B and T Cell Collaboration in Lymphoid and Nonlymphoid Microenvironments (L4)
March 16-19, 2026
| Keystone Resort, Keystone, CO, United States
Stephanie C. Eisenbarth, Jason G Cyster and Ziv Shulman
Scholarship Deadline: Nov. 14, 2025 | Abstract Deadline: Feb. 24, 2026 | Early Registration Deadline: Jan. 15, 2026
| 12:00–3:00 PM |
CU Anschutz Pre-Conference Workshop: Networking & Communication Skills (separate registration required) Learn more at: https://keysym.us/CUAnschutz26 |
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| 4:00–8:00 PM |
Registration |
Longs Peak Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
Longs Peak Foyer |
| 7:00–8:00 AM |
Breakfast |
Shavano/Torreys/Red Cloud |
| 8:00–8:10 AM |
Welcome Remarks (Joint) |
Longs/Grays Peaks |
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* Kim Good-Jacobson, Monash University
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* Stephanie C. Eisenbarth, Northwestern University Feinberg School of Medicine
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| 8:10–9:00 AM |
Keynote Address (Joint) |
Longs/Grays Peaks |
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Carola G Vinuesa, Francis Crick Institute
Regulation of Humoral Immunity |
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| 9:00–11:30 AM |
Generation and Maintenance of Humoral Memory (Joint) |
Longs/Grays Peaks |
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* Chris Scharer, Emory University
Session Chair |
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* Neil D. Romberg, University of Pennsylvania
Session Chair |
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Taras Kreslavsky, Karolinska Institutet
Remote Presentation: The Multilayered Identity of B Cell Memory |
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Kim Good-Jacobson, Monash University
Memory B Cells and Plasma Cells in Acute and Chronic Viral Infections |
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Frances E. Lund, University of Alabama at Birmingham
IRF1: A Master Regulator of B Cell Fate Decisions in Chronic Inflammatory Disease |
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Konjit G Muleta, Lund University
Short Talk: Maternal Immunity Protects Offspring From Enteric Viral Infection Without Negatively Affecting Humoral Immune Memory |
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Gowthaman Uthaman, University of Massachusetts Chan Medical School
Short Talk: Lymph Node ILC2s Drive Tfh13 Cell Differentiation and Anaphylactic IgE Responses |
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| 9:30–9:50 AM |
Coffee Break |
Longs Peak Foyer |
| 9:50–9:55 AM |
Award Recipient Acknowledgement (Joint) |
Longs/Grays Peaks |
| 11:30–1:00 PM |
Poster Setup |
Shavano/Torreys/Red Cloud |
| 11:30–5:00 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
Shavano/Torreys/Red Cloud |
| 2:30–4:30 PM |
Symposia Spotlight 1 |
Grays Peak |
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* Tullia C. Bruno, University of Pittsburgh
Session Chair |
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* Brian J Laidlaw, Washington University in St. Louis
Session Chair |
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Lauren A. Hesser, Eli Lilly & Company
Intestinal T-bet+ Plasmablasts Mediate Epithelial Barrier Dysfunction and Inflammatory Bowel Disease |
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Gabrielle R Berman, NYU Langone Health
Lymphatic Control of Germinal Centers in Settings of De Novo Formation and Chronic Activation |
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Youngnim Choi, Seoul National University
B cells Function as Innate Antigen-Presenting Cells through BCR-independent Bacterial Uptake |
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Prasanti Kotagiri, Monash University
B Cell Analysis with Multiplexed Antigen Panels Defines Determinants of Antibody Breadth in Human Vaccination and Infection |
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Jinyi Tang, University of Virginia
Local Immune Networks Promote Respiratory IgA Responses After Mucosal Vaccination |
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Susana Cheetham, The University of Alabama at Birmingham
Influenza-Specific Lung-Resident Memory B cells assist CD4 Recall Responses during Challenge Infections |
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Amalie Grenov, Francis Crick Institute
Autoantibody Origins in Lupus and in Relapse Post CAR-T Therapy |
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Natalia Freund, Tel Aviv University
Potent Neutralization by Antibodies Targeting the Mpox virus |
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| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–7:00 PM |
Canonical B Cell Immune Responses |
Grays Peak |
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* Mauro N. Gaya, Centre d’Immunologie de Marseille-Luminy
Session Chair |
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* Natalia Freund, Tel Aviv University
Session Chair |
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Jason G Cyster, HHMI/University of California, San Francisco
Guidance Factors and the B Cell Response |
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Teddy Yewdell, Genentech
Dysregulated Antibody Class Switching in IBD |
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Brian J Laidlaw, Washington University in St. Louis
Establishment of Lung-Resident Memory B Cells |
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Julia Merkenschlager, Harvard
Short Talk: Coupled Affinity Dynamics Between T Follicular Helper Cells and B Cells in the Germinal Cente |
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Vipul Shukla, Northwestern University
Short Talk: Metabolic and Epigenetic Control Of Germinal Center B Cell Responses |
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| 7:00–8:00 PM |
Social Hour with Dinner |
Shavano/Torreys/Red Cloud |
| 7:30–10:00 PM |
Poster Session 1 |
Shavano/Torreys/Red Cloud |
Wednesday, March 18, 2026
| 7:00–8:00 AM |
Breakfast |
Shavano/Torreys/Red Cloud |
| 8:00–11:00 AM |
Humoral Immunity in Mucosal Tissues |
Grays Peak |
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* Alice O Kamphorst, Icahn School of Medicine at Mount Sinai
Session Chair |
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* Joanna Groom, Walter and Eliza Hall Institute of Medical Research
Session Chair |
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Stephanie C. Eisenbarth, Northwestern University Feinberg School of Medicine
Origins of IgA in the Gut |
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Mauro N. Gaya, Centre d’Immunologie de Marseille-Luminy
B Cell Instruction to Mucosal Antigens |
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Jagan R. Muppidi, NCI, National Institutes of Health
issue Specific Cues in the Pathogenesis of Germinal Center-Derived Malignancy |
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Maria A Curotto de Lafaille, Icahn School of Medicine at Mount Sinai
IgE Responses |
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Danika L Hill, Monash University
Short Talk: Sugar-Coated Or Protein-Packed? How Antigen Type Shapes The B Cell Response To Mucosal Bacterial Infection In Humans |
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Jenna Guthmiller, University of Colorado SOM
Short Talk: Ectopic Germinal Centers in Human Nasal Mucosa are an Inductive Site for Local Humoral Immunity |
|
| 9:00–9:20 AM |
Coffee Break |
Longs Peak Foyer |
| 11:00–1:00 PM |
Poster Setup |
Shavano/Torreys/Red Cloud |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Shavano/Torreys/Red Cloud |
| 1:30–3:15 PM |
Panel Discussion: Defining B Cell Subsets (Joint) |
Longs Peak |
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* Emily Siniscalco, Yale University
Session Moderator |
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* Liam C Kealy, Monash University
Session Moderator |
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Frances E. Lund, University of Alabama at Birmingham
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Nicole Baumgarth, Johns Hopkins Bloomberg School of Public Health
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Stephanie C. Eisenbarth, Northwestern University Feinberg School of Medicine
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Kim Good-Jacobson, Monash University
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Jason G Cyster, HHMI/University of California, San Francisco
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Mark J. Shlomchik, University of Pittsburgh School of Medicine
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Ziv Shulman, Weizmann Institute
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| 3:30–4:30 PM |
Career Roundtable (Joint) |
Longs Peak |
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Marla Glass, Allen Institute
Scientist III |
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Julia L McKechnie, AstraZeneca
Associate Director |
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Dorine Sichien, argenx
Senior Scientist |
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Kavitha Scranton, Immunity
Senior Scientific Editor |
|
| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–7:00 PM |
Humoral Helpers (Joint) |
Longs/Grays Peaks |
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* Rebecca A Elsner, University of Pittsburgh
Session Chair |
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* Andre Ballesteros-Tato, National Institutes of Health
Session Chair |
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Tri G Phan, Garvan Institute of Medical Research
B Cell-Macrophage Interactions in Immunity and Autoimmunity |
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Michelle A Linterman, Malaghan Institute of Medical Research
Transient Disruption of T Cell Help Impairs Germinal Center Dynamics and Memory Responses |
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Laura M Walker, Moderna
Vaccine Induced Antibody Responses |
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David R Fooksman, Albert Einstein College of Medicine
Short Talk: Investigating the Rrle of CD138 and APRIL in the Plasma Cell Survival And Dynamics In The Bone Marrow Niche |
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Hiroyuki Yoshitomi, Kyoto University
Short Talk: Peripheral Helper T Cells Go Beyond B-Cell Help In The Microenvironments Of Rheumatoid Arthritis |
|
| 7:00–8:00 PM |
Social Hour with Dinner |
Shavano/Torreys/Red Cloud |
| 7:30–10:00 PM |
Poster Session 2 |
Shavano/Torreys/Red Cloud |
| 7:00–8:00 AM |
Breakfast |
Shavano/Torreys/Red Cloud |
| 8:00–11:00 AM |
B-T Cell Interactions in Complex Microenvironments (Cancer, TLS, EF) |
Grays Peak |
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* Joshua F Koenig, McMaster University
Session Chair |
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* Kavitha Scranton, Immunity
Session Chair |
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Ziv Shulman, Weizmann Institute
Germinal Centers in Atypical Locations |
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Tullia C. Bruno, University of Pittsburgh
Germinal Centers in Cancer Associated TLS |
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Shiv Pillai, Massachusetts General Hospital
Durability and Function of Class-Switched Extrafollicular Memory B Cells |
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Jason Weinstein, Rutgers New Jersey Medical School
Specialized Tfh Cells Driving B Cell Differentiation |
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Joanna Groom, Walter and Eliza Hall Institute of Medical Research
Short Talk: Cellular and Molecular Networks Driving the Formation and Maturation of Tumor-Associated Tertiary Lymphoid Structures |
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Alice O Kamphorst, Icahn School of Medicine at Mount Sinai
Short Talk: CD4-help and B Cells are Essential for Therapeutic Efficacy of PD-1 Targeted Therapy in Liver Cancer |
|
| 9:00–9:20 AM |
Coffee Break |
Longs Peak Foyer |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 2:30–4:30 PM |
Symposia Spotlight 2 |
Grays Peak |
| |
* Gowthaman Uthaman, University of Massachusetts Chan Medical School
Session Chair |
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* Sarah Michalets, Regeneron Pharmaceuticals
Session Chair |
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Seren Baygün, DKFZ (DKTK) & Technical University Munich
Hyperreactive B Cell-Induced T Cell Control Regulates Autoimmunity And Lymphomagenesis |
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Joe Mackie, Children's Hospital of Philadelphia
SARS-COV2 Vaccine Responses in Patients with Inborn Errors of Cytokine Signaling |
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Ester Marina-Zarate, La Jolla Institute for Immunology
Highly Functional and Prolonged Germinal Center T Follicular Helper Cell Responses Are Associated with Enhanced Neutralizing Antibody Development |
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Dudley McNitt, Vanderbilt University Medical Center
T-B Lymphocyte Interactions Mediated by SLAM-Associated Protein (SAP) are Essential for Diabetes in Transgenic Anti-Insulin VH125SD.NOD Mice |
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Suzanna Rachimi, University of Pennsylvania
Fate Progression Beyond the Human Tfh cell Stage |
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Scott Hale, University of Utah
Dnmt3a-dependent De Novo DNA Methylation Enforces Lineage Commitment and Preserves Functionality of Memory Th1 and Tfh Cells |
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Junko Sawada, Johns Hopkins All Children's Hospital
Inducing Tertiary Lymphoid Structures: Insights into Potential Stromal Reprogramming |
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Jafar Al Souz, Yale University
Intrarenal Differentiation of Stem-like CD8 T Cells Drives Tissue Injury in Lupus Nephritis |
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| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–6:45 PM |
Non-Canonical B Cell Immune Responses |
Grays Peak |
| |
* Vipul Shukla, Northwestern University
Session Chair |
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* Julia Merkenschlager, Harvard
Session Chair |
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Patrick Wilson, Weill Cornell Medicine
Honing B cell memory for effective immunity against infectious diseases |
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Ian A Cockburn, Australian National University
Regulation of B Cell Responses in Complex Infections |
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Mark J. Shlomchik, University of Pittsburgh School of Medicine
B-T Collaboration in the Initiation and Spreading of Systemic Autoimmunity |
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Christopher D C Allen, University of California, San Francisco
Short Talk: Regulation of IgE Switching by BCR Signaling and Cytokines |
|
| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Grays Peak |
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* Ziv Shulman, Weizmann Institute
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|
| 7:00–8:00 PM |
Social Hour with Dinner |
Shavano/Torreys/Red Cloud |
| 8:00–9:00 PM |
Cash Bar |
Shavano/Torreys/Red Cloud |
| 8:00–9:00 PM |
Entertainment |
Shavano/Torreys/Red Cloud |
