5:00–7:00 PM |
Perspectives: T Cell Residence vs. Exhaustion |
Columbia Ballroom |
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* Justin Milner, UNC
Session Chair |
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* Laura K. Mackay, University of Melbourne
Deconvoluting Tissue-Resident and Exhausted T Cells in Tissues and Tumors |
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Sharanya Wijesinghe, The Peter Doherty Institute for Infection and Immunity/ The University of Melbourne
Short Talk: Induction of TRM Programming by Tumor Residing Stem-Like CD8+ T Cells Limit Anti-Cancer Immunity |
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Will D Green, University of North Carolina at Chapel Hill
Short Talk: Molecular Architecture of CD8 T Cell Adaptation to Tissue and Tumor Microenvironments |
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Hanna N Degefu, Dartmouth College
Short Talk: Resident Memory T Cell Heterogeneity in the Human Brain |
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E. John Wherry, University of Pennsylvania
Exhaustion and Residency of CD8+ T Cells |
|
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Pacific Ballroom, Vancouver Island Room |
| 7:30–10:00 PM |
Poster Session 2 |
Pacific Ballroom, Vancouver Island Room |
Wednesday, February 5, 2025
| 7:30–8:30 AM |
Breakfast |
Pacific Ballroom, Vancouver Island Room |
| 8:30–11:30 AM |
Differentiation of T Cells Within Tissues in Disease |
Columbia Ballroom |
| |
* Michel DuPage, University of California, Berkeley
Session Chair |
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Christine Carine Moussion, Genentech, Inc.
T Cell Function in Tumor Tissue, in situ Tumor Arrays |
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Stephen C Jameson, University of Minnesota Medical School
T Cell Differentiation in Tissues |
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* Nikhil S Joshi, Yale University School of Medicine
Tissue Cues of T Cell Differentiation in Autoimmunity and Cancer |
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Fiona M. Powrie, University of Oxford
Tissue Instruction of T Cell Differentiation |
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Niklas Beumer, University Medical Center of the Johannes Gutenberg University Mainz
Short Talk: Transposable Elements Become Demethylated During the Differentiation of Human Regulatory T Cells in Skin Tissue |
|
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Jie Sun, University of Virginia
Short Talk: Blimp-1-expressing respiratory Th1 effector cells help mucosal IgA production |
|
| 9:30–9:50 AM |
Coffee Break |
British/Columbia Foyer |
| 11:30–1:00 PM |
Poster Setup |
Pacific Ballroom, Vancouver Island Room |
| 11:30–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Pacific Ballroom, Vancouver Island Room |
| 2:30–4:30 PM |
Symposia Spotlight 3 |
Columbia Ballroom |
| |
* Simone L Park, University of Pennsylvania
Session Chair |
|
| |
* Lalit K Beura, Brown University
Session Chair |
|
| |
Upasana Das Adhikari, Massachusetts General Hospital/ Harvard med School
Immunometabolic Dysregulation of Intestinal CD8+ T Cells Results in Loss of Intestinal Barrier Integrity in People with HIV |
|
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Robert L Eil, Oregon Health & Science University
Ionic Imbalances in the TME Shape T Cell Metabolism Through Nutrient Processing and Consumption |
|
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Tessa Bergsbaken, Rutgers New Jersey Medical School
GPR132 Regulates the Magnitude of T cell Responses During Infection and Cancer |
|
| |
Nicole Scharping, UCSD
Proteostasis Enables T Cell Differentiation Potential and Sustains TIL Function in Cancer |
|
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Sagar P Bapat, University of California, San Francisco
Diet on Disease Onset is a Critical Modifier of Inflammatory Disease Trajectory |
|
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Sydney Ramirez, La Jolla Institute for Immunology
Longitudinal Tracking of Human Upper Airway T Cells |
|
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Leticia Monin Aldama, Imperial College London
Regulation Of Gut Γδ T Cell Activation by Innate and Adaptive TCR Engagement |
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| 4:30–5:00 PM |
Coffee Available |
British/Columbia Foyer |
| 5:00–6:45 PM |
Epigenetic Training of Innate-like and Adaptive Lymphocytes (Joint) |
Columbia Ballroom |
| |
* Greg M Delgoffe, University of Pittsburgh
Session Chair |
|
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Ananda W. Goldrath, University of California, San Diego
Epigenetic Regulation of CD8 T Cell Differentiation and Function |
|
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* Colleen Lau, Cornell University
AP-1 Factors Epigenetically Regulate Innate and Adaptive Immune Memory Formation During Viral Infection |
|
| |
Maziar Divangahi, McGill University
Innate and Adaptive Cross-Talk in Infection |
|
| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) (Joint) |
Columbia Ballroom |
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Pacific Ballroom, Vancouver Island Room |
| 7:30–10:00 PM |
Poster Session 3 |
Pacific Ballroom, Vancouver Island Room |
Thursday, February 6, 2025
