Ending HIV: At the Crossroads of Innovation and Delivery (N4)
May 16-19, 2027  | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Julie Ake, Esper Georges Kallas, Devi SenGupta and Darrell J. Irvine
Scholarship Deadline: Jan. 20, 2027 | Abstract Deadline: Apr. 27, 2027 | Early Registration Deadline: Mar. 18, 2027
* Session Chair † Invited but not yet accepted | Program current as of May 16, 2026 9 PM | For the most up-to-date details, visit https://www.keystonesymposia.org
Sunday, May 16, 2027
4:00–8:00 PM Registration
6:00–8:00 PM Welcome Mixer
Monday, May 17, 2027
7:00–8:00 AM Breakfast
8:00–8:10 AM Welcome Remarks (Joint)
8:10–9:00 AM Keynote Address (Joint)
  Michel C. Nussenzweig, HHMI/Rockefeller University
Immune Strategies to Combat Infectious Diseases: What Works and What Doesn't
 
9:00–11:15 AM Transformative Technologies for Infectious Disease Therapeutics and Vaccines (Joint)
  Debora Marks, Harvard Medical School
Beating Viruses at their Own Game
 
  Kevin Wiehe, Duke University
Mutation Guided Immunogen Design
 
  Pamela J Bjorkman, California Institute of Technology
Structure based Vaccine Design
 
  Darrell J. Irvine, Scripps Research Institute
Harnessing Novel Vaccine Dosing and Adjuvant Strategies
 
  Short Talk(s) Chosen from Abstracts
 
9:30–9:50 AM Coffee Break
11:15–12:15 PM Panel Discussion: Vaccine Hesitancy and Distrust (Joint)
11:15–1:00 PM Poster Setup
11:15–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing
2:30–4:30 PM Symposia Spotlight 1: Monoclonal Antibody Focus - Prevention or Cure Indications: Multi-Specific Antibodies, mAb Escape
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available
5:00–7:00 PM Emerging Cure Concepts
  Thumbi Ndung'u, University of KwaZulu-Natal
HIV Cure Strategies for the Global South
 
  David D. Ho, Aaron Diamond AIDS Research Center (ADARC), Columbia University Medical Center
Novel Small Molecules for Cure
 
  Lishomwa C Ndhlovu, Weill Cornell Medicine
Transcriptional Silencing to Advance Remission
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM Social Hour with Dinner
7:30–10:00 PM Posters
Tuesday, May 18, 2027
7:00–8:00 AM Breakfast
8:00–11:00 AM HIV Preclinical Pipeline Progress
  Raiees A Andrabi, University of Pennsylvania
Broad HIV Neutralization by Targeted Sequential Vaccination
 
  Nicole A Doria-Rose, NIAID, National Institutes of Health
High throughput Monoclonal Antibody Discovery
 
  Mohamad-Gabriel Alameh, Children's Hospital of Philadelphia
Optimizing mRNA Vaccines for Cure and Preventive Indications
 
  Short Talk(s) Chosen from Abstracts
 
9:00–9:20 AM Coffee Break
11:00–1:00 PM Poster Setup
11:00–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing
3:00–4:30 PM Career Roundtable
4:30–5:00 PM Coffee Available
5:00–7:00 PM Frontiers of HIV Cure
  Devi SenGupta, Gilead Sciences, Inc.
Combination Therapy for Post Intervention Control
 
  Charity Wambui Kanyoro †, Moi University College of Health Sciences
Dual Affinity Re-Targeting Proteins and Latency Reversal
 
  Michael J Peluso, University of California, San Francisco
Emerging Clinical Data: Cytokines and CAR-T Cells in HIV Cure
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM Social Hour with Dinner
7:30–10:00 PM Posters
Wednesday, May 19, 2027
7:00–8:00 AM Breakfast
8:00–11:00 AM Clinical Innovation in Immunologic HIV Countermeasures
  Margaret J McElrath, Fred Hutchinson Cancer Center
Emerging Data from the HVTN Discovery Medicine Portfolio
 
  Julie Ake, Walter Reed Army Institute of Research
Rapidvax: Learning from the Lymph Node
 
  Esper Georges Kallas, University of São Paulo
Global Health Vaccines: Lessons from Instituto Butantan
 
  Richard M Dunham, ViiV Healthcare
The N6 Clinical Experience
 
  Short Talk(s) Chosen from Abstracts
 
9:00–9:20 AM Coffee Break
11:00–5:00 PM On Own for Lunch
2:30–4:30 PM Symposia Spotlight 2: Emerging Data from Vaccine and Cure Phase 1 Clinical Trials: GrAd Vectored HIV Vaccines, T Cell Engagers for Cure
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available
5:00–6:45 PM Wrangling the Reservoir
  Nadia R Roan, University of California, San Francisco
The Reservoir across Compartments: Everything Everywhere all at Once
 
  Amanda M. Brown, Johns Hopkins University School of Medicine
Fundamental Mechanisms Shaping Complex Sex-Dependent Inflammatory and Neuroendocrine Responses in HIV Infection
 
  Katharine J Bar, University of Pennsylvania
Strategies for Reservoir Reduction: Lessons from the ACTG Cure Portfolio
 
  Short Talk(s) Chosen from Abstracts
 
6:45–7:00 PM Meeting Wrap-Up: Outcomes and Future Directions
7:00–8:00 PM Social Hour with Dinner
7:30–10:00 PM Posters
Thursday, May 20, 2027
12:00–11:59 PM Departure