Induced Proximity: Emerging Technologies and Clinical Translation (Q1)
January 1-5, 2028
| Location to be Determined
Georg E. Winter, Michael A. Erb and Gwenn M Hansen
| 4:00–8:00 PM |
Registration |
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| 6:00–8:00 PM |
Welcome Mixer |
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Tuesday, February 8, 2028
| 12:40–1:00 PM |
Poster Setup |
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| 8:00–8:10 AM |
Welcome Remarks |
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| 8:10–9:40 AM |
Keynote Session (Joint) |
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Carolyn R. Bertozzi †, Stanford University
Beyond the Proteasome: Lysosomal Routes for Targeted Degradation |
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Stephen J. Elledge †, Harvard Medical School
SCF E3 Ligases and New Technologies |
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| 9:40–10:00 AM |
Coffee Break |
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| 9:40–11:30 AM |
Targeted Protein Degradation (Joint) |
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Michael Rape †, University of California, Berkeley
Fundamental and Translational Aspects of Ubiquitin Biology |
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Eric S. Fischer †, Dana-Farber Cancer Institute
Small Molecules Targeting the Ubiquitin Proteasome System |
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Sharon A Townson †, Monte Rosa Therapeutics
Designing Molecular Glue Degraders |
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Short Talk(s) Chosen from Abstracts
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| 11:40–12:40 PM |
Meet-the-Editors |
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| 12:40–5:00 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
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| 2:30–4:30 PM |
Symposia Spotlight 1: Emerging Mechanisms Beyond Protein Degradation |
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Short Talks Chosen from Abstracts
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–7:00 PM |
Chemical Tools for Induced Proximity |
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Benjamin F. Cravatt III †, The Scripps Research Institute
Protein and Ligand Discovery on a Global Scale |
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Xiaoyu Zhang †, Northwestern University
Chemical Concepts to Expand the Accessible Proteome |
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Fleur M. Ferguson †, University of California, San Diego
Chemical Strategies to Expand the Reach and Selectivity of Induced Proximity |
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Short Talk(s) Chosen from Abstracts
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| 7:00–8:00 PM |
Social Hour with Dinner |
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Wednesday, February 9, 2028
| 8:00–11:00 AM |
Molecular Mechanism of Action of Degraders and CIPs |
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Michael A. Erb, The Scripps Research Institute
Rewiring Chromatin-Regulated Processes with Proximity Pharmacology |
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Cristina Mayor-Ruiz †, IRB Barcelona
Deciphering and Designing Molecular Glues |
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Georg E. Winter, CeMM Research Center for Molecular Medicine
Reprogramming Biological Circuits with Small Molecules |
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Alessio Ciulli †, University of Dundee, School of Life Sciences
Structural Principles and Rational Design of Induced Proximity Complexes |
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Short Talk(s) Chosen from Abstracts
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| 9:00–9:20 AM |
Coffee Break |
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| 11:00–1:00 PM |
Poster Setup |
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| 11:00–5:00 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
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| 3:00–4:30 PM |
Career Roundtable |
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–7:00 PM |
Clinical Translation of Small-Molecule Degraders/CIPs |
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Gwenn M Hansen, Nurix Therapeutics
Rewriting the Rules of Small Molecule Pharmacology with Degraders |
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Gundula Min-Oo †, Gilead Sciences
Clinical Development of IRAK4 Degraders for I&I Indications |
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Jan A. Smith †, Revolution Medicines, Inc.
Targeting RAS Driven Cancers through Induced Proximity |
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Short Talk(s) Chosen from Abstracts
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| 7:00–8:00 PM |
Social Hour with Dinner |
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Thursday, February 10, 2028
| 8:00–11:00 AM |
Advancing Proximity Induction via AI/ML |
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Regina Barzilay †, Massachusetts Institute of Technology
Democratizing Biomolecular Interaction Modeling |
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Raquel Rodríguez-Pérez †, Novartis Biomedical Research
AI Advancing Drug Design in the Pharmaceutical Industry |
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Bruno Emanuel Correia †, École Polytechnique Fédérale de Lausanne
Computational Tools for Protein Design |
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Marinka Zitnik †, Harvard Medical School
Foundation Models for Molecular Drug Design and Clinical Drug Development |
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Short Talk(s) Chosen from Abstracts
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| 9:00–9:20 AM |
Coffee Break |
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| 11:10–12:10 PM |
Panel Discussion: From Bench to Biotech: How to Start a Company |
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| 12:10–5:00 PM |
On Own for Lunch |
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| 2:30–4:30 PM |
Symposia Spotlight 2: AI and Computational Innovations in Proximity Design |
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Short Talk(s) Chosen from Abstracts
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–6:15 PM |
Extracellular and Cell-Surface Proximity |
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Mohamad Abedi †, University of California, Los Angeles (UCLA)
De novo Designed Protein Switches for Programmable Cell-Surface Proximity |
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Xin Zhou †, Dana-Farber Cancer Institute
Engineering Cellular Communication |
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Short Talk(s) Chosen from Abstracts
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| 6:15–7:00 PM |
Closing Keynote Address |
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James E. Bradner †, Amgen Inc.
T Cell Engagers: From Discovery to Drug |
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| 7:00–7:15 PM |
Meeting Wrap-Up: Outcomes and Future Directions |
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| 7:15–8:15 PM |
Social Hour with Dinner |
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| 8:00–11:00 PM |
Entertainment |
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Friday, February 11, 2028
