Induced Proximity and Targeted Protein Degradation: Emerging Technologies and Therapeutic Applications (K3)
February 8-11, 2027
| Fairmont Banff Springs, Banff, AB, Canada
Christina Woo, William Forrester and Alessio Ciulli
| 4:00–8:00 PM |
Registration |
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| 6:00–8:00 PM |
Welcome Mixer |
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Tuesday, February 9, 2027
| 8:00–9:00 AM |
Welcome and Keynote Address |
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| 9:00–11:15 AM |
Clinic to First Approval, TPD Medicinal Chemistry to in vivo |
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Angela Cacace †, Arvinas Inc
Neurodegenerative Targets in TPD |
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Juliet Williams †, Kymera Therapeutics
Solving Big Problems with Small Molecule Degraders |
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William Forrester, Novartis
The Novartis Targeted Protein Degradation Platform |
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Gwenn Hansen †, Nurix Therapeutics
Clinical Development of Nurix’s Degrader Drugs |
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Short Talk(s) Chosen from Abstracts
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| 9:30–9:50 AM |
Coffee Break |
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| 11:15–12:15 PM |
Meet the Editors |
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| 11:15–1:00 PM |
Poster Setup |
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| 12:15–5:00 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
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| 2:30–4:30 PM |
Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions |
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Short Talks Chosen from Abstracts
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–7:00 PM |
Induced Proximity Modalities to Treat Human Disease |
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Lauren V Albrecht, University of California Irvine
Methyl Arginine TACs |
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Steven Banik, Stanford University
Shuttle Proteins |
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Mikko Taipale, University of Toronto
Pervasive Mislocalization of Pathogenic Coding Variants Underlying Human Disorders: Cell |
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Short Talk(s) Chosen from Abstracts
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| 7:00–8:00 PM |
Social Hour with Dinner |
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Wednesday, February 10, 2027
| 8:00–11:00 AM |
New Frontiers for E3 Ligases in TPD |
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Nicolas H Thomä, EPFL Lausanne
Haven't Got a Glue: Protein Surface Variation for the Design of Molecular Glue Degraders |
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Lindsey Ingerman James †, University of North Carolina at Chapel Hill
E3 Ligase and Degrader Discovery |
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Jacob E. Corn, ETH Zürich
Recognition and Removal of Proteins with Weird Stuff Attached to Them |
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Christina Woo, Harvard University
Probing Cereblon Allosterically |
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Short Talk(s) Chosen from Abstracts
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| 9:00–9:20 AM |
Coffee Break |
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| 11:00–12:00 PM |
Panel Discussion: How to Start a Company |
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| 11:00–1:00 PM |
Poster Setup |
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| 12:00–5:00 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
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| 3:00–4:30 PM |
Career Roundtable |
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–7:00 PM |
Discovery Chemistry for Novel Induced Proximity Modalities |
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Alessio Ciulli, University of Dundee, School of Life Sciences
Trivalent TAC Chemistry |
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Nir London †, Weizmann Institute of Science
A Pharmacological Modality to Sequester Homomeric Proteins |
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Ekaterina Vinogradova †, Rockefeller University
Chemical Immunology and Proteomics for Small Molecule Degraders |
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Short Talk(s) Chosen from Abstracts
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| 7:00–8:00 PM |
Social Hour with Dinner |
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Thursday, February 11, 2027
| 8:00–11:00 AM |
Antibody and Biologic Degraders from the Lab to the Clinic |
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Laura L. Kiessling †, Massachusetts Institute of Technology
Cell Surface Induced Proximity Engineering |
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Hui-Kuan Lin, Duke University
Degrader Delivery through CD36 |
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John Flygare †, Eli Lilly
Delving into Novel Design and Development to Strive for Next-Generation ADCs Providing Long-Term Benefit to Patients |
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Short Talk(s) Chosen from Abstracts
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| 9:00–9:20 AM |
Coffee Break |
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| 11:00–5:00 PM |
On Own for Lunch |
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| 2:30–4:30 PM |
Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions |
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| |
Short Talks Chosen from Abstracts
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–6:30 PM |
Glues at the AI and ML Interface |
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Bruno Emanuel Correia †, École Polytechnique Fédérale de Lausanne
PP Interface |
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Victor Guallar, Barcelona Supercomputing Center and Nostrum Biodiscovery
There is more than one Ligase and Molecular Glue for each Target... & we know Them |
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Short Talk(s) Chosen from Abstracts
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| 6:30–7:15 PM |
Closing Keynote Address |
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David Baker †, University of Washington
Future of PPIs |
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| 7:15–7:30 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
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| 7:30–8:30 PM |
Social Hour with Dinner |
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| 8:00–11:00 PM |
Entertainment |
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Friday, February 12, 2027
