Targeted Protein Degradation (Q3)
January 21-24, 2024
| Keystone Resort, Keystone, CO, United States
James E. Bradner, Eric S. Fischer and Brenda A. Schulman
Scholarship Deadline: Oct. 26, 2023 | Abstract Deadline: Oct. 26, 2023 | Early Registration Deadline: Nov. 16, 2023
| 4:00–8:00 PM |
Arrival and Registration |
Longs Peak Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
Longs Peak Foyer |
| 7:00–8:00 AM |
Breakfast |
Quandary Peaks |
| 8:00–9:00 AM |
Welcome and Keynote Address (Joint) |
Grays/Longs Peak |
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Ning Zheng, University of Washington
Targeting Ubiquitin Ligases: From Hormones to Metabolites |
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| 9:00–11:15 AM |
Mechanisms of the Ubiquitin System (Joint) |
Grays/Longs Peak |
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Brenda A. Schulman, Max Planck Institute of Biochemistry
Structural Mechanisms of Dynamic Multiprotein E3 Ligases |
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Michael Rape, University of California, Berkeley
Novel Cullin-RING E3 Ligase Mechanisms Discovered through Deciphering Pathways Underlying Cellular Differentiation |
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Henry M. Colecraft, Columbia University
Developing Targeted Deubiquitination: Opportunities for Therapeutic Protein Stabilization |
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Jin Wang, Baylor College of Medicine
Short Talk: Short Talk: Unexpected Discoveries Through Developing BTK PROTACs |
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Ana Marcu, Genentech
Short Talk: Short Talk: Developing Discovery Proteomics Technologies to Elucidate HLA Neoantigen Presentation |
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| 9:30–9:50 AM |
Coffee Break |
Longs Peak Foyer |
| 11:15–1:00 PM |
Poster Setup |
Quandary Peaks |
| 11:15–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Quandary Peaks |
| 2:30–4:30 PM |
Workshop |
Longs Peak |
| |
Sebastian Kenny, University of Washington
De novo Design of Virus-Inspired 'Molecular Glues' to Efficiently Degrade Target Proteins |
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Hai-Tsang Huang, Broad Institute
Profiling E3 Substrate Ubiquitylation by Ubiquitin-specific Proximity Labeling |
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Justin Reitsma, AbbVie, Inc.
Degrader Speedometer: Quantitative Measurement of Degrader Rate of Targeted Protein Degradation |
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Jessie Kroonen, UMC Utrecht
Surface Removal and Lysosomal Degradation of PD-L1 using SureTACTM Technology |
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Hui Myeong Wang, Postech
Encoded Display of Chemical Libraries on Nanoparticles for Rapid Discovery of Potent Protein Ligands |
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Shourya S. Roy Burman, Dana-Farber Cancer Institute
Continuous Evolution of Compact Protein Degradation Tags Regulated by Selective Cereblon Molecular Glues |
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Lori Emert-Sedlak, University of Pittsburgh School of Medicine
Targeted Degradation of HIV-1 Nef Efficiently Restores Cell-surface CD4 and MHC-I Expression and Blocks HIV-1 Replication |
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Juliane Elisabeth Müller, Julius Maximilians Universität Würzburg
Targeted Protein Degradation Reveals a Scaffolding Function of Aurora-A Kinase |
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| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–7:00 PM |
Chemical Biology of Protein Degradation |
Longs Peak |
| |
Alessio Ciulli, University of Dundee, School of Life Sciences
How PROTAC Degraders Work and Why the Ternary Complex Matters |
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Nathanael Gray, Stanford University
Transcription Factor Chemical Induced Proximity – Reprogramming Cellular Function |
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James E. Bradner, Novartis
The Chemical Biology of Targeted Protein Degradation |
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Ashley Julio, UCLA
Short Talk: Short Talk: Pervasive Aggregation and Degradation of Host and Viral Proteins in Response to Cysteine-Reactive Electrophilic Compounds |
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Brian B. Liau, Harvard University
Short Talk: Short Talk: Chemical Facsimile of KBTBD4 Cancer Mutations Promotes Corepressor Degradation |
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| 7:00–8:00 PM |
Social Hour with Lite Bites |
Quandary Peaks |
| 7:30–10:00 PM |
Poster Session 1 |
Quandary Peaks |
Tuesday, January 23, 2024
| 7:00–8:00 AM |
Breakfast |
Quandary Peaks |
| 8:00–11:00 AM |
Strategies and Targets for Therapeutics in the Ubiquitin Proteasome System |
Longs Peak |
| |
Russell A. DeBose-Boyd, University of Texas Southwestern Medical Center
Proteostatic Control of the Cholesterol Biosynthetic Pathway |
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Raymond J. Deshaies, Amgen, Inc.
Cutting-Edge Developments in Targeted Protein Degradation |
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Nicolas H. Thomä, Friedrich Miescher Institute for Biomedical Research
Mechanisms of Transcriptional Regulation by E3 Ligases and Harnessing for Targeted Protein Degradation |
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Tanja Mittag, St. Jude Children's Research Hospital
Malleable Higher-Order Structures in Substrate Receptor SPOP Function and Pathophysiology |
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Liron Bar-Peled, Massachusetts General Hospital/Harvard Medical School
Short Talk: Short Talk: DrugMap: A Quantitative Pan-Cancer Analysis of Cysteine Ligandability |
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| 9:00–9:20 AM |
Coffee Break |
Longs Peak Foyer |
| 11:00–1:00 PM |
Poster Setup |
Quandary Peaks |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Quandary Peaks |
| 1:30–2:30 PM |
Women in TPD & IP Networking Social - Open to All! |
Castle Peak 1-2 |
| 3:00–4:30 PM |
Career Roundtable (Joint) |
Longs Peak |
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Michelle R. Arkin, University of California, San Francisco
Professor & Chair, Codirector, Small Molecule Discovery Center (SMDC) |
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Helen Walden, University of Glasgow
Professor of Structural Biology, Head of School (Molecular Biosciences) |
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Ramon J. Whitson, Novartis
Principal Scientist II |
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Byram Hirsch Ozer, National Cancer Institute
Assistant Research Physician |
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Heather Bisbee, Cell Press
Associate Scientific Editor, Molecular Cell |
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| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–7:00 PM |
Novel Opportunities in the Ubiquitin System |
Longs Peak |
| |
Sara Buhrlage, Dana-Farber Cancer Institute
Harnessing DUBs for Protein Stability Therapeutics |
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Helen Walden, University of Glasgow
Targeting USP1-UAF1 in DNA Repair |
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Ivan Dikic, Goethe University Medical School
Novel Ubiquitin Modifications Deployed by Pathogenic Bacteria |
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Zacharias Thiel, Novartis Biomedical Research
Short Talk: Short Talk: Identification of New Entry Points for Autophagy-Mediated Targeted Protein and Organelle Degradation using an Induced-Proximity Screen |
|
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Quandary Peaks |
| 7:30–10:00 PM |
Poster Session 2 |
Quandary Peaks |
Wednesday, January 24, 2024
| 7:00–8:00 AM |
Breakfast |
Quandary Peaks |
| 8:00–11:00 AM |
Methodologies and Technologies for the Investigation of Protein Degradation |
Longs Peak |
| |
Marta Cortes-Cros, Novartis Institutes for BioMedical Research
Degraders by Design vs. Serendipity: What have we Learned? |
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Yifat Merbl, Weizmann Institute of Science
Proteasome Profiling : Global Views of Degradation |
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Xin Zhou, Dana-Farber Cancer Institute
TransTAC |
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Angela Cacace, Arvinas Inc
Oral PROTAC® Degrader Molecules Selectively Clear Pathologic Proteins Underlying Neurodegenerative Diseases |
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Weicheng Li, UCSF
Short Talk: Short Talk: Intracellular Ubiquitination of a Synthetic Small Molecule Inhibits the UPS |
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| 9:00–9:20 AM |
Coffee Break |
Longs Peak Foyer |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–6:45 PM |
Development and Discovery of Molecular Glues (Joint) |
Grays/Longs Peak |
| |
Eric S. Fischer, Dana-Farber Cancer Institute
New Mechanism for Protein Degradation Therapeutics |
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Mary E. Matyskiela, Neomorph Inc.
Expanding the Target Space of Molecular Glue Degraders |
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Keriann Marie Backus, David Geffen School of Medicine at UCLA
Global Proteome Rewiring by Fragment Electrophiles |
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Michael A. Erb, The Scripps Research Institute
Short Talk: Short Talk: Systematic Remodeling of Protein-Ligand Surfaces for Prospective Molecular Glue Discovery |
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| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Grays/Longs Peak |
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Quandary Peaks |
| 8:00–9:00 PM |
Trivia |
Longs Peak |
| 8:00–9:00 PM |
Cash Bar |
Quandary Peaks |
Thursday, January 25, 2024
