Proximity Based Biology and Therapeutics: Targeted Protein Degradation and Beyond (K6)
February 23-26, 2026  | Fairmont Banff Springs, Banff, AB, Canada
Neil Bence, Cheryl Arrowsmith and Amit Choudhary
Scholarship Deadline: Nov. 26, 2025 | Abstract Deadline: Feb. 3, 2026 | Early Registration Deadline: Dec. 30, 2025
* Session Chair † Invited but not yet accepted | Program current as of February 25, 2026 2 AM | For the most up-to-date details, visit https://www.keystonesymposia.org
Monday, February 23, 2026
4:00–8:00 PM Registration Van Horne Foyer
6:00–8:00 PM Welcome Mixer Van Horne Foyer
Tuesday, February 24, 2026
7:00–8:00 AM Breakfast President's Hall
8:00–8:10 AM Welcome Remarks Van Horne A
  Cheryl Arrowsmith, University of Toronto
  
  Neil Bence, Bristol Myers Squibb
  
8:10–9:00 AM Keynote Address Van Horne A
  * Amit Choudhary, Harvard Medical School
Session Chair		  
  Ning Zheng, University of Washington
Stuck on You: The Omnipresence of Molecular Glues		  
9:00–11:15 AM Transformation of Drug Discovery and Induced Proximity through AI/ML Van Horne A
  * Michelle R. Arkin, University of California, San Francisco
Session Chair		  
  Nicholas F. Polizzi, Dana-Farber Cancer Institute
Designing Biosensors from Scratch Using Principles of Induced Proximity		  
  Ryan Potts, Amgen
Reprogramming Biology through Induced Proximity		  
  Mikko Taipale, University of Toronto
Navigating the Proteome with Induced Proximity		  
  Björn Schwalb, NEOsphere Biotechnologies GmbH
Short Talk: AI/ML-based Prediction of Molecular Glue Degraders using Proteomics Profiles and Molecular Fingerprints		  
9:30–9:50 AM Coffee Break Van Horne Foyer
11:15–12:15 PM Meet the Editors (Joint) Van Horne B
  Bekky Feltham, Walter and Eliza Hall Institute of Medical Research
*Session Chair		  
  Hartmut C Vodermaier, The EMBO Journal
Senior Editor		  
  Katie Pickup, The Company of Biologists
Reviews Editor		  
  Heather Bisbee, Cell Press
Scientific Editor – Molecular Cell 		  
11:15–1:00 PM Poster Setup Van Horne C
11:15–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing Van Horne C
2:30–4:30 PM Symposia Spotlight: Emerging Technologies and Approaches in Proximity Induction Van Horne A
  * Karishma Kailass, Brigham & Women's Hospital
Session Chair		  
  Evan T Judd, Novartis
Remote Presentation: Discovery of Pan-GATA Molecular Glues for Targeted Transcription Factor Degradation		  
  Hanna Budayeva, Genentech, Inc.
Broadening the CRBN Molecular Glue Degrader Target Space Through Unbiased Proteomic Profiling		  
  Simon P Shen, Harvard
A Novel Combinatorial Screening Platform Decodes the Chemical-Genetic Landscape of Molecular Glue-Neosubstrate Interactions		  
  Matthew Maitland, University of Toronto
Deconstructing Degraders with New BioID-Based Tools		  
  Karolina Krygier, McMaster University
Covalent Stabilization of Ternary Complexes for Cell-Cell 'Induced Proximity”		  
  Matthew Robers, Promega Corporation
Dissecting Molecular Glue Cooperativity at Biomolecular Complexes in Cells with BRETTSA		  
4:30–5:00 PM Coffee Available Van Horne Foyer
5:00–6:45 PM Novel Induced Proximity based Approaches Van Horne A
  * Mikko Taipale, University of Toronto
Session Chair		  
  Amit Choudhary, Harvard Medical School
Proximity-Inducing Molecules for Protein Editing		  
  Gerald R. Crabtree, Stanford University
Hijacking the Hijackers: TCIPs for Rewiring Oncogenic Circuits to Cell Death		  
  Elena De Vita, Queen Mary University of London
Targeted Protein Dephosphorylation vial PHOSTACs		  
  Eric Bilotta, The Scripps Research Institute
Short Talk: Rewiring DNA Repair with PARP-Based Chemical Inducers of Proximity		  
7:00–8:00 PM Social Hour with Dinner President's Hall
7:05–8:05 PM Women in Science Networking Event Van Horne B
  * Brenda A Schulman, Max Planck Institute of Biochemistry
  
  * Ingrid E Wertz, Lyterian Therapeutics
  
  * Michelle R. Arkin, University of California, San Francisco
  
  * Elena De Vita, Queen Mary University of London
  
  * Jennifer Kong, University of Washington
  
  * Soraya Carrancio, BMS
  
  * Emma C Fink, Dana Farber Cancer Institute
  
  * Susan Shao, Harvard Medical School
  
  * Yifat Merbl, Weizmann Institute of Science
  
7:30–10:00 PM Poster Session 1 Van Horne C
Wednesday, February 25, 2026
7:00–8:00 AM Breakfast President's Hall
8:00–11:00 AM Leveraging Novel Protein Degradation Machinery for Next Generation Protein Degraders Van Horne A
  * Cheryl Arrowsmith, University of Toronto
Increasing the Repertoire of Chemically Recruitable E3 Ligases for Targeted Protein Degradation		  
  Gwenn M Hansen, Nurix Therapeutics
Expanding Access to E3 Ligase Effectors for Induced Proximity Applications Using DEL-AI Foundation Models		  
  Daniel K Nomura, University of California, Berkeley
Enabling Novel Ligases		  
  Simon Glerup, Aarhus University
Short Talk: Reshaping the Progranulin/Sortilin Interaction for Targeted Degradation of Extracellular Proteins		  
  Gina Gotthardt, Goethe University Frankfurt
Short Talk: Targeted Degradation of E3 Ligase Functions in Acute Myeloid Leukemia		  
  Lucie Wolf, University of Toronto
Short Talk: Proteome-scale Induced Proximity Screens Reveal Kinase-dependent Targeted Protein Degradation of Oncogenic Beta-catenin		  
  Louise Modis, Amphista Therapeutics
Short Talk: Expanding Targeted Glue Applications for Clinical Use by Recruiting Novel E3 Ligases		  
9:00–9:20 AM Coffee Break Van Horne Foyer
9:20–9:25 AM Award Recipient Acknowledgement Van Horne A
11:00–1:00 PM Poster Setup Van Horne C
11:00–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing Van Horne C
3:00–4:30 PM Career Roundtable (Joint) Van Horne B
  Nicholas F. Polizzi, Dana-Farber Cancer Institute
Assistant Professor		  
  Simon Glerup, Aarhus University
Associate Professor		  
  Antonia Lopez-Girona, Bristol Myers Squibb
Executive Director | Discovery Oncology		  
  Heather Bisbee, Cell Press
Scientific Editor – Molecular Cell 		  
4:30–5:00 PM Coffee Available Van Horne Foyer
5:00–7:00 PM Induced Proximity to Modulate Protein Complexes Van Horne A
  * Georg E. Winter, CeMM Research Center for Molecular Medicine
Session Chair		  
  Katherine Kayser-Bricker, Halda Therapeutics
Remote Presentation: Regulated Induced Proximity Targeting Chimeras (RIPTACs): A Novel, Powerful Modality to Treat Cancer and Other Diseases		  
  Michelle R. Arkin, University of California, San Francisco
Utilization of Stabilizers of Protein-Protein Interactions		  
  Jian Jin, Icahn School of Medicine at Mount Sinai
New Approaches to Target Undruggable Proteins		  
  Asad Taherbhoy, Foghorn Therapeutics
Rewiring Transcription via Induced Proximity		  
7:00–8:00 PM Social Hour with Dinner President's Hall
7:30–10:00 PM Poster Session 2 Van Horne C
Thursday, February 26, 2026
7:00–8:00 AM Breakfast President's Hall
8:00–11:00 AM Clinical Progress in Induced Proximity Approaches Van Horne A
  * Lauren V Albrecht, University of California Irvine
Session Chair		  
  Neil Bence, Bristol Myers Squibb
BMS Protein Degrader from Discovery to Clinical Development		  
  Paula O’Connor, Nurix Therapeutics
Advancing Novel Degraders to the Clinic (BTK and Beyond)		  
  Michael Feldman, Kymera Therapeutics
KT-621: First STAT6-Targeted Medicine in Clinical Development		  
  Sheryl Gough, Arvinas Inc
The PROTAC Mode of Action Makes Therapeutic Targeting of BCL6 Possible		  
  Soraya Carrancio, BMS
Short Talk: CK1α Degradation Unlocks p53 Activation and Pathway Rewiring in HR-MDS and AML: Translational and Clinical Evidence for BMS-986397		  
9:00–9:20 AM Coffee Break Van Horne Foyer
11:00–5:00 PM On Own for Lunch
4:30–5:00 PM Coffee Available Van Horne Foyer
5:00–6:45 PM Enabling Discovery and Development of Novel Induced Proximity Molecules and Glues Van Horne A
  * Ryan Potts, Amgen
Session Chair		  
  Georg E. Winter, CeMM Research Center for Molecular Medicine
Novel Glue Discovery via Isogenic Morphological Profiling		  
  Alessio Ciulli, University of Dundee, School of Life Sciences
Expanding the Target Space of Protein Degraders		  
  Lauren V Albrecht, University of California Irvine
MrTAC: Proximity Induced Methylation and Lysosomal Degradation		  
  Takamitsu Hattori, University Health Network
Short Talk: Creating Cancer-Specific Neoantigens with Covalent Inhibitors and Targeting Them with Bispecific T-cell Engagers		  
6:45–7:00 PM Meeting Wrap-Up: Outcomes and Future Directions Van Horne A
  Neil Bence, Bristol Myers Squibb
  
7:00–8:00 PM Social Hour with Dinner President's Hall
8:30–9:30 PM Entertainment President's Hall
Friday, February 27, 2026
12:00–11:59 PM Departure