Proximity Based Biology and Therapeutics: Targeted Protein Degradation and Beyond (K6)
February 23-26, 2026  | Fairmont Banff Springs, Banff, AB, Canada
Neil Bence, Cheryl Arrowsmith and Amit Choudhary
Scholarship Deadline: Nov. 26, 2025 | Abstract Deadline: Feb. 3, 2026 | Early Registration Deadline: Dec. 30, 2025
* Session Chair † Invited but not yet accepted | Program current as of January 7, 2026 5 AM | For the most up-to-date details, visit https://www.keystonesymposia.org
Monday, February 23, 2026
4:00–8:00 PM Registration Van Horne Foyer
6:00–8:00 PM Welcome Mixer Van Horne Foyer
Tuesday, February 24, 2026
7:00–8:00 AM Breakfast President's Hall
8:00–8:10 AM Welcome Remarks Van Horne A
8:10–9:00 AM Keynote Address Van Horne A
  Ning Zheng, University of Washington
Stuck on You: The Omnipresence of Molecular Glues		  
9:00–11:15 AM Transformation of Drug Discovery and Induced Proximity through AI/ML Van Horne A
  Nicholas F. Polizzi, Dana-Farber Cancer Institute
Designing Biosensors from Scratch Using Principles of Induced Proximity		  
  George M Burslem, University of Pennsylvania
Chemical Tools to Edit Protein Sequences and Post-Translational Modifications		  
  Mikko Taipale, University of Toronto
Navigating the Proteome with Induced Proximity		  
  Björn Schwalb †, NEOsphere Biotechnologies GmbH
Short Talk: AI/ML-based Prediction of Molecular Glue Degraders using Proteomics Profiles, Molecular Fingerprints and Co-folding Models		  
9:30–9:50 AM Coffee Break Van Horne Foyer
11:15–1:00 PM Poster Setup Van Horne C
11:15–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing Van Horne C
2:30–4:30 PM Symposia Spotlight: Emerging Technologies and Approaches in Proximity Induction Van Horne A
  Hanna Budayeva †, Genentech, Inc.
Broadening the CRBN Molecular Glue Degrader Target Space Through Unbiased Proteomic Profiling		  
  Simon P Shen †, Harvard
A Novel Combinatorial Screening Platform Decodes the Chemical-Genetic Landscape of Molecular Glue-Neosubstrate Interactions		  
  Evan T Judd †, Novartis
Discovery of Pan-GATA Molecular Glues for Targeted Transcription Factor Degradation		  
  Matthew Maitland †, University of Toronto
Deconstructing Degraders with New BioID-Based Tools		  
  Karolina Krygier †, McMaster University
Covalent Stabilization of Ternary Complexes for Cell-Cell 'Induced Proximity”		  
  Skye Montoya †, Yale
Targeting Oncogenic Transcription Effectors: A RIPTAC for Dual BCL6-BRD4 Inhibition in Lymphoma		  
  Matthew Robers †, Promega Corporation
Dissecting Molecular Glue Cooperativity at Biomolecular Complexes in Cells with BRETTSA		  
4:30–5:00 PM Coffee Available Van Horne Foyer
5:00–7:00 PM Novel Induced Proximity based Approaches Van Horne A
  Amit Choudhary, Harvard Medical School
Proximity-Inducing Molecules for Protein Editing		  
  Gerald R. Crabtree, Stanford University
Hijacking the Hijackers: TCIPs for Rewiring Oncogenic Circuits to Cell Death		  
  Elena De Vita, Queen Mary University of London
Targeted Protein Dephosphorylation vial PHOSTACs		  
  Eric Bilotta †, The Scripps Research Institute
Short Talk: Rewiring DNA Repair with PARP-Based Chemical Inducers of Proximity		  
7:00–8:00 PM Social Hour with Dinner President's Hall
7:30–10:00 PM Poster Session 1 Van Horne C
Wednesday, February 25, 2026
7:00–8:00 AM Breakfast President's Hall
8:00–11:00 AM Leveraging Novel Protein Degradation Machinery for Next Generation Protein Degraders Van Horne A
  Cheryl Arrowsmith, University of Toronto
Increasing the Repertoire of Chemically Recruitable E3 Ligases for Targeted Protein Degradation		  
  Gwenn M Hansen, Nurix Therapeutics
Enabling Novel Ligases for Targeted Protein Degradation through DEL based Approaches		  
  Daniel K Nomura, University of California, Berkeley
Enabling Novel Ligases		  
  Simon Glerup †, Aarhus University
Short Talk: Reshaping the Progranulin/Sortilin Interaction for Targeted Degradation of Extracellular Proteins		  
  Gina Gotthardt †, Goethe University Frankfurt
Short Talk: Targeted Degradation of E3 Ligase Functions in Acute Myeloid Leukemia		  
  Lucie Wolf †, University of Toronto
Short Talk: Proteome-scale Induced Proximity Screens Reveal Kinase-dependent Targeted Protein Degradation of Oncogenic Beta-catenin		  
  Louise Modis †, Amphista Therapeutics
Short Talk: Expanding Targeted Glue Applications for Clinical Use by Recruiting Novel E3 Ligases		  
9:00–9:20 AM Coffee Break Van Horne Foyer
9:20–9:25 AM Award Recipient Acknowledgement Van Horne A
11:00–1:00 PM Poster Setup Van Horne C
11:00–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing Van Horne C
3:00–4:30 PM Career Roundtable (Joint) Van Horne B
4:30–5:00 PM Coffee Available Van Horne Foyer
5:00–7:00 PM Induced Proximity to Modulate Protein Complexes Van Horne A
  Katherine Kayser-Bricker, Halda Therapeutics
Regulated Induced Proximity Targeting Chimeras (RIPTACs)		  
  Michelle R. Arkin, University of California, San Francisco
Utilization of Stabilizers of Protein-Protein Interactions		  
  Jian Jin, Icahn School of Medicine at Mount Sinai
New Approaches to Target Undruggable Proteins		  
  Asad Taherbhoy, Foghorn Therapeutics
Novel Strategies of Targeting the Transcriptional Machinery for Degradation		  
7:00–8:00 PM Social Hour with Dinner President's Hall
7:30–10:00 PM Poster Session 2 Van Horne C
Thursday, February 26, 2026
7:00–8:00 AM Breakfast President's Hall
8:00–11:00 AM Clinical Progress in Induced Proximity Approaches Van Horne A
  Neil Bence, Bristol Myers Squibb
BMS Protein Degrader from Discovery to Clinical Development		  
  Paula O’Connor, Nurix Therapeutics
Advancing Novel Degraders to the Clinic (BTK and Beyond)		  
  Michael Feldman, Kymera Therapeutics
KT-621: First STAT6-Targeted Medicine in Clinical Development		  
  Sheryl Gough, Arvinas Inc
The PROTAC Mode of Action Makes Therapeutic Targeting of BCL6 Possible		  
  Soraya Carrancio †, BMS
Short Talk: CK1α Degradation Unlocks p53 Activation and Pathway Rewiring in HR-MDS and AML: Translational and Clinical Evidence for BMS-986397		  
9:00–9:20 AM Coffee Break Van Horne Foyer
11:00–5:00 PM On Own for Lunch
2:30–4:30 PM Panel Discussion: Driving Innovation: From Concept to Company, how to Start a Company around a New Idea Van Horne A
4:30–5:00 PM Coffee Available Van Horne Foyer
5:00–6:45 PM Enabling Discovery and Development of Novel Induced Proximity Molecules and Glues Van Horne A
  Georg E. Winter, CeMM Research Center for Molecular Medicine
Novel Glue Discovery via Isogenic Morphological Profiling		  
  Alessio Ciulli, University of Dundee, School of Life Sciences
Expanding the Target Space of Protein Degraders		  
  Lauren V Albrecht, University of California Irvine
MrTAC: Proximity Induced Methylation and Lysosomal Degradation		  
  Takamitsu Hattori †, University Health Network
Short Talk: Creating Cancer-Specific Neoantigens with Covalent Inhibitors and Targeting Them with Bispecific T-cell Engagers		  
6:45–7:00 PM Meeting Wrap-Up: Outcomes and Future Directions Van Horne A
7:00–8:00 PM Social Hour with Dinner President's Hall
8:30–9:30 PM Entertainment President's Hall
Friday, February 27, 2026
12:00–11:59 PM Departure