Proximity Based Therapeutics (Q4)
January 21-24, 2024
| Keystone Resort, Keystone, CO, United States
Ryan Potts and Michelle R. Arkin
Scholarship Deadline: Oct. 26, 2023 | Abstract Deadline: Oct. 26, 2023 | Early Registration Deadline: Nov. 16, 2023
| 4:00–8:00 PM |
Arrival and Registration |
Longs Peak Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
Longs Peak Foyer |
| 7:00–8:00 AM |
Breakfast |
Quandary Peaks |
| 8:00–9:00 AM |
Welcome and Keynote Address (Joint) |
Grays/Longs Peaks |
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Ning Zheng, University of Washington
Targeting Ubiquitin Ligases: From Hormones to Metabolites |
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| 9:00–11:15 AM |
Mechanisms of the Ubiquitin System (Joint) |
Grays/Longs Peaks |
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Brenda A. Schulman, Max Planck Institute of Biochemistry
Structural Mechanisms of Dynamic Multiprotein E3 Ligases |
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Michael Rape, University of California, Berkeley
Novel Cullin-RING E3 Ligase Mechanisms Discovered through Deciphering Pathways Underlying Cellular Differentiation |
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Henry M. Colecraft, Columbia University
Developing Targeted Deubiquitination: Opportunities for Therapeutic Protein Stabilization |
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Jin Wang, Baylor College of Medicine
Short Talk: Short Talk: Unexpected Discoveries Through Developing BTK PROTACs |
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Ana Marcu, Genentech
Short Talk: Short Talk: Developing Discovery Proteomics Technologies to Elucidate HLA Neoantigen Presentation |
|
| 9:30–9:50 AM |
Coffee Break |
Longs Peak Foyer |
| 11:15–1:00 PM |
Poster Setup |
Quandary Peaks |
| 11:15–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Quandary Peaks |
| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–7:00 PM |
Emerging Proximity Biology for Target Degradation |
Grays Peak |
| |
Leon O. Murphy, Casma Therapeutics
Drugging the Autophagy-Lysosomal Pathway |
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Ryan Potts, Amgen
RNATACs: Targeted mRNA Degradation |
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William Gibson, Dana Farber Cancer Institute
Short Talk: Short Talk: Bifunctional Small Molecules that Induce Nuclear Localization and Targeted Transcriptional Regulation |
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Ziwen Jiang, University of California, San Francisco
Short Talk: Short Talk: Autophagy Receptor-inspired Antibody-fusion Proteins for Targeted Intracellular Degradation |
|
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Quandary Peaks |
| 7:30–10:00 PM |
Poster Session 1 |
Quandary Peaks |
Tuesday, January 23, 2024
| 7:00–8:00 AM |
Breakfast |
Quandary Peaks |
| 8:00–11:00 AM |
Stabilizing Protein-Protein Interactions with Molecular Glues |
Grays Peak |
| |
Michelle R. Arkin, University of California, San Francisco
Modulating 14-3-3 Interactome |
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Jan Anne Smith, Revolution Medicines, Inc.
Targeting the Oncogenic State of RAS Mutants with Tricomplex Inhibitors |
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Goutham Narla, University of Michigan Medical School
From Mutations to Molecules: Lessons Learned from Protein Phosphatase 2A |
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Ella Livnah, Weizmann Institute of Science
Short Talk: Short Talk: Rationally Designed Bifunctional Ligands Induce Intracellular Precipitation of Symmetric Protein Targets |
|
| 9:00–9:20 AM |
Coffee Break |
Longs Peak Foyer |
| 11:00–1:00 PM |
Poster Setup |
Quandary Peaks |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Quandary Peaks |
| 1:30–2:30 PM |
Women in TPD & IP Networking Social - Open to All! |
Castle Peak 1-2 |
| 3:00–4:30 PM |
Career Roundtable (Joint) |
Longs Peak |
| |
Michelle R. Arkin, University of California, San Francisco
Professor & Chair, Codirector, Small Molecule Discovery Center (SMDC) |
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Helen Walden, University of Glasgow
Professor of Structural Biology, Head of School (Molecular Biosciences) |
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Ramon J. Whitson, Novartis
Principal Scientist II |
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Byram Hirsch Ozer, National Cancer Institute
Assistant Research Physician |
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Mishtu Dey, Cell Press
Editor-in-Chief |
|
| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–7:00 PM |
Predicting and Discovering Ternary Complexes |
Grays Peak |
| |
Jesus Izaguirre, Stealth Startup
Towards Rational Design of Selective Protein Degraders |
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Georg A. Petzold, Monte Rosa Therapeutics
Teaching CRBN New Tricks |
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Heidi Greulich, Broad Institute of MIT and Harvard
Activation of the SLFN12 RNase by Velcrin-Induced PDE3A-SLFN12 Complex Formation |
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Pranam Chatterjee, Duke University
Short Talk: Short Talk: Design of Programmable Peptide-Guided Proteome Editors via Generative Language Models |
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| 7:00–8:00 PM |
Social Hour with Lite Bites |
Quandary Peaks |
| 7:30–10:00 PM |
Poster Session 2 |
Quandary Peaks |
Wednesday, January 24, 2024
| 7:00–8:00 AM |
Breakfast |
Quandary Peaks |
| 8:00–11:00 AM |
Controlling Post-Translational Modifications by Induced Proximity |
Grays Peak |
| |
Daniel K. Nomura, University of California, Berkeley
Reimagining Druggability Using Chemoproteomic Platforms |
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Amit Choudhary, Harvard Medical School
Protein Editing using Small Molecules |
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Gopal P. Sapkota, University of Dundee
Targeted Ubiquitylation and Dephosphorylation of Proteins Through Proximity-Induction |
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Endri Karaj, The Broad Institute of MIT and Harvard
Short Talk: Short Talk: Development of Haptenizing Chimeras from Known Drugs for Cancer Immunotherapy |
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Lionel Chia, Foghorn Therapeutics
Short Talk: Short Talk: Hijacking the Transcriptional Activation Potential of BAF for Novel Therapeutic Opportunities |
|
| 9:00–9:20 AM |
Coffee Break |
Longs Peak Foyer |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 3:30–4:30 PM |
Workshop: New Screening and Profiling Technologies |
Grays Peak |
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Kyle Seamon, Revolution Medicines
Induction of Complexes Between Cyclophilin A and GTP-Bound RAS(ON) Enable Covalent Modification of KRAS(G12D) for Inhibition of G12D-Mutant Cancer Growth |
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Violeta L. Marin, AbbVie, Inc.
CRISPR Screen Reveals BRD2/4 Molecular Glue Degrader Via Recruitment of DCAF16 |
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Madelon M. Maurice, University Medical Center Utrecht
Employing Membrane-bound E3 Ligases for Targeted Degradation of Cell Surface Proteins using SureTACs Technology |
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Erik Ehinger, La Jolla Institute for Immunology
Improving Anti-tumor Responses by Degrading Proteins that Impose T Cell Exhaustion |
|
| 4:30–5:00 PM |
Coffee Available |
Longs Peak Foyer |
| 5:00–6:45 PM |
Development and Discovery of Molecular Glues (Joint) |
Grays/Longs Peaks |
| |
Eric S. Fischer, Dana-Farber Cancer Institute
New Mechanism for Protein Degradation Therapeutics |
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Mary E. Matyskiela, Neomorph Inc.
Expanding the Target Space of Molecular Glue Degraders |
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Keriann Marie Backus, David Geffen School of Medicine at UCLA
Global Proteome Rewiring by Fragment Electrophiles |
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Varun Jayeshkumar Shah, Institute of Biochemistry II, Medical Dpt of Univ. Hosp. Frankfurt, Goethe University
Short Talk: Short Talk: Discovery of Novel Molecular Glue Degraders |
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Michael A. Erb, The Scripps Research Institute
Short Talk: Short Talk: Systematic Remodeling of Protein-Ligand Surfaces for Prospective Molecular Glue Discovery |
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| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Grays/Longs Peaks |
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Quandary Peaks |
| 8:00–9:00 PM |
Trivia |
Longs Peak |
| 8:00–9:00 PM |
Cash Bar |
Quandary Peaks |
Thursday, January 25, 2024
