Innate Immune Memory: Mechanisms and Consequences (J8)
February 2-5, 2025
| Fairmont Hotel Vancouver, Vancouver, BC, Canada
Shruti Naik, Keke C. Fairfax and Renato Ostuni
Scholarship Deadline: Nov. 6, 2024 | Abstract Deadline: Jan. 10, 2025 | Early Registration Deadline: Dec. 13, 2024
| 4:00–8:00 PM |
Registration |
British/Columbia Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
British/Columbia Foyer |
| 7:30–8:30 AM |
Breakfast |
Pacific Ballroom, Vancouver Island Room |
| 8:00–8:30 AM |
Poster Setup |
Pacific Ballroom, Vancouver Island Room |
| 8:00–5:00 PM |
Poster Viewing |
Pacific Ballroom, Vancouver Island Room |
| 8:30–9:30 AM |
Welcome and Keynote Address (Joint) |
Columbia Ballroom |
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* Shruti Naik, Icahn School of Medicine at Mount Sinai
Session Chair |
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* Nikhil S Joshi, Yale University School of Medicine
Session Chair |
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Yasmine Belkaid, Pasteur Institut
Inflammatory Memory and Heterologous Protection |
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| 9:30–11:30 AM |
Vaccines and Anti-Pathogen Responses (Joint) |
Columbia Ballroom |
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* Amanda Lund, New York University
Session Chair |
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* Renato Ostuni, Ospedale San Raffaele S.r.l.
Session Chair |
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Bana Jabri, University of Chicago
Exploring the Drivers of Viral Pathogenicity |
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David B Masopust, University of Minnesota
Resident Memory in Infection and Vaccination |
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Mihai G. Netea, Radboud University
Trained Immunity in Infection |
|
| 10:00–10:20 AM |
Coffee Break |
British/Columbia Foyer |
| 10:20–10:25 AM |
Award Recipient Acknowledgement |
Columbia Ballroom |
| 11:30–12:30 PM |
Lunch |
Pacific Ballroom, Vancouver Island Room |
| 12:00–2:30 PM |
Poster Session 1 |
Pacific Ballroom, Vancouver Island Room |
| 2:30–4:30 PM |
Symposia Spotlight 1: Late Breaking Research |
British Ballroom |
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* Payal Damani-Yokota, NYU Langone Medical Center
Session Chair |
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Vanessa Cristaldi, NYU Langone
Remote Presentation: A Persistent Vascular Endothelial Inflammatory State Maintains Local Immune Surveillance in Skin Post Infection |
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M. Carrie Miceli, University of California, Los Angeles
Transcriptomics Reveals DMD Driven Cell Dynamics and Mechanisms of Fibroblast Inflammatory Tissue Priming in Human Dystrophic Muscle |
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Payal Damani-Yokota, NYU Langone Medical Center
Helminth-Driven NAM Reprogramming Confers Disease Tolerance Against Subsequent Respiratory Viral Infection |
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Roni Nowarski, BRIGHAM AND WOMEN'S HOSPITAL
A Metabolic Switch Orchestrated by Il-18 and Cgamp Programs Tolerogenic Memory in the Gut |
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Alexander Lercher, The Rockefeller University
Antiviral Innate Immune Memory in Alveolar Macrophages Following SARS-Cov-2 Infection |
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In Su Cheon, University of Virginia
Infection-Experienced Alveolar Macrophages Sustain Airway T Cell Memory |
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* Quen J. Cheng, University of California, Los Angeles
IRF1 Cooperates with ISGF3 or GAF To Regulate Specificity of De Novo Enhancers |
|
| 4:30–5:00 PM |
Coffee Available |
British/Columbia Foyer |
| 5:00–7:00 PM |
Mechanisms of Innate Immune Memory |
British Ballroom |
| |
Golnaz Vahedi, University of Pennsylvania
Remote Presentation: Optical Reconstruction of Chromatin Architecture Reveals Dynamics of Genome Organization |
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* Renato Ostuni, Ospedale San Raffaele S.r.l.
Mechanisms of Response and Memory to Stimulation in Macrophages |
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* Diana Hargreaves, The Salk Institute for Biological Studies
Regulation of Macrophage Inflammation by BAF Chromatin Remodeling Complexes |
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Aoife O'Farrell, University of Pennsylvania
Short Talk: Long Term Stimulus Specificity of Memory in Human Macrophages |
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Aleksandr Gorin, University of California, Los Angeles
Short Talk: Interferon Gamma Induced Innate Immune Memory in Macrophages is Dependent on Sustained JAK/STAT Signaling |
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| 7:00–8:00 PM |
On Own for Dinner |
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Tuesday, February 4, 2025
| 7:30–8:30 AM |
Breakfast |
Pacific Ballroom, Vancouver Island Room |
| 7:35–8:25 AM |
Meet the Editors (Joint) |
Pacific Ballroom, Vancouver Island Room |
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* Montserrat Cols Vidal, Journal of Experimental Medicine
Senior Scientific Editor |
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* Ursula Weiss, Nature
Senior Editor |
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* Laurie A. Dempsey, Springer Nature
Senior Editor, Nature Immunology |
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* Lucy A Bird, Springer Nature
Senior Editor, Nature Reviews Immunology |
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* Cheri Sirois, Cell Press
Senior Scientific Editor, Cell |
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* Jodi Gullicksrud, Cell Press
Scientific Editor, Immunity |
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* Claire Olingy, American Association for the Advancement of Science (AAAS)
Senior Editor, Science Immunology |
|
| 8:30–11:30 AM |
Inflammatory Memory and Disease |
British Ballroom |
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* Kari C Nadeau, Harvard T.H. Chan School of Public Health
Exposome, Inflammatory Training and Allergic Disease |
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Przemyslaw Sapieha, University of Montreal
Obesity, Innate Immune Training, and Neuroinflammation |
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Kathryn J Moore, New York University Medical Center
Inflammatory Memory in Cardiovascular Disease and Cancer |
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Dusan Bogunovic, Columbia University
Post-Translational Governance of Innate Immune Memory |
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Cassia Braga, Yale University
Short Talk: Chronic Lung Inflammation in Cystic Fibrosis Drives Maladaptive Innate Immune Memory in Hematopoietic Stem Cells |
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* Helene M Liu, National Taiwan University
Short Talk: Dysregulated MDA5-Mediated Innate Immune Memory and M5c RNA Modification in Autoimmune Disease |
|
| 9:30–9:50 AM |
Coffee Break |
British/Columbia Foyer |
| 11:30–1:00 PM |
Poster Setup |
Pacific Ballroom, Vancouver Island Room |
| 11:30–1:30 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Pacific Ballroom, Vancouver Island Room |
| 1:30–3:30 PM |
Symposia Spotlight 2: Emerging Technologies (Joint) |
Columbia Ballroom |
| |
* Priyadharshini Devarajan, Stony Brook University School of Medicine
Session Chair |
|
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Zoltan Maliga, Harvard Medical School
Single Cell Spatial Atlas of T-Cell Phenotypes in Patient Tumors, Inflamed Tissues and Neoadjuvant Response |
|
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Whitney Harrington, University of Washington
The Impact of Age on T Cell Phenotype in the Lower Female Genital Tract |
|
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Jia Zhu, University of Washington
Spatial Immune Profiling Reveals T-cell Landscape and Local Interactions Associated with Disease Expression in Human Herpesvirus Infection |
|
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Kelli A McCord, Baylor College of Medicine
Phenotypic Analysis and Spatial Profiling of Antigen-Specific T Cells in Head and Neck Cancer |
|
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* Hannah R Knight, University of Chicago
High-Throughput Screen Identifies Non-Inflammatory Small Molecule Inducers of Trained Immunity |
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Zoe Schaefer, University of Florida
Multi-Level Proteomics Reveals Epigenetic Signatures in BCG-mediated Macrophage Activation |
|
| 3:30–4:30 PM |
Career Roundtable (Joint) |
British Ballroom |
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Megan K. MacLeod, Glasgow University
Associate Professor |
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Charles E. Whitehurst, Boehringer Ingelheim Pharmaceuticals, Inc.
Distinguished Research Fellow, Immunology & Respiratory Discovery Sciences |
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Ai Ing Lim, Princeton University
Assistant Professor |
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Maximilian Heeg, Allen Institute
Assistant Investigator |
|
| 4:30–5:00 PM |
Coffee Available |
British/Columbia Foyer |
| 5:00–7:00 PM |
Inflammatory Memory in Long-Lived Tissue Progenitor Cells |
British Ballroom |
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* Shruti Naik, Icahn School of Medicine at Mount Sinai
Inflammatory Memory in Epithelial Stem Cells |
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Semir Beyaz, Cold Spring Harbor Laboratory
Metabolic Training of Intestinal Stem Cells |
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Steven Z. Josefowicz, Weill Cornell Medical College
Epigenetic Regulation of Inflammation |
|
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* Megan K. MacLeod, Glasgow University
Short Talk: Lung Structural Cells are Altered by Influenza Virus Leading to Rapid Immune Protection Following Re-Challenge |
|
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Phoenix P Miao, The University of Chicago
Short Talk: Aging-Associated Chronic Inflammation Induces Epigenetic Scars in Epithelial Stem Cells |
|
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Pacific Ballroom, Vancouver Island Room |
| 7:30–10:00 PM |
Poster Session 2 |
Pacific Ballroom, Vancouver Island Room |
Wednesday, February 5, 2025
| 7:30–8:30 AM |
Breakfast |
Pacific Ballroom, Vancouver Island Room |
| 8:30–11:30 AM |
Intergenerational, Transgenerational and Early Life Training |
British Ballroom |
| |
* Keke C. Fairfax, University of Utah
Dissecting the Role of Biological Sex in Training of the Myeloid Lineage |
|
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Colin C. Conine, University of Pennsylvania
Transgenerational Inheritance of Host-Microbe Crosstalk |
|
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Ai Ing Lim, Princeton University
Maternal-Offspring Immune Partnership |
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Petter Brodin, Karolinska Institutet
Early Life Imprinting of Human Immune System |
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* Jonas Schulte-Schrepping, German Center for Neurodegenerative Diseases (DZNE)
Short Talk: A Journey of Resilience: Investigating Hematopoietic Adaptations to Early-Life Stress and their Impact on Neurodegenerative Disease Development |
|
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Taylor Miller-Ensminger, University of Pennsylvania
Short Talk: Paternal Immune Activation Confers Epigenetically Inherited Protection to Offspring During Viral Infection |
|
| 9:30–9:50 AM |
Coffee Break |
British/Columbia Foyer |
| 11:30–1:00 PM |
Poster Setup |
Pacific Ballroom, Vancouver Island Room |
| 11:30–2:30 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Pacific Ballroom, Vancouver Island Room |
| 3:00–4:30 PM |
Health Equity Forum |
British Ballroom |
| |
* Graeme J Koelwyn, Simon Fraser University
Session Chair |
|
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* Stephanie Z Xie, University Health Network
Session Chair |
|
| |
Jed Friedman, University of Oklahoma
Colonization with Enterobacteriaceae Strain from Human Neonates Born to Mothers with Obesity Promotes Immune Cell Remodeling in Mice |
|
| |
Graeme J Koelwyn, Simon Fraser University
Myocardial Infarction Imprints Long-Term Dysfunctional Monocyte Reprogramming |
|
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Eva Kaufmann, Queen's University
Deciphering the Influence of the Immune Environment on Trained Immunity Induction |
|
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Sarah Crome, University Health Network & University of Toronto
Natural Killer Cells Exhibit Resistance to Immunosuppression and Develop a Memory-Like Phenotype in Kidney Antibody-Mediated Rejection |
|
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Iris K Gratz, University of Salzburg
Skin Cancer in Patients With Recessive Dystrophic Epidermolysis Bullosa Is Associated With Dysregulated T Cells |
|
| |
Stephanie Z Xie, University Health Network
A Human Blood Stem Cell Subset That Retains Memory of Inflammatory Stress |
|
| 4:30–5:00 PM |
Coffee Available |
British/Columbia Foyer |
| 5:00–6:45 PM |
Epigenetic Training of Innate-like and Adaptive Lymphocytes (Joint) |
Columbia Ballroom |
| |
* Greg M Delgoffe, University of Pittsburgh
Session Chair |
|
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Ananda W. Goldrath, University of California, San Diego
Epigenetic Regulation of CD8 T Cell Differentiation and Function |
|
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* Colleen Lau, Cornell University
AP-1 Factors Epigenetically Regulate Innate and Adaptive Immune Memory Formation During Viral Infection |
|
| |
Maziar Divangahi, McGill University
Trained Immunity in Anti-Pathogen Responses |
|
| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) (Joint) |
Columbia Ballroom |
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Pacific Ballroom, Vancouver Island Room |
| 7:30–10:00 PM |
Poster Session 3 |
Pacific Ballroom, Vancouver Island Room |
Thursday, February 6, 2025
