Ubiquitin: New Frontiers in Signaling and Cellular Regulation (K2)
February 7-10, 2028
| Keystone Resort, Keystone, CO, United States
David Komander, J. Wade W Harper and Sonja Lorenz
| 4:00–8:00 PM |
Registration |
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| 6:00–8:00 PM |
Welcome Mixer |
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Tuesday, February 8, 2028
| 8:00–8:10 AM |
Welcome Remarks |
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| 8:10–9:40 AM |
Keynote Session (Joint) |
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Carolyn R. Bertozzi †, Stanford University
Beyond the Proteasome: Lysosomal Routes for Targeted Degradation |
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Stephen J. Elledge †, Harvard Medical School
SCF E3 Ligases and New Technologies |
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| 9:30–9:50 AM |
Coffee Break |
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| 9:40–11:30 AM |
Targeted Protein Degradation (Joint) |
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Michael Rape †, University of California, Berkeley
Fundamental and Translational Aspects of Ubiquitin Biology |
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Eric S. Fischer †, Dana-Farber Cancer Institute
Small Molecules Targeting the Ubiquitin Proteasome System |
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Sharon A Townson †, Monte Rosa Therapeutics
Designing Molecular Glue Degraders |
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Short Talk(s) Chosen from Abstracts
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| 11:15–1:00 PM |
Poster Setup |
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| 11:15–5:00 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
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| 2:30–4:30 PM |
Symposia Spotlight 1: Emerging Talent in Ubiquitin Research |
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Short Talks Chosen from Abstracts
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–7:00 PM |
E3 Ligase Biology |
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Brenda A Schulman †, Max Planck Institute of Biochemistry
Decoding Specificity in Ubiquitin-Mediated Protein Turnover |
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Heeseon An †, Memorial Sloan Kettering
MTOR Control of Protein Turnover |
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Sonja Lorenz, Max Planck Institute for Multidisciplinary Sciences
Substrate Specificity Mechanisms in HECT-Type Ligases |
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Short Talk(s) Chosen from Abstracts
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| 7:00–8:00 PM |
Social Hour with Dinner |
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Wednesday, February 9, 2028
| 8:00–11:00 AM |
New Ub and Ubl Cell Biology |
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Fumiyo Ikeda †, Osaka University
Physiology of Non-Lysine Ubiquitination |
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Yogesh Kulathu †, University of Dundee
Regulation by the Ub-Like Modifier UFM1 |
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Boxun Lu †, Fudan University
Exploiting ERAD for Targeted Degradation |
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Rune Busk Damgaard †, Danmarks Tekniske Universitet
Met1 Ubiquitination and LUBAC in AMPK Regulation and Metabolism |
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Short Talk(s) Chosen from Abstracts
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| 9:00–9:20 AM |
Coffee Break |
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| 11:00–1:00 PM |
Poster Setup |
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| 11:00–5:00 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
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| 3:00–4:30 PM |
Career Roundtable |
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–7:00 PM |
Ubiquitin in Organelle Dynamics |
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J. Wade W Harper, Harvard Medical School
Ubiquitin in Organelle Quality Control |
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Ruey-Hwa Chen †, Academia Sinica
Lys6-Linked Ubiquitination and the Purinosome |
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Sylvie Urbé †, University of Liverpool
Crosstalk within Mitophagy Pathways |
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Short Talk(s) Chosen from Abstracts
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| 7:00–8:00 PM |
Social Hour with Dinner |
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Thursday, February 10, 2028
| 8:00–10:00 AM |
Ubiquitin in Disease States |
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Victoria M. Richon †, Entact Bio
Generation of ENTACs to Stabilize Tumor Suppressors |
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Yifat Merbl †, Weizmann Institute of Science
Proteasomes in Disease States |
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Achim Werner †, National Institutes of Health
Molecular Dissection of VEXAS Syndrome |
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Short Talk(s) Chosen from Abstracts
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| 9:00–9:20 AM |
Coffee Break |
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| 10:00–11:00 AM |
Keynote Address |
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Cynthia Wolberger †, Johns Hopkins University School of Medicine
Histone Ubiquitination and Deubiquitination |
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| 11:00–5:00 PM |
On Own for Lunch |
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| 2:30–4:30 PM |
Symposia Spotlight 2: Ubiquitination in Hot-Topic Areas: Ub Spatialomics, Ub Phase Separation, Ub PTMs in Structure-Predictions |
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Short Talks Chosen from Abstracts
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–6:45 PM |
A New Frontier: Non-Protein Ubiquitination |
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Felix Randow †, Medical Research Council
RNF213 and Non-Protein Ubiquitination |
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Tim Clausen †, Research Institute of Molecular Pathology, IMP
Structural Basis for Non-Protein Ubiquitination |
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David Komander, Walter and Eliza Hall Institute of Medical Research
Non-Protein Ubiquitination in Cells and Tissues |
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Short Talk(s) Chosen from Abstracts
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| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions |
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| 7:00–8:00 PM |
Social Hour with Dinner |
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| 8:00–11:00 PM |
Entertainment |
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Friday, February 11, 2028
