Precision Genome Engineering: From Laboratory to Clinic (J7)
January 25-28, 2027
| Keystone Resort, Keystone, CO, United States
Erik J. Sontheimer and Leonela Amoasii
| 4:00–8:00 PM |
Registration |
|
| 6:00–8:00 PM |
Welcome Mixer |
|
Tuesday, January 26, 2027
| 8:00–9:00 AM |
Welcome and Keynote Address (Joint) |
|
| |
Eric N. Olson †, University of Texas Southwestern Medical Center
Single-AAV base Editing Therapies for Duchenne Muscular Dystrophy |
|
| 9:00–11:15 AM |
Viral Delivery of Genome Editors and Genetic Medicines (Joint) |
|
| |
Beverly L. Davidson, Children’s Hospital of Philadelphia and University of Pennsylvania
AAV Capsid Engineering for Broad CNS Distribution |
|
| |
Sonia Vallabh †, Broad Institute
Development of Medicines to Treat Prion Diseases: A Personal Journey |
|
| |
Charles Gersbach, Duke University
AAV-Delivered Epigenome Editors |
|
| |
Short Talk(s) Chosen from Abstracts
|
|
| 9:30–9:50 AM |
Coffee Break |
|
| 11:15–12:15 PM |
Panel Discussion: Lessons Learned So Far: From Concept to Clinic |
|
| 12:15–1:00 PM |
Poster Setup |
|
| 12:15–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
|
| 2:30–4:30 PM |
Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions |
|
| |
Short Talks Chosen from Abstracts
|
|
| 4:30–5:00 PM |
Coffee Available |
|
| 5:00–7:00 PM |
Next-Generation Editing Tools: Continuing Innovation to Push the Limits of Genome Engineering |
|
| |
Jennifer A. Doudna, HHMI/University of California, Berkeley
CRISPR Genome Editing |
|
| |
Erik J. Sontheimer, University of Massachusetts Medical School
Next-Generation Genome Editing Platforms |
|
| |
Luigi M. Naldini †, San Raffaele Telethon Institute for Gene Therapy
Genome Editing in Hematopoietic Stem Cells |
|
| |
Short Talk(s) Chosen from Abstracts
|
|
| 7:00–8:00 PM |
Social Hour with Dinner |
|
Wednesday, January 27, 2027
| 8:00–9:00 AM |
Keynote Speaker (Joint) |
|
| |
David R. Liu †, Broad Institute, HHMI, and Harvard University
Development and Application of Virus-Like Particles for Genome Editing in vivo |
|
| 9:00–9:20 AM |
Coffee Break |
|
| 9:00–11:00 AM |
In vivo Genome Editing via Non-Viral Delivery (Joint) |
|
| |
Birgit C Schultes, Intellia Therapeutics Inc.
mRNA/LNP based Gene Editing |
|
| |
Rebecca Ahrens-Nicklas, Children's Hospital of Philadelphia
Personalized Therapeutic Genome Editing for Hepatic Inborn Errors of Metabolism |
|
| |
Leah R Sabin †, Regeneron Pharmaceuticals
Novel Delivery Strategies for Genetic Medicines |
|
| |
Short Talk(s) Chosen from Abstracts
|
|
| 11:00–1:00 PM |
Poster Setup |
|
| 11:00–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
|
| 3:00–4:30 PM |
Career Roundtable |
|
| 4:30–5:00 PM |
Coffee Available |
|
| 5:00–7:00 PM |
Editing with Confidence: Evaluating Safety, Specificity, and Genomic Integrity |
|
| |
Maria Mirotsou, Scribe Therapeutics
Advancing In Vivo CRISPR CasX-Based Therapies to Target Key Dyslipidemia Drivers |
|
| |
Shengdar Q Tsai, St. Jude Children's Research Hospital
Off-Target Profiling for Base and Prime Editing |
|
| |
Marcello Maresca, AstraZeneca
Enhancing Prime Editing Platforms for in vivo Applications |
|
| |
Short Talk(s) Chosen from Abstracts
|
|
| 7:00–8:00 PM |
Social Hour with Dinner |
|
Thursday, January 28, 2027
| 8:00–11:00 AM |
Redefining Editors: From CRISPR Biology to Recombination and Integration |
|
| |
Sangsu Bae, Seoul National University
Precise ADAR Base Editors and Prime Editor Enhancers |
|
| |
Kathleen Collins, University of California, Berkeley
Transgene Insertion Editing with Engineered Retroelements |
|
| |
Hiroshi Nishimasu, RCAST, The University of Tokyo
Engineering Programmable Transposases |
|
| |
Short Talk(s) Chosen from Abstracts
|
|
| 9:00–9:20 AM |
Coffee Break |
|
| 11:00–5:00 PM |
On Own for Lunch |
|
| 2:30–4:30 PM |
Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions |
|
| |
Short Talks Chosen from Abstracts
|
|
| 4:30–5:00 PM |
Coffee Available |
|
| 5:00–6:45 PM |
Machine-Learned Molecules: AI-Driven Design in Genome Engineering & Delivery |
|
| |
Silvana Konermann †, Stanford University School of Medicine
Protein Design and Genome Editor Enhancement |
|
| |
Peter Cameron †, Profluent Bio
Building Customized Editors via Large Language Model-Based Protein Design |
|
| |
Bruno Emanuel Correia †, École Polytechnique Fédérale de Lausanne
BindCraft, Protein Design, and Control over Genome Editing |
|
| |
Short Talk(s) Chosen from Abstracts
|
|
| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
|
| 7:00–8:00 PM |
Social Hour with Dinner |
|
| 8:00–11:00 PM |
Entertainment |
|
