Aging: Immune Function and Organ Health (L8)
March 22-25, 2026
| Fairmont Banff Springs, Banff, AB, Canada
Anne Brunet, Eric M. Verdin, Manuel Serrano and P. Eline Slagboom
Scholarship Deadline: Dec. 11, 2025 | Abstract Deadline: Feb. 27, 2026 | Early Registration Deadline: Jan. 22, 2026
| 4:00–8:00 PM |
Registration |
Riverview Lounge |
| 6:00–8:00 PM |
Welcome Mixer |
Riverview Lounge |
| 7:00–8:00 AM |
Breakfast |
Alberta/New Brunswick |
| 8:00–8:10 AM |
Welcome Remarks (Joint) |
Cascade Ballroom |
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* Anne Brunet, Stanford University
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| 8:10–9:00 AM |
Keynote Address (Joint) |
Cascade Ballroom |
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Beth Stevens, Boston Children's Hospital, Harvard Medical School
Macrophage-Microglia Crosstalk in Aging |
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| 9:00–11:30 AM |
Targeting Innate Immunity for Healthy Aging (Joint) |
Cascade Ballroom |
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Katrin Andreasson, Stanford University
Talk Title to be Announced |
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* Andrea Ablasser, Ecole Polytechnique Fédérale de Lausanne
cGAS-STING Modulators and Cell Senescence |
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Oliver Hahn, Calico Life Sciences LLC
Short Talk: Decoding Drivers of Microglia Aging Via Heterochronic Myeloid Cell Replacement |
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Cecilia G de Magalhaes, Brigham and Women's Hospital - Harvard Medical School
Short Talk: Targeting Brain Biological Age and Function through Young Microglia Transplantation |
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Susan B Carpenter, University of California, Santa Cruz
Short Talk: The Long Noncoding RNA, GAPLINC, Functions in Trans as a Critical Regulator of Metabolic and Inflammatory Genes in Macrophages |
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Byron F Mobbs, The institute for Molecular Bioscience, The University of Queensland
Short Talk: Inflammasome Inhibitors in Disease: Is There a Therapeutic Trade-off of Compromised Host Defence? |
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| 9:30–9:50 AM |
Coffee Break |
Riverview Lounge |
| 9:50–9:55 AM |
Award Recipient Acknowledgement |
Cascade Ballroom |
| 11:30–1:00 PM |
Poster Setup |
Alberta/New Brunswick |
| 11:30–5:00 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
Alberta/New Brunswick |
| 2:30–4:30 PM |
Symposia Spotlight 1: Immune System and Aging |
Alhambra Ballroom |
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Stephan Culemann, University Medicine Halle
Ontogeny Matters: Unraveling Origin-Specific Macrophage Responses in Systemic Inflammation and Aging |
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Ariel Adkisson-Floro, Buck Institute for Research on Aging
Ketone Ester Supplementation in Aged Mice Reduces Activation of B Cell Subsets |
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* Casey Beppler, Stanford University
Aging Restricts Maturation of CXCL13⁺ Tfh Cells in Human Immunity |
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Alex C.Y. Chen, Massachusetts General Hospital - Harvard Medical School
Dissecting Intrinsic and Extrinsic T Cell Aging for Better Tumor Control |
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* Anthony J Covarrubias, UCLA
P21+TREM2+-Senescent Macrophages Fuel Inflammaging and Metabolic Dysfunction-Associated Steatotic Liver Disease |
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Clarisabel Garcia Rodriguez, Institut Pasteur
A Switch in Macrophage Ontogeny During Aging Leads to Increased Fibrosis After Myocardial Infarction |
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Moonhyeon Jeon, Korea Advanced Institute of Science and Technology
FARSA Balances Aging and Immunity by Suppressing Mitochondrial Double-stranded RNAs and their Signaling Activity |
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Yong Fan, Allegheny Health Network
Pharmacologic Restoration of Foxn1 Expression to Reverse Thymic Aging |
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| 4:30–5:00 PM |
Coffee Available |
Riverview Lounge |
| 5:00–7:00 PM |
Inflammation, Immune Function, Senescence |
Alhambra Ballroom |
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* Anne Schaefer, Max Planck Institute for Biology of Ageing
Role of Microglia in Brain Aging |
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* Saul A. Villeda, University of California, San Francisco
Importance of Platelet Factors for Rejuvenation of the Old Brain |
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Noga Ron-Harel, Technion-Israel Institute of Technology
T Cells in Aging |
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Manuel Serrano, Altos Labs
Cellular Senescence and Reprogramming |
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| 7:00–8:00 PM |
Social Hour with Dinner |
Alberta/New Brunswick |
| 7:30–10:00 PM |
Poster Session 1 |
Alberta/New Brunswick |
| 7:00–8:00 AM |
Breakfast |
Alberta/New Brunswick |
| 8:00–11:00 AM |
Organ Regeneration and Aging |
Alhambra Ballroom |
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* Margaret A Goodell, Baylor College of Medicine
Aging in the Blood – Accumulation of Somatic Mutations |
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Anne Brunet, Stanford University
Brain Aging and Rejuvenation |
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Thomas A Rando, University of California, Los Angeles
Mechanisms of Muscle Aging and Regeneration |
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Mirco J Friedrich, MIT
Short Talk: Transient Hepatic Reconstitution of Trophic Factors Rejuvenates Aging Immunity |
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Sofia Vieto, Yale University
Short Talk: Loss of Macrophages Drives Mitochondrial Dysfunction and Tissue Aging |
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Anja Michl, Helmholtz Munich
Short Talk: Multimodal Analysis of Human Lung Aging |
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* Michael Segel, Harvard University
Short Talk: Brain-Body Communication Defects Underpin Innate Immune Dyshomeostasis in Aging |
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| 9:00–9:20 AM |
Coffee Break |
Riverview Lounge |
| 11:00–1:00 PM |
Poster Setup |
Alberta/New Brunswick |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Alberta/New Brunswick |
| 1:45–2:45 PM |
Health Equity Panel (joint) sponsored by The Burroughs Wellcome Fund |
Cascade Ballroom |
| 3:00–4:30 PM |
Career Roundtable (Joint) |
Alhambra Ballroom |
| 4:00–5:00 PM |
Coffee Break with Hot Chocolate, Firepits & Mountain Views |
Conservatory Terrace |
| 5:00–7:00 PM |
Inflammaging (Joint) |
Cascade Ballroom |
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Vishva M. Dixit, Genentech, Inc.
The Circuitry of Inflammatory Cell Death Signaling |
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Eicke Latz, German Rheumatology Research Center (DRFZ)
Inflammasomes in Innate Immune Memory and Inflammaging |
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* Emily Goldberg, UCSF
Inflammaging |
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Julia Belk, Stanford
Short Talk: Clonal Hematopoiesis and the Aging Brain |
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Kirsten Kenney, Institute for Molecular Bioscience
Short Talk: Stress, Diet and the Inflammasome: NLRP3’s Role in Maintaining Hepatic Homeostasis |
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| 7:00–8:00 PM |
Social Hour with Dinner |
Alberta/New Brunswick |
| 7:30–10:00 PM |
Poster Session 2 |
Alberta/New Brunswick |
Wednesday, March 25, 2026
| 7:00–8:00 AM |
Breakfast |
Alberta/New Brunswick |
| 8:00–11:00 AM |
Organ-Organ Communication and Systemic Aging |
Alhambra Ballroom |
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* Itamar Harel, Hebrew University of Jerusalem
Germline-soma Communication in Aging Killifish |
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Andrew G. Dillin, University of California, Berkeley
Talk Title to be Announced |
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Dario Riccardo Valenzano, Leibniz Institute on Aging
Immune System and Microbiome Aging in Vertebrates |
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* María Mittelbrunn, Molecular Biology Center, CSIC
Systemic Role of T Cells |
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Fabricio Loayza-Puch, German Cancer Research Center
Short Talk: Senescence-Associated Non-Canonical Translation Generates Selective Immune Targets for TCR-Based Senolytic Immunotherapy |
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John C Martinez, University of Rochester
Short Talk: cGas Deficient Mice Display Premature Aging Associated with De-Repression of LINE1 Elements and Inflammation |
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| 9:00–9:20 AM |
Coffee Break |
Riverview Lounge |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 2:30–4:30 PM |
Symposia Spotlight 2: Organ Health |
Alhambra Ballroom |
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Amanda Johnson, McMaster University
The Effects of Exercise and Senolytics as Interventions for Improving Skeletal Muscle Function and Quality in Advanced Age |
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* Ajay Pillai, NIH
SenNet: Open Multimodal Atlases, Standards, and AI Ready Tools to Detect and Map Cellular Senescence Across Tissues and Lifespan |
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Bérangère Solomiac, CNRS RESTORE INSTITUT
KilliPATH: A Geropathology Study of the African Turquoise Killifish, a Robust Model of Aging |
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Felipe ten Caten, Emory University
Mechanisms of Inflammation Across the Lifespan in Individuals with Down Syndrome |
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* Shuo Han, Duke University School of Medicine
Human Gut Bifidobacteria Strains Regulate Host Longevity Via Shared and Divergent Mechanisms in C. elegans |
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Chiara Herzog, Universität Innsbruck/King’s College London
Dissecting Immune-Organ Interactions in Human Aging Using Longitudinal Multi-Tissue Multi-Omics |
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Apoorva Thatavarty †, Baylor College of Medicine
Asxl1 Mutant Cells Suppress Dnmt3a Mutant Clonal Expansion |
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Mariah Lee, Memorial Sloan Kettering Cancer Center
Age-Related Dysregulation of NK cell Development, Homeostasis, and Anti-Tumor Responses |
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| 4:30–5:00 PM |
Coffee Available |
Riverview Lounge |
| 5:00–7:00 PM |
Biomarkers, Aging Clocks, and Human Longevity |
Alhambra Ballroom |
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* Dario Riccardo Valenzano, Leibniz Institute on Aging
Session Chair |
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Vadim Gladyshev, Brigham & Women's Hospital, Harvard Medical School
Quantifying Aging and Longevity at the Level of Systems and Organs |
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* Jingdong Jackie Han, Peking University
Systems Biology of Human Aging |
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P. Eline Slagboom, Leiden University
Older Adults: On Longevity Genetics and the Response to Lifestyle Interventions |
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Eric M. Verdin, Buck Institute for Research on Aging
Human Aging |
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| 7:00–7:15 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Alhambra Ballroom |
| 7:15–8:15 PM |
Social Hour with Dinner |
Alberta/New Brunswick |
