Autophagy: Mechanisms to Therapy (P1)
February 2-5, 2026
| Keystone Resort, Keystone, CO, United States
Anne Simonsen, Sharon A. Tooze and Dan Baird
Scholarship Deadline: Nov. 7, 2025 | Abstract Deadline: Jan. 14, 2026 | Early Registration Deadline: Dec. 5, 2025
| 4:00–8:00 PM |
Registration |
Longs Peak Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
Longs Peak Foyer |
Tuesday, February 3, 2026
| 7:00–8:00 AM |
Breakfast |
Quandary Peak |
| 8:00–8:10 AM |
Welcome Remarks (Joint) |
Longs Peak |
| 8:10–9:00 AM |
Keynote Address (Joint) |
Longs Peak |
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* Anne Simonsen, University of Oslo
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* James H. Hurley, University of California, Berkeley
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Erika L Holzbaur, University of Pennsylvania
Mitophagy and Lysophagy in Neurons |
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| 9:00–11:15 AM |
Intersections of Specialized Autophagy Mechanisms (Joint) |
Longs Peak |
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* Anne Simonsen, University of Oslo
Session Chair |
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Felix Randow, Medical Research Council
Selective Autophagy through Ubiquitylation of Non-protein Targets |
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Oliver Florey, Babraham Institute
Conjugation of ATG8s to Single Membranes |
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Jayanta Debnath, University of California, San Francisco
Non-Canonical ATG8ylation and Secretion |
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| 9:30–9:50 AM |
Coffee Break |
Longs Peak Foyer |
| 11:15–1:00 PM |
Poster Setup |
Quandary Peak |
| 11:15–2:30 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
Quandary Peak |
| 2:30–4:30 PM |
Symposia Spotlight 1 (Joint) |
Longs Peak |
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* Oliver Florey, Babraham Institute
Session Chair |
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* James A Olzmann, University of California, Berkeley
Session Chair |
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Rupert Beale, The Francis Crick Institute
Targeting of ATG8s to Different Compartments Mediated by V-ATPase V1H Recruitment of ATG16L1 |
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Ruben D Elias, Scripps Research
LLOMe Exposure Results in the Cathepsin C-Mediated Intralysosomal Generation of Membranolytic Amyloid Fibrils Alongside Promiscuous Dipeptide Ligation |
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Andreas Jenny, Albert Einstein College of Medicine
The Role of Lamp1 in the Non-Cell Autonomous Regulation of Endo-Lysosomal Acidification |
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Minghao Chen, UC Berkeley
Structure and Activation of the Human Autophagy-initiating ULK1C:PI3KC3-C1 Supercomplex |
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Michael G Hanna, Penn State University
Bridge-like Lipid transfer Protein 3A (BLTP3A) in the Response to Lysosome Damage |
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Ya-Cheng Liao, Columbia University Medical Center
ANXA11 Coordinates RNA Granules and mRNA Translation at Damaged Lysosomes |
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Jonathan X Meng, Gladstone Institutes
Metabolism-Dependent GARP Complex Protection of Neurons Against Alpha-Synuclein Toxicity |
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Juliet Goldsmith, Thomas Jefferson University
ALS/FTD Associated Mutation in UBQLN2 Disrupts Homeostatic Autophagy of Mitochondria |
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| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–7:00 PM |
Membrane Dynamics and Cargo Selection in Autophagy Initiation |
Longs Peak |
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* Chris Shoemaker, Dartmouth College
Session Chair |
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Maho Hamasaki, Osaka University
Mechanistic Insights into Membrane Dynamics in Macroautophagy |
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Zvulun Elazar, Weizmann Institute of Science
Autophagosome Morphogenesis |
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J. Wade W Harper, Harvard Medical School
Charting Organelle Structural Interactomes with EndoMap and GolgiFold |
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Liang Ge, Tsinghua University
Short Talk: Golgi PI4P Overload Triggers Piezo1-dependent Ca²⁺ Signaling to Initiate RIMMBA Formation |
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| 7:00–8:00 PM |
Social Hour with Dinner |
Quandary Peak |
| 7:30–10:00 PM |
Poster Session 1 |
Quandary Peak |
Wednesday, February 4, 2026
| 7:00–8:00 AM |
Breakfast |
Quandary Peak |
| 8:00–8:45 AM |
Keynote Address (Joint) |
Longs Peak |
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* Dan Baird, Casma Tx
Session Chair |
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* Phyllis Hanson, University of Michigan
Session Chair |
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Harald Stenmark, Oslo University Hospital
An ER for Injured Lysosomes |
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| 8:45–11:00 AM |
Lysosomal Membrane Repair: ESCRTs and Beyond (Joint) |
Longs Peak |
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* Dan Baird, Casma Tx
Session Chair |
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Phyllis Hanson, University of Michigan
Calcium and ESCRTs in Membrane Repair |
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James H. Hurley, University of California, Berkeley
ESCRTs as Suppressors of Amyloid Spread |
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Claudio Bussi, Nanyang Technological University
Biomolecular Condensates and Lysosome Repair |
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| 9:00–9:20 AM |
Coffee Break |
Longs Peak Foyer |
| 9:20–9:25 AM |
Award Recipient Acknowledgement |
Longs Peak |
| 11:00–1:00 PM |
Poster Setup |
Quandary Peak |
| 11:00–3:00 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
Quandary Peak |
| 3:00–4:30 PM |
Career Roundtable (Joint) |
Longs Peak |
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Joseph D. Mancias, Dana-Farber Cancer Institute
Associate Professor & Attending Radiation Oncologist |
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Nicholas T Hertz, Montara Therapeutics, Inc.
President & CEO |
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Samantha Nelson, Cell Press
Scientific Editor |
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Pei-I Tsai, ASAP/Berkeley
Project Manager | ASAP program / Autophagy Drug discovery |
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| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–7:00 PM |
Selective Autophagy Pathways: Regulation, Function, and Disease Relevance |
Longs Peak |
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* Jayanta Debnath, University of California, San Francisco
Session Chair |
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* Anastasia G Henry, Denali Therapeutics
Session Chair |
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Sharon A. Tooze, Francis Crick Institute
Molecular Function of WIPI Proteins in Autophagy |
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Ivan Dikic, Goethe University Medical School
Remodeling of ER-mitochondria contact sites via Contact-phagy |
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Ai Yamamoto, Columbia University
Autophagy in Neurodegenerative Diseases |
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Yogaditya Chakrabarty, California Institute of Technology
Short Talk: Hierarchical Stress Licensing of ER-Phagy: Chaperone Signaling and Autophagy-Initiation Control Define Organelle-Selective Turnover |
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Jonathan Friedman, UT Southwestern Medical Center
Short Talk: Mitophagy Amplitude is Regulated By An Interplay Between Receptor Protection and Turnover |
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| 7:00–8:00 PM |
Social Hour with Dinner |
Quandary Peak |
| 7:30–10:00 PM |
Poster Session 2 |
Quandary Peak |
Thursday, February 5, 2026
| 7:00–8:00 AM |
Breakfast |
Quandary Peak |
| 8:00–11:00 AM |
Advancing Autophagy-Based Therapies: Novel Strategies and Innovations |
Longs/Grays Peaks |
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* Sharon A. Tooze, Francis Crick Institute
Session Chair |
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Anastasia G Henry, Denali Therapeutics
Mechanisms and Consequences of GCase loss-of-function in Parkinson's Disease |
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Joseph D. Mancias, Dana-Farber Cancer Institute
Targeting Autophagy in Cancer |
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Dan Baird, Casma Tx
Pharmacological Tools to Study Autophagy and Treat Disease |
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Emma Guilbaud, Fox Chase Cancer Center
Short Talk: Targeting Mitophagy to Enhance the Immunostimulatory Effects of Radiation in Estrogen Receptor-Positive Breast Cancer |
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Nicholas T Hertz, Montara Therapeutics, Inc.
Short Talk: BrainOnly Pharmacology Enables Brain-Specific mTOR Inhibition to Restore Autophagy in Neurological Disease |
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Helmut Krämer, University of Texas Southwestern Medical Center
Short Talk: Pharmacological Activation of CDK5-Dependent Autophagy |
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| 9:00–9:20 AM |
Coffee Break |
Longs Peak Foyer |
| 11:00–2:30 PM |
On Own for Lunch |
|
| 2:30–4:30 PM |
Symposia Spotlight 2 (Joint) |
Longs Peak |
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* Martin Graef, Cornell University
Session Chair |
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Zi Gao, Scripps Research
TAX1BP1 Emerges as a Candidate Proteaphagy Receptor Through Global Protein Turnover Mapping |
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Chris Shoemaker, Dartmouth College
Decoding and Predicting Autophagy Interactions at Scale |
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Stephanie Spada, NIH/Oxford
TRIM5α Couples Membrane Targeting with Noncanonical Autophagy to Restrict Viral Infection |
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Simon Wilkinson, University of Edinburgh
FAM134B Clustering and ER-phagy Driven by Multi-functional, Phase-separated Degradation Hubs |
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Spencer Nelson, University of California, San Diego
Protein Ubiquitination and Phase Separation Regulate Membrane Scission in a Minimally Reconstructed HIV-1 Budding System |
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Berrak Ugur, Yale University
Exploring Targeting Mechanisms and Potential Function of VPS13B in Golgi Membrane Dynamics |
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Noah Weisleder, University of Kentucky
Modified Antibody Fusion Proteins with Tripartite Motif Family Protein 72 (TRIM72) Increase Plasma Membrane Repair to Treat Muscular Dystrophy Models |
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| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–6:45 PM |
Mitochondrial Clearance Pathways |
Longs Peak |
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* Erika L Holzbaur, University of Pennsylvania
Session Chair |
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Anne Simonsen, University of Oslo
Regulation of HIF1a Induced Mitophagy |
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Michael Lazarou, Monash University
Mitophagy's Impact on Cell Health |
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Chantell S Evans, Duke University School of Medicine
Mitochondrial Quality Control in Neurodegenerative Diseases |
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Hagai Abeliovich, Hebrew University of Jerusalem
Short Talk: Regulation of the Atg32 Mitophagy Receptor By Signaling From Within The Mitochondrial Matrix |
|
| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions |
Longs Peak |
| 7:00–8:00 PM |
Social Hour with Dinner |
Quandary Peak |
| 8:00–9:00 PM |
Cash Bar |
Quandary Peak |
| 8:00–9:00 PM |
Entertainment |
Quandary Peak |
