| 4:00–8:00 PM | Registration | Macdonald Foyer |
| 6:00–8:00 PM | Welcome Mixer | Macdonald Foyer |
| 7:00–8:00 AM | Breakfast | Frontenac Ballroom |
| 8:00–8:10 AM | Welcome Remarks (Joint) | Macdonald ABCD |
| * Julia TCW, Boston University Session Chair |
| 8:10–9:30 AM | Keynote Session (Joint) | Macdonald ABCD |
| * Julia TCW, Boston University Session Chairs |
| Christian Haass, Ludwig-Maximilians University Munich Modulation of Microglial Function |
| Astrid Iversen, University of Oxford Genomic Risk for Neuroinflammation |
| 9:30–9:50 AM | Coffee Break | Macdonald Foyer |
| 9:50–11:30 AM | Integrating Degeneration and Inflammation (Joint) | Macdonald ABCD |
| * Michael V. Sofroniew, University of California, Los Angeles Session Chair |
| * Christian Haass, Ludwig-Maximilians University Munich Session Chair |
| Maria de Lourdes Gamez G Tansey, Indiana University Role of Central-Peripheral Neuroimmune Cross-Talk in Neurodegeneration |
| Bart De Strooper, University College London Key Inflection Points in Alzheimer’s Disease Pathogenesis |
| Naresha Saligrama, Washington University School of Medicine in Saint Louis Short Talk: Specificity of CD4 T Cell Response in Parkinson Disease and in a Mouse Model of Synucleinopathy |
| Pengjiao Wang, Boston University Short Talk: Unique Progenitor Cells in the APOE3 Christchurch Brain and Their Potential Resilient Roles in Alzheimer’s Disease |
| 11:30–1:00 PM | Poster Setup | Frontenac Ballroom |
| 11:30–5:00 PM | On Own for Lunch |
| 1:00–10:00 PM | Poster Viewing | Frontenac Ballroom |
| 3:00–4:30 PM | Symposia Spotlight: Inflammation and Neurodegenerative Disease | Macdonald CD |
| * Bart De Strooper, University College London Session Chair |
| Juan E Maldonado Weng, Eli Lilly Short Talk: Mapping Inflammation in Cerebral Amyloid Angiopathy: AI-Accelerated Spatial Omics Reveals Complement-Driven Vascular Signatures in Alzheimer's Disease |
| Henrike K Grosshans, University Medical Center Hamburg-Eppendorf Short Talk: The Interferon-Stimulated Gene Apolipoprotein L6 Demonstrates an Evolutionary Trade-off between Host Defense and Neurodegeneration |
| Julio Aguado, University of Colorado Short Talk: Virus-Induced Senescence as a Driver of Neuroinflammation and Brain Aging |
| Zoe Moore, The University of Sheffield Short Talk: Systemic Infection Significantly Impacts the Astrocyte Phenotype in Alzheimer’s Disease |
| Leah Beauchamp, Brigham & Women's Hospital Short Talk: Dissecting Immune Mechanisms by Which Gut Microbes Contribute to Alzheimer’s Disease Using Closely Related Bacterial Strains |
| Adeline Walsh, University of Virginia Short Talk: Loss of the Alzheimer’s Disease Genetic Risk Factor CASS4 Disrupts Neuroprotective Microglial Responses and Promotes Amyloid Beta-Driven Pathology |
| 4:30–5:00 PM | Coffee Available | Macdonald Foyer |
| 5:00–7:00 PM | Inflammation to Maintain Health | Macdonald CD |
| * Astrid Iversen, University of Oxford Session Chair |
| Susanna Rosi, Altos Labs Silencing of LINE-1 RNA Protects against Heterochromatin Drift and Neurodegeneration |
| Josephine W Thinwa, University of Texas Southwestern Medical Center Fine-Tuning Autophagy to Limit Virus-Induced Neuroinflammation |
| Robyn S Klein, Western University, London, Ontario Host-Pathogen Neuroimmunology Gone Wrong |
| Sydney A Labuzan, University of Virginia Short Talk: Astrocytic but not Microglial Antigen Presentation Shapes Protective Immunity to Toxoplasma gondii Neuroinfection |
| Casey Mahoney-Crane, NIH National Institute of Aging Short Talk: LRRK2 Activity Increases Release of Cathepsins from Human-iPSC-Derived Microglia |
| 7:00–8:00 PM | Social Hour with Dinner | Frontenac Ballroom |
| 7:05–8:00 PM | Women in Science Networking Event | Frontenac Ballroom |
| * Julia TCW, Boston University |
| * Christian Haass, Ludwig-Maximilians University Munich |
| * Emma Mead, Oxford Drug Discovery Institute |
| * Robyn S Klein, Western University, London, Ontario |
| * Maria de Lourdes Gamez G Tansey, Indiana University |
| * Henne Holstege, Amsterdam UMC |
| 7:30–10:00 PM | Poster Session 1 | Frontenac Ballroom |
| 7:00–8:00 AM | Breakfast | Frontenac Ballroom |
| 8:00–9:00 AM | CNS Glia and Neuroinflammation | Macdonald CD |
| * Marie-Ève Tremblay, University of Victoria Session Chair |
| Michael V. Sofroniew, University of California, Los Angeles Astrocytes and CNS Innate Immunity |
| Ukpong B Eyo, University of Virginia Microglia at the Neurovascular Interface in Health and Disease. |
| 9:00–9:20 AM | Coffee Break | Macdonald Foyer |
| 9:30–11:00 AM | CNS Glia, Neuroinflammation and Behavior | Macdonald CD |
| * Andy Shih, Seattle Children’s Research Institute and University of Washington Session Chair |
| Jennifer Felger, Emory University Inflammation and Anhedonia in Depression: Biomarkers, Mechanisms, and Therapeutic Implications |
| Marie-Ève Tremblay, University of Victoria New insights into the roles of stressed microglia |
| Diala El Masri, Research Center du Centre Hospitalier de l'Université de Montréal Short Talk: Glial-derived Stress Ligand MULT1, an NKG2D Ligand, Modulates Neuroinflammation in MS Model Through Immune-Glial Cell Crosstalk |
| Urjashi Laha, University of Western Ontario Short Talk: Sex-differential Microglial Programs are Associated with Impaired Cognitive Recovery in Males after West Nile Neuroinvasive Disease |
| 11:00–1:00 PM | Poster Setup | Frontenac Ballroom |
| 11:00–5:00 PM | On Own for Lunch |
| 1:00–10:00 PM | Poster Viewing | Frontenac Ballroom |
| 1:15–2:45 PM | Health Equity Panel (Joint) sponsored by The Burroughs Wellcome Fund | Macdonald AB |
| * Maria de Lourdes Gamez G Tansey, Indiana University |
| Jennifer Manly, Columbia University |
| Kathryn Monroe, Denali Therapeutics |
| Dennis J. Selkoe, Harvard Medical School |
| Jamaine Davis, Belmont University |
| 3:00–4:30 PM | Career Roundtable (Joint) | Macdonald AB |
| Erin E Gray, National Institute on Aging, NIH Program Director |
| Gabriella E Martyn, Arc Institute Senior Scientist |
| Erin Knock, STEMCELL Technologies Canada Ltd Associate Director |
| Sam Rose, Cell Press Editor |
| 4:30–5:00 PM | Coffee Available | Macdonald Foyer |
| 5:00–7:00 PM | Gut and Systemic Influences on CNS Inflammation, Neurodegeneration and Behavior | Macdonald CD |
| * Maria de Lourdes Gamez G Tansey, Indiana University Session Chair |
| Laura M Cox, Harvard Medical School Gut Microbiome, Autoimmunity and Neurodegeneration |
| Andrea Merchak, Indiana University Microbial Metabolites and Immune Regulation |
| Eleonore Beurel, University of Miami Stress, Inflammation, Microbiome and Depression |
| Laura H. Corbit, University of Toronto Short Talk: Diet-Induced Activation of Striatal Microglia Contributes to Impairments In Cognitive Control and Flexible Decision-Making |
| Claire Young, Baylor College of Medicine Short Talk: Leptin Directly Modulates Microglia Cytokine Response in the Arcuate Nucleus of the Hypothalamus |
| 7:00–8:00 PM | Social Hour with Dinner | Frontenac Ballroom |
| 7:30–10:00 PM | Poster Session 2 | Frontenac Ballroom |
| 7:00–8:00 AM | Breakfast | Frontenac Ballroom |
| 8:00–11:00 AM | Drug Delivery (Joint) | Macdonald ABCD |
| * Lynette C Foo, F.Hoffman-La Roche Session Chair |
| * Haiyan Peng, Alnylam Pharmaceuticals Session Chair |
| Fiona C. Elwood, Janssen R&D Developing Drugs for CNS Disorders: Considerations for Therapies That Cross the BBB |
| Kathryn Monroe, Denali Therapeutics Targeting Co-Pathologies with TransportVehicle Engineered Antibodies for Alzheimer's Disease |
| Sebastian Boland, Prevail Therapeutics, Eli Lilly Gene Therapy for Type 2 Gaucher Disease — Interim Results From the PROVIDE Clinical Trial |
| Christopher J. Barnum, INmune Bio Inc. Selective Targeting of Soluble TNF to Mitigate Neuroinflammation in Neurodegenerative Diseases |
| Emily Han, University of Pennsylvania Short Talk: Understanding the Chemical and Biological Phenomena That Drive mRNA Lipid Nanoparticle Delivery to the Brain |
| Urs Langen, Roche Innovation Center Basel Short Talk: Beyond the Shuttle: Advances in Brain Delivery of Biologics for the Treatment of Neurodegenerative Diseases |
| 9:00–9:20 AM | Coffee Break | Macdonald Foyer |
| 9:20–9:25 AM | Award Recipient Acknowledgement | Macdonald ABCD |
| 11:00–5:00 PM | On Own for Lunch |
| 2:30–4:30 PM | Panel Discussion: Neuroinflammation and Psychiatric/Behavioral Disorders | Macdonald CD |
| * Marie-Ève Tremblay, University of Victoria |
| * Eleonore Beurel, University of Miami |
| * Maria de Lourdes Gamez G Tansey, Indiana University |
| * Robyn S Klein, Western University, London, Ontario |
| 4:30–5:00 PM | Coffee Available | Macdonald Foyer |
| 5:00–6:15 PM | Blood-Brain Barrier and Inflammation | Macdonald CD |
| * Robyn S Klein, Western University, London, Ontario Session Chair |
| Catherine Hall, University of Sussex Neurovascular Function and Brain Hypoxia |
| Andy Shih, Seattle Children’s Research Institute and University of Washington Brain Capillaries, Pericytes, and Neuroinflammation |
| Jorge I. Alvarez, University of Pennsylvania Short Talk: Vascular Control of NeuroInflammation: A Nanoparticle Based Approach to Probe BBB–Immune Interactions |
| 6:15–7:00 PM | Closing Keynote Address | Macdonald CD |
| * Robyn S Klein, Western University, London, Ontario Session Chair |
| Jenny P Ting, University of North Carolina at Chapel Hill Innate Immune Receptors in Neuroinflammation |
| 7:00–7:15 PM | Meeting Wrap-Up: Outcomes and Future Directions | Macdonald CD |
| * Michael V. Sofroniew, University of California, Los Angeles Session Chair |
| * Maria de Lourdes Gamez G Tansey, Indiana University Session Chair |
| * Robyn S Klein, Western University, London, Ontario Session Chair |
| 7:15–8:15 PM | Social Hour with Dinner | Frontenac Ballroom |
| 8:00–9:00 PM | Entertainment | Frontenac Ballroom |
| 8:00–9:00 PM | Cash Bar | Frontenac Ballroom |
| 12:00–11:59 PM | Departure |