| 4:00–8:00 PM | Registration | Grand Foyer |
| 6:00–8:00 PM | Welcome Mixer | Grand Foyer |
| 7:00–8:00 AM | Breakfast | Sea to Sky A |
| 8:00–8:10 AM | Welcome Remarks (Joint) | Sea to Sky C |
| Lisa M. Coussens, Oregon Health & Science University |
| 8:10–9:00 AM | Keynote Address (Joint) | Sea to Sky C |
| * Lisa M. Coussens, Oregon Health & Science University Session Chair |
| Gabriel A. Rabinovich, Instituto de Biologia y Medicina Experimental The Power of Glycocheckpoints: Translating Glycan-Encoded Information into Novel Therapies in Cancer and Autoimmune Inflammation |
| 9:00–11:30 AM | Aging in Human Health and Disease (Joint) | Sea to Sky C |
| * Lisa M. Coussens, Oregon Health & Science University Session Chair |
| Clemens A. Schmitt, Max Delbrück Center for Molecular Medicine Targeting the Root of Cancer Reprogression - Eradicating Senescent Persisters |
| Donna L Farber, Columbia University Medical Center Immune Aging Across the LifeSpan |
| Peter D. Adams, Sanford Burnham Prebys Medical Discovery Institute The Epigenetic Landscape of Aging |
| Jian Zheng, University of Louisville Short Talk: Prostaglandin D2 Axis in Aging-associated Immune Dysfunction of Melanoma and Lung Metastases |
| Milos Spasic, Brigham & Women's Hospital, Harvard Medical School Short Talk: Leveraging HDAC Inhibition to Combat Paclitaxel Resistance in Aging Triple Negative Breast Cancer |
| 9:30–9:50 AM | Coffee Break | Grand Foyer |
| 11:30–1:00 PM | Poster Setup | Sea to Sky A |
| 11:30–5:00 PM | On Own for Lunch |
| 1:00–10:00 PM | Poster Viewing | Sea to Sky A |
| 4:30–5:00 PM | Coffee Available | Grand Foyer |
| 5:00–7:00 PM | Cross-Talk in the TME Driving Cancer Progression and Therapeutic Resistance | Sea to Sky C |
| * Sandra S. McAllister, Brigham & Women's Hospital/Harvard Medical School Session Chair |
| Sheila A. Stewart, Washington University School of Medicine Senescent Fibroblasts that Drive Immune Suppression and Cancer Progression |
| Teresa Zimmers, Oregon Health and Science University Knight Cancer Institute Cachexia Reprograms the Macroenvironment in Pancreatic Cancer |
| Daniela F Quail, McGill University Impact of Obesity on Tumor-Associated Chronic Inflammation |
| Giuseppina Caligiuri, Cold Spring Harbor Laboratory Short Talk: WNT7 Orchestrates Myofibroblast Heterogeneity to Induce Desmoplasia |
| Brittney Poole, University of Florida Short Talk: Tumor-Derived CTGF Modulates the Tumor Microenvironment to Promote Cancer-Associated Cachexia through TGF-beta |
| 7:00–8:00 PM | Social Hour with Dinner | Sea to Sky A |
| 7:30–10:00 PM | Poster Session 1 | Sea to Sky A |
| 7:00–8:00 AM | Breakfast | Sea to Sky A |
| 8:00–10:45 AM | Pathways Controlling Inflammation and Tissue Homeostasis (Joint) | Sea to Sky C |
| Andrea Ablasser, Ecole Polytechnique Fédérale de Lausanne Remote Presentation: cGAS STING Pathway in Inflammation |
| Melissa Davis, Morehouse School of Medicine Impact of Genetics, Biology, and Social Determinants on Cancer Risk |
| Jenny P Ting, University of North Carolina at Chapel Hill Impact of Innate Immune Receptors in Cancer |
| Karen Agaronyan, Yale University Short Talk: How Do Tissues Adapt to Proteolytic Stress? |
| Chang Liao, Amgen Short Talk: TSLP Links Intestinal GLP-2 Nutrient Sensing with Amplification of the ILC2–tuft Cell Circuit |
| Jaroslav Zak, University of Utah Short Talk: An IL-34–IGF-1 Axis Fuels KRAS-Mutant Lung Cancer Progression |
| 9:00–9:20 AM | Coffee Break | Grand Foyer |
| 9:20–9:25 AM | Award Recipient Acknowledgement | Sea to Sky C |
| 11:00–1:00 PM | Poster Setup | Sea to Sky A |
| 11:00–5:00 PM | On Own for Lunch |
| 1:00–10:00 PM | Poster Viewing | Sea to Sky A |
| 1:45–2:45 PM | Career Roundtable (Joint) | Sea to Sky B |
| Kevin L Bennewith, BC Cancer Research Institute Distinguished Scientist & Deputy Head |
| Johannes Stortz, Springer Verlag Associate Editor |
| Justin Budka, Kite, a Gilead Company Director |
| Rocio Vicario, Calico Life Sciences Senior Scientist |
| 3:00–4:30 PM | Workshop: Data Jamboree/Workshop leveraging the NCI Human Tumor Atlas Data (HTAN) to study the TME | Sea to Sky C |
| Erik A. Sahai, Francis Crick Institute |
| Elana Fertig, University of Maryland School of Medicine Novel Analytical Approaches for Data Forecasting and Data Integration with HTAN |
| Jeremy Goecks, Moffitt Cancer Center |
| 4:30–5:00 PM | Coffee Available | Grand Foyer |
| 5:00–7:00 PM | Inflammatory Responses in the TME | Sea to Sky C |
| * Laura L. Kiessling, Massachusetts Institute of Technology Session Chair |
| Sandra S. McAllister, Brigham & Women's Hospital/Harvard Medical School Impact of the Aging TME Cellular and Molecular Landscape on Response to Therapy |
| Lisa M. Coussens, Oregon Health & Science University Innate-Adaptive Crosstalk Mechanisms as Leverage Points for Therapy |
| Erik A. Sahai, Francis Crick Institute Why Liver Metastases are so Hard to Treat with Immunotherapy |
| David Kung-Chun Chiu, Stanford University Short Talk: A Liver-Imposed Immunoregulatory Circuit Drives Immune Exclusion in Primary Liver Cancer and Pan-Gastrointestinal Liver Metastasis |
| Mariko Morimoto, University of Notre Dame Short Talk: Selective Chemical Remodeling of Tumor-Associated Macrophages to Overcome Immunotherapy Resistance |
| 7:00–8:00 PM | Social Hour with Dinner | Sea to Sky A |
| 7:30–10:00 PM | Poster Session 2 | Sea to Sky A |
| 7:00–8:00 AM | Breakfast | Sea to Sky A |
| 8:00–10:00 AM | Therapeutic Targeting in Chronic Disease | Sea to Sky C |
| * Sheila A. Stewart, Washington University School of Medicine Session Chair |
| Laura L. Kiessling, Massachusetts Institute of Technology Critical Role of Glycosylation in Regulating Tissue Homeostasis and Disease Progression |
| Michael Klichinsky, Carisma Therapeutics Engineering Myeloid Cells for Cancer, Autoimmunity, and Fibrosis |
| Malia E Leifheit, Rush University Short Talk: Combination of Gilteritinib and mTOR Inhibitors for the Treatment of FLT3+ Acute Myeloid Leukemia Post Allogeneic Hematopoietic Stem Cell Transplantation |
| Stanislav Drapela, Moffitt Cancer Center Short Talk: Aging Exposes a Targetable Metabolic Achilles’ Heel in Triple-Negative Breast Cancer Lung Metastasis |
| 9:00–9:20 AM | Coffee Break | Grand Foyer |
| 11:00–5:00 PM | On Own for Lunch |
| 2:30–4:30 PM | Symposia Spotlight | Sea to Sky C |
| * Milos Spasic, Brigham & Women's Hospital, Harvard Medical School Session Chair |
| David Askew, Case Western Reserve University The Bone Marrow Niche Promotes Relapse of T Cell Acute Lymphoblastic Leukemia after Stem Cell Transplant |
| Alma Banuelos, Mayo Clinic Sex-dependent Regulation of CD8⁺ T-Cell Antitumor Immunity by the ATP-exporting Channel Pannexin-1 |
| Stefanie Cassoday, Rush University Medical Center Intratumoral Influenza Vaccine Combined with IL-15 and PD-1 Blockade Induces Durable Antitumor Immunity in Triple-Negative Breast Cancer |
| Rohin Chakraborty, Krembil Research Institute, University Health Network Role of Natural Killer-like T Cells in Inducing Pre-tumor Cell Growth to Initiate Medulloblastoma |
| Jesse Popover, Moffitt Cancer Center Aging Drives the Differential Evolution of KRAS-driven Lung Adenocarcinoma Towards a Primitive Stem-Like State |
| Mojdeh Shakiba, CSHL Pancreatitis Promotes Pancreatic Ductal Adenocarcinoma (PDAC) through Epigenetic Reprogramming of Macrophages |
| Emma Saart, Zucker School of Medicine at Hofstra/Northwell Exploring the Role of Genetic Ancestry in Shaping the Endometrial Tumor Microenvironment |
| Theresa A. Weis, University of Louisville Temporal Dynamics to Macrophage Depletion in Mediating Tumor Microenvironment and Cancer-Kidney Crosstalk |
| 4:30–5:00 PM | Coffee Available | Grand Foyer |
| 5:00–6:45 PM | Unraveling the TME | Sea to Sky C |
| * Daniela F Quail †, McGill University Session Chair |
| Jeremy Goecks, Moffitt Cancer Center Using Machine Learning to Quantify the Tumor Microenvironment and Predict Response to Therapy |
| Elana Fertig, University of Maryland School of Medicine Forecasting Cancer Signatures |
| Daniella Liao, BC Cancer Research Institute Short Talk: Longitudinal Peripheral Immune Profiling During Immunotherapy for Advanced Non-Small Cell Lung Cancer Patients |
| Tuulia Vallius, Harvard Medical School Short Talk: Spatial Determinants of Tumor Cell Dedifferentiation and Plasticity in Primary Cutaneous Melanoma |
| Willie Wu, BC Cancer Research Institute Short Talk: Decoding the Spatial Architecture of the Lung Tumor Microenvironment in Early-Stage Non-Small Cell Lung Cancer |
| 6:45–7:00 PM | Meeting Wrap-Up: Outcomes and Future Directions (Organizers) | Sea to Sky C |
| 7:00–8:00 PM | Social Hour with Dinner | Sea to Sky A |
| 7:30–8:30 PM | Entertainment | Sea to Sky A |
| 12:00–11:59 PM | Departure |