| 4:00–8:00 PM | Registration | Macdonald Foyer |
| 6:00–8:00 PM | Welcome Mixer | Macdonald Foyer |
| 7:00–8:00 AM | Breakfast | Macdonald EF |
| 8:00–8:10 AM | Welcome Remarks (Joint) | Macdonald ABCD |
| 8:10–9:30 AM | Keynote Address (Joint) | Macdonald ABCD |
| Christian Haass, Ludwig-Maximilians University Munich Modulation of Microglial Function |
| Astrid Iversen, University of Oxford Genomic Risk for Neuroinflammation |
| 9:30–9:50 AM | Coffee Break | Macdonald Foyer |
| 9:50–11:30 AM | Integrating Degeneration and Inflammation (Joint) | Macdonald ABCD |
| Maria de Lourdes Gamez G Tansey, Indiana University Role of Central-Peripheral Neuroimmune Cross-Talk in Neurodegeneration |
| Bart De Strooper, University College London Key Inflection Points in Alzheimer’s Disease Pathogenesis |
| Naresha Saligrama, Washington University School of Medicine in Saint Louis Short Talk: Specificity of CD4 T Cell Response in Parkinson Disease and in a Mouse Model of Synucleinopathy |
| Pengjiao Wang, Boston University Short Talk: Unique Progenitor Cells in the APOE3 Christchurch Brain and Their Potential Resilient Roles in Alzheimer’s Disease |
| 11:30–1:00 PM | Poster Setup | Macdonald EF |
| 11:30–5:00 PM | On Own for Lunch |
| 1:00–10:00 PM | Poster Viewing | Macdonald EF |
| 3:30–4:30 PM | Panel Discussion: From Research to Clinical Practice | Macdonald AB |
| * Julia TCW, Boston University |
| Emma Mead, Oxford Drug Discovery Institute |
| Christian Haass, Ludwig-Maximilians University Munich |
| Kate Monroe, Denali Therapeutics |
| Justin Ichida, USC Keck School of Medicine |
| Haiyan Peng, Alnylam Pharmaceuticals |
| Dennis J. Selkoe, Harvard Medical School |
| 4:30–5:00 PM | Coffee Available | Macdonald Foyer |
| 5:00–7:00 PM | Neurodegenerative Disease Diagnostic to Therapeutics | Macdonald AB |
| Yimin Zou, University of California, San Diego Planar Cell Polarity Proteins in Synapse Degeneration |
| Henne Holstege, Amsterdam UMC Biomarker for Centenarians |
| Matthias Brendel, LMU Munich Molecular Imaging with PET for Translation towards Therapeutics |
| Sam Gandy, Icahn School of Medicine at Mount Sinai Short Talk: Endogenously generated Alzheimer's Nonfibrillar Oligomeric Aβ: Association with Dysfunctional Presynaptic Cytoplasmic Organelles And Visualization In Vivo with a Novel PET Ligand |
| Peisheng Xu, University of South Carolina Short Talk: Brain-Targeted Nano-ERASER Downregulates PD-L1 for Alzheimer’s Disease Therapy |
| 7:00–8:00 PM | Social Hour with Dinner | Macdonald EF |
| 7:05–8:00 PM | Women in Science Networking Event | Macdonald EF |
| * Julia TCW, Boston University |
| * Christian Haass, Ludwig-Maximilians University Munich |
| * Emma Mead, Oxford Drug Discovery Institute |
| * Robyn S Klein, Western University, London, Ontario |
| * Maria de Lourdes Gamez G Tansey, Indiana University |
| 7:30–10:00 PM | Poster Session 1 | Macdonald EF |
| 7:00–8:00 AM | Breakfast | Macdonald EF |
| 8:00–11:00 AM | Disease Overarching Mechanisms of Neurodegenerative Diseases | Macdonald AB |
| Julia TCW, Boston University Lipophagic Defect by APOE4 in AD Glia |
| Justin Ichida, USC Keck School of Medicine Using Patient Stem Cells to Identify Therapeutic Targets for Familial and Sporadic ALS |
| Aaron D. Gitler, Stanford University School of Medicine Single Cell Mechanisms of Neurodegeneration |
| Michael D Gallagher, Whitehead Institute for Biomedical Research Short Talk: Perturb-Seq in Human Microglia-Like Cells Links Neurodegenerative GWAS Variants to Causal Risk Genes and Shared Downstream Pathways |
| Laura Bott, Northwestern University Short Talk: Interindividual Variation in Proteostasis Shapes Resilience and Disease Trajectories in Protein Misfolding Disorders |
| Garrett Fogo, Brigham and Women's Hospital Short Talk: Multi-omic Profiling of Human iPSC-derived Glial Cells Identifies Genetic and Molecular Drivers of Mitochondrial and Lysosomal Systems |
| Zhen Yan, State University of New York at Buffalo Short Talk: Histone Demethylase PHF2 Regulates Inflammatory Genes in Alzheimer's Disease |
| 9:00–9:20 AM | Coffee Break | Macdonald Foyer |
| 11:00–1:00 PM | Poster Setup | Macdonald EF |
| 11:00–5:00 PM | On Own for Lunch |
| 1:00–10:00 PM | Poster Viewing | Macdonald EF |
| 1:15–2:45 PM | Health Equity Panel (Joint) sponsored by The Burroughs Wellcome Fund | MacDonald CD |
| Jennifer Manly, Columbia University |
| Maria de Lourdes Gamez G Tansey, Indiana University |
| Kate Monroe, Denali Therapeutics |
| Dennis J. Selkoe, Harvard Medical School |
| Jamaine Davis, Belmont University |
| 3:00–4:30 PM | Career Roundtable (Joint) | Macdonald AB |
| 4:30–5:00 PM | Coffee Available | Macdonald Foyer |
| 5:00–7:00 PM | Myeloid-Based Disease Mechanisms for Neurodegenerative Diseases | Macdonald AB |
| Donna M. Wilcock, Indiana University School of Medicine Therapeutic Trem2 Activation Ameliorates Amyloid-beta Deposition and Improves Cognition in the 5XFAD Model of Amyloid Deposition |
| Zhiqiang An, The University of Texas Health Science Center at Houston Antibodies Targeting the LILRB2/TREM2 Axis in AD |
| Jessie Premereur, VIB-CMN Short Talk: ABCA7 Controls Microglial Activation in Alzheimer’s Disease by Regulating Phosphatidyl Inositol Metabolism |
| Jean Paul Chadarevian, UC Irvine Short Talk: Therapeutic Potential of iPSC-derived Microglia Replacement for the Treatment of GRN-related Frontotemporal Dementia |
| 7:00–8:00 PM | Social Hour with Dinner | Macdonald EF |
| 7:30–10:00 PM | Poster Session 2 | Macdonald EF |
| 7:00–8:00 AM | Breakfast | Macdonald EF |
| 8:00–11:00 AM | Drug Delivery (Joint) | Macdonald ABCD |
| Fiona C. Elwood, Janssen R&D Developing Drugs for CNS Disorders: Considerations for Therapies That Cross the BBB |
| Kate Monroe, Denali Therapeutics Human Genetics Identifies Novel Microglial Targeting Therapeutic Approaches for Alzheimer's Disease |
| Sebastian Boland, Prevail Therapeutics, Eli Lilly Talk Title to be Announced |
| Christopher J. Barnum, INmune Bio Inc. Selective Targeting of Soluble TNF to Mitigate Neuroinflammation in Neurodegenerative Diseases |
| Emily Han, University of Pennsylvania Short Talk: Understanding the Chemical and Biological Phenomena That Drive mRNA Lipid Nanoparticle Delivery to the Brain |
| Urs Langen, Roche Innovation Center Basel Short Talk: Beyond the Shuttle: Advances in Brain Delivery of Biologics for the Treatment of Neurodegenerative Diseases |
| 9:00–9:20 AM | Coffee Break | Macdonald Foyer |
| 9:20–9:25 AM | Award Recipient Acknowledgement | Macdonald ABCD |
| 11:00–5:00 PM | On Own for Lunch | Macdonald EF |
| 2:30–4:30 PM | Symposia Spotlight | Macdonald AB |
| Tae Wan Kim, DGIST Next Generation of hPSC-Based Cell Replacement Therapy for Parkinson's Disease |
| Theodore J Zwang, Massachusetts General Hospital and Harvard Medical School Tau Drives Cell Specific Functional Isolation of the Hippocampal Formation |
| Shuo-Chien Ling, National University of Singapore Horizontal Transfer of Excess Cholesterol from Motor Neurons Enhances Myelination and Preserves Motor Circuit Function |
| Joshua Samuels, University of Virginia SHP-1 Loss Enhances Microglial Immune Functions and Reduces Aβ Plaque Burden Via MMP-12-Mediated Degradation in Aβ Amyloidosis |
| Dominic Acri, National Institute on Aging Transcriptional Reprogramming Links PIKfyve Inhibition to Microglial Activation |
| Thomas Marsh, Washington University in St. Louis Discovery of Genes Robustly Associated with ADAD Through Integration of Three Human Model Systems |
| Rebecca L Pinals, Stanford University Engineering a 3D Human Blood-Brain Barrier-on-Chip to Model Inflammation-Driven Dysfunction in Alzheimer’s Disease |
| 4:30–5:00 PM | Coffee Available | Macdonald Foyer |
| 5:00–6:30 PM | Target-Based Therapeutics | Macdonald AB |
| Emma Mead, Oxford Drug Discovery Institute USP11 Inhibitors and tau Proteostasis |
| Haiyan Peng, Alnylam Pharmaceuticals The Application of RNAi Therapeutics in Neurodegenerative Diseases |
| Christiane D Wrann, Massachusetts General Hospital How Physical Activity Protects the Brain—Cell by Cell—in Alzheimer's Disease |
| 6:30–7:15 PM | Closing Keynote Address | Macdonald AB |
| Dennis J. Selkoe, Harvard Medical School A Century of Alzheimer’s Research – Did We Finally Reach Our Goal? |
| 7:15–7:30 PM | Meeting Wrap-Up: Outcomes and Future Directions | Macdonald AB |
| 7:30–8:30 PM | Social Hour with Dinner | Macdonald EF |
| 8:30–9:30 PM | Entertainment | MacDonald CD |
| 8:30–9:30 PM | Cash Bar | Macdonald EF |
| 12:00–11:59 PM | Departure |