Immunologic Approaches to Ending HIV: At the Crossroads of Innovation and Delivery (N4)
May 16-19, 2027  | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Julie Ake, Esper Georges Kallas, Devi SenGupta and Darrell J. Irvine
Scholarship Deadline: Jan. 20, 2027 | Abstract Deadline: Apr. 27, 2027 | Early Registration Deadline: Mar. 18, 2027
* Session Chair † Invited but not yet accepted | Program current as of December 25, 2025 1 AM | For the most up-to-date details, visit https://www.keystonesymposia.org
Sunday, May 16, 2027
4:00–8:00 PM Registration
6:00–8:00 PM Welcome Mixer
Monday, May 17, 2027
7:00–8:00 AM Breakfast
8:00–8:10 AM Welcome Remarks (Joint)
8:10–9:00 AM Keynote Address (Joint)
  Michel C. Nussenzweig †, HHMI/Rockefeller University
Immune Strategies to Combat Infectious Diseases: What Works and What Doesn't
 
9:00–11:15 AM Transformative Technologies for Infectious Disease Therapeutics and Vaccines (Joint)
  Debora Marks, Harvard Medical School
Beating Viruses at their Own Game
 
  Kevin Wiehe †, Duke University
Mutation Guided Immunogen Design
 
  Fernando Ulloa Montoya †, Sanofi
AI-Guided mRNA Vaccines Design
 
  Darrell J. Irvine, Scripps Research Institute
Harnessing Novel Vaccine Dosing and Adjuvant Strategies
 
  Short Talk(s) Chosen from Abstracts
 
9:30–9:50 AM Coffee Break
11:15–1:00 PM Poster Setup
11:15–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing
2:30–4:30 PM Symposia Spotlight 1: Monoclonal Antibody Focus - Prevention or Cure Indications: Multi-Specific Antibodies, mAb Escape
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available
5:00–7:00 PM Emerging Cure Concepts
  Jonah B. Sacha †, Oregon Health & Science University
Leronlimab with bNabs: Timing is Everything
 
  David D. Ho †, Aaron Diamond AIDS Research Center (ADARC), Columbia University Medical Center
Novel Small Molecules for Cure
 
  Lishomwa C. Ndhlovu †, Weill Cornell Medicine
Transcriptional Silencing to Advance Remission
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM Social Hour with Dinner
7:30–10:00 PM Posters
Tuesday, May 18, 2027
7:00–8:00 AM Breakfast
8:00–11:00 AM HIV Preclinical Pipeline Progress
  Raiees A Andrabi †, University of Pennsylvania
The Relentless Pursuit of Neutralization
 
  Nicole A Doria-Rose †, NIAID, National Institutes of Health
High throughput Monoclonal Antibody Discovery
 
  Mohamad-Gabriel Alameh †, Children's Hospital of Philadelphia
Optimizing mRNA Vaccines for Cure and Preventive Indications
 
  Short Talk(s) Chosen from Abstracts
 
9:00–9:20 AM Coffee Break
11:00–1:00 PM Poster Setup
11:00–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing
3:00–4:30 PM Career Roundtable
4:30–5:00 PM Coffee Available
5:00–7:00 PM Frontiers of HIV Cure
  Devi SenGupta, Gilead Sciences, Inc.
Combination Therapy for Post Intervention Control
 
  Charity Wambui Kanyoro †, Moi University College of Health Sciences
Dual Affinity Re-Targeting Proteins and Latency Reversal
 
  Michael J Peluso †, University of California, San Francisco
Emerging Clinical Data: Cytokines and CAR-T Cells in HIV Cure
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM Social Hour with Dinner
7:30–10:00 PM Posters
Wednesday, May 19, 2027
7:00–8:00 AM Breakfast
8:00–11:00 AM Clinical Innovation in Immunologic HIV Countermeasures
  William Hahn †, Fred Hutchinson Cancer Center,
Emerging Data from the HVTN Discovery Medicine Portfolio
 
  Julie Ake, Walter Reed Army Institute of Research
Rapidvax: Learning from the Lymph Node
 
  Esper Georges Kallas, University of São Paulo
Global Health Vaccines: Lessons from Instituto Butantan
 
  Richard M Dunham †, ViiV Healthcare
The N6 Clinical Experience
 
  Short Talk(s) Chosen from Abstracts
 
9:00–9:20 AM Coffee Break
11:00–5:00 PM On Own for Lunch
2:30–4:30 PM Symposia Spotlight 2: Emerging Data from Vaccine and Cure Phase 1 Clinical Trials: GrAd Vectored HIV Vaccines, T Cell Engagers for Cure
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available
5:00–6:45 PM Wrangling the Reservoir
  Nadia R Roan †, University of California, San Francisco
The Reservoir across Compartments: Everything Everywhere all at Once
 
  Amanda M. Brown †, Johns Hopkins University School of Medicine
Determinants of HIV CNS Reservoirs
 
  Jonathan Jonathan Li †, Brigham and Women's Hospital
Strategies for Reservoir Reduction: Lessons from the ACTG Cure Portfolio
 
  Short Talk(s) Chosen from Abstracts
 
6:45–7:00 PM Meeting Wrap-Up: Outcomes and Future Directions
7:00–8:00 PM Social Hour with Dinner
7:30–10:00 PM Posters
Thursday, May 20, 2027
12:00–11:59 PM Departure