Antibodies as Drugs: Evolving Designs, Formats and Approaches (K7)
February 22-25, 2027  | Fairmont Banff Springs, Banff, AB, Canada
James E Crowe, Jr., Lisa Purcell and Jonah Rainey
* Session Chair † Invited but not yet accepted | Program current as of October 8, 2025 6 PM | For the most up-to-date details, visit https://www.keystonesymposia.org
Friday, January 1, 2027
4:00–8:00 PM Registration
6:00–8:00 PM Welcome Mixer
Saturday, January 2, 2027
7:00–8:00 AM Breakfast
8:00–9:00 AM Welcome and Keynote Address (Joint)
  James Zou †, Stanford University
The Virtual Lab
 
9:00–11:15 AM Drug Design and Preclinical Development: Stimulating Therapeutics and Translation (Joint)
  Dean Ho †, National University of Singapore
Simulating First-in-Human Dosing Studies in Oncology
 
  Regina Barzilay †, Massachusetts Institute of Technology
ML for Drug Discovery and Oncology Success Stories
 
  Philip Kim †, University of Toronto
Computation and Artificial Intelligence-Based Methods for Better Antibody Development
 
  Mohamed Shahin †, Pfizer
Modeling and Simulations Meet AI for Clinical Pharmacology
 
  Short Talk(s) Chosen from Abstracts
 
9:30–9:50 AM Coffee Break
11:15–1:00 PM Poster Setup
11:15–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing
2:30–4:30 PM Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available
5:00–7:00 PM Bispecific Antibodies for Co-Engagement and Co-Stimulation
  Shelley Force Aldred †, Rondo Therapeutics
Co-Stimulatory Bispecifics
 
  Koorosh Korfi †, Roche
CD28 and 4-1BB Costimulation in Combination Therapies
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM Social Hour with Dinner
7:30–10:00 PM Posters
Sunday, January 3, 2027
7:00–8:00 AM Breakfast
8:00–11:00 AM New Dosing and Use Paradigms for Multispecific Antibodies
  Ton M. Logtenberg †, Gyes B.V./Olethros
Deep-Depletion of Tissue-Resident Pathogenic Immune Cells
 
  Yvonne Y. Chen †, University of California, Los Angeles
Bispecific Logic-Gated CAR-T Cells
 
  Nina Weisser †, Zymeworks BC Inc.
Trispecific T-Cell Engagers
 
  Peyton Greenside †, BigHat Biosciences
TCE for Diverse Targets
 
  Jonah Rainey, Lilly
Talk Title to be Announced
 
  Short Talk(s) Chosen from Abstracts
 
9:00–9:20 AM Coffee Break
11:00–1:00 PM Poster Setup
11:00–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing
3:00–4:30 PM Career Roundtable
4:30–5:00 PM Coffee Available
5:00–6:30 PM Conditionally and Selectively Active Antibodies
  Dario A Gutierrez †, Merida Biosciences
Selective Binding and Clearance of Pathogenic Antibodies
 
  Cathy Chang †, BioAlta, LLC.
Protein-Associated Chemical Switches for Conditionally Active Biologics
 
  Short Talk(s) Chosen from Abstracts
 
6:30–7:00 PM Panel Discussion 1: The Cutting-Edge of Antibody Engagement
7:00–8:00 PM Social Hour with Dinner
7:30–10:00 PM Posters
Monday, January 4, 2027
7:00–8:00 AM Breakfast
8:00–11:00 AM Application of Innovations to Exogenous Antibody Targets to Expand Breadth and Efficacy
  David Veesler †, University of Washington
Antibody Inhibition of Activation Mechanisms of Coronavirus Spike
 
  Michael S. Diamond †, Washington University School of Medicine
Novel Antibody Modalities to Alphaviruses
 
  James E Crowe, Jr., Vanderbilt University Medical Center
Talk Title to be Announced
 
  Lisa Purcell, Third Rock Ventures
Novel Structure-Guided Functional Improvement of Antibody Breadth and Potency
 
  Short Talk(s) Chosen from Abstracts
 
9:00–9:20 AM Coffee Break
11:00–5:00 PM On Own for Lunch
2:30–4:30 PM Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available
5:00–6:30 PM Novel Scaffolds and Immunoconjugates
  Bradley Pentelute †, Massachusetts Institute of Technology
Efficient Drug Delivery through Selective Modification of Proteins
 
  Pawel Stocki †, Ossianix
Brain Shuttles for Targeted Delivery
 
  Jason Laliberte †, AstraZeneca
VHH-Based Antibodies for Broad Influenza Targeting
 
  Short Talk(s) Chosen from Abstracts
 
6:30–7:00 PM Panel Discussion 2: How Far Is Too Far: Target Engagement, Computational Design and New Scaffolds
6:45–7:00 PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
7:00–8:00 PM Social Hour with Dinner
8:00–11:00 PM Entertainment
8:00–11:00 PM Cash Bar
Tuesday, January 5, 2027
12:00–11:59 PM Departure