Genetic Medicines to Treat Cardiovascular Disease (N3)
January 1-4, 2027  | Location to be Determined
* Session Chair † Invited but not yet accepted | Program current as of September 5, 2025 10 AM | For the most up-to-date details, visit https://www.keystonesymposia.org
Friday, January 1, 2027
4:00–8:00 PM Registration
6:00–8:00 PM Welcome Mixer
Saturday, January 2, 2027
7:00–8:00 AM Breakfast
8:00–9:00 AM Welcome and Keynote Address
  Sekar Kathiresan †, Verve Therapeutics
The Human Genome as Teacher and Target: Two Decades of Genomic Discovery to Genomic Medicines
 
9:00–11:15 AM New Trailheads: Target Identification for Genetic Medicines in CV Disease
  James S. Ware, Imperial College London
Large Scale Genomic Discovery of Causal Mechanisms in Heart Failure
 
  Victoria Parikh †, Stanford University School of Medicine
Genotype-Phenotype Correlation in Inherited Cardiovascular Disease
 
  Rick Dewey, Versant Ventures
Target Selection for Genetic Medicines: Biobanks to Human Proof of Concept
 
  Short Talk(s) Chosen from Abstracts
 
9:30–9:50 AM Coffee Break
11:15–12:15 PM Panel Discussion 1: Development, Regulatory, Safety, and Ethical Considerations (including long-term and off-target effects of genetic medicines)
11:15–1:00 PM Poster Setup
11:15–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing
2:30–4:30 PM Symposia Spotlight 1: Emerging Biological Insights Driving the Next Generation of Genetics Medicines for CV Disease
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available
5:00–7:00 PM Mechanisms and Models: From Variation to Validation
  Cassady Rupert †, Propria LLC
Modeling Human Cardiac Biology with Multi-Dimensional Engineered Human Heart Tissues
 
  Christine E. Seidman †, Harvard Medical School
Modeling Cardiovascular Disease: Genetics, Cellular Systems, Human Models
 
  Litsa G. Kranias, University of Cincinnati
PLN Cardiomyopathy: From Bedside to Bench and Back to Bedside
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM Social Hour with Dinner
7:30–10:00 PM Posters
Sunday, January 3, 2027
7:00–8:00 AM Breakfast
8:00–11:00 AM Gene Silencing in Cardiovascular Disease and Promising Avenues
  Marianna Fontana †, University College London
CRISPR-Cas9 Gene Editing for TTR Amyloid Cardiomyopathy
 
  Kate A Fitzgerald †, University of Massachusetts Medical School
From RNAi Mechanism to Medicine; the Path to a New Class of Genetic Medicines
 
  Rebecca Ahrens-Nicklas †, Children's Hospital of Philadelphia
In vivo Personalized Genome Editing
 
  Jin Billy Li †, Stanford University
Endogenous RNA Editing in CV Disease: Mechanisms and Therapeutic Applications
 
  Short Talk(s) Chosen from Abstracts
 
9:00–9:20 AM Coffee Break
11:00–1:00 PM Poster Setup
11:00–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing
3:00–4:30 PM Career Roundtable
4:30–5:00 PM Coffee Available
5:00–7:00 PM Therapeutic Gene Augmentation Strategies in CV Disease
  Roger J. Hajjar †, Mass General Brigham
Engineering the Failing Heart: Innovations in Cardiac Gene Therapy
 
  Annemieke Aartsma-Rus †, Leiden University Medical Center
Exon Skipping to Restore Gene Expression in Muscle Disease
 
  Speaker to be Announced
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM Social Hour with Dinner
7:30–10:00 PM Posters
Monday, January 4, 2027
7:00–8:00 AM Breakfast
8:00–11:00 AM Homing for Cures: Cardiomyocyte-Directed Delivery Approaches
  Luk H. Vandenberghe †, Harvard Medical School
Engineering Viral Delivery Systems
 
  Speaker to be Announced
 
  James Dahlman †, Georgia Tech / Emory Medical School
Lipid Nanoparticles: Past, Present, and Future of RNA Delivery
 
  William M Flanagan †, Avidity Biosciences, Inc.
Antibody-Oligo Conjugates for Striated Muscle-Enriched Delivery
 
  Short Talk(s) Chosen from Abstracts
 
9:00–9:20 AM Coffee Break
11:00–5:00 PM On Own for Lunch
2:30–4:30 PM Symposia Spotlight 2: Emerging Translational Strategies in CV Disease
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available
5:00–6:45 PM Products to Patients: Therapeutic Development and Trial Design
  Laura F. Michael †, Eli Lilly and Company
Lp(a) - From Genetic Insight to Novel Biology and Breakthrough Therapy
 
  Pushkal Garg †, Alnylam Pharmaceuticals, Inc.
Industry Perspective on Clinical Development of Genetic Therapies
 
  Gene Bukhman †, Brigham and Women's Hospital
Global Health Equity Considerations for New Treatments for CV Disease
 
  Short Talk(s) Chosen from Abstracts
 
6:45–7:00 PM Meeting Wrap-Up: Outcomes and Future Directions
7:00–8:00 PM Social Hour with Dinner
8:00–11:00 PM Entertainment
8:00–11:00 PM Cash Bar
Tuesday, January 5, 2027
12:00–11:59 PM Departure