Autophagy: Mechanisms to Therapy (P1)
February 2-5, 2026
| Keystone Resort, Keystone, CO, United States
Anne Simonsen, Sharon A. Tooze and Dan Baird
Scholarship Deadline: Nov. 7, 2025 | Abstract Deadline: Jan. 14, 2026 | Early Registration Deadline: Dec. 5, 2025
| 4:00–8:00 PM |
Registration |
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| 6:00–8:00 PM |
Welcome Mixer |
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Tuesday, February 3, 2026
| 8:00–8:10 AM |
Welcome Remarks (Joint) |
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| 8:10–9:00 AM |
Keynote Address (Joint) |
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Erika L Holzbaur, University of Pennsylvania
Mitophagy and Lysophagy in Neurons |
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| 9:00–11:15 AM |
Intersections of Autophagy and Lysosomal Membrane Repair: Mechanisms and Implications (Joint) |
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Sharon A. Tooze, Francis Crick Institute
Role of PI 4-Kinases in Autophagy and Membrane Repair |
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Oliver Florey, Babraham Institute
Conjugation of ATG8s to Single Membranes |
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Jayanta Debnath, University of California, San Francisco
Non-Canonical ATG8ylation and Secretion |
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| 9:30–9:50 AM |
Coffee Break |
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| 11:15–1:00 PM |
Poster Setup |
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| 11:15–2:30 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
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| 2:30–4:30 PM |
Symposia Spotlight 1 (Joint) |
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Rupert Beale †, The Francis Crick Institute
Targeting of ATG8s to Different Compartments Mediated by V-ATPase V1H Recruitment of ATG16L1 |
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Lizhen Cheng †, Ludwig-Maximilians-Universität München
Dissecting Canonical and Non-Canonical Autophagy Pathways in Microglia in Healthy and Disease States |
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Ruben D Elias †, Scripps Research
LLOMe Exposure Results in the Cathepsin C-Mediated Intralysosomal Generation of Membranolytic Amyloid Fibrils Alongside Promiscuous Dipeptide Ligation |
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Andreas Jenny †, Albert Einstein College of Medicine
The role of Lamp1 in the Non-Cell Autonomous Regulation of Endo-Lysosomal Acidification |
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–7:00 PM |
Membrane Dynamics and Cargo Selection in Autophagy Initiation |
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Maho Hamasaki, Osaka University
Mechanistic Insights into Membrane Dynamics in Macroautophagy |
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Zvulun Elazar, Weizmann Institute of Science
Autophagosome Morphogenesis |
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J. W Harper, Harvard Medical School
Autophagy Proteomics |
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Liang Ge †, Tsinghua University
Short Talk: Golgi PI4P Overload Triggers Piezo1-dependent Ca²⁺ Signaling to Initiate RIMMBA Formation |
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| 7:00–8:00 PM |
Social Hour with Dinner |
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| 7:30–10:00 PM |
Poster Session 1 |
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Wednesday, February 4, 2026
| 8:00–8:45 AM |
Keynote Address (Joint) |
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Harald Stenmark, Oslo University Hospital
Integration of ESCRTs and ATG8 Conjugation in Membrane Repair |
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| 8:45–11:00 AM |
Lysosomal Membrane Repair: ESCRTs and Beyond (Joint) |
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Phyllis Hanson, University of Michigan
Calcium and ESCRTs in Membrane Repair |
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James H. Hurley, University of California, Berkeley
ESCRTs as Suppressors of Amyloid Spread |
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Claudio Bussi, Nanyang Technological University
Biomolecular Condensates and Lysosome Repair |
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| 9:00–9:20 AM |
Coffee Break |
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| 11:00–1:00 PM |
Poster Setup |
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| 11:00–3:00 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
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| 3:00–4:30 PM |
Career Roundtable (Joint) |
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–7:00 PM |
Selective Autophagy Pathways: Regulation, Function, and Disease Relevance |
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Lifeng Pan, Shanghai Institute of Organic Chemistry, CAS
Mechanistic Insights into Selective Autophagy of Glycogen in Mammals |
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Ivan Dikic, Goethe University Medical School
ER-Phagy and Novel Pathways for Ubiquitination |
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Ai Yamamoto, Columbia University
Autophagy in Neurodegenerative Diseases |
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Yogaditya Chakrabarty †, California Institute of Technology
Short Talk: Hierarchical Stress Licensing of ER-Phagy: Chaperone Signaling and Autophagy-Initiation Control Define Organelle-Selective Turnover |
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Jonathan Friedman †, UT Southwestern Medical Center
Short Talk: Mitophagy Amplitude is Regulated By An Interplay Between Receptor Protection and Turnover |
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| 7:00–8:00 PM |
Social Hour with Dinner |
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| 7:30–10:00 PM |
Poster Session 2 |
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Thursday, February 5, 2026
| 8:00–11:00 AM |
Advancing Autophagy-Based Therapies: Novel Strategies and Innovations |
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Anastasia G Henry, Denali Therapeutics
Pharmacological Targeting of Parkinson's Disease |
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Joseph D. Mancias, Dana-Farber Cancer Institute
Targeting Autophagy in Cancer |
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Dan Baird, Casma Tx
Pharmacological Tools to Study Autophagy and Treat Disease |
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Angela Cacace †, Arvinas Inc
Talk Title to be Announced |
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Emma Guilbaud †, Fox Chase Cancer Center
Short Talk: Targeting Mitophagy to Enhance the Immunostimulatory Effects of Radiation in Estrogen Receptor-Positive Breast Cancer |
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Nicholas T Hertz †, Montara Therapeutics, Inc.
Short Talk: BrainOnly Pharmacology Enables Brain-Specific mTOR Inhibition to Restore Autophagy in Neurological Disease |
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| 9:00–9:20 AM |
Coffee Break |
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| 11:00–2:30 PM |
On Own for Lunch |
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| 2:30–4:30 PM |
Symposia Spotlight 2 (Joint) |
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Zi Gao †, Scripps Research
TAX1BP1 Emerges as a Candidate Proteaphagy Receptor Through Global Protein Turnover Mapping |
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Chris Shoemaker †, Dartmouth College
Decoding and Predicting Autophagy Interactions at Scale |
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Stephanie Spada †, NIH/Oxford
TRIM5α Couples Membrane Targeting with Noncanonical Autophagy to Restrict Viral Infection |
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Simon Wilkinson †, University of Edinburgh
FAM134B Clustering and ER-phagy Driven by Multi-functional, Phase-separated Degradation Hubs |
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–6:45 PM |
Mitochondrial Clearance Pathways |
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Anne Simonsen, University of Oslo
Regulation of HIF1a Induced Mitophagy |
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Michael Lazarou, Monash University
Mitophagy's Impact on Cell Health |
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Chantell S Evans, Duke University School of Medicine
Mitochondrial Quality Control in Neurodegenerative Diseases |
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Hagai Abeliovich †, Hebrew University of Jerusalem
Short Talk: Regulation of the Atg32 Mitophagy Receptor By Signaling From Within The Mitochondrial Matrix |
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| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions |
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| 7:00–8:00 PM |
Social Hour with Dinner |
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| 8:00–11:00 PM |
Entertainment |
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