Neural-Immune Interactions: Immune Modulation of CNS Biology (M2)
April 11-14, 2027  | Whistler Conference Centre, Whistler, BC, Canada
Dimitry Ofengeim, Martin Kerschensteiner and Soyon Hong
Scholarship Deadline: Dec. 16, 2026 | Abstract Deadline: Mar. 20, 2027 | Early Registration Deadline: Feb. 10, 2027
* Session Chair † Invited but not yet accepted | Program current as of August 26, 2026 1 AM | For the most up-to-date details, visit https://www.keystonesymposia.org
Sunday, April 11, 2027
4:00–8:00 PM Registration Grand Foyer
6:00–8:00 PM Welcome Mixer Grand Foyer
Monday, April 12, 2027
7:00–8:00 AM Breakfast Sea to Sky A
8:00–8:10 AM Welcome Remarks (Joint) Sea to Sky B/C
8:10–9:00 AM Keynote Session (Joint) Sea to Sky B/C
  Alfred Njamnshi, University of Yaoundé
Infectious Disease Life-Time Impact on Cognition
 
9:00–11:30 AM Molecular Insights into the Interplay between Neurodegeneration and Neuroinflammation (Joint) Sea to Sky B/C
  Li Gan, Weill Cornell Medicine
Converging Molecular Mechanisms of Neurodegeneration
 
  Mariko Bennett, University of Pennsylvania
The Potential of Microglia-Based Therapies in Neurodegeneration
 
  David M Holtzman, Washington University
Innate and Adaptive Immune System in tau-Mediated Neurodegeneration
 
  Short Talk(s) Chosen from Abstracts
 
9:30–9:50 AM Coffee Break Grand Foyer
11:40–12:40 PM Panel Discussion 1: New Modalities in Neuro-Diagnosis and Therapeutics (Joint) Sea to Sky B/C
12:40–1:00 PM Poster Setup Sea to Sky A
12:40–2:30 PM On Own for Lunch
1:00–10:00 PM Poster Viewing Sea to Sky A
2:30–4:30 PM Symposia Spotlight 1 Sea to Sky C
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available Grand Foyer
5:00–7:00 PM Glial and Innate Drivers of CNS Inflammation Sea to Sky C
  Brad Zuchero, Stanford University
Cellular Mechanisms Driving Myelin Dysfunction in Disease
 
  Soyon Hong, University College London
Microglia-Synapse Biology in Brain Homeostasis and Pathology
 
  Martin Kerschensteiner, Ludwig Maximilians University Munich
Myeloid Cell Actions and Interactions in the Inflamed CNS
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM Social Hour with Dinner Sea to Sky A
7:30–10:00 PM Poster Session 1 Sea to Sky A
Tuesday, April 13, 2027
12:10–1:00 PM Poster Setup Sea to Sky A
12:10–5:00 PM On Own for Lunch
7:00–8:00 AM Breakfast Sea to Sky A
8:00–11:00 AM The Role of the Adaptive Immune System Beyond Autoimmunity Sea to Sky C
  Menna R Clatworthy, University of Cambridge
Immune Cells in Border Tissues Protect the CNS from Infection and Contribute to CNS Diseases
 
  Arthur Liesz, Ludwig-Maximilians-Universität München
Deleterious and Beneficial Roles of the Adaptive Immune System following Brain Ischemia
 
  Doron Merkler, University of Geneva
Role of Tissue Resident T cells in CNS Infection and Immunity
 
  Dimitry Ofengeim, Novartis
Interplay of the Innate and Adaptive Immune System in Neurodegeneration
 
  Short Talk(s) Chosen from Abstracts
 
9:00–9:20 AM Coffee Break Grand Foyer
11:10–12:10 PM Panel Discussion 2: Different Perspectives on the Emerging Challenges/Opportunities for Research and Therapy in Neuroimmunology Sea to Sky C
1:00–10:00 PM Poster Viewing Sea to Sky A
3:00–4:30 PM Career Roundtable Sea to Sky C
4:30–5:00 PM Coffee Available Grand Foyer
5:00–7:00 PM Emerging Concepts of Neuro-Immune Communication Sea to Sky C
  Michael T Heneka, University of Luxembourg
Structural and Molecular Bridges between Neurons and Microglia
 
  Isaac Chiu, Harvard Medical School
Neuronal Pathogen Sensing Mechanism in Neuroinflammation and Neurodegeneration
 
  Rejane Rua, CIML
Exploring the Functions of the Immune Sentinels at the Brain Borders to Control Neuroinflammation
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM Social Hour with Dinner Sea to Sky A
7:30–10:00 PM Poster Session 2 Sea to Sky A
Wednesday, April 14, 2027
7:00–8:00 AM Breakfast Sea to Sky A
8:00–11:00 AM Translating Innovation: Clinical Advances in Neurodegeneration and Neuroimmunology (Joint) Sea to Sky B/C
  Henrik Zetterberg, University of Gothenburg
Biomarkers in Neurodegeneration and Neuroinflammation
 
  Manuela Polydoro, MUNA THERAPEUTICS
Translational Biomarkers in Drug Discovery
 
  James Keaney, F. Hoffmann-La Roche
Targeting Intrinsic and Extrinsic Mechanisms of Neurodegeneration in CNS Drug Discovery
 
  Joy Yu Zuchero, Denali Therapeutics Inc
Challenges for CNS Drug-Discovery
 
  Short Talk(s) Chosen from Abstracts
 
9:00–9:20 AM Coffee Break Grand Foyer
11:10–12:10 PM Workshop: How we can Work Together to Strengthen our Scientific Integrity and Communication with Public and also the Current Naysayers about Translational Avenues in Neurodegeneration Sea to Sky B/C
12:10–2:30 PM On Own for Lunch
2:30–4:30 PM Symposia Spotlight 2 Sea to Sky C
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available Grand Foyer
5:00–6:15 PM Regulation of Immune Responses across Compartments Sea to Sky C
  Andrew Yang, University of California, San Francisco
Decoding Immune and Protein Crosstalk between the Brain and Body
 
  Maria Lehtinen, Harvard Medical School
The Choroid Plexus: A Command Center for Brain-Body Communication during Inflammation
 
  Short Talk(s) Chosen from Abstracts
 
6:15–7:00 PM Closing Keynote Address Sea to Sky C
  Daniel S. Reich, NINDS, National Institutes of Health
Combining Advanced Imaging and Biological Insights for Understanding and Treating Progressive Multiple Sclerosis
 
7:00–7:15 PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Sea to Sky C
7:15–8:00 PM Social Hour with Dinner Sea to Sky A
8:00–11:00 PM Cash Bar
8:00–11:00 PM Entertainment
Thursday, April 15, 2027
12:00–11:59 PM Departure