Somatic Mosaicism in Human Development, Aging, and Diseases (L3)
March 7-10, 2027
| Fairmont Hotel Vancouver, Vancouver, BC, Canada
Nuria Lopez-Bigas, Gilad Evrony and Young Seok Ju
| 4:00–8:00 PM |
Registration |
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| 6:00–8:00 PM |
Welcome Mixer |
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| 8:00–9:00 AM |
Welcome and Keynote Address (Joint) |
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Benjamin L. Ebert †, Dana-Farber Cancer Institute
Clonal Expansions in the Hematopoetic System in Health and Disease |
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| 9:00–11:15 AM |
Joint Session |
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Laura A. Johnston, Columbia University
Cell Competition as a Framework for Diverse Areas of Biology |
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Nuria Lopez-Bigas, IRB Barcelona
Somatic Mosaicism and its Association to Cancer Risk |
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Short Talk(s) Chosen from Abstracts
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| 9:30–9:50 AM |
Coffee Break |
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| 11:15–1:00 PM |
Poster Setup |
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| 11:15–5:00 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
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| 2:30–4:30 PM |
Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions |
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Short Talks Chosen from Abstracts
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–7:00 PM |
Development and Modeling of Somatic Mosaicism |
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Tim Coorens, European Molecular Biology Laboratory
Somatic Mosaicism in Healthy Tissues as a Window into Cancer Development |
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Young Seok Ju, Korea Advanced Institute of Science and Technology
Clonal Dynamics in Early Human Embryogenesis Inferred from Somatic Mutations and Epimutations |
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Joe Gleeson †, University of California, San Diego
Somatic Mosaicism in Brain Development |
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Short Talk(s) Chosen from Abstracts
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| 7:00–8:00 PM |
Social Hour with Dinner |
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| 8:00–11:00 AM |
Aging and Mechanisms of Somatic Mosaicism |
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Inigo Martincorena †, Wellcome Trust Sanger Institute
Large-Scale Profiling of Somatic Mutations as a New Epidemiologic Tool |
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Gilad Evrony, NYU Grossman School of Medicine
Modifiers and Determinants of Somatic Mutation Burdens and Patterns |
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Raheleh Rahbari, Wellcome Trust Sanger Institute
Aging-Related Germline Mutation and Selection |
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Seishi Ogawa †, Kyoto University
Somatic Mosaicism in Human Tissues Related to Aging and Disease |
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Short Talk(s) Chosen from Abstracts
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| 9:00–9:20 AM |
Coffee Break |
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| 11:00–1:00 PM |
Poster Setup |
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| 11:00–5:00 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
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| 3:00–4:30 PM |
Career Roundtable |
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–7:00 PM |
Technology and Tool Development |
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Kathleen H Burns, Dana Farber Cancer Institute | Harvard Medical School
Scalable Detection of Somatic Retrotransposition |
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Nicholas Navin †, University of Texas MD Anderson Cancer Center
High-Throughput Single-Cell Multi-Omic Profiling of Somatic Mutations and Cellular Phenotypes |
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Fei Chen †, Broad Institute of MIT and Harvard
High-Resolution Spatial Profiling of Somatic Mosaicism |
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Short Talk(s) Chosen from Abstracts
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| 7:00–8:00 PM |
Social Hour with Dinner |
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Wednesday, March 10, 2027
| 8:00–11:00 AM |
Somatic Mosaicism in the Clinic |
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Steven A. McCarroll, Harvard Medical School
The Ticking DNA Clock: How Lifelong Somatic Expansion of DNA Repeats Leads to Neurodegeneration |
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Mariona Graupera, Josep Carreras Leukaemia Research Institute
Somatic Mutations as the cause of Vascular Malformations in Humans |
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Jeong Ho Lee, Korea Advanced Institute of Science and Technology
Brain Somatic Mutations in MTOR as cause of Focal Epilepsy |
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Francesca Ciccarelli, Barts Cancer Institute
The Role of Somatic Mutations in Maintaining or Hindering Tissue Homeostasis |
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Short Talk(s) Chosen from Abstracts
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| 9:00–9:20 AM |
Coffee Break |
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| 11:00–5:00 PM |
On Own for Lunch |
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| 2:30–4:30 PM |
Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions |
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| |
Short Talks Chosen from Abstracts
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|
| 4:30–5:00 PM |
Coffee Available |
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| 5:00–6:45 PM |
Premalignancies, Cancer Initiation and Cancer Risk |
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Maria Alcolea, University of Cambridge
Tracing the Origin of Clonal Pathogenesis |
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Rosana Risques, University of Washington
Detecting Somatic Cancer Driver Mutations in Normal Bladder and Urine with Duplex Sequencing |
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Dan A. Landau, Weill Cornell Medicine
New Technology to Study Functional, Temporal and Spatial Features of Somatic Cell Evolution |
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Short Talk(s) Chosen from Abstracts
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| 6:00–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
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| 7:00–8:00 PM |
Social Hour with Dinner |
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| 8:00–11:00 PM |
Entertainment |
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