Tumor Metabolism: Novel Pathways and Therapeutic Challenges (R4)
January 1-5, 2028  | Location to be Determined
Matthew G Vander Heiden, Daniel E. Frigo and Lydia Finley
* Session Chair † Invited but not yet accepted | Program current as of September 21, 2026 8 AM | For the most up-to-date details, visit https://www.keystonesymposia.org
Saturday, January 1, 2028
1:00–6:00 PM Registration
3:00–3:10 PM Welcome Remarks
3:10–4:00 PM Keynote Address
  Ralph J DeBerardinis †, University of Texas Southwestern Medical Center
Cancer as a Systemic Metabolic Disease
 
4:00–6:00 PM Metabolites as Signaling Molecules to Influence Cancer
  Kathryn E. Wellen †, University of Pennsylvania
How Environmental Metabolite Availability Shapes Gene Regulation
 
  Navdeep S Chandel †, Northwestern University
Systemic Impact of Metabolites
 
  Lydia Finley, Memorial Sloan Kettering Cancer Center
Decoding Metabolic Signals during Cell Fate Transitions
 
  Short Talk(s) Chosen from Abstracts
 
6:00–8:00 PM Welcome Reception
Sunday, January 2, 2028
12:25–1:00 PM Poster Setup
7:00–8:00 AM Breakfast
8:00–11:15 AM New Insights into Metabolic Pathways
  Gina M DeNicola †, Moffitt Cancer Center
Impact of Metals on Pathways
 
  Arkaitz Carracedo †, Center for Cooperative Research in Biosciences
Emerging Intersections between Metabolism and Signaling
 
  Lucas B. Sullivan †, Fred Hutchinson Cancer Research Center
Novel Mass Spectrometry Methods to Study Cysteine Metabolism and the Impact on Drug Response
 
  Gerta Hoxhaj †, UT Southwestern Medical Center
Novel Regulation of Cancer Cell Metabolism
 
  Short Talk(s) Chosen from Abstracts
 
9:30–9:50 AM Coffee Break
11:25–12:25 PM Meet-the-Editor
12:25–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing
2:30–4:30 PM Symposia Spotlight 1: Systemic Metabolism
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available
5:00–7:00 PM Altered Organellar Metabolism in Cancer
  Payam Anthony Gammage †, Cancer Research UK Scotland Institute
How Mitochondria Shape Immune Responses in Cancer
 
  Kivanc Birsoy †, Rockefeller University
Approaches to Study Organelle Metabolite Transport
 
  Jared Rutter †, University of Utah
Pathway Regulation by Organellar Metabolites
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM Social Hour with Dinner
7:30–10:00 PM Posters
Monday, January 3, 2028
7:00–8:00 AM Breakfast
8:00–11:00 AM Impact of the Microenvironment on Tumor Metabolism
  Alexander Muir †, University of Chicago
Influence of Environmental Metabolites on Cancer Phenotypes
 
  Sarah-Maria Fendt †, VIB-KU Leuven
Local and Systemic Metabolic Influences on Metastasis
 
  Wilhelm Palm †, German Cancer Reserach Center
Cancer Cell Scavenging from the Environment
 
  Jessalyn M. Ubellacker †, Harvard T.H. Chan School of Public Health
The Impact of Regional Metabolic Environments on Immunological Control of Tumor Growth
 
  Short Talk(s) Chosen from Abstracts
 
9:00–9:20 AM Coffee Break
11:00–1:00 PM Poster Setup
11:00–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing
3:00–4:30 PM Career Roundtable
4:30–5:00 PM Coffee Available
5:00–7:00 PM Metabolic Drivers of Tumor Evolution
  Maria Rodriguez Colman †, UMC Utrecht
Use of Metabolite Sensors to Assess Redox Regulation of Cancer Phenotypes
 
  Christian Frezza †, University of Cologne
From Genotype to Metabolic Phenotype: Multi-Omic Approaches to Cancer Evolution
 
  Matthew G Vander Heiden, Massachusetts Institute of Technology
Impact of Metabolism on Cancer Heterogeneity
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM Social Hour with Dinner
7:30–10:00 PM Posters
Tuesday, January 4, 2028
7:00–8:00 AM Breakfast
8:00–11:00 AM Intersections between Tumor and Host
  Rachel J. Perry †, Yale University
How Host Metabolism Shapes Tumor Metabolism
 
  Liza Makowski †, The Ohio State University
Impact of Surgical and Pharmacological Weight Loss on Cancer
 
  Daniel J. Drucker †, Lunenfeld-Tanenbaum Research Institute
GLP-1 Medicines: Emerging Opportunities in Cancer Prevention and Therapy
 
  Thales Papagiannakopoulos †, Salk Institute for Biological Studies
How Cancer-Nerve Interactions Influence Host Metabolism
 
  Short Talk(s) Chosen from Abstracts
 
9:00–9:20 AM Coffee Break
11:00–5:00 PM On Own for Lunch
2:30–4:30 PM Symposia Spotlight 2
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available
5:00–6:45 PM Metabolic Considerations for Successful Cancer Therapy
  Daniel E. Frigo, University of Texas MD Anderson Cancer Center
Targeting Prostate Cancer Metabolism Across Shifting Endocrine States
 
  Costas A. Lyssiotis †, University of Michigan
Treating Cancer by Targeting Salvage Metabolism
 
  Karen H. Vousden †, Francis Crick Institute
Systemic Metabolic Approaches to Target Cancer
 
  Short Talk(s) Chosen from Abstracts
 
6:45–7:00 PM Meeting Wrap-Up: Outcomes and Future Directions
7:00–8:00 PM Social Hour with Dinner
8:00–11:00 PM Entertainment
8:00–11:00 PM Cash Bar
Thursday, January 6, 2028
12:00–11:59 PM Departure