Neurodegeneration: From Mechanisms to Precision Diagnosis and Therapies (M1)
April 11-14, 2027
| Whistler Conference Centre, Whistler, BC, Canada
Bruce Miller, Ana Maria Cuervo and Brandy Matthews
| 4:00–8:00 PM |
Registration |
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| 6:00–8:00 PM |
Welcome Mixer |
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| 8:00–9:30 AM |
Welcome and Keynote Session (Joint) |
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Alfred Njamnshi †, University of Yaoundé
Infectious Disease Life-Time Impact on Cognition |
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Daniel S. Reich †, NINDS, National Institutes of Health
Combining Advanced Imaging and Biological Insights for Better Disease Progression |
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| 9:30–9:50 AM |
Coffee Break |
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| 9:30–11:15 AM |
Molecular Insights into the Interplay between Neurodegeneration and Neuroinflammation (Joint) |
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Li Gan †, Weill Cornell Medicine
Converging Molecular Mechanisms of Neurodegeneration |
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Mariko Bennett, University of Pennsylvania
The Potential of Microglia-Based Therapies in Neurodegeneration |
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David M Holtzman †, Washington University
Innate and Adaptive Immune System in tau-Mediated Neurodegeneration |
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Short Talk(s) Chosen from Abstracts
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| 11:15–12:15 PM |
Panel Discussion 1: New Modalities in Neuro-Diagnosis and Therapeutics (Joint) |
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| 12:15–1:00 PM |
Poster Setup |
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| 12:15–5:00 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
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| 2:30–4:30 PM |
Symposia Spotlight 1: AI/Machine Learning - from basic Discovery to Clinical Diagnosis |
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Short Talks Chosen from Abstracts
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–7:00 PM |
Cellular Mechanisms of Defense against Proteotoxicity in the Central Nervous System |
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Carmela Sidrauski †, Calico Life Sciences LLC
The Integrated Stress Response in Neurodegeneration |
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Ana Maria Cuervo, Albert Einstein College of Medicine
Selective Autophagy Malfunction in Neurodegeneration |
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Lidia Wróbel, International Institute of Molecular and Cell Biology
Nuclear Protein Quality Control in Neurodegenerative Diseases |
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Short Talk(s) Chosen from Abstracts
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| 7:00–8:00 PM |
Social Hour with Dinner |
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| 8:00–11:00 AM |
Genetic and Non-Genetic Disease Modifiers |
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Daniel H. Geschwind †, University of California, Los Angeles
Gene Networks in Neurodegeneration |
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Sarah Marzi †, King's College London
Epigenetic Regulation of Neurodegenerative Diseases |
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Fen-Biao Gao †, University of Massachusetts Medical School
Pathogenic Pathways in ALS |
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Rosa Rademakers †, VIB-UAntwerp Center for Molecular Neurology
Advances in frontotemporal Dementia Genetics |
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Short Talk(s) Chosen from Abstracts
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| 9:00–9:20 AM |
Coffee Break |
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| 11:00–1:00 PM |
Poster Setup |
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| 11:00–5:00 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
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| 3:00–4:30 PM |
Career Roundtable |
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–7:00 PM |
Cognitive Decline Beyond AD: Non AD Dementias |
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Bruce Miller, University of California, San Francisco
Non-AD Dementias |
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Fanny Elahi, Icahn School of Medicine at Mount Sinai
Vascular Aging and Dementia |
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Pedro Pinheiro-Chagas, University of California, San Francisco
AI Advances in the Clinic |
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Short Talk(s) Chosen from Abstracts
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| 7:00–8:00 PM |
Social Hour with Dinner |
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Wednesday, April 14, 2027
| 8:00–11:00 AM |
Translating Innovation: Clinical Advances in Neurodegeneration and Neuroimmunology (Joint) |
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Henrik Zetterberg †, University of Gothenburg
Biomarkers in Neurodegeneration and Neuroinflammation |
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Manuela Polydoro †, Muna Therapeutics
Translational Biomarkers in Drug Discovery |
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James Keaney, F. Hoffmann-La Roche
Targeting Intrinsic and Extrinsic Mechanisms of Neurodegeneration in CNS Drug Discovery |
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Joy Yu Zuchero, Denali Therapeutics Inc
Challenges for CNS Drug-Discovery |
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Short Talk(s) Chosen from Abstracts
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| 9:00–9:20 AM |
Coffee Break |
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| 11:00–5:00 PM |
On Own for Lunch |
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| 2:30–4:30 PM |
Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions |
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Short Talks Chosen from Abstracts
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–6:45 PM |
Emerging Therapeutics for Neurodegenerative Disorders |
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Brandy Matthews, Eli Lilly and Company
Efficacy of Clinical Trials for Amyloid Lowering |
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Olga Uspenskaya-Cadoz †, VectorY Therapeutics
Investigational Therapeutics for FTD |
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Ivana Rubino †, Biogen
Challenges for Clinical Translation across Neuroinflammation and Neurodegeneration |
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Short Talk(s) Chosen from Abstracts
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| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
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| 7:00–8:00 PM |
Social Hour with Dinner |
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| 8:00–11:00 PM |
Entertainment |
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