Precision Genome Engineering: From Basic Mechanisms to Application (L1)
March 9-12, 2026
| Fairmont Banff Springs, Banff, AB, Canada
Jonathan S. Weissman, Cecilia Cotta-Ramusino and Joseph Bondy-Denomy
Scholarship Deadline: Nov. 21, 2025 | Abstract Deadline: Feb. 18, 2026 | Early Registration Deadline: Jan. 9, 2026
| 4:00–8:00 PM |
Registration |
Van Horne Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
Van Horne Foyer |
| 7:00–8:00 AM |
Breakfast |
President's Hall |
| 8:00–8:10 AM |
Welcome Remarks (Joint) |
Van Horne A/B |
| 8:10–9:00 AM |
Keynote Session (Joint) |
Van Horne A/B |
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Jennifer A. Doudna, HHMI/University of California, Berkeley
CRISPR Enzyme Evolution and Applications |
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| 9:00–11:00 AM |
Delivery (Joint) |
Van Horne A/B |
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Daniel J. Siegwart, University of Texas Southwestern Medical Center
New LNP Modalities for Target Lung, Heart and Other Tissues |
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Michael A. Fischbach, Stanford University
Engineered Viral-Like Particle for Targeted Delivery of Gene Editors |
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Leah R Sabin, Regeneron Pharmaceuticals
Antibody-AAV Targeting: Fundamental Principle Behind Achieving BBB Crossing |
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| 9:30–9:50 AM |
Coffee Break |
Van Horne Foyer |
| 9:50–9:55 AM |
Award Recipient Acknowledgement |
Van Horne A/B |
| 11:00–1:00 PM |
Poster Setup |
Van Horne C |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Van Horne C |
| 2:30–4:30 PM |
Symposia Spotlight 1: Screening and Delivery |
Van Horne A |
| |
Clare Cahir, The Rockefeller University
Cap1 Forms a Cyclic Tetra-adenylate-induced Membrane Pore during the Type III-A CRISPR-Cas Immune Response |
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Chris J Frangieh, Columbia University Medical Center
Resolving Ambiguity from Variants of Uncertain Significance by Linking Variants, Phenotype, and Allele-specific Expression Bias in Inborn Errors of Immunity |
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Bria Macklin †, Gladstone Institutes
Mutation Agnostic CRISPR Therapeutics to Treat Dominant Neurodegenerative Disease |
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Bushra Raj, University of Pennsylvania
High throughput in vivo Mapping of Signaling Histories with CRISPR Barcodes |
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Shengdar Q Tsai, St. Jude Children's Research Hospital
High-throughput Biochemical and Cellular Approaches towards Developing a CRISPR Therapeutic Genome Editing Platform |
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Christopher Baehr, UC Berkeley
Chemically Modified CRISPR Enzymes for Multi-organ Genome Editing in vivo |
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Wayne Ngo, University of California, Berkeley
Amplifying Editing Efficiencies by Making Genome Editing Vesicles in the Body |
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Wells Burrell, New York Genome Center
Rational Design of Synthetic Proteins Using a Genome-Scale CRISPR Screen |
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| 4:30–5:00 PM |
Coffee Available |
Van Horne Foyer |
| 5:00–7:00 PM |
New Editing Modality |
Van Horne A |
| |
Samuel H Sternberg, Columbia University
CRISPR Guided Transposons |
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Cecilia Cotta-Ramusino, Tessera Therapeutics
Discovery and Application of New Gene Editing Modalities to Treat Disease |
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Erik J Sontheimer †, University of Massachusetts Medical School
Short Talk: Prime Assembly with Linear DNA Donors Enables Large Genomic Insertions |
|
| 7:00–8:00 PM |
Social Hour with Dinner |
President's Hall |
| 7:30–10:00 PM |
Poster Session 1 |
Van Horne C |
Wednesday, March 11, 2026
| 7:00–8:00 AM |
Breakfast |
President's Hall |
| 8:00–11:00 AM |
Understanding and Therapeutic Application of CRISPR |
Van Horne A |
| |
Emma Wang, YolTech Therapeutics
Design of Therapeutic Editors Aided by AI and High Throughput Approaches |
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Xiao Wang, University of Pennsylvania
Developing Bespoke Gene Editing Treatments for Patients with Carbamoyl Phosphate Synthetase 1 (CPS1) Deficiency in Real Time: Successes and Challenges |
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Britt Adamson, Princeton University
DNA Damage Response and CRISPR |
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Benjamin P. Kleinstiver, Massachusetts General Hospital
Engineered Technologies for Modifying Single Bases to Several Kilobases |
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Gerald Schwank, University Zurich
Short Talk: Rescue of Monogenic Obesity by In Vivo Base and Prime Editing in the Brain |
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Dowoon Gu †, Korea University
Short Talk: Combination of Abasic Substitution and Extension in Guide RNA Inherently Harness Fidelity of SpCas9 for Genome Editing |
|
| 9:00–9:20 AM |
Coffee Break |
Van Horne Foyer |
| 11:00–1:00 PM |
Poster Setup |
Van Horne C |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Van Horne C |
| 3:00–4:30 PM |
Career Roundtable (Joint) |
Van Horne B |
| 4:30–5:00 PM |
Coffee Available |
Van Horne Foyer |
| 5:00–7:00 PM |
Intersection of Gene Editing High Throughput Screening and Machine Learning |
Van Horne A |
| |
Hyongbum Henry Kim, Yonsei University College of Medicine
Experimental and Machine Learning Approaches to Create New Genome Editing Tools |
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Jonathan S. Weissman, Whitehead Institute, HHMI, and MIT
In vivo Multiple Modal Information-Rich CRISPR Screens |
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Randall J. Platt, ETH Zurich
Functional Genomic Approaches |
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Charles Gersbach, Duke University
Short Talk: Cell Reprogramming by CRISPR-based Activation of Endogenous Master Transcription Factors |
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Noa Oded Elkayam, EmendoBio
Short Talk: AI-Enhanced Optimization of OMNI Nucleases Expands the CRISPR Toolbox for Therapeutic Applications |
|
| 7:00–8:00 PM |
Social Hour with Dinner |
President's Hall |
| 7:30–10:00 PM |
Poster Session 2 |
Van Horne C |
| 7:00–8:00 AM |
Breakfast |
President's Hall |
| 8:00–11:00 AM |
Therapeutic Application |
Van Horne A |
| |
Jennifer Gori, Prime Medicine, Inc.
Application of Prime Editing to Treat Disease |
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Haihua Chu, Beam Therapeutics
Unlocking the Potential of base Edited HSCs for Therapeutic Applications with Epitope Engineering |
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Laura Sepp-Lorenzino, Intellia Therapeutics
TTR Therapies |
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Luigi M Naldini, San Raffaele Telethon Institute for Gene Therapy
Gene Editing: Therapeutics and Genotoxicity |
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X. Shawn Liu, Columbia University Medical Center
Short Talk: Epigenetic Silencing of Pathological Allele in Inborn Errors Immunity by CRISPR-IMPRINT |
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Sarah Pierce, Broad Institute
Short Talk: Prime Editing-installed Suppressor tRNAs for Disease-Agnostic Genome Editing |
|
| 9:00–9:20 AM |
Coffee Break |
Van Horne Foyer |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 2:30–4:30 PM |
Symposia Spotlight 2: New Editing Modality and Therapeutics |
Van Horne A |
| |
Shirley P Chia, National University of Singapore
Variant-By-Variant Activity Profiling Reprograms A CRISPR-Associated Transposon Towards Precise DNA Insertion |
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Phoebe A Rice, University of Chicago
Structural Basis for Directionality of Large Serine Integrases |
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Sébastien Levesque, Boston Children's Hospital - Harvard Medical School
In Cellulo DNA Assembly for Targeted Genomic Integration and Rearrangement in Human Cells |
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Shannon M Miller, Scripps Research
Programmable CRISPR-free gene insertion |
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Holt A Sakai, Broad Institute
Directed Evolution of Small RNA-stabilizing Motifs that Improve Prime Editing |
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Lilly van de Venn, ETH Zurich
AutoDISCO Enables Sensitive and High-throughput CRISPR/Cas Off-target Detection in Cells and Organisms |
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Kah Min Yap, Peter MacCallum Cancer Centre
Rewiring Endogenous Genes in CAR T Cells for Tumour-Restricted Payload Delivery |
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Aditya V Ansodaria, UMass Chan Medical School
Enhancing the Efficacy and Purity of Prime Editing using Chemically Modified Editing Templates and Modification-Tolerant Polymerases |
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| 4:30–5:00 PM |
Coffee Available |
Van Horne Foyer |
| 5:00–6:45 PM |
CRISPR Biology |
Van Horne A |
| |
Joseph Bondy-Denomy, University of California, San Francisco
AntiCRISPR Phage Defense Against CRISPR Systems |
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Mitchell R. O'Connell, University of Rochester Medical Center
Pulling the Plug on Bacteriophage Infection: The Pore Behavior of CRISPR and Anti-phage Defense Associated Membrane Proteins |
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Elizabeth Kellogg, St. Jude Children's Research Hospital
Mechanism of Programmable Transposases |
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Kazuo Nakamura, Gladstone Institutes
Short Talk: Phage Defense and Genome Editing using Novel Retrons Sourced from Isolated Environmental Bacteria |
|
| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions |
Van Horne A |
| 7:00–8:00 PM |
Social Hour with Dinner |
President's Hall |
| 8:00–11:00 PM |
Entertainment |
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