Membrane Dynamics, Repair and Disease (P2)
February 2-5, 2026
| Keystone Resort, Keystone, CO, United States
James H. Hurley, Phyllis Hanson and Gilbert Di Paolo
Scholarship Deadline: Nov. 7, 2025 | Abstract Deadline: Jan. 14, 2026 | Early Registration Deadline: Dec. 5, 2025
| 4:00–8:00 PM |
Registration |
Longs Peak Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
Longs Peak Foyer |
Tuesday, February 3, 2026
| 7:00–8:00 AM |
Breakfast |
Quandary Peak |
| 8:00–8:10 AM |
Welcome Remarks (Joint) |
Longs/Grays Peaks |
| 8:10–9:00 AM |
Keynote Address (Joint) |
Longs/Grays Peaks |
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Erika L Holzbaur, University of Pennsylvania
Mitophagy and Lysophagy in Neurons |
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| 9:00–11:15 AM |
Intersections of Autophagy and Lysosomal Membrane Repair: Mechanisms and Implications (Joint) |
Longs/Grays Peaks |
| |
Sharon A. Tooze, Francis Crick Institute
Role of PI 4-Kinases in Autophagy and Membrane Repair |
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Oliver Florey, Babraham Institute
Conjugation of ATG8s to Single Membranes |
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Jayanta Debnath, University of California, San Francisco
Non-Canonical ATG8ylation and Secretion |
|
| 9:30–9:50 AM |
Coffee Break |
Longs Peak Foyer |
| 11:15–1:00 PM |
Poster Setup |
Quandary Peak |
| 11:15–2:30 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Quandary Peak |
| 2:30–4:30 PM |
Symposia Spotlight 1 (Joint) |
Longs/Grays Peaks |
| |
Rupert Beale, The Francis Crick Institute
Targeting of ATG8s to Different Compartments Mediated by V-ATPase V1H Recruitment of ATG16L1 |
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Lizhen Cheng, Ludwig-Maximilians-Universität München
Dissecting Canonical and Non-Canonical Autophagy Pathways in Microglia in Healthy and Disease States |
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Ruben D Elias, Scripps Research
LLOMe Exposure Results in the Cathepsin C-Mediated Intralysosomal Generation of Membranolytic Amyloid Fibrils Alongside Promiscuous Dipeptide Ligation |
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Andreas Jenny, Albert Einstein College of Medicine
The role of Lamp1 in the Non-Cell Autonomous Regulation of Endo-Lysosomal Acidification |
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Minghao Chen, UC Berkeley
Structure and Activation of the Human Autophagy-initiating ULK1C:PI3KC3-C1 Supercomplex |
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Michael G Hanna, Penn State University
Bridge-like Lipid transfer Protein 3A (BLTP3A) in the Response to Lysosome Damage |
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Ya-Cheng Liao, Columbia University Medical Center
ANXA11 Coordinates RNA Granules and mRNA Translation at Damaged Lysosomes |
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Jonathan X Meng, Gladstone Institutes
Metabolism-Dependent GARP Complex Protection of Neurons Against Alpha-Synuclein Toxicity |
|
| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–7:00 PM |
Mitochondria and Ferroptosis |
Grays Peak |
| |
Ana J. García-Sáez, Max Planck Institute of Biophysics
Mitochondrial Membrane Dynamics in Cell Death |
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James A Olzmann, University of California, Berkeley
Ferroptosis, Lipotoxicity, and Organelle Homeostasis |
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Whitney Henry, Massachusetts Institute of Technology
Ferroptosis and Cancer |
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Lena Pernas, University of California, Los Angeles and HHMI
Short Talk: Mitochondria Give Rise to Proto-organelles during Infection |
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| |
Shilong Yang, Rutgers the State University of New Jersey
Short Talk: Membrane Phase Separation Drives NINJ1 In-Plane Assembly |
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| 7:00–8:00 PM |
Social Hour with Dinner |
Quandary Peak |
| 7:30–10:00 PM |
Poster Session 1 |
Quandary Peak |
Wednesday, February 4, 2026
| 7:00–8:00 AM |
Breakfast |
Quandary Peak |
| 8:00–8:45 AM |
Keynote Address (Joint) |
Longs/Grays Peaks |
| |
Harald Stenmark, Oslo University Hospital
An ER for Injured Lysosomes |
|
| 8:45–11:00 AM |
Lysosomal Membrane Repair: ESCRTs and Beyond (Joint) |
Longs/Grays Peaks |
| |
Phyllis Hanson, University of Michigan
Calcium and ESCRTs in Membrane Repair |
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James H. Hurley, University of California, Berkeley
ESCRTs as Suppressors of Amyloid Spread |
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Claudio Bussi, Nanyang Technological University
Biomolecular Condensates and Lysosome Repair |
|
| 9:00–9:20 AM |
Coffee Break |
Longs Peak Foyer |
| 11:00–1:00 PM |
On Own for Lunch |
|
| 11:00–1:00 PM |
Poster Setup |
Quandary Peak |
| 1:00–10:00 PM |
Poster Viewing |
Quandary Peak |
| 1:00–10:00 PM |
Career Roundtable (Joint) |
Longs Peak |
| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–7:00 PM |
Membrane Damage and Resilience |
Grays Peak |
| |
Patrick Lusk, Yale University
Nuclear Membrane Rupture and Resilience |
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Vishva M. Dixit, Genentech, Inc.
Membrane Damage and Inflammation |
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Feng Shao, National Institute of Biological Sciences
Membrane Damage in Infection and Innate Immunity |
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Aakriti Jain, UT Southwestern Medical Center
Short Talk: LASER Senses Lysosomal Damage and Initiates ESCRT Assembly for Membrane Repair |
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Suhong Xu, Zhejiang University
Short Talk: ESCRT-III Oligomerization Restores Membrane Tension to Facilitate Membrane Repair |
|
| 7:00–8:00 PM |
Social Hour with Dinner |
Quandary Peak |
| 7:30–10:00 PM |
Poster Session 2 |
Quandary Peak |
Thursday, February 5, 2026
| 7:00–8:00 AM |
Breakfast |
Quandary Peak |
| 8:00–11:00 AM |
Membrane Homeostasis and Neurodegeneration |
Grays Peak |
| |
Alyssa Coyne, Johns Hopkins University School of Medicine
Overactivation of ESCRT-III Nuclear Surveillance in Neurodegeneration: Mechanistic Insights and Therapeutic Targeting |
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Shawn Ferguson, Yale University
LRRK2-Dependent Responses to Lysosome Stress |
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Judith Frydman, Stanford University
ESCRTs and Proteostasis |
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Angela Cacace, Arvinas Inc
Targeting LRRK2 |
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Utpal Das, University of California San Diego
Short Talk: Aβ Induces Endolysosomal Dysfunction by Prompting Hyperphosphorylation of RabGTPases, Disrupting Membrane Integrity |
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Patrick A. Lewis, Royal Veterinary College
Short Talk: A Role for GPNMB in Sensing and Responding to Lysosomal Stress |
|
| 9:00–9:20 AM |
Coffee Break |
Longs Peak Foyer |
| 11:00–2:30 PM |
On Own for Lunch |
|
| 2:30–4:30 PM |
Symposia Spotlight 2 (Joint) |
Longs/Grays Peaks |
| |
Zi Gao, Scripps Research
TAX1BP1 Emerges as a Candidate Proteaphagy Receptor Through Global Protein Turnover Mapping |
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Chris Shoemaker, Dartmouth College
Decoding and Predicting Autophagy Interactions at Scale |
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Stephanie Spada, NIH/Oxford
TRIM5α Couples Membrane Targeting with Noncanonical Autophagy to Restrict Viral Infection |
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Simon Wilkinson, University of Edinburgh
FAM134B Clustering and ER-phagy Driven by Multi-functional, Phase-separated Degradation Hubs |
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Spencer Nelson, University of California, San Diego
Protein Ubiquitination and Phase Separation Regulate Membrane Scission in a Minimally Reconstructed HIV-1 Budding System |
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Berrak Ugur, Yale University
Exploring Targeting Mechanisms and Potential Function of VPS13B in Golgi Membrane Dynamics |
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Noah Weisleder, University of Kentucky
Modified Antibody Fusion Proteins with Tripartite Motif Family Protein 72 (TRIM72) Increase Plasma Membrane Repair to Treat Muscular Dystrophy Models |
|
| 4:30–5:00 PM |
Coffee Available |
Quandary Peak |
| 5:00–6:45 PM |
Lysosome Homeostasis and Lysosome-Directed Drug Discovery |
Grays Peak |
| |
Haoxing Xu, Zhejiang University
Molecular Physiology of Lysosomes |
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Hijai Regina Shin, University of Texas Southwestern Medical Center
Lysosome Cholesterol Signaling in Neuronal Health and Disease |
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| |
Gilbert Di Paolo, Denali Therapeutics Inc.
Leveraging a Transferrin Receptor-Based Transport Vehicle for Lysosomal Enzyme/Protein Replacement Therapy in Neurodegenerative Diseases |
|
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Jay Xiaojun Tan, University of Pittsburgh
Short Talk: Directional ER-to-Lysosome Lipid Transfer Mediates Lysosomal Vacuolation |
|
| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions |
Grays Peak |
| 7:00–8:00 PM |
Social Hour with Dinner |
Quandary Peak |
| 8:00–9:00 PM |
Entertainment |
Longs Peak |
| 8:00–9:00 PM |
Cash Bar |
Quandary Peak |
