| 7:30–10:00 PM | Posters |
| 4:00–8:00 PM | Registration |
| 6:00–8:00 PM | Welcome Mixer |
| 7:30–8:30 AM | Breakfast |
| 8:30–8:40 AM | Welcome Remarks |
| 8:40–9:30 AM | Keynote Address (Joint) |
| Steven P. Gygi †, Harvard Medical School Proteomics Beyond the Reference Proteome: Identifying Non-Canonical Translation Products with Confidence |
| 9:30–11:45 AM | Uncovering the Hidden Proteome (Joint) |
| Marie Anne Brunet †, Université de Sherbrooke From Translation to Function: Discovering Functional Microproteins and Peptideins |
| Sarah Slavoff †, Yale University The Hidden Human Proteome: From Discovery to Molecular Function |
| Francis O'Reilly †, St. Jude Childen's Research Hospital Rigorous Proteomic Strategies for Mapping Protein Interactions and the Expanded Proteome |
| Short Talk(s) Chosen from Abstracts |
| 10:00–10:20 AM | Coffee Break |
| 11:55–12:55 PM | Panel Discussion: When is a Non-Canonical Protein Real? (Joint) |
| 11:55–1:00 PM | Lunch |
| 1:00–2:00 PM | Poster Setup |
| 2:00–10:00 PM | Poster Viewing |
| 2:30–4:30 PM | Symposia Spotlight 1: Microprotein Discovery and Function |
| Short Talks Chosen from Abstracts |
| 4:30–5:00 PM | Coffee Available |
| 5:00–7:00 PM | The Origins and Diversity of Microproteins |
| Gisela Storz †, NICHD, NIH Hidden Proteins in Bacteria: Lessons from the Smallest Proteomes |
| Ami S. Bhatt †, Stanford University Hidden Translation in Microbial Communities: Discovering Small Proteins in the Human Microbiome |
| Susan B Carpenter †, University of California, Santa Cruz Small Proteins in Immunity: From Non-Canonical Translation to Function |
| Short Talk(s) Chosen from Abstracts |
| 7:00–8:00 PM | Social Hour with Dinner |
| 7:30–8:30 AM | Breakfast |
| 8:30–11:30 AM | Decoding Non-Canonical Translation |
| Jonathan Mudge, Institute of Cancer Research and EBI uORF Translation in Microprotein Evolution and Dosage Control |
| Can Cenik, University of Texas at Austin Decoding Translons: Predictive Models of Translation from Sequence |
| Ezgi Hacisuleyman †, Scripps Institute RNA Architecture and the Regulation of Non-Canonical Translation |
| Short Talk(s) Chosen from Abstracts |
| 9:30–9:50 AM | Coffee Break |
| 11:30–12:30 PM | Lunch |
| 11:30–1:00 PM | Poster Setup |
| 1:00–10:00 PM | Poster Viewing |
| 3:00–4:30 PM | Career Roundtable |
| 4:30–5:00 PM | Coffee Available |
| 5:00–7:00 PM | Predicting the Expanded Proteome: From Sequence to Function |
| Julie Aspden †, University of Leeds Non-Canonical Translation in Development: From Small ORFs to Biological Function |
| Alan Saghatelian †, The Salk Institute for Biological Studies Expanding the Bioactive Proteome: From Microprotein Discovery to Biological Function |
| Sonia Chothani, A*STAR Genome Institute of Singapore Hidden Translation in Human Physiology and Disease |
| Debora Marks †, Harvard Medical School Learning Protein Sequence to Function Relationships in the Dark Proteome |
| Short Talk(s) Chosen from Abstracts |
| 7:00–8:00 PM | Social Hour with Dinner |
| 7:30–10:00 PM | Posters |
| 7:30–8:30 AM | Breakfast |
| 8:30–11:30 AM | Microproteins in Disease and Therapeutics |
| Kevan M. Shokat †, University of California, San Francisco Drugging the Previously Undruggable: Chemical Strategies for Hidden Protein Biology |
| Juan C. Alvarez †, Merck From Hidden Protein to Drug Target: Translating the Expanded Proteome into Therapeutic Strategy |
| John Prensner †, University of Michigan Non-Canonical ORFs as Tumour-Specific Dependencies and Therapeutic Vulnerabilities |
| Short Talk(s) Chosen from Abstracts |
| 9:30–9:50 AM | Coffee Break |
| 11:30–12:30 PM | Lunch |
| 2:30–4:30 PM | Symposia Spotlight 2: Microproteins in Disease and Therapeutics |
| Short Talks Chosen from Abstracts |
| 4:30–5:00 PM | Coffee Available |
| 5:00–6:45 PM | The Hidden Proteome in Cancer: From Dark Antigens to Therapeutic Targets (Joint) |
| Bing Zhang †, Baylor College of Medicine Proteogenomic Landscapes of Cancer: Integrating Non-Canonical Translation into Tumor Biology |
| Jyoti Choudhary †, Institute of Cancer Research Mapping the Hidden Proteome: Proteogenomic Discovery of Non-Canonical Translation |
| Steven A. Carr †, Broad Institute Immunopeptidomics for Mapping Tumor-Specific Antigens |
| Vinidhra Mani †, ProFound Therapeutics Mining the Dark Proteome for New Therapeutic Targets |
| Short Talk(s) Chosen from Abstracts |
| 6:45–7:00 PM | Meeting Wrap-Up: Outcomes and Future Directions |
| 6:55–7:55 PM | Panel Discussion 2: From Discovery to Medicine: Moving Dark Proteins from the Lab to the Clinic (Joint) |
| 7:00–8:00 PM | Social Hour with Dinner |
| 8:00–11:00 PM | Entertainment |
| 8:00–11:00 PM | Cash Bar |
| 12:00–11:59 PM | Departure |