Fueling MASH: Metabolic Drivers and Inflammatory Crosstalk (M1)
April 12-15, 2026  | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Utpal B. Pajvani, Jennifer L. Estall and Ariel E. Feldstein
Scholarship Deadline: Dec. 10, 2025 | Abstract Deadline: Mar. 20, 2026 | Early Registration Deadline: Feb. 12, 2026
* Session Chair † Invited but not yet accepted | Program current as of August 23, 2025 8 AM | For the most up-to-date details, visit https://www.keystonesymposia.org
Sunday, April 12, 2026
4:00–8:00 PM Registration British/Columbia Foyer
6:00–8:00 PM Welcome Mixer British/Columbia Foyer
Monday, April 13, 2026
7:30–8:30 AM Breakfast Vancouver Island Room
8:30–10:00 AM Welcome and Keynote Session Columbia Ballroom
  Linda G. Griffith, Massachusetts Institute of Technology
Humanizing Drug Discovery: Microphysiological Systems to Model MASH
 
  Rohit Loomba, University of California, San Diego, Salk Institute
Translational Update on MASH
 
10:00–10:20 AM Coffee Break British/Columbia Foyer
10:20–11:45 AM Mechanisms of Hepatocyte Metabolic Dysfunction in Obesity Columbia Ballroom
  Rotonya Carr, University of Washington
Unraveling the Role of Lipid Droplet Proteins in MASLD
 
  Mark A Herman, Baylor College of Medicine
Carbohydrate Metabolism and Steatosis, Intersection of Hepatokines and Metabolism
 
  Jennifer L. Estall, Institut de Recherches Cliniques de Montréal
Understanding the Fasting Response in Hepatic Lipid Metabolism
 
  Short Talk(s) Chosen from Abstracts
 
11:45–1:00 PM Poster Setup British/Columbia Ballroom
11:45–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing British/Columbia Ballroom
2:30–4:30 PM Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions Columbia Ballroom
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available British/Columbia Foyer
5:00–7:00 PM Endocrine Regulators of Hepatocyte Metabolic Functions Columbia Ballroom
  Magdalene K. Montgomery, University of Melbourne
Using Genome-Wide CRISPR Screens to Identify Novel Regulators of Hepatic Lipid Metabolism in MASH
 
  Kristina Schoonjans, École Polytechnique Fédérale de Lausanne – EPFL
Gut-Liver Axis
 
  Timothy P. Rolph, Akero Therapeutics
FGFs in MASH Pathogenesis and Therapy
 
  Filip K. Knop, Gentofte Hospital, University of Copenhagen
Role of Glucagon and Incretins in MASH
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM Social Hour with Dinner Vancouver Island Room
7:30–10:00 PM Poster Session 1 British/Columbia Ballroom
Tuesday, April 14, 2026
7:30–8:30 AM Breakfast Vancouver Island Room
8:00–8:30 AM Poster Setup British/Columbia Ballroom
8:15–5:00 PM Poster Viewing British/Columbia Ballroom
8:30–11:30 AM Intercellular and Interorgan Crosstalk in Development of Liver Disease Columbia Ballroom
  Xingxing Kong, Fudan University
Adipose-Muscle-Liver Crosstalk
 
  Ruchi Bansal, University of Twente
Single-Cell Phenomics and EV-Omics to Unravel Cellular and Organ Crosstalk in MASH and Liver Cancer
 
  Ornella Barrandon, Cellarity
Revealing Novel MASH Biology at Single Cell Resolution
 
  Short Talk(s) Chosen from Abstracts
 
9:30–9:50 AM Coffee Break British/Columbia Foyer
11:30–12:30 PM Lunch Vancouver Island Room
12:00–2:30 PM Poster Session 2 British/Columbia Ballroom
3:00–4:30 PM Career Roundtable British Ballroom
4:30–5:00 PM Coffee Available British/Columbia Foyer
5:00–7:00 PM Intrahepatic Determinants of Liver Inflammation and Fibrosis in MASH Columbia Ballroom
  Utpal B. Pajvani, Columbia University Medical Center
Adipogenic Reprogramming of Hepatocytes as a Contributor to Fibrosis
 
  Mathias Florian Heikenwälder, German Cancer Research Center, DKFZ
Fueling MASH: Metabolic Drivers and Inflammatory Crosstalk
 
  Ariel E. Feldstein, University of California, San Diego & Novo Nordisk
Novel Drivers of the Inflammatory Response in Liver Injury and Fibrosis
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM On Own for Dinner
Wednesday, April 15, 2026
7:30–8:30 AM Breakfast Vancouver Island Room
8:30–11:30 AM Mechanisms of Liver Regeneration and Progression to HCC Columbia Ballroom
  Hao Zhu, University of Texas Southwestern Medical Center
Somatic Mutations in MASH Progression
 
  Robert F. Schwabe, Columbia University
Regulation of Hepatocyte Metabolism by Hepatic Stellate Cells in MASH: Looking Beyond Fibrogenesis
 
  KyeongJin Kim, Inha University
Mechanisms of MASH-Induced HCC
 
  Short Talk(s) Chosen from Abstracts
 
9:30–9:50 AM Coffee Break British/Columbia Foyer
11:30–5:00 PM On Own for Lunch
1:00–2:00 PM Panel: Perspectives: Personalized Medicine and Patient-Centered Strategies (joint) Columbia Ballroom
2:30–4:30 PM Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions Columbia Ballroom
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available British/Columbia Foyer
5:00–6:45 PM Emerging Translational Approaches to MASH Columbia Ballroom
  Simon J Cockell, University of Newcastle upon Tyne
Proteo-Transcriptomic Profiles in MASLD
 
  Diana Julie Leeming, Nordic Bioscience
Circulating Markers of Extracellular Matrix for MASLD Risk Stratification and Prediction of Response to Therapy
 
  Katy Wack, PathAI
Bringing Precision to Pathologic Assessment for MASH: Clinical Validation of an AI-based Drug Development Tool
 
  Short Talk(s) Chosen from Abstracts
 
6:45–7:00 PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Columbia Ballroom
7:00–8:00 PM Social Hour with Dinner Vancouver Island Room
8:00–11:00 PM Cash Bar
8:00–11:00 PM Entertainment
Thursday, April 16, 2026
12:00–11:59 PM Departure