Nucleic Acid Therapeutics and Targeted Delivery (L2)
March 9-12, 2026
| Fairmont Banff Springs, Banff, AB, Canada
Anastasia Khvorova, Eric Vallabh Minikel, Annemieke Aartsma-Rus and Holly Kordasiewicz
Scholarship Deadline: Nov. 21, 2025 | Abstract Deadline: Feb. 18, 2026 | Early Registration Deadline: Jan. 9, 2026
| 4:00–8:00 PM |
Registration |
Van Horne Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
Van Horne Foyer |
| 7:00–8:00 AM |
Breakfast |
President's Hall |
| 8:00–8:10 AM |
Welcome Remarks (Joint) |
Van Horne A/B |
| 8:10–9:00 AM |
Keynote Session (Joint) |
Van Horne A/B |
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Jennifer A. Doudna, HHMI/University of California, Berkeley
CRISPR Enzyme Evolution and Applications |
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| 9:00–11:00 AM |
Delivery (Joint) |
Van Horne A/B |
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Daniel J. Siegwart, University of Texas Southwestern Medical Center
LNP-SORT - Targeted Delivery Through Size and Charge |
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Michael A. Fischbach, Stanford University
Engineered Viral-Like Particle for Targeted Delivery of Gene Editors |
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Leah R Sabin, Regeneron Pharmaceuticals
Antibody-AAV Targeting: Fundamental Principle Behind Achieving BBB Crossing |
|
| 9:30–9:50 AM |
Coffee Break |
Van Horne Foyer |
| 9:50–9:55 AM |
Award Recipient Acknowledgement |
Van Horne A/B |
| 11:00–1:00 PM |
Poster Setup |
Van Horne C |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Van Horne C |
| 2:30–4:30 PM |
Symposia Spotlight 1 |
Van Horne B |
| |
Short Talks Chosen from Abstracts
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|
| 4:30–5:00 PM |
Coffee Available |
Van Horne Foyer |
| 5:00–7:00 PM |
Delivery Systems based on Conjugates, vs. Delivery Systems based on Particles Targeted Nucleic Acid Delivery |
Van Horne B |
| |
Anastasia Khvorova, University of Massachusetts Medical School
Barcoded Libraries for Targeted siRNA Delivery |
|
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Andrea L. Kasinski, Purdue University and LigamiR Therapeutics
Folate-miRNA Conjugates for Tumor Delivery |
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Steven F. Dowdy, University of California, San Diego
How to Tackle Endosomal Escape |
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Short Talk(s) Chosen from Abstracts
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|
| 7:00–8:00 PM |
Social Hour with Dinner |
President's Hall |
| 7:30–10:00 PM |
Poster Session 1 |
Van Horne C |
Wednesday, March 11, 2026
| 7:00–8:00 AM |
Breakfast |
President's Hall |
| 8:00–11:00 AM |
Distribution of RNA-based Drugs |
Van Horne B |
| |
Brendon E Cook, Biogen
Studying Oligonucleotide Distribution after Intrathecal Treatment using Imaging |
|
| |
Shalini Andersson, AstraZeneca R&D
Oligonucleotide Biodistribution after Systemic Treatment |
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Short Talk(s) Chosen from Abstracts
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|
| 9:00–9:20 AM |
Coffee Break |
Van Horne Foyer |
| 11:00–1:00 PM |
Poster Setup |
Van Horne C |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Van Horne C |
| 3:00–4:30 PM |
Career Roundtable (Joint) |
Van Horne B |
| 4:30–5:00 PM |
Coffee Available |
Van Horne Foyer |
| 5:00–7:00 PM |
New Approaches to Extrahepatic Delivery |
Van Horne B |
| |
Liqun Wang, Wyss Institute at Harvard University
Brain Delivery of Antibody-Oligonucleotide Conjugates for CNS Diseases |
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Holly Kordasiewicz, Ionis Pharmaceuticals
Extra Hepatic Delivery of Oligonucleotides |
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Scarlett Barker, Denali Therapeutics
Delivery of ASOs to the CNS using hTfR Antibodies |
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June Y Park, Cenos Therapeutics
Micellar RNAi Conjugates for Extrahepatic Delivery |
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| 7:00–8:00 PM |
Social Hour with Dinner |
President's Hall |
| 7:30–10:00 PM |
Poster Session 2 |
Van Horne C |
| 7:00–8:00 AM |
Breakfast |
President's Hall |
| 8:00–11:00 AM |
Nucleic Acid Chemistry, Structure, Mechanism, Potency |
Van Horne B |
| |
Ken Yamada, University of Massachusetts Chan Medical School
exNA and Ionizable Motifs Towards Next Generation RNA Therapeutics |
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Anna Marie Pyle, Yale University
Structural Exploration of RNA Drug Function |
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| |
Punit P. Seth, Alnylam Pharmaceuticals
Chemical Modifications of siRNA and ASOs |
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| |
Short Talk(s) Chosen from Abstracts
|
|
| 9:00–9:20 AM |
Coffee Break |
Van Horne Foyer |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 2:30–4:30 PM |
Symposia Spotlight 2 |
Van Horne B |
| |
Short Talks Chosen from Abstracts
|
|
| 4:30–5:00 PM |
Coffee Available |
Van Horne Foyer |
| 5:00–7:00 PM |
Clinical Innovation in RNA-based Drug Development |
Van Horne B |
| |
Scott Schobel, VICO Therapeutics
ASO Development for Neurodegenerative Diseases |
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Annemieke Aartsma-Rus, Leiden University Medical Center
N-of1 based ASOs |
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Eric Vallabh Minikel, Broad Institute
Progress in PrP-Lowering Oligonucleotides for Prion Disease |
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Scott Johnson, Comanche
Developing RNA-based Drugs for Diseases of Pregnancy: The Preeclampsia Story |
|
| 7:00–7:15 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Van Horne B |
| 7:15–8:00 PM |
Social Hour with Dinner |
President's Hall |
| 8:00–11:00 PM |
Entertainment |
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