Targeting Dry Age-related Macular Degeneration: Pathophysiology and Emerging Therapies (T1)
September 17-20, 2024
| Asilomar Hotel and Conference Grounds, Pacific Grove, CA, United States
Wai T. Wong and Aparna Lakkaraju
Scholarship Deadline: Jul. 2, 2024 | Abstract Deadline: Aug. 28, 2024 | Early Registration Deadline: Aug. 1, 2024
Tuesday, September 17, 2024
| 4:00–6:00 PM |
Registration |
Kiln |
| 5:00–6:00 PM |
Pre-Dinner Drinks and Mixer |
Kiln |
| 6:00–7:00 PM |
Dinner for Hotel Guests |
Crocker Dining Room |
| 7:00–9:00 PM |
Welcome Mixer and Registration |
Kiln |
Wednesday, September 18, 2024
| 7:30–9:00 AM |
Breakfast for Hotel Guests |
Crocker Dining Room |
| 8:00–12:00 PM |
Poster Setup |
Kiln |
| 8:50–9:00 AM |
Welcome Remarks |
Fred Farr Forum |
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* Wai T. Wong, Tiresias Biopharma Consulting
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* Aparna Lakkaraju, University of California, San Francisco
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| 9:00–10:00 AM |
Keynote Address |
Fred Farr Forum |
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Botond Roska, Institute of Molecular and Clinical Ophthalmology (IOB) Basel
Optogenetic Vision Restoration |
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| 10:00–11:15 AM |
Speaker Session 1: Drusen in Intermediate AMD: How do they Arise, how they Drive Disease, how do we Treat? |
Fred Farr Forum |
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Imre Lengyel, Queen's University Belfast
Overview of Drusenoid Deposits in AMD and their Pathophysiology |
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Robyn H Guymer, Centre for Eye Research Australia
Targeting Intermediate AMD as a Therapeutic Concept |
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Goldis Malek, Duke University
Lipid Dysregulation as a Mechanism for Drusen Formation and a Target |
|
| 11:00–11:15 AM |
Coffee Break |
Fred Farr Forum |
| 11:15–11:50 AM |
Session 1 Panel Discussion: Drusen in Intermediate AMD: How do they Arise, how they Drive Disease, how do we Treat? (Drs. Lengyel, Guymer and Malek) |
Fred Farr Forum |
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* Wai T. Wong, Tiresias Biopharma Consulting
Moderator |
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| 12:00–1:00 PM |
Lunch for Hotel Guests |
Crocker Dining Room |
| 12:00–1:00 PM |
Women in Science Networking Event |
Crocker Dining Room |
| 1:00–2:30 PM |
Free Time/Scheduled Activities |
|
| 1:00–9:00 PM |
Poster Viewing |
Kiln |
| 2:30–3:15 PM |
Workshop Session 1: Pros and Cons of in vivo and in vitro Models to Study AMD Pathology |
Fred Farr Forum |
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* David Williams, UCLA
Moderator |
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Nathan Boles, Neural Stem Cell Institute
Panelist |
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Holly Chen, University of Alabama at Birmingham
Panelist |
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Patsy Nishina, The Jackson Laboratory
Panelist |
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| 3:15–4:00 PM |
Workshop Session 2: Translating Research Findings to Therapeutic Applications and Innovations |
Fred Farr Forum |
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* Marie Csete, OkuloVision Inc
Moderator |
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John G Flannery, University of California, Berkeley
Panelist |
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Erik Karrer, Character Biosciences
Panelist |
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Sri Mudumba, PYC Therapeutics
Panelist |
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Rusty Kelley, Foundation Fighting Blindness
Panelist |
|
| 4:00–4:15 PM |
Coffee Available |
Fred Farr Forum |
| 4:15–5:30 PM |
Speaker Session 2: Geographic Atrophy (GA) in Advanced AMD: Mechanisms Underlying Disease Progression |
Fred Farr Forum |
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Emily Chew, NEI, National Institutes of Health
Nature of the Beast: How GA Arises and Grows and what are the Drivers? |
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Robert Mullins, University of Iowa
Choroidal Vascular Change: How it Drives GA and how we can Target It |
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James Handa, Johns Hopkins University
Mechanisms Driving RPE Demise: What they are and how to Target? |
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| 5:30–5:55 PM |
Session 2 Panel Discussion: Geographic Atrophy (GA) in Advanced AMD: Mechanisms Underlying Disease Progression (Drs. Chew, Mullins and Handa) |
Fred Farr Forum |
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* Patricia A. D'Amore, Mass Eye and Ear, Harvard Medical School
Moderator |
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| 6:00–7:00 PM |
Dinner for Hotel Guests |
Crocker Dining Room |
| 7:00–9:00 PM |
Poster Session 1 |
Kiln |
Thursday, September 19, 2024
| 7:30–8:30 AM |
Breakfast for Hotel Guests |
Crocker Dining Room |
| 8:00–12:00 PM |
Poster Setup |
Kiln |
| 8:30–9:45 AM |
Speaker Session 3: Pathogenic Mechanisms and Targets in Non-Exudative AMD: Complement and Beyond |
Fred Farr Forum |
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Anneke Den Hollander, AbbVie
What (Gen)omics are Telling us about the Etiology of AMD |
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Florian Sennlaub, Institut de la Vision
Neuroinflammatory Mechanisms Driving Atrophy in GA |
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Aparna Lakkaraju, University of California, San Francisco
Multifunctional Therapeutics for AMD: Complement, Lipids, and Neuroprotection |
|
| 9:45–10:15 AM |
Session 3 Panel Discussion: Pathogenic Mechanisms and Targets in Non-Exudative AMD: Complement and Beyond (Drs. Den Hollander, Sennlaub and Lakkaraju) |
Fred Farr Forum |
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* Sarah L. Doyle, Trinity College Dublin
Moderator |
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| 10:15–10:45 AM |
Coffee Break |
Fred Farr Forum |
| 10:45–11:45 AM |
Short Talks From Abstracts |
Fred Farr Forum |
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* Sydney Williams, UCSF
Moderator |
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Glenn Yiu, University of California, Davis
Short Talk: Drusen and AMD: Insights from Nonhuman Primates |
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Emily Tom, University of California, Irvine
Short Talk: Rescue of Age-related Vision Decline: Targeting ELOVL2-Mediated Fatty Acid Elongation |
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Ruchi Sharma, NEI/NIH
Short Talk: Human Endogenous Retrovirus (HERV)-K Upregulation Triggers Degeneration in Induced Pluripotent Stem Cell Derived Retinal Pigment Epithelium (Ipsc-RPE) and Mice Model |
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Kaitryn E Ronning, Sorbonne Université
Short Talk: Deregulation of the Inflammatory Reflex Exacerbates Pathogenic Subretinal Inflammation in Age-Related Macular Degeneration |
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| 12:00–1:00 PM |
Lunch for Hotel Guests |
Crocker Dining Room |
| 1:00–3:30 PM |
Free Time/Scheduled Activities |
|
| 1:00–9:30 PM |
Poster Viewing |
Kiln |
| 3:15–3:30 PM |
Coffee Available |
Fred Farr Forum |
| 3:30–4:55 PM |
Speaker Session 4: Therapeutic Approaches Moving to the Clinic: The Present and the Future |
Fred Farr Forum |
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Alex McKeown, Apellis Pharmaceuticals
Treatments for GA: Intravitreal Pegcetacoplan and Beyond |
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Wai T. Wong, Tiresias Biopharma Consulting
Neuroinflammatory Targets for the Treatment of GA |
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Valeria Canto-Soler, University of Colorado School of Medicine
Cell Transplantation as a Treatment for GA |
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| 4:55–5:25 PM |
Session 4 Panel Discussion: Therapeutic Approaches Moving to the Clinic: The Present and the Future (Drs. McKeown, Wong and Canto-Soler) |
Fred Farr Forum |
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* Deepak Lamba, Genentech
Moderator |
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| 5:25–6:25 PM |
Short Talks From Abstracts |
Fred Farr Forum |
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* Nan Hultgren, University of California, Los Angeles
Moderator |
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Douglas Vollrath, Stanford University School of Medicine
Short Talk: A Critical Role for RPE Coenzyme Q Oxidation in Outer Retinal Health |
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Cristhian J Ildefonso, University of Florida College of Medicine
Short Talk: Unraveling the Role of the Mitochondrial Common Deletion on RPE Function |
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Lindsey A Chew, Duke University
Short Talk: Truncated Complement Factor H (Y402) Gene Therapy Restores Complement Regulation in Multiple Organ Systems |
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Jessica D Gumerson, REGENXBIO
Short Talk: Suprachoroidal Delivery of a Novel Capsid Expressing a C5 Inhibitor as a Potential Treatment for Dry Age-Related Macular Degeneration |
|
| 6:25–6:30 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Fred Farr Forum |
| 6:30–7:30 PM |
Banquet Dinner for Hotel Guests |
Crocker Dining Room |
| 7:30–9:30 PM |
Poster Session 2 |
Kiln |
Friday, September 20, 2024
| 7:30–9:00 AM |
Breakfast for Hotel Guests |
Crocker Dining Room |
| 9:00–10:00 AM |
Career Development: Exploring Research Paths and Possibilities in Academia, Industry, and Beyond |
Fred Farr Forum |
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* Claire M. Gelfman, CMG Consulting
Independent Consultant |
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Kathy Boesze Battaglia, University of Pennsylvania
Professor |
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Preeti Subramanian, BrightFocus Foundation
Director of Vision Science |
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Andrew Kocab, ONL Therapeutics, Inc.
Vice President, Research |
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Sun Young Lee, University of Southern California
Assistant Professor of Ophthalmology |
|
| 10:00–11:00 AM |
Navigating your Professional Role(s): Overcoming Challenges and Discovering Solutions, Facing Barriers and Finding Allies |
Fred Farr Forum |
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* Aparna Lakkaraju, University of California, San Francisco
Professor |
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Robert Mullins, University of Iowa
Professor of Ophthalmology and Visual Sciences |
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Diane Bovenkamp, BrightFocus Foundation
Vice President of Scientific Affairs |
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Goldis Malek, Duke University
Professor |
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Sydney Williams, UCSF
Graduate Student |
|
| 11:00–1:00 PM |
Checkout/Departure |
Social Hall |
| 12:00–1:00 PM |
Lunch for Hotel Guests |
Crocker Dining Room |
