Host-Microbe Co-Evolution in Human Health: The Microbiome-Pathobiont Continuum (Q8)
February 18-21, 2025  | Fairmont Banff Springs, Banff, AB, Canada
Bana Jabri, Caetano Reis e Sousa and Philippe J. Sansonetti
Scholarship Deadline: Dec. 6, 2024 | Abstract Deadline: Jan. 29, 2025 | Early Registration Deadline: Jan. 4, 2025
* Session Chair † Invited but not yet accepted | Program current as of November 4, 2025 2 PM | For the most up-to-date details, visit https://www.keystonesymposia.org
Tuesday, February 18, 2025
4:00–8:00 PM Registration Van Horne Foyer
6:00–8:00 PM Welcome Mixer Van Horne Foyer
Wednesday, February 19, 2025
7:00–8:00 AM Breakfast President's Hall
8:00–9:00 AM Welcome and Keynote Address (Joint) Van Horne A
  * Suzanne Devkota, Cedars-Sinai Medical Center
Session Chair		  
  * Bana Jabri, University of Chicago
Session Chair		  
  Dan R. Littman, HHMI/New York University School of Medicine
Commensals and Pathobionts in the Gut		  
9:00–9:30 AM Coffee Break Van Horne Foyer
9:30–11:15 AM Viruses Within Us Van Horne B
  * George Kassiotis, The Francis Crick Institute
Endogenous Retroelements and Immunity		  
  Luis Barreiro, University of Chicago
Exploring Evolutionary Immunogenomics: Lessons from our Ancestors and Past Pandemics		  
  Vivien Béziat, Institut Imagine
Human Genetic Determinants of Immunity to Muco-Cutaneous Papillomavirus		  
  Danielle E Campbell, Washington University in Saint Louis School of Medicine
Short Talk: Single-Cell Viral Tagging Identifies Novel Human Gut Bacteriophages and Bacterial Hosts Associated with Inflammatory Bowel Diseasea		  
11:15–1:00 PM Poster Setup Van Horne C
11:15–3:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing Van Horne C
2:30–4:00 PM Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions Van Horne B
  Kevin Bonham, Tufts Medical Center
Co-Development of Gut Microbial Metabolism and Visual Neural Circuitry Over Human Infancy		  
  Michael G Constantinides, Scripps Research
MAIT Cell Responses to Intracellular and Extracellular Pathogens Are Mediated by Distinct Antigen-Presenting Cells		  
  Maude Jans, VIB-UGent
Colibactin-Driven Colon Cancer Requires Adhesin-Mediated Epithelial Binding		  
  * Jeannette Messer, Cleveland Clinic
A Direct Antimicrobial Function of HMGB1 That Determines Bacterial Virulence In The Gut		  
  Patrick Schimmel, Med Uni Graz
Mechanisms of FMT Efficacy in IBD Beyond Strain Engraftment		  
  Andrew Patterson, University of Pennsylvania
A Phylogenetic Approach to Quantification of Human Endogenous Retrovirus RNA Expression		  
4:00–4:30 PM Coffee Available Van Horne Foyer
5:00–7:00 PM Microbes Within Us Van Horne B
  Salomé LeibundGut-Landmann, University of Zürich
Living with Commensal Fungi		  
  Sophie Helaine, Harvard Medical School
Persisters Curing Infection		  
  * Emma Slack, ETH Zurich
Mechanisms the Host uses to Control the Gut Microbiota		  
  Mohammad Arifuzzaman, Weill Cornell Medicine
Short Talk: Co-Evolution With Gut Microbiota: Host Metabolism Balances Microbial Regulation Of Bile Acid Signaling		  
  Reinhard Hinterleitner, University of Pittsburgh
Short Talk: Type-2 Immune-Mediated Adaptations in Epithelial Cells in Response to Commensal Protists and Helminth Infection		  
7:00–8:00 PM Social Hour with Lite Bites President's Hall
7:30–10:00 PM Poster Session 1 Van Horne C
Thursday, February 20, 2025
7:00–8:00 AM Breakfast President's Hall
8:00–11:00 AM What is a Pathobiont? Microbial Adaptations and Host Damage (Joint) Van Horne A
  Peter J Turnbaugh, University of California, San Francisco
Harnessing the Gut Microbiome to Counteract and Predict Cancer Chemotherapy Toxicity		  
  Purna C Kashyap, Mayo Clinic
Time to Turn the Spotlight on the Small Intestinal Microbiome		  
  * Russell E Vance, University of California, Berkeley
Mechanisms of mucosal immunity against the intracellular gut pathogen Shigella flexneri		  
  Iliyan D Iliev, Weill-Cornell Medical College
Fungal Commensalism and the Co-evolution of Type 2 Immunity		  
  Darryl A Abbott, University of Pittsburgh
Short Talk: Maternal Immunoglobulin a Regulates the Development of the Neonatal Microbiota and Intestinal Microbiota-Specific CD4+ T Cell Responses		  
  Darian T Carroll, Vanderbilt University Medical Center
Short Talk: Regulation of Enterocyte Lipid Metabolism by the Microbiota-derived Metabolite, Phenyllactic Acid		  
9:00–9:20 AM Coffee Break Van Horne Foyer
9:20–9:25 AM Award Recipient Acknowledgement Van Horne A
11:00–1:00 PM Poster Setup Van Horne C
11:00–2:45 PM On Own for Lunch
1:00–2:30 PM Career Roundtable (Joint) Van Horne B
  Ashlee M Earl, Broad Institute
Director, Bacterial Genomics		  
  Trevor Lawley, Microbiotica/Wellcome Sanger Institute
Founder & CSO/Group Leader		  
  Marin Vulic, Seres Therapeutics
Senior Principal Scientist		  
  Alex Rodriguez-Palacios, Case Western Reserve University School of Medicine
Assistant Professor		  
  Jessica Langer, Helmsley Charitable Trust
Program Officer		  
1:00–10:00 PM Poster Viewing Van Horne C
2:45–4:30 PM Panel Discussion 1: Toward Molecular Mechanisms in Microbiome Research: Insights from Genetic Systems and Co-Evolved Pathways (Joint) Van Horne A
  Ramnik Xavier, Massachusetts General Hospital
Panel Co-Leader		  
  Ami S. Bhatt, Stanford University
Panel Co-Leader		  
  Suzanne Devkota, Cedars-Sinai Medical Center
  
  Michael A. Fischbach, Stanford University
  
  Andrew L Goodman, Yale School of Medicine
  
  George Kassiotis, The Francis Crick Institute
  
4:30–5:00 PM Coffee Available Van Horne Foyer
5:00–5:05 PM Jessica Langer, Helmsley Trust Introduction Van Horne A
5:05–7:00 PM Host Colonization and Co-Evolution of Host-Microbial Interactions (Joint) Van Horne A
  Maria Manuel Dias da Mota, GIMM- Gulbenkian Institute For Molecular Medicine
Inter-Kingdom Interactions Shaping Malaria Infections		  
  Andrew L Goodman, Yale School of Medicine
Bacterial Diversity and Host Response to Medications		  
  * Melanie Blokesch, École Polytechnique Fédérale de Lausanne
When Microbes Turn Hosts: Phage Defense Evolution in Pandemic Vibrio cholerae		  
  Clarissa Campbell, The Research Center for Molecular Medicine of the Austrian Academy of Sciences (CeMM)
Short Talk: Bacterial Quorum Sensing Molecules Produced Via HdtS Homologs Affect Host T Cell Immunity In The Mammalian Gut		  
  Gregory P Donaldson, UCLA
Short Talk: Gut Microbiota Induce an Immunoglobulin A-DMBT1 Feedback Loop to Tune Epithelial Cycling and Tumor Risk		  
7:00–8:00 PM Social Hour with Lite Bites President's Hall
7:30–10:00 PM Poster Session 2 Van Horne C
Friday, February 21, 2025
7:00–8:00 AM Breakfast President's Hall
8:00–11:00 AM Role of Gut Microbiota in Disease Van Horne B
  Michael A. Fischbach, Stanford University
Discovery and Engineering of the Antibody Response to a Prominent Skin Commensal		  
  Pascale Vonaesch, University of Lausanne
The Gut Ecosystem in Childhood Undernutrition		  
  * Bana Jabri, University of Chicago
Intestinal Barrier, Commensals and Immunopathology		  
  Arushana A Maknojia, Baylor College of Medicine
Short Talk: Gut-bone marrow crosstalk: How microbiota-derived signals regulate steady-state hematopoiesis?		  
  Fanny Matheis, New York University School of Medicine
Short Talk: Rewilding of Laboratory Mice Defines a “Microbiometer,” Reveals Major Loss of Bacterial Density and Fungal Invasion, and Improves Pathogen Resistance-Associated Innate Immunity		  
  Kali M. Pruss, Washington University School of Medicine, St. Louis
Short Talk: Effects Of Intergenerational Transmission of Small Intestinal Bacteria Cultured From Stunted Bangladeshi Children With Enteropathy		  
  Wataru Ebina, NYU Langone Health
Short Talk: Enteric Murine Norovirus Infection Enhances Immune Checkpoint Inhibitor Treatment Of Distal Tumor		  
9:00–9:20 AM Coffee Break Van Horne Foyer
11:00–2:30 PM On Own for Lunch
2:30–4:15 PM Symposia Spotlight 2: Interface of Nutrition, Microbiome and Disease Van Horne B
  Hyunji Park, POSTECH
Gut Microbial Production of Imidazole Propionate Drives Parkinson’s Pathologies		  
  * Sean Spencer, Stanford University
Capsule-Based Sampling of the Human Small Intestine Enables Rational Design of Therapeutic Bacterial Consortia for Precision Modulation of Small Intestinal Microbiota		  
  Hallie Avalos, Vanderbilt
Salmonella Typhimurium Relies on Vitamin C Utilization for Expansion During Intestinal Inflammation		  
  Marie A Crane, Washington University School of Medicine
Comparative Genomics Analyses of the Microbial Targets of Microbiota-Directed Foods Yield Insights into Structure-Function Relationships		  
  Hyoung-Soo Cho, Harvard Medical School
Colonization with Fusobacterium Remodels the Intestinal Epithelium of the Host		  
  Elaine Kouame, UCSF
Antigen-Presenting Cells Recognizing Cell Death Modulate Immunity to Dietary Antigens During Viral Infections		  
  Meghan Chafee, Seres Therapeutics, Inc.
Pharmacokinetic (PK) and Pharmacodynamic (PD) Results From A Phase 1b Study of SER-155, An Investigational, Oral, Live Biotherapeutic Evaluated In Adults Undergoing Allogeneic Stem Cell Transplant (allo-HCT)		  
4:30–5:00 PM Coffee Available Van Horne Foyer
5:00–6:30 PM Therapeutic Lessons from Bugs Van Horne B
  Ramnik Xavier, Massachusetts General Hospital
Learning Mucosal Immunity from Gut Bugs		  
  * Caetano Reis e Sousa, Francis Crick Institute
Micronutrients, the Microbiome and Cancer Immunity		  
  Marlies Meisel, University of Pittsburgh
Metabolism, Microbiota and Cancer Immunity		  
6:30–7:15 PM Closing Keynote Address Van Horne B
  * Caetano Reis e Sousa, Francis Crick Institute
Session Chair		  
  Wendy S Garrett, Harvard School of Public Health
Interplay Between the Gastrointestinal Immune System and the Gut Microbiota in Health and Disease		  
7:15–7:30 PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Van Horne B
7:15–8:15 PM Social Hour with Lite Bites President's Hall
8:15–9:15 PM Entertainment Van Horne A
Saturday, February 22, 2025
12:00–11:59 PM Departure