Decoding HIV Persistence: Strategies for Curing HIV Infection (P3)
April 16-19, 2026  | Beaver Run Conference Center, Breckenridge, CO, United States
Mathias Lichterfeld, Afam Okoye, Marina F. Caskey and Caroline T. Tiemessen
Scholarship Deadline: Dec. 17, 2025 | Abstract Deadline: Mar. 27, 2026 | Early Registration Deadline: Feb. 18, 2026
* Session Chair † Invited but not yet accepted | Program current as of August 23, 2025 4 AM | For the most up-to-date details, visit https://www.keystonesymposia.org
Thursday, April 16, 2026
4:00–8:00 PM Registration
6:00–8:00 PM Welcome Mixer
Friday, April 17, 2026
7:00–8:00 AM Breakfast
8:00–9:00 AM Welcome and Keynote Address (Joint)
  Alexandra Trkola, University of Zürich
HIV Vaccines: Learning from the Swiss X-BNAb Cohort for Prevention and Cure
 
9:00–11:15 AM Immune Interventions Interfacing HIV Prevention and Cure (Joint)
  Mauricio A. Martins, University of Florida
Promoting Persistent bNAb Expression in NHPs through AAV-Mediated Gene Transfer
 
  Devi SenGupta, Gilead Sciences, Inc.
Long-acting ART in HIV Prevention and Cure
 
  Leonidas Stamatatos, Fred Hutchinson Cancer Research Center
Vaccination of PLWH, using 426C Derived Immunogens
 
  Short Talk(s) Chosen from Abstracts
 
9:30–9:50 AM Coffee Break
11:15–1:00 PM Poster Setup
11:15–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing
2:30–4:30 PM Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available
5:00–7:00 PM Immune Targeting of HIV-1 Reservoir Cells: Obstacles and Opportunities
  Brad Jones, Weill Cornell Medicine
HIV Reservoir Cell Resistance to Immune-Mediated Killing
 
  Michel C. Nussenzweig, HHMI/Rockefeller University
HIV-1 Reservoir Dynamics
 
  Kiera L. Clayton, University of Massachusetts Medical School
NK Cell Targeting of the HIV Reservoir
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM Social Hour with Dinner
7:30–10:00 PM Poster Session 1
Saturday, April 18, 2026
7:00–8:00 AM Breakfast
8:00–11:00 AM Tailoring Gene- and Cell-Therapy Approaches for HIV Cure: Promises and Pitfalls
  Afam Okoye, Oregon Health & Science University
Optimizing T Cell Responses for Post-ART Control
 
  James L. Riley, University of Pennsylvania
Immune-Based Cell Therapies
 
  Lydie Trautmann, Military HIV Research Program
Therapeutic Vaccine Trials in Humans
 
  Daniel Dornbusch, Excision Bio Inc.
CRISPR for HIV Cure: Human Clinical Trial Data
 
  Short Talk(s) Chosen from Abstracts
 
9:00–9:20 AM Coffee Break
11:00–1:00 PM Poster Setup
11:00–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing
1:30–2:45 PM Panel: Perspectives: Personalized Medicine & Patient-Centered Strategies (Joint)
3:00–4:30 PM Career Roundtable (Joint)
4:30–5:00 PM Coffee Available
5:00–7:00 PM Mechanisms of HIV Persistence: Insights and Innovations
  Mathias Lichterfeld, Brigham and Women's Hospital
Epigenetic Mechanisms of HIV Persistence
 
  Roy Matkovic, Université de Paris, Institut Cochin
The HUSH Complex and HIV Silencing
 
  Nomonde Bengu, Umkhuseli Innovations
Sex Differences in HIV Reservoir Cell Persistence
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM Social Hour with Dinner
7:30–10:00 PM Poster Session 2
Sunday, April 19, 2026
7:00–8:00 AM Breakfast
8:00–11:00 AM No One Left Behind: HIV Cure Research Across the Age Continuum
  Caroline T. Tiemessen, National Institute for Communicable Diseases
HIV Immune Responses Across the Age Spectrum
 
  Deborah Persaud, Johns Hopkins University School of Medicine
HIV Remission in Infants
 
  Roger Shapiro, Harvard School of Public Health
Triple Combinations of Broadly-Neutralizing Antibodies in Children
 
  Catherine K. Koofhethile, Botswana Harvard Health Partnership
Viral Reservoirs and Immune Responses in Adolescents and Young Adults with HIV
 
  Short Talk(s) Chosen from Abstracts
 
9:00–9:20 AM Coffee Break
11:00–5:00 PM On Own for Lunch
2:30–4:30 PM Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available
5:00–6:45 PM B Cell Responses and Broadly-Neutralizing Antibodies: Trials and Tribulations (Joint)
  Marina F. Caskey, Rockefeller University
Combined Immunotherapy with IL-15 Agonists and Broadly-Neutralizing Antibodies
 
  Paula M. Cannon, University of Southern California, Keck School of Medicine
Engineering B Cells as in vivo bnAb Factories
 
  William Schief, The Scripps Research and IAVI
Combining Germline Targeting Approaches Across Diverse bNAb Epitopes
 
  Short Talk(s) Chosen from Abstracts
 
6:45–7:00 PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
7:00–8:00 PM Social Hour with Dinner
8:00–11:00 PM Entertainment
8:00–11:00 PM Cash Bar
Monday, April 20, 2026
12:00–11:59 PM Departure