B and T Cell Collaboration in Lymphoid and Nonlymphoid Microenvironments (L4)
March 16-19, 2026
| Keystone Resort, Keystone, CO, United States
Stephanie C. Eisenbarth, Jason G. Cyster and Ziv Shulman
Scholarship Deadline: Nov. 14, 2025 | Abstract Deadline: Feb. 24, 2026 | Early Registration Deadline: Jan. 15, 2026
| 12:00–3:00 PM |
CU Anschutz Pre-Conference Workshop: Networking & Communication Skills (separate registration required) Learn more at: https://keysym.us/CUAnschutz26 |
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| 4:00–8:00 PM |
Registration |
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| 6:00–8:00 PM |
Welcome Mixer |
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| 8:00–8:10 AM |
Welcome Remarks (Joint) |
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| 8:10–9:00 AM |
Keynote Address (Joint) |
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Carola G. Vinuesa, Francis Crick Institute
Regulation of Humoral Immunity |
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| 9:00–11:30 AM |
Generation and Maintenance of Humoral Memory (Joint) |
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Kim Good-Jacobson, Monash University
Memory B Cells and Plasma Cells in Acute and Chronic Viral Infections |
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Taras Kreslavsky, Karolinska Institutet
The Multilayered Identity of B Cell Memory |
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Frances E. Lund, University of Alabama at Birmingham
Pathogen-Specific Memory B Cell Subsets and Antibody Production |
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Shane Crotty, La Jolla Institute for Immunology
Short Talk: Germline-Targeting Vaccine Elicits HIV Broadly Neutralizing Antibodies In Nonhuman Primates |
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Gowthaman Uthaman, University of Massachusetts Chan Medical School
Short Talk: Lymph Node ILC2s Drive Tfh13 Cell Differentiation and Anaphylactic IgE Responses |
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| 9:30–9:50 AM |
Coffee Break |
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| 11:30–1:00 PM |
Poster Setup |
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| 11:30–5:00 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
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| 1:15–2:15 PM |
Meet the Editors (Joint) |
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| 2:30–4:30 PM |
Symposia Spotlight 1 |
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Lauren A. Hesser, Eli Lilly & Company
Intestinal T-bet+ Plasmablasts Mediate Epithelial Barrier Dysfunction and Inflammatory Bowel Disease |
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Gabrielle R Berman, NYU Langone Health
Lymphatic Control of Germinal Centers in Settings of De Novo Formation and Chronic Activation |
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Youngnim Choi, Seoul National University
B cells Function as Innate Antigen-Presenting Cells through BCR-independent Bacterial Uptake |
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Prasanti Kotagiri, Monash University
B Cell Analysis with Multiplexed Antigen Panels Defines Determinants of Antibody Breadth in Human Vaccination and Infection |
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Seren Baygün †, Translatum
Hyperreactive B Cell-Induced T Cell Control Regulates Autoimmunity And Lymphomagenesis |
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Susana Cheetham †, The University of Alabama at Birmingham
Influenza-Specific Lung-Resident Memory B cells assist CD4 Recall Responses during Challenge Infections |
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Amalie Grenov †, Francis Crick Institute
Autoantibody Origins in Lupus and in Relapse Post CAR-T Therapy |
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Natalia Freund †, Tel Aviv University
Potent Neutralization by Antibodies Targeting the Mpox virus |
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–7:00 PM |
Canonical B Cell Immune Responses |
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Jason G. Cyster, HHMI/University of California, San Francisco
Guidance Factors and the B Cell Response |
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Teddy Yewdell, Genentech
Dysregulated Antibody Class Switching in Autoimmunity |
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Brian J Laidlaw, Washington University in St. Louis
Establishment of Lung-Resident Memory B Cells |
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Julia Merkenschlager, Harvard
Short Talk: Coupled Affinity Dynamics Between T Follicular Helper Cells and B Cells in the Germinal Cente |
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Vipul Shukla †, Northwestern University
Short Talk: Metabolic and Epigenetic Control Of Germinal Center B Cell Responses |
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| 7:00–8:00 PM |
Social Hour with Dinner |
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| 7:30–10:00 PM |
Poster Session 1 |
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Wednesday, March 18, 2026
| 8:00–11:00 AM |
Humoral Immunity in Mucosal Tissues |
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Stephanie C. Eisenbarth, Northwestern University Feinberg School of Medicine
Origins of IgA in the Gut |
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Mauro N. Gaya, Centre d’Immunologie de Marseille-Luminy
B Cell Instruction to Mucosal Antigens |
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Jagan R. Muppidi, NCI, National Institutes of Health
Tissue Specific Cues in the Pathogenesis of Germinal Center-Derived Malignancy |
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Maria A. Curotto de Lafaille, Icahn School of Medicine at Mount Sinai
IgE Responses |
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Danika L Hill, Monash University
Short Talk: Sugar-Coated Or Protein-Packed? How Antigen Type Shapes The B Cell Response To Mucosal Bacterial Infection In Humans |
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Jenna Guthmiller, University of Colorado SOM
Short Talk: Ectopic Germinal Centers In Human Nasal Mucosa Are Inductive Site For Local Humoral Immunity |
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| 9:00–9:20 AM |
Coffee Break |
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| 11:00–1:00 PM |
Poster Setup |
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| 11:00–5:00 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
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| 1:30–3:15 PM |
Panel Discussion: Defining B Cell Subsets (Joint) |
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Frances E. Lund, University of Alabama at Birmingham
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Nicole Baumgarth, Johns Hopkins Bloomberg School of Public Health
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Stephanie C. Eisenbarth, Northwestern University Feinberg School of Medicine
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Kim Good-Jacobson, Monash University
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Jason G. Cyster, HHMI/University of California, San Francisco
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Mark J. Shlomchik, University of Pittsburgh School of Medicine
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Ziv Shulman, Weizmann Institute
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|
| 3:30–4:30 PM |
Career Roundtable (Joint) |
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–7:00 PM |
Humoral Helpers (Joint) |
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Tri G Phan, Garvan Institute of Medical Research
B Cell-Macrophage Interactions in Immunity and Autoimmunity |
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Michelle A Linterman, Malaghan Institute of Medical Research
Instruction of Antibody Responses Over Time |
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Laura M Walker, Moderna
Vaccine Induced Antibody Responses |
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David R Fooksman, Albert Einstein College of Medicine
Short Talk: Investigating the Rrle of CD138 and APRIL in the Plasma Cell Survival And Dynamics In The Bone Marrow Niche |
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Di Yu, University of Queensland
Short Talk: Lipid Metabolism Drives Dietary Effects on Ferroptosis In Tfh Cells and Modulates Humoral Immunity |
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| 7:00–8:00 PM |
Social Hour with Dinner |
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| 7:30–10:00 PM |
Poster Session 2 |
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| 8:00–11:00 AM |
B-T Cell Interactions in Complex Microenvironments (Cancer, TLS, EF) |
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Ziv Shulman, Weizmann Institute
Germinal Centers in Atypical Locations |
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Tullia C. Bruno, University of Pittsburgh
Germinal Centers in Cancer Associated TLS |
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Steven H Kleinstein, Yale School of Medicine
Computational Frameworks to Understand T-B Cell Interactions |
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Jason Weinstein, Rutgers New Jersey Medical School
Specialized Tfh Cells Driving B Cell Differentiation |
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Joanna R Groom, Walter and Eliza Hall Institute of Medical Research
Short Talk: Cellular and Molecular Networks Driving the Formation and Maturation of Tumor-Associated Tertiary Lymphoid Structures |
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Alice O Kamphorst, Icahn School of Medicine at Mount Sinai
Short Talk: CD4-help and B Cells are Essential for Therapeutic Efficacy of PD-1 Targeted Therapy in Liver Cancer |
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| 9:00–9:20 AM |
Coffee Break |
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| 11:00–5:00 PM |
On Own for Lunch |
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| 2:30–4:30 PM |
Symposia Spotlight 2 |
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Hui Hu †, University of Alabama at Birmingham
A Novel Bidirectional Regulatory Mechanism Coordinating Systemic CXCR5– versus CXCR5+ CD4+ T Cell Differentiation |
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Joe Mackie, Children's Hospital of Philadelphia
SARS-COV2 Vaccine Responses in Patients with Inborn Errors of Cytokine Signaling |
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Ester Marina-Zarate, La Jolla Institute for Immunology
Highly Functional and Prolonged Germinal Center T Follicular Helper Cell Responses Are Associated with Enhanced Neutralizing Antibody Development |
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Dudley McNitt, Vanderbilt University Medical Center
T-B Lymphocyte Interactions Mediated by SLAM-Associated Protein (SAP) are Essential for Diabetes in Transgenic Anti-Insulin VH125SD.NOD Mice |
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Suzanna Rachimi, University of Pennsylvania
Determinants of Fate Progression Beyond the Human Tfh cell Stage |
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Hiroyuki Yoshitomi, Kyoto University
Peripheral Helper T Cells Go Beyond B-Cell Help In The Microenvironments Of Rheumatoid Arthritis |
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Scott Hale †, University of Utah
Dnmt3a-dependent De Novo DNA Methylation Enforces Lineage Commitment and Preserves Functionality of Memory Th1 and Tfh Cells |
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Junko Sawada, Johns Hopkins All Children's Hospital
Inducing Tertiary Lymphoid Structures: Insights into Potential Stromal Reprogramming |
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–6:45 PM |
Non-Canonical B Cell Immune Responses |
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Joseph E. Craft, Yale University
T Cell Instruction of Antibody Responses |
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Ian A Cockburn, Australian National University
Regulation of B Cell Responses in Complex Infections |
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Mark J. Shlomchik, University of Pittsburgh School of Medicine
B Cells in Autoimmunity |
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Christopher D Allen †, University of California, San Francisco
Short Talk: Regulation of IgE Switching by BCR Signaling and Cytokines |
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| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
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| 7:00–8:00 PM |
Social Hour with Dinner |
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| 8:00–11:00 PM |
Entertainment |
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