Trajectories to Heart Failure: Immunometabolic Mechanisms (Q1)
February 10-13, 2025
| Keystone Resort, Keystone, CO, United States
Joseph A. Hill, Geneviève Derumeaux, Chiara Giannarelli and Gabriele G Schiattarella
Scholarship Deadline: Dec. 6, 2024 | Abstract Deadline: Jan. 22, 2025 | Early Registration Deadline: Dec. 19, 2024
Monday, February 10, 2025
| 4:00–8:00 PM |
Registration |
Longs Peak Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
Longs Peak Foyer |
Tuesday, February 11, 2025
| 7:00–8:00 AM |
Breakfast |
Quandary Peak |
| 8:00–9:00 AM |
Welcome and Keynote Address (Joint) |
Grays/Longs Peak |
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* Joseph A. Hill, University of Texas Southwestern Medical Center
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* María Mittelbrunn, Molecular Biology Center, CSIC
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Kathryn J Moore, New York University Medical Center
Immunometabolism in Cardiovascular Disease |
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| 9:00–11:30 AM |
Immunometabolism in Heart Failure and Vascular Diseases (Joint) |
Grays/Longs Peak |
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* Ronald J Vagnozzi, University of Colorado Anschutz Medical Campus
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Chiara Giannarelli, NYU Grossman School of Medicine
Immune Mechanisms of Vascular Disease |
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Kathleen Martin, Yale School of Medicine
Novel Smooth Muscle Mechanisms in Transplant Vasculopathy |
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Xing Li Wang, Fosun Pharma
Challenges and Opportunities for Cardiovascular Drug Development |
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Esther Lutgens, Mayo Clinic
Co-Stimulatory Immune Checkpoints: Maintaining Immune Cell Homeostasis |
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| 9:30–9:50 AM |
Coffee Break |
Longs Peak Foyer |
| 9:50–9:55 AM |
Award Recipient Acknowledgement |
Grays/Longs Peak |
| 11:30–1:00 PM |
Poster Setup |
Quandary Peak |
| 11:30–2:30 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
Quandary Peak |
| 2:30–4:30 PM |
Panel Discussion 1: Dialogue with Scientists and Physician-Scientists in Industry |
Grays Peak |
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Alberto Guarnieri, Genentech
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Douglas Hinerfeld, Alamar Biosciences
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Caitlin Langford, Perspectum
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Xiao-Jun Ma, Alamar Biosciences
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Anne N Murphy, Cytokinetics, Inc.
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Akshay Shekhar, Regeneron Pharmaceuticals
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Kelly Yip, Perspectum Ltd.
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James G Karras, Haya Therapeutics
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Coleman Komishane, Monte Rosa Therapeutics
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Xing Li Wang, Fosun Pharma
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Jordan Shin, HAYA Therapeutics
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* Adam E Mullick, Ionis Pharmaceuticals, Inc.
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* James Priest, Tenaya Therapeutics
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* Martin Borch Jensen, Gordian Biotechnology
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| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–7:00 PM |
Ischemic HFrEF |
Grays Peak |
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* Patrick C.H. Hsieh, Academia Sinica
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* Long-Sheng Song, Univ of Iowa
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Biykem Bozkurt, Baylor College of Medicine
Ischemic HFrEF: Clinical Presentation and Unmet Needs |
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James Priest, Tenaya Therapeutics
Modulation of Fibrosis in HFrEF |
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Zoltan Arany, University of Pennsylvania
How do SGLT2 Inhibitors Benefit Heart Failure? (Hint: it’s not SGLT2) |
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Lena Ho, Duke-NUS Medical School
Short Talk: Respiratory Chain Supercomplexes Protect Against Ischemic Heart Failure |
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Gregory Wyant, MGH
Short Talk: Plasmalogen Control of Peroxisome Degradation Confers Ischemic Protection |
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| 7:00–8:00 PM |
Social Hour with Lite Bites |
Quandary Peak |
| 7:05–8:05 PM |
Women in Science Networking Event |
Quandary Peak Foyer |
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* María Mittelbrunn, Molecular Biology Center, CSIC
Session Chair |
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* Gemma A Figtree, Kolling Institute, University of Sydney
Session Chair |
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* Kathryn E. Wellen, University of Pennsylvania
Session Chair |
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* Chiara Giannarelli, NYU Grossman School of Medicine
Session Chair |
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* Esther Lutgens, Mayo Clinic
Session Chair |
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* Pilar Alcaide, Tufts University School of Medicine
Session Chair |
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* Marlies Meisel, University of Pittsburgh
Session Chair |
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| 7:30–10:00 PM |
Poster Session 1 |
Quandary Peak |
Wednesday, February 12, 2025
| 7:00–8:00 AM |
Breakfast |
Quandary Peak |
| 8:00–11:00 AM |
Cardiometabolic HFpEF |
Grays Peak |
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* Karen A Ocorr, SBP Medical Discovery Institute
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Sanjiv Shah, Northwestern University
HFpEF: Clinical Presentations and Unmet Needs |
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Gabriele G Schiattarella, Charité University Medical Center
Metabolic Regulation of HFpEF |
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Virginia Hahn, Johns Hopkins University
Single Cell Analysis of HFpEF |
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Ling Yang, University of Iowa
Short Talk: Lysosome Maintains Cardiac Immuno-metabolic Homeostasis in HFpEF |
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Ulrich Kintscher, Charité-Universitätsmedizin Berlin
Short Talk: Endothelial Deletion of Adipose Triglyceride Lipase Protects Against Heart Failure with Preserved Ejection Fraction |
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Martin Borch Jensen, Gordian Biotechnology
Short Talk: Novel in Vivo Screen System to Identify Therapeutic Targets in Heart Failure with Preserved Ejection Fraction |
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Giuseppe D Norata, University of Milan
Short Talk: PCSK9 at the Crossroad of Cardiac Metabolic Reprogramming During Hfpef |
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| 9:00–9:20 AM |
Coffee Break |
Longs Peak Foyer |
| 11:00–1:00 PM |
Poster Setup |
Quandary Peak |
| 11:00–5:00 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
Quandary Peak |
| 3:00–4:30 PM |
Career Roundtable (Joint) |
Grays Peak |
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James Priest, Tenaya Therapeutics
Senior Director of Cardiovascular Genetics |
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Maria Rescigno, Humanitas University
Professor, Group Leader, and Deputy Scientific Director |
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Meng-Ju Wu, University of Massachusetts Chan Medical School
Assistant Professor |
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Anne N Murphy, Cytokinetics, Inc.
Vice President, Scientific Affairs |
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| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–7:00 PM |
Immunometabolic Exposome in HFpEF (Joint) |
Grays/Longs Peak |
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* Matthew J Feinstein, Northwestern University
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Edward Thorp, Northwestern University
Myeloid Metabolism in the Amplification and Resolution of Cardiac Inflammation |
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Geneviève Derumeaux, INSERM U955, Université Paris-Est Creteil
HFpEF: Obesity-Induced Immuno-Inflammation |
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Pilar Alcaide, Tufts University School of Medicine
Immune Crosstalk in HFpEF |
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Joseph A. Hill, University of Texas Southwestern Medical Center
Immuno-Metabolic Mechanisms of HFpEF |
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| 7:00–8:00 PM |
Social Hour with Lite Bites |
Quandary Peak |
| 7:30–10:00 PM |
Poster Session 2 |
Quandary Peak |
Thursday, February 13, 2025
| 7:00–8:00 AM |
Breakfast |
Quandary Peak |
| 8:00–11:00 AM |
Afterload-Induced HFrEF |
Grays Peak |
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* Vlad Zaha, University of Texas Southwestern Medical Center
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Peter Liu, University of Ottawa Heart Institute
Coordination between Immunity, Metabolism and Microvasculature in Heart Failure: Now Reaching the Brain |
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Anthony Rosenzweig, University of Michigan
Age-related Pathways in Heart Failure - Not Just for the Old |
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Fady Malik, Cytokinetics Inc.
Sarcomere-Targeted Drugs |
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Gemma A Figtree, Kolling Institute, University of Sydney
Short Talk: Advanced Immune and Lipidomic Profiling in Humans and Chimpanzees to Unravel Novel Factors in CT-Image Defined Coronary Artery Disease Susceptibility and Resilience |
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Niranjana Natarajan, Universitty of Pittsburgh
Short Talk: Spatial Transcriptomic Profiling of Macrophage–Fibroblast Dynamics in Heart Failure |
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Justin H Berger, Washington University School of Medicine
Short Talk: SGLT2 Inhibitors Act Independently of SGLT2 to Confer Benefit for HFrEF in Mice |
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Hyun Kook, Chonnam National University
Short Talk: Loss of p300/CBP-Associated Factor Aggravates Cardiac Remodeling Via Regulation Of Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 Acetylation |
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| 9:00–9:20 AM |
Coffee Break |
Longs Peak Foyer |
| 11:00–2:30 PM |
On Own for Lunch |
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| 3:00–4:30 PM |
Panel Discussion 2: Dialogue with Journal Editors (Joint) |
Grays Peak |
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Joseph A. Hill, University of Texas Southwestern Medical Center
*Session Chair, Editor in Chief, Circulation |
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Gabriele G Schiattarella, Charité University Medical Center
*Session Chair, Associate Editor, Circulation |
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Vesna Todorovic, Springer Nature
Chief Editor, Nature Cardiovascular Research |
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Bruce D. Koppelman, Cell Press
Scientific Editor, Immunity |
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| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–6:45 PM |
HFrEF: Other Mechanisms |
Grays Peak |
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* Ryan L Boudreau, University of Iowa
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Stavros G. Drakos, University of Utah
Metabolism and Myocardial Recovery in Heart Failure |
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Daniela Carnevale, University La Sapienza in Rome
Neuroimmune Mechanisms of Cardiac Remodeling |
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Adam E Mullick, Ionis Pharmaceuticals, Inc.
RNA Therapeutic Approaches for Heart Failure |
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Luca Scorrano, University of Padova
Short Talk: Coordination Between Mitochondrial Dynamics and Autophagy in Heart Failure |
|
| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Grays Peak |
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Quandary Peak |
| 8:00–9:00 PM |
Entertainment |
Longs Peak |
| 8:00–9:00 PM |
Cash Bar |
Quandary Peak |
Friday, February 14, 2025
