Neurodevelopmental Disorders: Mechanisms and Therapeutics (S4)
January 1-4, 2027  | Location to be Determined
Tomasz Nowakowski, Xin Jin, Stephan Sanders and Zhaolan (Joe) Zhou
* Session Chair † Invited but not yet accepted | Program current as of August 23, 2025 8 AM | For the most up-to-date details, visit https://www.keystonesymposia.org
Friday, January 1, 2027
4:00–8:00 PM Registration
6:00–8:00 PM Welcome Mixer
Saturday, January 2, 2027
7:00–8:00 AM Breakfast
8:00–9:00 AM Welcome and Keynote Address
  Huda Y. Zoghbi †, Baylor College of Medicine
A Journey in Rett Syndrome: From Basic Science Discovery of Causal Gene to Therapies of Patients
 
9:00–11:15 AM Genetics and Genomics of Neurodevelopmental Disorders
  Hyejung Won †, University of North Carolina, Chapel Hill
Testic Causal Hypothesis of Common Variants in Neurodevelopmental Disorders
 
  Xin Jin, Scripps Research Institute
Massively Parallel Dissection of Gene to Phenotype Relationships using Perturb-seq
 
  Thomas Bourgeron †, Institut Pasteur
PARIS: Paris Autism Research International Sib-Pair Study
 
  Short Talk(s) Chosen from Abstracts
 
9:30–9:50 AM Coffee Break
11:15–12:15 PM Meet the Editors
12:15–1:00 PM Poster Setup
12:15–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing
2:30–4:30 PM Symposia Spotlight 1: Emerging technologies in the study of Neurodevelopmental Disorders
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available
5:00–7:00 PM Genes to Molecular Phenotypes
  Yukiko Gotoh †, University of Tokyo
Genetic and Epigenetic Mechanisms of Cortical Development
 
  Willow Coyote-Maestas †, University of California, San Francisco
Deep Mutational Scanning Approaches to Correlate Structure and Function of Proteins
 
  Sila Ultanir †, Francis Crick Institute
Kinase Signaling in Neurodevelopmental Disorders
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM Social Hour with Dinner
7:30–10:00 PM Posters
Sunday, January 3, 2027
7:00–8:00 AM Breakfast
8:00–11:00 AM Circuits to Phenotypes
  Gabrielle Pouchelon †, Cold Spring Harbor Laboratory
Interplay between Sensory and Neuromodulatory Inputs and Genetic Programs in Circuit Maturation
 
  Guillermina López Bendito †, Instituto de Neurociencias
Thalamic Spontaneous Activity in Cortical Sensory Maps Development and Plasticity
 
  Botond Roska †, Institute of Molecular and Clinical Ophthalmology (IOB) Basel
Asynchrony of Functional Connectivity in Developing Brain of ASD Models
 
  Catherine G. Dulac †, Harvard University and HHMI
Hypothalamic Regulation of Social Behaviors
 
  Short Talk(s) Chosen from Abstracts
 
9:00–9:20 AM Coffee Break
11:00–12:00 PM Panel Discussion 1: What to translate? When to translate? How to translate?
12:00–1:00 PM Poster Setup
12:00–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing
3:00–4:30 PM Career Roundtable
4:30–5:00 PM Coffee Available
5:00–7:00 PM Human and Non-Human Models
  Tomasz Nowakowski, University of California, San Francisco
Establishing Tools for Human Neuroscience
 
  Pierre Vanderhaeghen †, KU Leuven
Interrogating Human Specific and Neurodevelopmental Risk Genes using Chimeric Models
 
  Paola Arlotta †, Harvard University
Brain Organoids to Study Neurodevelopmental Disorders
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM Social Hour with Dinner
7:30–10:00 PM Posters
Monday, January 4, 2027
7:00–8:00 AM Breakfast
8:00–11:00 AM Environment and Experience
  Zhaolan (Joe) Zhou, University of Pennsylvania
Epigenetic Dissection of Mechanisms underlying Neurodevelopmental Disorders
 
  Kristen J. Brennand †, Yale School of Medicine
Insights into Gene-Environment Interactions in Neurodevelopmental Disorders
 
  Gloria Choi †, Massachusetts Institute of Technology
Cytokine Regulation of Brain and Behavior
 
  Anca M. Pasca †, Stanford University
Neonatal Hypoxia and Pediatric Risk Factors
 
  Short Talk(s) Chosen from Abstracts
 
9:00–9:20 AM Coffee Break
11:00–12:00 PM Panel Discussion 2: Grand Challenges in NDDs
11:00–5:00 PM On Own for Lunch
2:30–4:30 PM Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available
5:00–7:00 PM Neurmodulation, Biomarkers, and Therapies
  Stephan Sanders, University of Oxford
Gene Targeting Strategies for Autism and Neurodevelopmental Disorders
 
  Allyson Berent †,  Foundation for Angelman Syndrome Therapeutics
A Roadmap to a Cure: Accelerating Drug Development for Angelman Syndrome
 
  Cassiano Carromeu †, Recursion
Using Human Pluripotent Stem Cell-Derived Neural Cultures to Assess Safety of New Drugs and Chemicals
 
  Short Talk(s) Chosen from Abstracts
 
6:45–7:00 PM Meeting Wrap-Up: Outcomes and Future Directions
7:00–8:00 PM Social Hour with Dinner
8:00–11:00 PM Entertainment
8:00–11:00 PM Cash Bar
Tuesday, January 5, 2027
12:00–11:59 PM Departure