Immunometabolism in Tissue Homeostasis and Diseases (Q2)
February 10-13, 2025
| Keystone Resort, Keystone, CO, United States
Ping-Chih Ho, María Mittelbrunn and Stanley Huang
Scholarship Deadline: Dec. 6, 2024 | Abstract Deadline: Jan. 22, 2025 | Early Registration Deadline: Dec. 19, 2024
Monday, February 10, 2025
| 4:00–8:00 PM |
Registration |
Longs Peak Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
Longs Peak Foyer |
Tuesday, February 11, 2025
| 7:00–8:00 AM |
Breakfast |
Quandary Peak |
| 8:00–9:00 AM |
Welcome and Keynote Address (Joint) |
Grays/Longs Peak |
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* María Mittelbrunn, Molecular Biology Center, CSIC
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* Joseph A. Hill, University of Texas Southwestern Medical Center
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Kathryn J Moore, New York University Medical Center
Immunometabolism in Cardiovascular Disease |
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| 9:00–11:30 AM |
Immunometabolism in Heart Failure and Vascular Diseases (Joint) |
Grays/Longs Peak |
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* Ronald J Vagnozzi, University of Colorado Anschutz Medical Campus
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Chiara Giannarelli, NYU Grossman School of Medicine
Immune Mechanisms of Vascular Disease |
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Kathleen Martin, Yale School of Medicine
Novel Smooth Muscle Mechanisms in Transplant Vasculopathy |
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Xing Li Wang, Fosun Pharma
Challenges and Opportunities for Cardiovascular Drug Development |
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Esther Lutgens, Mayo Clinic
Co-Stimulatory Immune Checkpoints: Maintaining Immune Cell Homeostasis |
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| 9:30–9:50 AM |
Coffee Break |
Longs Peak Foyer |
| 9:50–9:55 AM |
Award Recipient Acknowledgement |
Grays/Longs Peak |
| 11:30–1:00 PM |
Poster Setup |
Quandary Peak |
| 11:30–5:00 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
Quandary Peak |
| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–7:00 PM |
Immunometabolism in Tissue and Systemic Aging |
Longs Peak |
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Katrin Andreasson, Stanford University
Declining Immune Metabolism Promotes Age-Associated Inflammation and Cognitive Decline |
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María Mittelbrunn, Molecular Biology Center, CSIC
T Cell Metabolism in Inflammaging and Senescence |
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Marcia C. Haigis, Harvard Medical School
Immunometabolic Modulations, Aging, and Diet in Orchestating Immune Responses in the TME |
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* Mariana Borsa, University of Oxford
Short Talk: DamAged Memories: How Autophagy-Dependent Mitochondrial Inheritance Controls T Cell Fate Decisions. |
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Jue Feng, Icahn School of Medicine at Mount Sinai
Short Talk: Haplodeficiency of the Mtap/Cdkn2 Locus Drives Immunometabolic Dysregulation And Stromal Cell Alterations Leading To Myelodysplastic Syndromes-Like Disease |
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| 7:00–8:00 PM |
Social Hour with Lite Bites |
Quandary Peak |
| 7:00–8:00 PM |
Women in Science Networking Event |
Quandary Peak Foyer |
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* Gemma A Figtree, Kolling Institute, University of Sydney
Session Chair |
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* Esther Lutgens, Mayo Clinic
Session Chair |
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* Pilar Alcaide, Tufts University School of Medicine
Session Chair |
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* Kathryn E. Wellen, University of Pennsylvania
Session Chair |
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* Chiara Giannarelli, NYU Grossman School of Medicine
Session Chair |
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* María Mittelbrunn, Molecular Biology Center, CSIC
Session Chair |
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* Marlies Meisel, University of Pittsburgh
Session Chair |
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| 7:30–10:00 PM |
Poster Session 1 |
Quandary Peak |
Wednesday, February 12, 2025
| 7:00–8:00 AM |
Breakfast |
Quandary Peak |
| 8:00–11:00 AM |
Immunometabolism in Cancer Immunology and Immunotherapy |
Longs Peak |
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Jonathan D. Powell, Calico Life Sciences
Metabolic Targeting for Cancer Immunotherapy |
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Stanley Huang, The Ohio State University
Amino Acid Metabolism and UPR Responses in Macrophage Immunity |
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David Sancho, Centro Nacional de Investigaciones Cardiovasculares, CNIC
Microbiota and Host Dialogue: Mechanisms Driving Bone Marrow Training and Atherosclerosis |
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Nicole Walker, Weill Cornell Graduate School
Short Talk: Metabolic-Epigenetic Mechanisms of T Cell Dysfunction and DJ-1 Enhancements in CAR-T Therapy |
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Isabel Shen, University of California, San Francisco
Short Talk: Elucidating the Role of Metabolic Regulation in Immune Cell Composition and Function within the Tumor Microenvironment. |
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* Gang Xin, OSU
Short Talk: The Neddylation Operates as A PTM Checkpoint for Regulating Metabolism in CD8+ T Cells |
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Chen Yao, UT Southwestern Medical Center
Short Talk: KEAP1-NRF2 Axis Balances Stemness and Exhaustion in CD8+ T Cells |
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| 9:00–9:20 AM |
Coffee Break |
Longs Peak Foyer |
| 11:00–5:00 PM |
On Own for Lunch |
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| 11:15–1:00 PM |
Poster Setup |
Quandary Peak |
| 1:00–10:00 PM |
Poster Viewing |
Quandary Peak |
| 3:00–4:30 PM |
Career Roundtable (Joint) |
Grays Peak |
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James Priest, Tenaya Therapeutics
Senior Director of Cardiovascular Genetics |
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Maria Rescigno, Humanitas University
Professor, Group Leader, and Deputy Scientific Director |
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Meng-Ju Wu, University of Massachusetts Chan Medical School
Assistant Professor |
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Anne N Murphy, Cytokinetics, Inc.
Vice President, Scientific Affairs |
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| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–7:00 PM |
Immunometabolic Exposome in HFpEF (Joint) |
Grays/Longs Peak |
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* Matthew J Feinstein, Northwestern University
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Edward Thorp, Northwestern University
Myeloid Metabolism in the Amplification and Resolution of Cardiac Inflammation |
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Geneviève Derumeaux, INSERM U955, Université Paris-Est Creteil
HFpEF: Obesity-Induced Immuno-Inflammation |
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Pilar Alcaide, Tufts University School of Medicine
Immune Crosstalk in HFpEF |
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Joseph A. Hill, University of Texas Southwestern Medical Center
Immuno-Metabolic Mechanisms of HFpEF |
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| 7:00–8:00 PM |
Social Hour with Lite Bites |
Quandary Peak |
| 7:30–10:00 PM |
Poster Session 2 |
Quandary Peak |
Thursday, February 13, 2025
| 7:00–8:00 AM |
Breakfast |
Quandary Peak |
| 8:00–11:30 AM |
Metabolites-Guided Signaling Regulations in Immune Responses |
Longs Peak |
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Kathryn E. Wellen, University of Pennsylvania
Acetyl-CoA Metabolism in Tissue Homeostasis and Systemic Lipid Regulation |
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Ping-Chih Ho, Ludwig Institute for Cancer Research
Heme-Mediated T Cell Exhaustion |
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Tiffany Horng, ShanghaiTech University
Metabolite-Guided Immune Activation in Innate Immune Responses |
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Yajing Gao, University of California, Los Angeles
Short Talk: T Cell Cholesterol Transport Is A Metabolic Checkpoint That Links Intestinal Immune Responses To Dietary Lipid Absorption |
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Guang Sheng Ling, University of Hong Kong
Short Talk: Hyperglycemia-Triggered Lipid Peroxidation Destabilizes STAT4 and Impairs Anti-Viral Th1 Responses in Type 2 Diabetes |
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Julia Sauer, Boehringer Ingelheim Pharma GmbH & Co KG/ University of Constanze
Short Talk: Redox-Active Macrophages Confer Ferroptosis Protection to Bystander Cancer Cells Via IL4i1 |
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* Meng-Ju Wu, University of Massachusetts Chan Medical School
Short Talk: R-2-Hydroxyglutarate Shapes the Tumor Microenvironment and Reveals Metabolic Vulnerabilities in Mutant IDH1 Cholangiocarcinoma |
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Jordy Saravia, St. Jude Children's Research Hospital
Short Talk: Lysosomal Signaling Dictates Heterogeneous Metabolic States of Treg Cells to Limit Immunopathology |
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Kim Rewitz, University of Copenhagen
Short Talk: Decoding the Interactions Between Gut Immune Responses and Systemic Metabolic and Behavioral Dynamics |
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| 9:00–9:20 AM |
Coffee Break |
Longs Peak Foyer |
| 11:30–4:30 PM |
On Own for Lunch |
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| 3:00–4:30 PM |
Dialogue with Journal Editors (Joint) |
Grays Peak |
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Joseph A. Hill, University of Texas Southwestern Medical Center
*Session Chair, Editor in Chief, Circulation |
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Gabriele G Schiattarella, Charité University Medical Center
*Session Chair, Associate Editor, Circulation |
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Vesna Todorovic, Springer Nature
Chief Editor, Nature Cardiovascular Research |
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Bruce D. Koppelman, Cell Press
Scientific Editor, Immunity |
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| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–6:30 PM |
Microbiota-Derived Metabolic Regulations |
Longs Peak |
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* Guang Sheng Ling, University of Hong Kong
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Marlies Meisel, University of Pittsburgh
Exercise-induced microbiota metabolite enhances cancer immunotherapy efficacy |
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Maria Rescigno, Humanitas University
Microbiome-Guided metabolic control of cancer treatment |
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Upasana Das Adhikari, Massachusetts General Hospital/ Harvard med School
Short Talk: Immunometabolic Dysregulation in Colonic CD8+ T Cells Results In Epithelial Barrier Disruption In People With HIV On Antiretroviral Therapy |
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| 6:30–6:45 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Longs Peak |
| 6:45–8:00 PM |
Social Hour with Lite Bites |
Quandary Peak |
| 8:00–9:00 PM |
Entertainment |
Quandary Peak Foyer |
| 8:00–9:00 PM |
Cash Bar |
Quandary Peak |
Friday, February 14, 2025
