Chronic Kidney Disease: Emerging Mechanisms, Consequences and Targeted Treatments (M2)
April 12-15, 2026
| Fairmont Hotel Vancouver, Vancouver, BC, Canada
Matthias Kretzler, Hiddo Lambers Heerspink, Olga G. Troyanskaya and Maria Chiara Magnone
Scholarship Deadline: Jan. 22, 2026 | Abstract Deadline: Mar. 20, 2026 | Early Registration Deadline: Feb. 12, 2026
| 4:00–8:00 PM |
Registration |
British/Columbia Foyer |
| 6:00–8:00 PM |
Welcome Mixer Sponsored by Lilly |
British/Columbia Foyer |
| 7:30–8:30 AM |
Breakfast |
British/Columbia Ballrooms |
| 8:30–8:40 AM |
Welcome Remarks |
British Ballroom |
| 8:40–9:30 AM |
Keynote Address |
British Ballroom |
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Gregory Germino, NIH
Advancing a National Vision for Chronic Kidney Disease- from Community to Precision Therapies |
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| 9:30–11:45 AM |
CKD Function and Failure; From Models to Man |
British Ballroom |
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Melissa Hallow, University of Georgia
Modelling Kidney Function: What Renal Physiology Teaches us in 2025 for CKD: Lessons Learned from Modeling Endothelin Function in CKD Trials |
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Samira Musah, Duke University
Kidney Tissue Bioengineering for Patient Level Precision Medicine |
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Jonathan Himmelfarb, Mount Sinai School of Medicine
Ex vivo Organ Cross Talk: Liver-Kidney System Defines Molecular Cross Talk in Toxin Induced CKD |
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Annie Moisan †, Roche Pharmaceuticals
Short Talk: A Human-Centric DKD Discovery Pipeline: Integrating Patient Multi-OMICS with Organoid-Derived Models to Identify Novel Renal Cytoprotectants |
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| 10:00–10:20 AM |
Coffee Break |
British/Columbia Foyer |
| 11:45–1:00 PM |
Poster Setup |
Vancouver Island Room |
| 11:45–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Vancouver Island Room |
| 2:30–4:30 PM |
Symposia Spotlight |
British Ballroom |
| |
Kyung Lee, Icahn School of Medicine at Mount Sinai
The Liver as a Silent Driver of CKD: From MASH to Kidney Cell Injury |
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Robert R Graham, Maze Therapeutics
Expanding the Universe of SLC6A19 Substrates: SLC Inhibition Protects Kidney from Nephrotoxic Metabolite Accumulation |
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Bernhard Dumoulin, University of Pennsylvania
Spatial Human Kidney Map Highlights B cell driven Kidney Disease Subgroup |
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Jeong Ho Joo †, Korea Advanced Institute of Science and Technology
Unbiased Transcriptomic Clustering Identifies a STAT1-Driven Inflammatory PEC Endotype at the Glomerular Vascular Pole |
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Erik Moedt, UMCG
Novel Biomarkers to Monitor Disease Progression and Treatment Response in Patients with CKD and Normoalbuminuria |
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Alfin Mohammad Abdillah, Chungnam National University
Multi-Omics Dissection of Immune and Epithelial Reprogramming by Small-Molecule CGP-60474 in a Male Murine Model of Adenine-Induced Chronic Kidney Disease |
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Farsad Afshinnia, University of Michigan
Heart Failure Specific Plasma Acylcarnitine Alterations in Chronic Kidney Disease |
|
| 4:30–5:00 PM |
Coffee Available |
British/Columbia Foyer |
| 5:00–7:00 PM |
Unraveling the Molecular Machinery of the Nephron in Function and Failure |
British Ballroom |
| |
Laura Barisoni, Duke University
Tissue is the Issue: AI Driven Image Analysis Maps Structural and Molecular Disease Trajectories |
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Katalin Susztak, University of Pennsylvania
From Mapping to Mechanism to Medicine |
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Olga G. Troyanskaya, Princeton University
Genes and Environment Driving CKD: Linking Environmental Exposures with Genetic Risk Assessment to Guide CKD Management |
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Christine Limonte, University of Washington
Short Talk: Redefining Kidney Disease – Clinico-pathological and Molecular Findings from the Kidney Precision Medicine Project |
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Insa Schmidt, Boston University
Short Talk: Self-Supervised Learning Identifies Prognostic Tissue Patterns in Chronic Kidney Disease Linked to Molecular Signatures |
|
| 7:00–8:00 PM |
Social Hour with Dinner |
British/Columbia Ballrooms |
| 7:30–10:00 PM |
Poster Session 1 |
Vancouver Island Room |
| 7:30–8:30 AM |
Breakfast |
British/Columbia Ballrooms |
| 8:00–8:30 AM |
Poster Setup |
Vancouver Island Room |
| 8:15–5:00 PM |
Poster Viewing |
Vancouver Island Room |
| 8:30–11:30 AM |
CKD in Obesity and Diabetes: Driving the Disease Burden in the Cardio Metabolic Pandemic |
British Ballroom |
| |
Tamer Coskun, Eli Lilly & Company
Obesity Driven Metabolic Reprogramming: From Metabolic Profiling to Drug Targets for Cardiorenal Disease |
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Petter Bjornstad, University of Washington
A Holistic View How Obesity and Diabetes Driving Kidney Disease in Children and Adolescents |
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Katherine R. Tuttle, University of Washington
Finally Breaking the Death Spiral of CKD: Mechanistic Trials Defining the Mode of Action of the Incretin System |
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Arianne van Koppen, TNO
Short Talk: Mechanisms, Modulation and Medication Efficacy in a Multifactorial Cardiovascular-Kidney-Metabolic Syndrome Mouse Model with Chronic Kidney Disease and HFpEF |
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Jennifer Schaub, University of Michigan
Short Talk: HIF Regulatory Network Reflects Kidney Disease Progression in Diabetes and Reversal with SGLT2 Inhibition |
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Aleksandra Kukla, Mayo Clinic
Short Talk: Inflammatory and Morphologic Characteristics of Perirenal Adipose Tissue in Living Kidney Donors with Obesity: A Prospective Cohort Study |
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Yukihiro Imakiire †, Chiba University
Short Talk: The Prediction of Renal Decline Reflecting Heterogeneous Aggravation of Diabetic Kidney Disease |
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| 9:30–9:50 AM |
Coffee Break |
British/Columbia Foyer |
| 9:50–9:55 AM |
Award Recipient Acknowledgement |
British Ballroom |
| 11:30–12:30 PM |
Lunch |
British/Columbia Ballrooms |
| 12:00–2:30 PM |
Poster Session 2 |
Vancouver Island Room |
| 3:00–4:30 PM |
Career Roundtable (Joint) |
British Ballroom |
| 4:30–5:00 PM |
Coffee Available |
British/Columbia Foyer |
| 5:00–7:00 PM |
Primary Glomerular Diseases Driving CKD: Insight into a Rapidly Evolving Targeted Therapy Landscape |
British Ballroom |
| |
Katherine Bull, University of Oxford
Defining Disease Neighborhoods in Autoimmune Glomerular Diseases |
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Brad H Rovin, Ohio State University College of Medicine
Innate Immunity Modulation in Lupus Nephritis, Bringing Insight from Trials Back to the Bench |
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Chee Kay Cheung, University of Leicester
The Right Drug for the Right IgAN in 2025: Impact of Endothelin Blockade on Glomerular Manifestations of IgA Nephritis |
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Tobias B Huber, University Medical Center Hamburg-Eppendorf
Understanding Filtration Barrier Failure Drives Novel Treatments in Nephrotic Syndrome |
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| 7:00–8:00 PM |
On Own for Dinner |
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Wednesday, April 15, 2026
| 7:30–8:30 AM |
Breakfast |
British/Columbia Ballrooms |
| 8:30–11:30 AM |
Genes and Kidney; Unique Opportunities for Targeted Therapies, Lessons Learned from ApoL1 and Beyond |
British Ballroom |
| |
Whitney Besse, Yale School of Medicine
Polycystic Kidney Disease: The Journey from Gene to Therapies |
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Martin Pollak, Beth Israel Deaconess Medical Center
ApoL1 Biology and Kidney Disease |
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Akinlolu Ojo, University of Kansa
ApoL1 across Continents: Lessons Learned on Gene Environment Interaction in H3 Africa KDRN |
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Glenn Chertow, Stanford University
Lessons Learned from the First Trials Targeting ApoL1 Kidney Disease |
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Lili Liu †, University of Michigan
Short Talk: Atlas of Glomerular Disease-specific Genetic Effects on Gene Regulation in Blood Empowers New Gene Discovery Studies |
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Peter Czarnecki, Beth Israel Deaconess Medical Center
Short Talk: Truncating Mutations in BICC1 Cause Autosomal Dominant Tubulointerstitial Kidney Disease |
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| 9:30–9:50 AM |
Coffee Break |
British/Columbia Foyer |
| 11:30–5:00 PM |
On Own for Lunch |
|
| 1:00–2:00 PM |
Panel: Perspectives: Personalized Medicine and Patient-Centered Strategies (joint) |
British Ballroom |
| 4:30–5:00 PM |
Coffee Available |
British/Columbia Foyer |
| 5:00–6:45 PM |
Precision Clinical Trial Strategies for Kidney Disease |
British Ballroom |
| |
Matthias Kretzler, University of Michigan
Lessons Learned from Matching Patients Renal Pathobiology to Targeted Therapies in Glomerular Disease |
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Maria Chiara Magnone, Abiologics, Inc
Precision Medicine in CKD - A Therapeutic Modality Angle |
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Hiddo Lambers Heerspink, University Medical Center Groningen
Precision Medicine Trials in CKD: Bringing Molecular Understanding of CKD Drugs to Clinical Care |
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Anil Karihaloo, Novo Nordisk A/S
Short Talk: From Genetics to Functional Validation: Identification of Putative Novel Genes Implicated in Pathogenesis of Chronic Kidney Disease |
|
| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
British Ballroom |
| 7:00–8:00 PM |
Social Hour with Dinner |
British/Columbia Ballrooms |
| 8:00–9:00 PM |
Entertainment |
Columbia Ballroom |
