Progress in Antibiotic Discovery and Development (S3)
January 1-4, 2027  | Location to be Determined
Cesar de la Fuente, James J. Collins and Ewa Szczurek
* Session Chair † Invited but not yet accepted | Program current as of August 23, 2025 4 AM | For the most up-to-date details, visit https://www.keystonesymposia.org
Friday, January 1, 2027
4:00–8:00 PM Registration
6:00–8:00 PM Welcome Mixer
Saturday, January 2, 2027
7:00–8:00 AM Breakfast
8:00–9:00 AM Welcome and Keynote Address
  Roy Kishony †, Technion – Israel Institute of Technology
The Future of Antibiotic Resistance
 
9:00–10:45 AM Antibiotics AI: Computational & AI-Enabled Antibiotic Discovery
  James J. Collins, Broad Institute of MIT & Harvard
AI Approaches for Antibiotic Discovery
 
  Cesar de la Fuente, University of Pennsylvania
Accelerating Antibiotic Discovery Using AI
 
  Ewa Szczurek, Helmholtz Munich
Controllable Generative AI for Antimicrobial Peptides Discovery
 
  Short Talk(s) Chosen from Abstracts
 
9:30–9:50 AM Coffee Break
10:45–11:15 AM Panel Discussion 1: Q&A with Drs. Collins, de la Fuente and Szczurek
11:15–1:00 PM Poster Setup
11:15–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing
2:30–4:30 PM Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available
5:00–7:00 PM Alternative Approaches to Antibiotics
  Manuela Raffatellu †, University of California, San Diego
Harnessing Iron Acquisition Machinery to Target Pathogens
 
  Deborah T. Hung †, Broad Institute of MIT & Harvard
Anti-Virulence Approaches to Target Pathogens
 
  Shura Mankin †, University of Illinois
Novel Concepts in Ribosomal Inhibition
 
  Jörg Vogel †, University of Würzburg
The Promises and Challenges of Programmable RNA Antibiotics
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM Social Hour with Dinner
7:30–10:00 PM Posters
Sunday, January 3, 2027
7:00–8:00 AM Breakfast
8:00–11:00 AM Natural-Product Biosynthesis and Engineering
  Gerry D. Wright †, McMaster University
The Natural History of Antibiotic Resistance
 
  Allison Lopatkin †, University of Rochester
Predictive Biology: Understanding and Reversing the Evolution of Antibiotic Resistance
 
  Helen I. Zgurskaya †, University of Oklahoma
Efflux Pumps and Antimicrobial Resistance
 
  Short Talk(s) Chosen from Abstracts
 
9:00–9:20 AM Coffee Break
11:00–12:00 PM Panel Discussion 2: The Next Generation of Antibiotic Hunters (inspiring new people into the field)
  Jo Handelsman †, University of Wisconsin-Madison
 
  Erin Duffy †, Boston University & CARB-X
 
  Paul E. Turner †, Yale University
 
11:00–1:00 PM Poster Setup
11:00–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing
3:00–4:30 PM Career Roundtable
4:30–5:00 PM Coffee Available
5:00–7:00 PM Antibiotic Discovery and Host Immunity
  Yifat Merbl †, Weizmann Institute of Science
Immune Proteasomes: An Untapped Source of Encrypted Peptide Antibiotics
 
  Olga Shevchuk †, University Hospital Essen
Production of Encrypted Peptide Antibiotics in Human Kidney Infections
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM Social Hour with Dinner
7:30–10:00 PM Posters
Monday, January 4, 2027
7:00–8:00 AM Breakfast
8:00–11:00 AM Frontiers in Non-Traditional Antimicrobials: Phages, Peptides & Beyond
  Paul E. Turner †, Yale University
Phage Therapy to Combat Infections by Antibiotic-Resistant Bacterial Pathogens
 
  Rino Rappuoli †, Fondazione Biotecnopolo di Siena
Vaccines against AMR
 
  Man-Wah Tan †, Genentech, Inc.
Novel Inhibitors against Gram-negative Pathogens
 
  Renee Fleeman †, University of Central Florida
Novel Antimicrobial Approaches Against Klebsiella
 
  Short Talk(s) Chosen from Abstracts
 
9:00–9:20 AM Coffee Break
12:30–5:00 PM On Own for Lunch
2:30–4:30 PM Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available
5:00–5:50 PM Translating Antibiotics into the Clinic
  Tommaso Biancalani †, Genentech
Talk Title to be Announced
 
  Erin Duffy †, Boston University & CARB-X
Talk Title to be Announced
 
  David Payne †, GlaxoSmithKline
Talk Title to be Announced
 
5:50–6:20 PM Panel Discussion 3: Q&A with Drs. Biancalani and Duffy
6:20–7:30 PM Machine Learning and Antimicrobial Peptides
  Jiangning Song †, Monash University
Machine Learning for Antimicrobial Peptide Design and Discovery
 
  Daniela Kalafatovic †, University of Rijeka
Self-Assembling Peptide Design with Generative AI
 
  Short Talk(s) Chosen from Abstracts
 
7:30–7:45 PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
7:45–8:45 PM Social Hour with Dinner
8:00–11:00 PM Cash Bar
8:00–11:00 PM Entertainment
Tuesday, January 5, 2027
12:00–11:59 PM Departure