Autophagy in Health and Disease: From Mechanisms to Therapeutics (S5)
January 1-4, 2027  | Location to be Determined
Hong Zhang, Susan Ferro-Novick and Hitoshi Nakatogawa
* Session Chair † Invited but not yet accepted | Program current as of August 23, 2025 4 AM | For the most up-to-date details, visit https://www.keystonesymposia.org
Friday, January 1, 2027
4:00–8:00 PM Registration
6:00–8:00 PM Welcome Mixer
Saturday, January 2, 2027
7:00–8:00 AM Breakfast
8:00–9:00 AM Welcome and Keynote Address
  Noboru Mizushima †, University of Tokyo
Machinery for Autophagosome Formation and Maturation
 
9:00–11:15 AM Autophagy Machinery and Regulation
  Hitoshi Nakatogawa, Tokyo Institute of Technology
Mechanism of ER-IM Contact Formation
 
  Claudine Kraft †, University of Freiburg
Phase Separation in Assembly of Autophagic Initiation Hubs on Cargo
 
  Nobuo N. Noda †, Hokkaido University
Lipid Transport in Autophagosome Formation
 
  Short Talk(s) Chosen from Abstracts
 
9:30–9:50 AM Coffee Break
11:15–12:15 PM Meet the Editors
11:15–1:00 PM Poster Setup
11:15–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing
2:30–4:30 PM Symposia Spotlight 1: Mechanistic Insights into Cargo-Specific Autophagy
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available
5:00–7:00 PM Mechanistic Insights into Cargo-Specific Autophagy
  Susan Ferro-Novick, University of California, San Diego
Autophagy Receptors Function at Distinct ER Domains
 
  Florian Wilfling †, Max-Planck-Institut of Biophysics
Structural Insights into Protein Aggregates Degraded by Autophagy
 
  Eric H. Baehrecke †, University of Massachusetts Medical School
Autophagy in Fly Midgut Degeneration
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM Social Hour with Dinner
7:30–10:00 PM Posters
Sunday, January 3, 2027
7:00–8:00 AM Breakfast
8:00–11:00 AM Autophagy in Cellular and Organismal Physiology
  Ana Maria Cuervo †, Albert Einstein College of Medicine
Chaperone-Mediated Autophagy in Metabolism
 
  Hong Zhang, Chinese Academy of Sciences
Systemic Regulation of Autophagy in C. Elegans
 
  Xiaochen Wang †, Southern University of Science and Technology
Autophagy in Lifespan Regulation
 
  Roberto Zoncu †, University of California Berkeley
Lysosomes in Integrating Biosynthetic and Catabolic Processes
 
  Short Talk(s) Chosen from Abstracts
 
9:00–9:20 AM Coffee Break
11:00–12:00 PM Panel Discussion: Big Picture Topics
11:00–1:00 PM Poster Setup
11:00–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing
3:00–4:30 PM Career Roundtable
4:30–5:00 PM Coffee Available
5:00–7:00 PM Beyond Degradation: Novel Autophagy-Related Pathways
  Vojo Deretic †, University of New Mexico Health Sciences Center
Noncanonical Roles of Atg8ylation in Membrane Dynamics
 
  Yan Zhao †, Southern University of Science and Technology
Autophagy Proteins Hijacked by Coronaviruses
 
  Mondira Kundu †, St. Jude Children's Hospital
ULK1/2 Physiological Functions
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM Social Hour with Dinner
7:30–10:00 PM Posters
Monday, January 4, 2027
7:00–8:00 AM Breakfast
8:00–11:00 AM Autophagic Dysfunction in Disease
  Dimitri Krainc †, Northwestern University
Lysosomal Function and Parkinson’s Disease
 
  Noor Gammoh †, The University of Edinburgh
Autophagy in Tumor Formation
 
  Patricia Boya †, University of Fribourg
Autophagy and Lysosomes in Aging and Age-Related Diseases
 
  Boxun Lu †, Fudan University
Molecular Glues for Targeted Mutant HTT Autophagic Degradation
 
  Short Talk(s) Chosen from Abstracts
 
9:00–9:20 AM Coffee Break
11:00–5:00 PM On Own for Lunch
2:30–4:30 PM Symposia Spotlight 2: Beyond Degradation: Novel Function of Autophagy Proteins
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available
5:00–6:45 PM Therapeutic Innovations: Harnessing Autophagy for Treatment
  Gilbert Di Paolo †, Denali Therapeutics Inc.
Harnessing Lipids in Neurodegenerative Diseases
 
  Mary E. Hamby †, Cognition Therapeutics, Inc.
Pharmacological Targeting of the Alzheimer's Disease
 
  Carolyn R. Bertozzi †, Stanford University
Lysosome-Targeting Chimeras for Extracellular Proteins
 
  Short Talk(s) Chosen from Abstracts
 
6:45–7:00 PM Meeting Wrap-Up: Outcomes and Future Directions
7:00–8:00 PM Social Hour with Dinner
8:00–11:00 PM Cash Bar
8:00–11:00 PM Entertainment
Tuesday, January 5, 2027
12:00–11:59 PM Departure