Membrane Dynamics, Repair and Disease (P2)
February 2-5, 2026
| Keystone Resort, Keystone, CO, United States
James H. Hurley, Phyllis Hanson and Gilbert Di Paolo
Scholarship Deadline: Nov. 7, 2025 | Abstract Deadline: Jan. 14, 2026 | Early Registration Deadline: Dec. 5, 2025
| 4:00–8:00 PM |
Registration |
Longs Peak Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
Longs Peak Foyer |
Tuesday, February 3, 2026
| 7:00–8:00 AM |
Breakfast |
Quandary Peak |
| 8:00–8:10 AM |
Welcome Remarks (Joint) |
Longs Peak |
| 8:10–9:00 AM |
Keynote Address (Joint) |
Longs Peak |
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* Anne Simonsen, University of Oslo
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* James H. Hurley, University of California, Berkeley
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Erika L Holzbaur, University of Pennsylvania
Mitophagy and Lysophagy in Neurons |
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| 9:00–11:15 AM |
Intersections of Specialized Autophagy Mechanisms (Joint) |
Longs Peak |
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* Anne Simonsen, University of Oslo
Session Chair |
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Felix Randow, Medical Research Council
Selective Autophagy through Ubiquitylation of Non-protein Targets |
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Oliver Florey, Babraham Institute
Conjugation of ATG8s to Single Membranes |
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Jayanta Debnath, University of California, San Francisco
Non-Canonical ATG8ylation and Secretion |
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| 9:30–9:50 AM |
Coffee Break |
Longs Peak Foyer |
| 11:15–1:00 PM |
Poster Setup |
Quandary Peak |
| 11:15–2:30 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
Quandary Peak |
| 2:30–4:30 PM |
Symposia Spotlight 1 (Joint) |
Longs Peak |
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* James A Olzmann, University of California, Berkeley
Session Chair |
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* Oliver Florey, Babraham Institute
Session Chair |
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Rupert Beale, The Francis Crick Institute
Targeting of ATG8s to Different Compartments Mediated by V-ATPase V1H Recruitment of ATG16L1 |
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Ruben D Elias, Scripps Research
LLOMe Exposure Results in the Cathepsin C-Mediated Intralysosomal Generation of Membranolytic Amyloid Fibrils Alongside Promiscuous Dipeptide Ligation |
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Andreas Jenny, Albert Einstein College of Medicine
The role of Lamp1 in the Non-Cell Autonomous Regulation of Endo-Lysosomal Acidification |
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Minghao Chen, UC Berkeley
Structure and Activation of the Human Autophagy-initiating ULK1C:PI3KC3-C1 Supercomplex |
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Michael G Hanna, Penn State University
Bridge-like Lipid transfer Protein 3A (BLTP3A) in the Response to Lysosome Damage |
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Ya-Cheng Liao, Columbia University Medical Center
ANXA11 Coordinates RNA Granules and mRNA Translation at Damaged Lysosomes |
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Jonathan X Meng, Gladstone Institutes
Metabolism-Dependent GARP Complex Protection of Neurons Against Alpha-Synuclein Toxicity |
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Juliet Goldsmith, Thomas Jefferson University
ALS/FTD Associated Mutation in UBQLN2 Disrupts Homeostatic Autophagy of Mitochondria |
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| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–7:00 PM |
Mitochondria and Ferroptosis |
Grays Peak |
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* Shawn Ferguson, Yale University
Session Chair |
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Ana J. García-Sáez, Max Planck Institute of Biophysics
Mitochondrial Membrane Dynamics in Cell Death |
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James A Olzmann, University of California, Berkeley
Guardians of the Membrane: Preventing Lipid Peroxidation and Ferroptosis |
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Whitney Henry, Massachusetts Institute of Technology
Peroxisomes, Membrane Lipids, and Iron: Tuning Ferroptosis Vulnerability in Cancer |
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Martin Graef, Cornell University
Short Talk: Mitophagy Scales Mitochondrial Network Size |
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Shilong Yang, Rutgers the State University of New Jersey
Short Talk: Membrane Phase Separation Drives NINJ1 In-Plane Assembly |
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| 7:00–8:00 PM |
Social Hour with Dinner |
Quandary Peak |
| 7:30–10:00 PM |
Poster Session 1 |
Quandary Peak |
Wednesday, February 4, 2026
| 7:00–8:00 AM |
Breakfast |
Quandary Peak |
| 8:00–8:45 AM |
Keynote Address (Joint) |
Longs Peak |
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* Phyllis Hanson, University of Michigan
Session Chair |
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* Dan Baird, Casma Tx
Session Chair |
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Harald Stenmark, Oslo University Hospital
An ER for Injured Lysosomes |
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| 8:45–11:00 AM |
Lysosomal Membrane Repair: ESCRTs and Beyond (Joint) |
Longs Peak |
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* Dan Baird, Casma Tx
Session Chair |
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Phyllis Hanson, University of Michigan
Calcium and ESCRTs in Membrane Repair |
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James H. Hurley, University of California, Berkeley
ESCRTs as Suppressors of Amyloid Spread |
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Claudio Bussi, Nanyang Technological University
Biomolecular Condensates and Lysosome Repair |
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| 9:00–9:20 AM |
Coffee Break |
Longs Peak Foyer |
| 9:20–9:25 AM |
Award Recipient Acknowledgement |
Longs Peak |
| 11:00–1:00 PM |
On Own for Lunch |
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| 11:00–1:00 PM |
Poster Setup |
Quandary Peak |
| 1:00–10:00 PM |
Poster Viewing |
Quandary Peak |
| 3:00–4:30 PM |
Career Roundtable (Joint) |
Longs Peak |
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Joseph D. Mancias, Dana-Farber Cancer Institute
Associate Professor & Attending Radiation Oncologist |
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Nicholas T Hertz, Montara Therapeutics, Inc.
President & CEO |
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Samantha Nelson, Cell Press
Scientific Editor |
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Pei-I Tsai, ASAP/Berkeley
Project Manager | ASAP program / Autophagy Drug discovery |
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| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–7:00 PM |
Membrane Damage and Resilience |
Grays Peak |
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* Hijai Regina Shin, University of Texas Southwestern Medical Center
Session Chair |
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Patrick Lusk, Yale University
Nuclear Membrane Rupture and Resilience |
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Vishva M. Dixit, Genentech, Inc.
Membrane Damage and Inflammation |
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Feng Shao, National Institute of Biological Sciences
Membrane Damage in Infection and Innate Immunity |
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Aakriti Jain, UT Southwestern Medical Center
Short Talk: LASER Senses Lysosomal Damage and Initiates ESCRT Assembly for Membrane Repair |
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Suhong Xu, Zhejiang University
Short Talk: ESCRT-III Oligomerization Restores Membrane Tension to Facilitate Membrane Repair |
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| 7:00–8:00 PM |
Social Hour with Dinner |
Quandary Peak |
| 7:30–10:00 PM |
Poster Session 2 |
Quandary Peak |
Thursday, February 5, 2026
| 7:00–8:00 AM |
Breakfast |
Quandary Peak |
| 8:00–11:00 AM |
Membrane Homeostasis and Neurodegeneration |
Grays Peak |
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* Patrick Lusk, Yale University
Session Chair |
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Alyssa Coyne, Johns Hopkins University School of Medicine
Overactivation of ESCRT-III Nuclear Surveillance in Neurodegeneration: Mechanistic Insights and Therapeutic Targeting |
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Shawn Ferguson, Yale University
LRRK2-Dependent Responses to Lysosome Stress |
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Angela Cacace, Arvinas Inc
LRRK2 Degradation in the Brain Reprograms Lysosomal and Neurodegenerative Pathways – Discovery to Clinical Translation |
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Utpal Das, University of California San Diego
Short Talk: Aβ Induces Endolysosomal Dysfunction by Prompting Hyperphosphorylation of RabGTPases, Disrupting Membrane Integrity |
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Patrick A. Lewis, Royal Veterinary College
Short Talk: A Role for GPNMB in Sensing and Responding to Lysosomal Stress |
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| 9:00–9:20 AM |
Coffee Break |
Longs Peak Foyer |
| 11:00–2:30 PM |
On Own for Lunch |
|
| 2:30–4:30 PM |
Symposia Spotlight 2 (Joint) |
Longs Peak |
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* Martin Graef, Cornell University
Session Chair |
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Zi Gao, Scripps Research
TAX1BP1 Emerges as a Candidate Proteaphagy Receptor Through Global Protein Turnover Mapping |
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Chris Shoemaker, Dartmouth College
Decoding and Predicting Autophagy Interactions at Scale |
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Stephanie Spada, NIH/Oxford
TRIM5α Couples Membrane Targeting with Noncanonical Autophagy to Restrict Viral Infection |
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Simon Wilkinson, University of Edinburgh
FAM134B Clustering and ER-phagy Driven by Multi-functional, Phase-separated Degradation Hubs |
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Spencer Nelson, University of California, San Diego
Protein Ubiquitination and Phase Separation Regulate Membrane Scission in a Minimally Reconstructed HIV-1 Budding System |
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Berrak Ugur, Yale University
Exploring Targeting Mechanisms and Potential Function of VPS13B in Golgi Membrane Dynamics |
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Noah Weisleder, University of Kentucky
Modified Antibody Fusion Proteins with Tripartite Motif Family Protein 72 (TRIM72) Increase Plasma Membrane Repair to Treat Muscular Dystrophy Models |
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| 4:30–5:00 PM |
Coffee Available |
Quandary Peak |
| 5:00–6:45 PM |
Lysosome Homeostasis and Lysosome-Directed Drug Discovery |
Grays Peak |
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* Wim Annaert, VIB & KU Leuven
Session Chair |
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Haoxing Xu, Zhejiang University
Molecular Physiology of Lysosomes |
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Hijai Regina Shin, University of Texas Southwestern Medical Center
Lysosome Cholesterol Signaling in Neuronal Health and Disease |
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Gilbert Di Paolo, Denali Therapeutics Inc.
Leveraging a Transferrin Receptor-Based Transport Vehicle for Lysosomal Enzyme/Protein Replacement Therapy in Neurodegenerative Diseases |
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Jay Xiaojun Tan, University of Pittsburgh
Short Talk: Directional ER-to-Lysosome Lipid Transfer Mediates Lysosomal Vacuolation |
|
| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions |
Grays Peak |
| 7:00–8:00 PM |
Social Hour with Dinner |
Quandary Peak |
| 8:00–9:00 PM |
Entertainment |
Quandary Peak |
| 8:00–9:00 PM |
Cash Bar |
Quandary Peak |
