The Ubiquitin Family in Biology and Disease (K5)
February 23-26, 2026
| Fairmont Banff Springs, Banff, AB, Canada
Michael Rape, Christopher D. Lima and Bekky Feltham
Scholarship Deadline: Nov. 26, 2025 | Abstract Deadline: Feb. 3, 2026 | Early Registration Deadline: Dec. 30, 2025
Monday, February 23, 2026
| 4:00–8:00 PM |
Registration |
Van Horne Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
Van Horne Foyer |
Tuesday, February 24, 2026
| 7:00–8:00 AM |
Breakfast |
President's Hall |
| 8:00–8:10 AM |
Welcome Remarks |
Van Horne B |
| 8:10–9:00 AM |
Keynote Address |
Van Horne B |
| |
Nicolas H Thomä, EPFL Lausanne
Ubiquitin Signaling in Transcription and DNA Repair |
|
| 9:00–11:15 AM |
Ubiquitin System – A Global View |
Van Horne B |
| |
Brenda A Schulman, Max Planck Institute of Biochemistry
Molecular Machines of Ubiquitylation |
|
| |
Eric J. Bennett, University of California, San Diego
Leveraging Plasticity within the Ubiquitin System |
|
| |
Michele Pagano, New York University School of Medicine
Talk Title to be Announced |
|
| |
Predrag Jevtic †, UC Berkeley
Short Talk: Dynamics of Gene Repression in Development and Disease |
|
| 9:30–9:50 AM |
Coffee Break |
Van Horne Foyer |
| 9:50–9:55 AM |
Award Recipient Acknowledgement |
Van Horne B |
| 11:15–1:00 PM |
Poster Setup |
Van Horne C |
| 11:15–5:00 PM |
On Own for Lunch |
|
| 11:15–12:15 PM |
Meet the Editors |
Van Horne B |
| 1:00–10:00 PM |
Poster Viewing |
Van Horne C |
| 2:30–4:30 PM |
Symposia Spotlight |
Van Horne B |
| |
Shannon Buckley †, Huntsman Cancer Institue
Targeting the Ubiquitin E3 Ligase FBXO21 Reveals a New Approach to Modulate Aberrant PI3K Signaling in Cancer |
|
| |
Emma C Fink †, Dana Farber Cancer Institute
CRL5(LRRC58) Controls Cysteine Catabolism by Cyst(e)ine-regulated Degradation of CDO1 |
|
| |
Peter Hsu †, Genentech
Template-mediated Multivalent Scaffolding of the SCF(FBXO42) E3 Ligase Regulates PP2A Degradation |
|
| |
Hani Zaher †, Washington University in St. Louis
eIF4E Links Transcription and Translation |
|
| |
Elijah Mena †, UT Southwestern
Proteasomal Surveillance of Exposed Cysteines |
|
| |
Hai Rao †, Southern University of Science and Technology
Tryptophan-sensing Ubiquitin Ligases Regulate Tryptophan Metabolism and Tumor Immune Suppression via IDO1 Modulation |
|
| |
Jennifer Kong †, University of Washington
Ubiquitin Signaling at the Plasma Membrane: Adapter-mediated Control of Receptor Abundance |
|
| |
Robert Piper †, University of Iowa
K48-Ubiquitin-Dependent Proteases Cut-Up Post-ER Proteins |
|
| 4:30–5:00 PM |
Coffee Available |
Van Horne Foyer |
| 5:00–7:00 PM |
SUMO: The First Ubiquitin-Like Molecule |
Van Horne B |
| |
Christopher D. Lima, Memorial Sloan Kettering Cancer Center
SUMOylation Mechanisms |
|
| |
Yifat Merbl, Weizmann Institute of Science
SUMO in the Immune Response |
|
| |
Stefan Müller †, Goethe-University Frankfurt
Short Talk: SUMO Signaling Rewires HSF1-dependent Gene Expression Programs |
|
| |
Nima Mosammaparast †, Washington University in St. Louis
Short Talk: Stalling of a Late Activated Spliceosome Recruits the ASC-1 Complex to Initiate Ubiquitin-dependent Spliceosomal Disassembly |
|
| 7:00–8:00 PM |
Social Hour with Dinner |
President's Hall |
| 7:30–10:00 PM |
Poster Session 1 |
Van Horne C |
Wednesday, February 25, 2026
| 7:00–8:00 AM |
Breakfast |
President's Hall |
| 8:00–11:00 AM |
Quality Control Ubiquitylation in Development and Disease |
Van Horne B |
| |
Sonya Neal, University of California, San Diego
ER-Associated Quality Control |
|
| |
Susan Shao, Harvard Medical School
Ribosome-Associated Quality Control |
|
| |
Michael Rape, University of California, Berkeley
Stress Response Silencing |
|
| |
David Komander, Walter and Eliza Hall Institute of Medical Research
Ubiquitin and Parkinson’s Disease |
|
| |
Lillie E Bell †, Research Institute of Molecular Pathology
Short Talk: Regulation of Cell Defence Factor RNF213 and its Targeting of Bacterial Pathogens |
|
| |
Ricardo Rajsbaum †, Rutgers University, New Jersey Medical School Cancer Center
Short Talk: The Role of Non-Covalent Ubiquitin Interactions in Virus-Induced Pathology |
|
| 9:00–9:20 AM |
Coffee Break |
Van Horne Foyer |
| 11:00–1:00 PM |
Poster Setup |
Van Horne C |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Van Horne C |
| 3:00–4:30 PM |
Career Roundtable |
Van Horne B |
| 4:30–5:00 PM |
Coffee Available |
Van Horne Foyer |
| 5:00–7:00 PM |
New Insights into Ubiquitin-Like Proteins |
Van Horne B |
| |
Yogesh Kulathu, University of Dundee
UFM1 in Ribosome Control |
|
| |
Eilika Weber-Ban, ETH Zürich
Pup Proteasome System and Mycobacterial Stress Responses |
|
| |
Reuven Wiener †, Hebrew University
Short Talk: E2 Enzymes Think Outside the HPN Box: New Insights into Ubiquitin-like Conjugation |
|
| |
Alexandra Whiteley †, University of Colorado, Boulder
Short Talk: A Model of Ubiquilin Function Relevant to Human Disease: UBQLN2, ALS, and the Virus-Like Protein PEG10 |
|
| |
Xing Liu †, Purdue University
Short Talk: Regulation of Cullin-RING Ubiquitin Ligases by CAND Proteins |
|
| |
Hao Dong †, Walter and ELiza Hall Institute
Short Talk: Branching Out: Coordinated E3-Driven K29/K48 Ubiquitination Enables Efficient PROTAC-Induced Proteolysis |
|
| 7:00–8:00 PM |
Social Hour with Dinner |
President's Hall |
| 7:30–10:00 PM |
Poster Session 2 |
Van Horne C |
Thursday, February 26, 2026
| 7:00–8:00 AM |
Breakfast |
President's Hall |
| 8:00–11:00 AM |
Learning from the Clinic |
Van Horne B |
| |
Gwenn M Hansen, Nurix Therapeutics
Learnings from BTK Degrader Trials in Brain |
|
| |
Ingrid E Wertz, Lyterian Therapeutics
Co-opting the Ubiquitin System for Therapeutic Benefit |
|
| |
Danette L Daniels †, Foghorn Therapeutics, Inc
Talk Title to be Announced |
|
| |
Stephen Hinshaw †, Stanford University
Talk title to be Announced |
|
| |
Madel Tutor †, AstraZeneca
Short Talk: Decoding Endogenous Cereblon Functions and PROTAC Impact in Prostate and Breast Cancer Cells |
|
| |
Daniela Rotin †, Hospital for Sick Children
Short Talk: Inactivating Mutations in NEDD4L Cause Liddle Syndrome with NDI and Deafness (LiNDID) |
|
| 9:00–9:20 AM |
Coffee Break |
Van Horne Foyer |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 4:30–5:00 PM |
Coffee Available |
Van Horne Foyer |
| 5:00–6:30 PM |
Ubiquitin at the Crossroads of Infection and Immunology |
Van Horne B |
| |
Bekky Feltham, Walter and Eliza Hall Institute of Medical Research
Ubiquitin Biology in Inflammation |
|
| |
Aaron T Whiteley, University of Colorado Boulder
Ubiquitin Transferase-Like Proteins in Bacterial Phage Resistance |
|
| |
Ivan Dikic, Goethe University Medical School
Non-Conventional Ubiquitylation |
|
| 6:30–7:15 PM |
Closing Keynote Address |
Van Horne B |
| |
Vishva M. Dixit, Genentech, Inc.
Virulence Factors Mediate Ubiquitin-Dependent Immunomodulation |
|
| 7:15–7:30 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Van Horne B |
| 7:30–8:30 PM |
Social Hour with Dinner |
President's Hall |
| 8:30–9:30 PM |
Entertainment |
|
Friday, February 27, 2026
