Precision Genome Engineering: From Basic Mechanisms to Application (L1)
March 9-12, 2026  | Fairmont Banff Springs, Banff, AB, Canada
Jonathan S. Weissman, Cecilia Cotta-Ramusino and Joseph Bondy-Denomy
Scholarship Deadline: Nov. 7, 2025 | Abstract Deadline: Feb. 18, 2026 | Early Registration Deadline: Jan. 9, 2026
* Session Chair † Invited but not yet accepted | Program current as of August 23, 2025 4 AM | For the most up-to-date details, visit https://www.keystonesymposia.org
Monday, March 9, 2026
4:00–8:00 PM Registration Van Horne Foyer
6:00–8:00 PM Welcome Mixer Van Horne Foyer
Tuesday, March 10, 2026
7:00–8:00 AM Breakfast President's Hall
8:00–9:00 AM Welcome and Keynote Session (Joint) Van Horne A/B
  Jennifer A. Doudna, HHMI/University of California, Berkeley
CRISPR Enzyme Evolution and Applications
 
9:00–11:15 AM Delivery (Joint) Van Horne A/B
  Daniel J. Siegwart, University of Texas Southwestern Medical Center
New LNP Modalities for Target Lung, Heart and Other Tissues
 
  Michael A. Fischbach, Stanford University
Engineered Viral-Like Particle for Targeted Delivery of Gene Editors
 
  Leah R. Sabin, Regeneron Pharmaceuticals
Antibody-AAV Targeting: Fundamental Principle Behind Achieving BBB Crossing
 
  Short Talk(s) Chosen from Abstracts
 
9:30–9:50 AM Coffee Break Van Horne Foyer
11:15–1:00 PM Poster Setup Van Horne C
11:15–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing Van Horne C
2:30–4:30 PM Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions Van Horne A
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available Van Horne Foyer
5:00–7:00 PM New Editing Modality Van Horne A
  Samuel H Sternberg, Columbia University
CRISPR Guided Transposons
 
  Patrick D. Hsu, Arc Institute | University of California, Berkeley
Bridge RNA-Directed Programmable Recombination
 
  Cecilia Cotta-Ramusino, Tessera Therapeutics
Discovery and Application of New Gene Editing Modalities to Treat Disease
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM Social Hour with Dinner President's Hall
7:30–10:00 PM Poster Session 1 Van Horne C
Wednesday, March 11, 2026
7:00–8:00 AM Breakfast President's Hall
8:00–11:00 AM Understanding and Therapeutic Application of CRISPR Van Horne A
  Emma Wang, YolTech Therapeutics
Design of Therapeutic Editors Aided by AI and High Throughput Approaches
 
  Xiao Wang, University of Pennsylvania
Developing Bespoke Gene Editing Treatments for Patients with Carbamoyl Phosphate Synthetase 1 (CPS1) Deficiency in Real Time: Successes and Challenges
 
  Britt Adamson, Princeton University
DNA Damage Response and CRISPR
 
  Speaker to be Announced
 
  Short Talk(s) Chosen from Abstracts
 
9:00–9:20 AM Coffee Break Van Horne Foyer
11:00–1:00 PM Poster Setup Van Horne C
11:00–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing Van Horne C
3:00–4:30 PM Career Roundtable (Joint) Van Horne B
4:30–5:00 PM Coffee Available Van Horne Foyer
5:00–7:00 PM Intersection of Gene Editing High Throughput Screening and Machine Learning Van Horne A
  Hyongbum Henry Kim, Yonsei University College of Medicine
Experimental and Machine Learning Approaches to Create New Genome Editing Tools
 
  Jonathan S. Weissman, Whitehead Institute, HHMI, and MIT
In vivo Multiple Modal Information-Rich CRISPR Screens
 
  Randall J. Platt, ETH Zurich
Functional Genomic Approaches
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM Social Hour with Dinner President's Hall
7:30–10:00 PM Poster Session 2 Van Horne C
Thursday, March 12, 2026
7:00–8:00 AM Breakfast President's Hall
8:00–11:00 AM Therapeutic Application Van Horne A
  Jennifer Gori, Prime Medicine, Inc.
Application of Prime Editing to Treat Disease
 
  Haihua Chu, Beam Therapeutics
Unlocking the Potential of base Edited HSCs for Therapeutic Applications with Epitope Engineering
 
  Laura Sepp-Lorenzino, Intellia Therapeutics
TTR Therapies
 
  Luigi M. Naldini, San Raffaele Telethon Institute for Gene Therapy
Gene Editing: Therapeutics and Genotoxicity
 
  Short Talk(s) Chosen from Abstracts
 
9:00–9:20 AM Coffee Break Van Horne Foyer
11:00–5:00 PM On Own for Lunch
2:30–4:30 PM Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions Van Horne A
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available Van Horne Foyer
5:00–6:45 PM CRISPR Biology Van Horne A
  Joseph Bondy-Denomy, University of California, San Francisco
AntiCRISPR Phage Defense Against CRISPR Systems
 
  Speaker to be Announced
 
  Elizabeth Kellogg, St. Jude Children's Research Hospital
Mechanism of Programmable Transposases
 
  Short Talk(s) Chosen from Abstracts
 
6:45–7:00 PM Meeting Wrap-Up: Outcomes and Future Directions Van Horne A
7:00–8:00 PM Social Hour with Dinner President's Hall
8:00–11:00 PM Cash Bar
8:00–11:00 PM Entertainment
Friday, March 13, 2026
12:00–11:59 PM Departure