Regulatory RNAs: Emerging Mechanisms (J8)
December 12-15, 2023  | Fairmont Banff Springs, Banff, AB, Canada
Mitchell Guttman, Phillip D. Zamore and Maite Huarte
Scholarship Deadline: Sep. 7, 2023 | Abstract Deadline: Sep. 25, 2023 | Early Registration Deadline: Oct. 12, 2023
* Session Chair † Invited but not yet accepted | Program current as of August 23, 2025 4 AM | For the most up-to-date details, visit https://www.keystonesymposia.org
Tuesday, December 12, 2023
4:00–8:00 PM Registration Van Horne Foyer
6:00–8:00 PM Welcome Mixer Van Horne Foyer
Wednesday, December 13, 2023
7:00–8:00 AM Breakfast Van Horne C
8:00–9:00 AM Welcome and Keynote Address (Joint) Van Horne A
  * Mitchell Guttman, California Institute of Technology
Session Chair
 
  * Eric A. Miska, University of Cambridge
Session Chair
 
  Caroline Dean, John Innes Centre
Antisense-Mediated Chromatin Silencing
 
9:00–11:15 AM RNAs in Immune Defenses (Joint) Van Horne A
  * Faezeh Jame-Chenarboo, University of Alberta
Session Chair
 
  Sandra L. Wolin, NCI, National Institutes of Health
Nicked tRNAs: Surveillance and Roles as Regulatory RNAs
 
  Eckhard Jankowsky, Moderna
Talk Title to be Announced
 
  Stacy M. Horner, Duke University Medical Center
RNA Modifications at the Virus-host Interface
 
  Christian Bellodi, Lund University
Short Talk: Short Talk: A New Role for the Pseudouridine Synthase 10 (PUS10) in Retrotransposon-driven Inflammation
 
  Diana Dou, Stanford University
Short Talk: Short Talk: Xist Ribonucleoproteins Promote Female Sex-biased Autoimmunity
 
9:30–9:50 AM Coffee Break Van Horne Foyer
11:15–1:00 PM Poster Setup President's Hall
11:15–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing President's Hall
  * Eugene W. Yeo, University of California, San Diego
Session Chair
 
3:00–4:30 PM Workshop: Cutting-Edge RNA Methods Van Horne B
4:30–5:00 PM Coffee Available Van Horne Foyer
5:00–7:00 PM RNAs in Chromatin Regulation Van Horne B
  * Yilin Lu, Georgia Institute of Technology
Session Chair
 
  Asifa Akhtar, Max Planck Institute of Immunobiology and Epigenetics
Epigenetic Mechanisms of Histone Acetylation by Long Non-Coding RNA
 
  Edith Heard, European Molecular Biology Laboratory
Mechanisms of Gene Silencing and Dosage Regulation During X-Chromosome Inactivation
 
  Phillip D. Zamore, University of Massachusetts Medical School
piRNAs, PIWI Proteins, Across the Animal Kingdom
 
  Howard Y. Chang, Stanford University
Non-Coding RNAs in Chromatin Regulation
 
  Josien van Wolfswinkel, Yale University
Short Talk: Short Talk: Crosstalk Between Regulatory RNA Pathways in Planarian Genome Defense
 
  Shannon Bailey, University of Massachusetts Chan Medical School
Short Talk: Short Talk: How Does GTSF1 Accelerate Target RNA Cleavage by PIWI-clade Argonaute Proteins?
 
  Jimmy Guo, Caltech
Short Talk: Short Talk: SPIDR: A Highly Multiplexed Method for Mapping RNA-protein Interactions Uncovers Novel RBP Functions and Indicates that PRC2 Does Not Directly Bind RNA in vivo
 
  Chen Davidovich, Monash University
Short Talk: Short Talk: Inseparable RNA Binding and Chromatin Modification Activities of a Nucleosome-interacting Surface in PRC2
 
7:00–8:00 PM Social Hour with Lite Bites Van Horne C
7:30–10:00 PM Poster Session 1 President's Hall
Thursday, December 14, 2023
7:00–8:00 AM Breakfast Van Horne C
8:00–11:00 AM RNAs in Translational Control, mRNA Stability, and Post-Transcriptional Gene Regulation Van Horne B
  Eliezer Calo, Massachusetts Institute of Technology
RNAs in Translational Control, mRNA Stability, and Post-Transcriptional Gene Regulation
 
  Yukihide Tomari, University of Tokyo
Regulation of Gene Expression by Small RNAs
 
  V. Narry Kim, Seoul National University Institute for Basic Science
Regulation and Biogenesis of microRNA
 
  Joshua T. Mendell, University of Texas Southwestern Medical Center
Target-Directed Destruction of Argonaute Proteins and their microRNA Guides
 
9:00–9:20 AM Coffee Break Van Horne Foyer
11:00–1:00 PM Poster Setup President's Hall
11:00–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing President's Hall
3:00–4:30 PM Career Roundtable (Joint) Van Horne A
4:30–5:00 PM Coffee Available Van Horne Foyer
5:00–7:00 PM RNA as Specificity Determinants Van Horne B
  * Shannon Bailey, University of Massachusetts Chan Medical School
Session Chair
 
  Oliver J. Rando, University of Massachusetts Medical School
Small RNAs in Reproductive Biology
 
  Ian MacRae, The Scripps Research Institute
Molecular Bases for Gene Regulation in miRNA and piRNA Systems
 
  Laura Landweber, Columbia University
Mechanisms of RNA-Guided Genome Rearrangement in the Ciliate Oxytricha
 
  Paula Cohen, Cornell University
Non-Canonical Roles for Argonautes in Sex Chromosome Regulation During Mammalian Meiosis
 
7:00–8:00 PM Social Hour with Lite Bites Van Horne C
7:30–10:00 PM Poster Session 2 President's Hall
Friday, December 15, 2023
7:00–8:00 AM Breakfast Van Horne C
8:00–11:00 AM Roles of ncRNAs in Nuclear and Cytoplasmic Compartmentalization Van Horne B
  Roy R. Parker, HHMI/University of Colorado
RNA-Mediated Granules
 
  Richard A. Young, Whitehead Institute for Biomedical Research
RNA and Nuclear Condensates
 
9:00–9:20 AM Coffee Break Van Horne Foyer
11:00–5:00 PM On Own for Lunch
4:30–5:00 PM Coffee Available Van Horne Foyer
5:00–6:45 PM RNAs and DNA Organization Van Horne B
  * Jimmy Guo, Caltech
Session Chair
 
  * Diana Dou, Stanford University
Session Chair
 
  Thomas R. Cech, HHMI/University of Colorado
How Might Molecular Condensates Enhance the Action of RNA-binding Proteins?
 
  Mitchell Guttman, California Institute of Technology
RNA Promotes the Formation of Spatial Compartments in the Nucleus
 
  Maite Huarte, Universidad de Navarra
Noncoding RNA Roles in the Coordination of DNA Replication and Stress Signaling
 
  Jonathan E. Henninger, Whitehead Institute for Biomedical Research
Short Talk: Short Talk: RNA Binding by Transcription Factors in Health and Disease
 
  Yilin Lu, Georgia Institute of Technology
Short Talk: Short Talk: Double Strand Break Repair Mediated by RNA Transcripts in Yeast and Human Cells
 
  Prashant Bhat, California Institute of Technology
Short Talk: Short Talk: 3D Genome Organization Around Nuclear Speckles Drives mRNA Splicing Efficiency
 
6:45–7:00 PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Van Horne B
7:00–8:00 PM Social Hour with Lite Bites Van Horne C
7:30–8:00 PM Entertainment Van Horne C
8:00–9:00 PM Cash Bar Van Horne C
Saturday, December 16, 2023
12:00–11:59 PM Departure