| 4:00–8:00 PM | Registration | Macdonald Foyer |
| 6:00–8:00 PM | Welcome Mixer | Macdonald Foyer |
| 7:00–8:00 AM | Breakfast | Frontenac Ballroom |
| 8:00–8:10 AM | Welcome Remarks (Joint) | Macdonald ABCD |
| * Julia TCW, Boston University Session Chair |
| 8:10–9:30 AM | Keynote Address (Joint) | Macdonald ABCD |
| * Julia TCW, Boston University Session Chair |
| Christian Haass, Ludwig-Maximilians University Munich Modulation of Microglial Function |
| Astrid Iversen, University of Oxford Genomic Risk for Neuroinflammation |
| 9:30–9:50 AM | Coffee Break | Macdonald Foyer |
| 9:50–11:30 AM | Integrating Degeneration and Inflammation (Joint) | Macdonald ABCD |
| * Michael V. Sofroniew, University of California, Los Angeles Session Chair |
| * Christian Haass, Ludwig-Maximilians University Munich Session Chair |
| Maria de Lourdes Gamez G Tansey, Indiana University Role of Central-Peripheral Neuroimmune Cross-Talk in Neurodegeneration |
| Bart De Strooper, University College London Key Inflection Points in Alzheimer’s Disease Pathogenesis |
| Naresha Saligrama, Washington University School of Medicine in Saint Louis Short Talk: Specificity of CD4 T Cell Response in Parkinson Disease and in a Mouse Model of Synucleinopathy |
| Pengjiao Wang, Boston University Short Talk: Unique Progenitor Cells in the APOE3 Christchurch Brain and Their Potential Resilient Roles in Alzheimer’s Disease |
| 11:30–1:00 PM | Poster Setup | Frontenac Ballroom |
| 11:30–5:00 PM | On Own for Lunch |
| 1:00–10:00 PM | Poster Viewing | Frontenac Ballroom |
| 2:30–4:30 PM | Panel Discussion: From Research to Clinical Practice | Macdonald AB |
| * Julia TCW, Boston University |
| Emma Mead, Oxford Drug Discovery Institute |
| Christian Haass, Ludwig-Maximilians University Munich |
| Kathryn Monroe, Denali Therapeutics |
| Justin Ichida, USC Keck School of Medicine |
| Haiyan Peng, Alnylam Pharmaceuticals |
| Dennis J. Selkoe, Harvard Medical School |
| 4:30–5:00 PM | Coffee Available | Macdonald Foyer |
| 5:00–7:00 PM | Neurodegenerative Disease Diagnostic to Therapeutics | Macdonald AB |
| * Kathryn Monroe, Denali Therapeutics Session Chair |
| * Dennis J. Selkoe, Harvard Medical School Session Chair |
| Yimin Zou, University of California, San Diego Planar Cell Polarity Proteins in Synapse Degeneration |
| Henne Holstege, Amsterdam UMC Decoding Natural Resilience against Cognitive Decline: The 100-plus Study |
| Matthias Brendel, LMU Munich Molecular Imaging with PET for Translation towards Therapeutics |
| Sam Gandy, Icahn School of Medicine at Mount Sinai Short Talk: Positron emission tomographic (PET) imaging with novel [64Cu]-NOTA-cyclic D,L-α-peptide ligands: Ab oligomer signals appear in the 5XFAD mouse thalamus before the cortex |
| Peisheng Xu, University of South Carolina Short Talk: Brain-Targeted Nano-ERASER Downregulates PD-L1 for Alzheimer’s Disease Therapy |
| 7:00–8:00 PM | Social Hour with Dinner | Frontenac Ballroom |
| 7:05–8:00 PM | Women in Science Networking Event | Frontenac Ballroom |
| * Julia TCW, Boston University |
| * Christian Haass, Ludwig-Maximilians University Munich |
| * Emma Mead, Oxford Drug Discovery Institute |
| * Robyn S Klein, Western University, London, Ontario |
| * Maria de Lourdes Gamez G Tansey, Indiana University |
| * Henne Holstege, Amsterdam UMC |
| 7:30–10:00 PM | Poster Session 1 | Frontenac Ballroom |
| 7:00–8:00 AM | Breakfast | Frontenac Ballroom |
| 8:00–11:00 AM | Disease Overarching Mechanisms of Neurodegenerative Diseases | Macdonald AB |
| * Sam Gandy, Icahn School of Medicine at Mount Sinai Session Chair |
| * Yimin Zou, University of California, San Diego Session Chair |
| Julia TCW, Boston University Astrocytic autophagic-lysosomal dysfunction induces lipid accumulation, tau pathology, and ferroptosis in APOE4 Alzheimer’s brain |
| Justin Ichida, USC Keck School of Medicine Using Patient Stem Cells to Identify Therapeutic Targets for Familial and Sporadic ALS |
| Tae Wan Kim, DGIST Human Stem Cell-based Cell Replacement Therapy and Dopamine Neuron Senescence in Parkinson's Disease |
| Mike Gallagher, Whitehead Institute for Biomedical Research Short Talk: Perturb-Seq in Human Microglia-Like Cells Links Neurodegenerative GWAS Variants to Causal Risk Genes and Shared Downstream Pathways |
| Laura Bott, Northwestern University Short Talk: Interindividual Variation in Proteostasis Shapes Resilience and Disease Trajectories in Protein Misfolding Disorders |
| Garrett Fogo, Brigham and Women's Hospital Short Talk: Multi-omic Profiling of Human iPSC-derived Glial Cells Identifies Genetic and Molecular Drivers of Mitochondrial and Lysosomal Systems |
| Zhen Yan, State University of New York at Buffalo Short Talk: Histone Demethylase PHF2 Regulates Inflammatory Genes in Alzheimer's Disease |
| 9:00–9:20 AM | Coffee Break | Macdonald Foyer |
| 11:00–1:00 PM | Poster Setup | Frontenac Ballroom |
| 11:00–5:00 PM | On Own for Lunch |
| 1:00–10:00 PM | Poster Viewing | Frontenac Ballroom |
| 1:15–2:45 PM | Health Equity Panel (Joint) sponsored by The Burroughs Wellcome Fund | Macdonald AB |
| * Maria de Lourdes Gamez G Tansey, Indiana University |
| Jennifer Manly, Columbia University |
| Kathryn Monroe, Denali Therapeutics |
| Dennis J. Selkoe, Harvard Medical School |
| Jamaine Davis, Belmont University |
| 3:00–4:30 PM | Career Roundtable (Joint) | Macdonald AB |
| Erin E Gray, National Institute on Aging, NIH Program Director |
| Gabriella E Martyn, Arc Institute Senior Scientist |
| Erin Knock, STEMCELL Technologies Canada Ltd Associate Director |
| Sam Rose, Cell Press Editor |
| 4:30–5:00 PM | Coffee Available | Macdonald Foyer |
| 5:00–7:15 PM | Myeloid-Based Disease Mechanisms for Neurodegenerative Diseases | Macdonald AB |
| * Emma Mead, Oxford Drug Discovery Institute Session Chair |
| * David Chambers, University College London Session Chair |
| Marco Colonna, Washington University School of Medicine Remote Presentation: Microglial Neurodegeneration Mechanisms |
| Zhiqiang An, The University of Texas Health Science Center at Houston Antibodies Targeting the LILRB2/TREM2 Axis in AD |
| Nalini R Rao, Gladstone Institutes Physiological Brain Clearance Architecture Revealed by Neuronal Protein Tracing |
| Jessie Premereur, VIB-CMN Short Talk: ABCA7 Controls Microglial Activation in Alzheimer’s Disease by Regulating Phosphatidyl Inositol Metabolism |
| Jean Paul Chadarevian, UC Irvine Short Talk: Therapeutic Potential of iPSC-derived Microglia Replacement for the Treatment of GRN-related Frontotemporal Dementia |
| Kimitoshi Kimura, Kyoto University Short Talk: Immune Checkpoint Molecule Tim-3 Regulates Microglial Function and the Development of Alzheimer’s Disease Pathology |
| 7:00–8:00 PM | Social Hour with Dinner | Frontenac Ballroom |
| 7:30–10:00 PM | Poster Session 2 | Frontenac Ballroom |
| 7:00–8:00 AM | Breakfast | Frontenac Ballroom |
| 8:00–11:00 AM | Drug Delivery (Joint) | Macdonald ABCD |
| * Lynette C Foo, F.Hoffman-La Roche Session Chair |
| * Haiyan Peng, Alnylam Pharmaceuticals Session Chair |
| Fiona C. Elwood, Janssen R&D Developing Drugs for CNS Disorders: Considerations for Therapies That Cross the BBB |
| Kathryn Monroe, Denali Therapeutics Targeting Co-Pathologies with TransportVehicle Engineered Antibodies for Alzheimer's Disease |
| Sebastian Boland, Prevail Therapeutics, Eli Lilly Gene Therapy for Type 2 Gaucher Disease — Interim Results From the PROVIDE Clinical Trial |
| Christopher J. Barnum, INmune Bio Inc. Selective Targeting of Soluble TNF to Mitigate Neuroinflammation in Neurodegenerative Diseases |
| Emily Han, University of Pennsylvania Short Talk: Understanding the Chemical and Biological Phenomena That Drive mRNA Lipid Nanoparticle Delivery to the Brain |
| Urs Langen, Roche Innovation Center Basel Short Talk: Beyond the Shuttle: Advances in Brain Delivery of Biologics for the Treatment of Neurodegenerative Diseases |
| 9:00–9:20 AM | Coffee Break | Macdonald Foyer |
| 9:20–9:25 AM | Award Recipient Acknowledgement | Macdonald ABCD |
| 11:00–5:00 PM | On Own for Lunch |
| 2:30–4:30 PM | Symposia Spotlight | Macdonald AB |
| * Henne Holstege, Amsterdam UMC Session Chair |
| * Hankum Park, Seoul National University Session Chair |
| Theodore J Zwang, Massachusetts General Hospital and Harvard Medical School Short Talk: Tau Drives Cell Specific Functional Isolation of the Hippocampal Formation |
| Shuo-Chien Ling, National University of Singapore Short Talk: Horizontal Transfer of Excess Cholesterol from Motor Neurons Enhances Myelination and Preserves Motor Circuit Function |
| Joshua Samuels, University of Virginia Short Talk: SHP-1 Loss Enhances Microglial Immune Functions and Reduces Aβ Plaque Burden Via MMP-12-Mediated Degradation in Aβ Amyloidosis |
| Dominic Acri, National Institute on Aging Short Talk: Transcriptional Reprogramming Links PIKfyve Inhibition to Microglial Activation |
| Thomas Marsh, Washington University in St. Louis Short Talk: Integration of Human ADAD Models Implicates Neuronal β-Oxidation as a Core, Targetable Disease Mechanism |
| Rebecca L Pinals, Stanford University Short Talk: Engineering a 3D Human Blood-Brain Barrier-on-Chip to Model Inflammation-Driven Dysfunction in Alzheimer’s Disease |
| Manisha Kunala, UMass Chan Medical School Short Talk: Metabolic Rewiring Precedes and Predicts Amyotrophic Lateral Sclerosis Progression |
| Celia McKee, Merck Short Talk: Automating High-Content Synaptic Imaging to Explore Recovery Potential in Amyloid Beta Immunotherapy |
| 4:30–5:00 PM | Coffee Available | Macdonald Foyer |
| 5:00–6:30 PM | Target-Based Therapeutics | Macdonald AB |
| * Justin Ichida, USC Keck School of Medicine Session Chair |
| * Jian Feng, University at Buffalo, State University of New York Session Chair |
| Emma Mead, Oxford Drug Discovery Institute USP11 Inhibitors and tau Proteostasis |
| Haiyan Peng, Alnylam Pharmaceuticals Mivelsiran (ALN-APP), the First Investigational RNAi Therapeutic in Development for Alzheimer’s Disease and Cerebral Amyloid Angiopathy |
| Christiane D Wrann, Massachusetts General Hospital How Physical Activity Protects the Brain—Cell by Cell—in Alzheimer's Disease and Multiple Sclerosis |
| 6:30–7:15 PM | Closing Keynote Address | Macdonald AB |
| * Christian Haass, Ludwig-Maximilians University Munich Session Chair |
| Dennis J. Selkoe, Harvard Medical School A Century of Alzheimer’s Research – Did We Finally Reach Our Goal? |
| 7:15–7:30 PM | Meeting Wrap-Up: Outcomes and Future Directions | Macdonald AB |
| * Julia TCW, Boston University Session Chair |
| 7:30–8:15 PM | Social Hour with Dinner | Frontenac Ballroom |
| 8:00–9:00 PM | Entertainment | Frontenac Ballroom |
| 8:00–9:00 PM | Cash Bar | Frontenac Ballroom |
| 12:00–11:59 PM | Departure |