Aging: New Frontiers in Rejuvenation and Gerotherapeutics (Q6)
February 17-20, 2025
| Beaver Run Conference Center, Breckenridge, CO, United States
Ashley Webb, Morgan Levine and Dario Riccardo Valenzano
Scholarship Deadline: Nov. 27, 2024 | Abstract Deadline: Jan. 28, 2025 | Early Registration Deadline: Dec. 24, 2024
Monday, February 17, 2025
| 4:00–8:00 PM |
Registration |
3rd Floor Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
3rd Floor Foyer |
Tuesday, February 18, 2025
| 7:00–8:00 AM |
Breakfast |
Summit Gallery |
| 8:00–9:00 AM |
Welcome and Keynote Address |
Colorado Ballroom |
| |
* Dario Riccardo Valenzano, Leibniz Institute on Aging
Session Chair |
|
| |
Anne Brunet, Stanford University
Quantifying and Targeting Aging |
|
| 9:00–11:15 AM |
Chromatin and Epigenetics in Aging |
Colorado Ballroom |
| |
* Dario Riccardo Valenzano, Leibniz Institute on Aging
Session Chair |
|
| |
Shelley L Berger, University of Pennsylvania
Mechanisms of Chromatin Regulation in Aging |
|
| |
Andrea Ablasser, Ecole Polytechnique Fédérale de Lausanne
Targeting Chronic Inflammation in the Brain |
|
| |
Vera Gorbunova, University of Rochester
DNA Repair Mechanisms in Aging and Longevity |
|
| |
Philine Guckelberger, Max-Planck Institute for Molecular Genetics
Short Talk: Cohesin-Mediated 3d Contacts Tune Enhancer-Promoter Regulation |
|
| 9:30–9:50 AM |
Coffee Break |
3rd Floor Foyer |
| 9:50–9:55 AM |
Award Recipient Acknowledgement |
Colorado Ballroom |
| 11:15–12:15 PM |
Meet the Editors |
Colorado Ballroom |
| |
Ines Alvarez-Garcia, PLOS Biology
*Session Chair, Senior Editor |
|
| |
Michael Basson, Springer Nature
Senior Editor |
|
| |
Ahmet M. Denli, Cold Spring Harbor Laboratory
Associate Editor |
|
| |
George Inglis, Nature Portfolio
Senior Editor |
|
| 11:15–1:00 PM |
Poster Setup |
Peaks 1 - 3 |
| 11:15–2:30 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Peaks 1 - 3 |
| 2:30–4:30 PM |
Symposia Spotlight 1: Therapeutics for Healthy Aging |
Colorado Ballroom |
| |
* Jacob Kimmel, NewLimit
Session Chair |
|
| |
* Philine Guckelberger, Max-Planck Institute for Molecular Genetics
Session Chair |
|
| |
Reza Dana, Harvard Medical School
Effects of Advancing Age on Dysregulation of Ocular Immune Homeostasis |
|
| |
Nancy Morones, Cedars-Sinai Medical Center
Age-Dependent Dysregulation of Hypothalamic Circuits Contributes to Thermoregulatory Decline and Water Homeostasis Deficits in Aged Mice |
|
| |
Hong Seok Shim, The University of Texas MD Anderson Cancer Center
Maintenance of Somatic Tert Levels as An Antiaging Strategy |
|
| |
Pengze Yan, Dana-Farber Cancer Institute
Midkine as a Key Driver of Both Aging and Mammary Tumorigenesis |
|
| |
Julio Aguado, University of Colorado
Virus-Induced Senescence: A Driver of Post-Acute Neurotropic Infection Syndrome |
|
| |
Albert T Higgins-Chen, Yale University
Responsiveness of Dnam Aging Biomarkers Across 51 Longevity Interventional Studies In Humans |
|
| |
Ee Phie Tan, Scripps Research Institute
Investigating Small Molecule Autophagy Activator Aa-20: From Lipophagy In Mammals To Longevity In C. Elegans |
|
| 4:30–5:00 PM |
Coffee Available |
3rd Floor Foyer |
| 5:00–7:00 PM |
Artificial Intelligence and Machine Learning Modeling of Cell States and Transitions |
Colorado Ballroom |
| |
* Morgan Levine, Altos Labs
Engineering Multiscale Health |
|
| |
Jacob Kimmel, NewLimit
In silico Design of Rejuvenating Interventions |
|
| |
Kejun Ying, Harvard University
Short Talk: MethylGPT: A Foundation Model for the Dna Methylome |
|
| |
Michael Wosczyna, NYU Grossman School of Medicine
Short Talk: Machine Learning-Based Dimensional Reduction Of Multiparameter Cellular Morphometrics Defines Senescence Across Age |
|
| |
Rupa Sridharan, University of Wisconsin-Madison
Short Talk: Untangling Cellular States Of Rejuvenation And Cell Identity In Induced Pluripotency |
|
| |
Lucas Paulo de Lima Camillo, Shift Bioscience
Short Talk: CpGPT: A Foundation Model For Dna Methylation |
|
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Peaks 1 - 3 |
| 7:30–10:00 PM |
Poster Session 1 |
Peaks 1 - 3 |
Wednesday, February 19, 2025
| 7:00–8:00 AM |
Breakfast |
Summit Gallery |
| 8:00–11:00 AM |
Metabolism and the Microbiome in Healthspan and Longevity |
Colorado Ballroom |
| |
Dario Riccardo Valenzano, Leibniz Institute on Aging
Host-Microbiome Interactions in Aging |
|
| |
* Meng C. Wang, HHMI/Janelia Research Campus
Organelle and Metabolic Homeostasis |
|
| |
Thomas Mortimer, IRB Barcelona
Circadian Clock Communication During Homeostasis and Ageing |
|
| |
Sean M. Gibbons, Institute for Systems Biology
Interactions Between the Gut Microbiome and Host Frailty |
|
| |
Peter James Mullen, University of Southern California
Short Talk: A Metabolic Atlas of Mouse Aging |
|
| |
Michael Petrascheck, Scripps Research
Short Talk: A Gero-Neuroprotector That Restores Mitochondrial Function To Extend Lifespan |
|
| 9:00–9:20 AM |
Coffee Break |
3rd Floor Foyer |
| 11:00–1:00 PM |
Poster Setup |
Peaks 1 - 3 |
| 11:00–1:30 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Peaks 1 - 3 |
| 3:30–4:30 PM |
Career Roundtable (Joint) |
Colorado Ballroom |
| |
Hao Zhu, University of Texas Southwestern Medical Center
Associate Professor & Attending Physician |
|
| |
Cindy Guidi, AstraZeneca
Principal Scientist |
|
| |
Mitchell Lee, Ora Biomedical, Inc.
|
|
| |
Michael J Corley, Weill Cornell Medicine
Associate Professor |
|
| 4:30–5:00 PM |
Coffee Available |
3rd Floor Foyer |
| 5:00–7:00 PM |
Stem Cells and Regeneration of Aged Tissues |
Colorado Ballroom |
| |
* Ashley Webb, Buck Institute on Aging
Session Chair |
|
| |
Michael A. Bonaguidi, University of Southern California
Harnessing Cell State Transitions for Cognitive Rejuvenation |
|
| |
Darcie L. Moore, University of Wisconsin-Madison
Mechanisms Underlying Neural Stem Cell Quiescence |
|
| |
Leanne Jones, University of California, San Francisco
Metabolic and Signaling Mechanisms of Stem Cell Homeostasis |
|
| |
Fabrizio d'Adda di Fagagna, IFOM ETS–The AIRC Institute of Molecular Oncology
Short Talk: Telomere Biology in Aging and Disease |
|
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Peaks 1 - 3 |
| 7:30–10:00 PM |
Poster Session 2 |
Peaks 1 - 3 |
Thursday, February 20, 2025
| 7:00–8:00 AM |
Breakfast |
Summit Gallery |
| 8:00–11:00 AM |
Epigenetic Reprogramming and Rejuvenation |
Colorado Ballroom |
| |
* Vittorio Sebastiano, Stanford University
Nuclear Reprogramming to Ameliorate Aging |
|
| |
Berenice A Benayoun, University of Southern California
Epigenetic Mechanisms of Immune Aging and Rejuvenation |
|
| |
Alejandro Ocampo, University of Lausanne
Improving Healthy Aging Through Cellular Reprogramming |
|
| |
Peng Liu, Retro Biosciences
In vivo Functional Rejuvenation by a Partial Reprogramming-based Approach |
|
| |
Todd Dowrey, Boston University
Short Talk: Uncovering the Mechanisms of Exceptional Longevity Through Ipsc-Based Modeling of Resiliency |
|
| |
Yinqing Li, Tsinghua University
Short Talk: ACC-seq Reveals Chromatin Condensate-Mediated Gene Regulation and its Role in Functional Decline |
|
| 9:00–9:20 AM |
Coffee Break |
3rd Floor Foyer |
| 11:00–2:30 PM |
On Own for Lunch |
|
| 3:00–4:30 PM |
Symposia Spotlight 2: Rejuvenation, Stem Cells, and Reprogramming |
Colorado Ballroom |
| |
* Kelsey Babcock, Brown University
Session Chair |
|
| |
Daniel J Simpson, Mayo Clinic
PRC2 Ageindex: A Universal Biomarker Of Aging And Rejuvenation |
|
| |
Walter Sandt, CECAD
Age Deceleration and Reversal Gene Patterns in Dauer Diapause |
|
| |
Angelina Holcom, Buck Institute for Research on Aging
Exploring Metabolic Dynamics in Quiescent Versus Activated Neural Stem Cells |
|
| |
Jingxun Chen, Stanford University - Stanford, CA
Vertebrate Organ Aging Impacted by Sexual Interaction |
|
| |
Irene de Lazaro, New York University
In Vivo Partial Reprogramming of Cardiomyocytes to a Molecularly Rejuvenated State Ameliorates Cardiac Failure |
|
| |
Manuel Collado, Health Research Institute of Santiago de Compostela Foundation - FIDIS
Senomorphic Effect of Partial Reprogramming |
|
| 4:30–5:00 PM |
Coffee Available |
3rd Floor Foyer |
| 5:00–7:00 PM |
Gerotherapeutics |
Colorado Ballroom |
| |
* Carlos Giovanni Silva Garcia, Brown University
Cross-Generational Mechanisms of Longevity |
|
| |
Mitchell Lee, Ora Biomedical, Inc.
Targeting Conserved Mechanisms of Aging |
|
| |
James Peyer, Cambrian Bio
Enhancing Healthspan Through Targeted Therapeutics |
|
| |
Ashley Webb, Buck Institute on Aging
Transcriptional Mechanisms of Brain Aging |
|
| 7:00–7:15 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Colorado Ballroom |
| 7:15–8:15 PM |
Social Hour with Lite Bites |
Peaks 1 - 3 |
| 8:00–9:00 PM |
Entertainment |
Colorado Ballroom |
| 8:00–9:00 PM |
Cash Bar |
Peaks 1 - 3 |
Friday, February 21, 2025
