Unraveling Vascular Layers to Understand Human Disease (T2)
March 17-19, 2024
| Buck Institute for Research on Aging, Novato, CA, United States
Rachel J. Roth Flach and Stephanie Wengert Watts
Scholarship Deadline: Jan. 2, 2024 | Abstract Deadline: Jan. 2, 2024 | Early Registration Deadline: Jan. 16, 2024
| 4:00–8:00 PM |
Arrival and Registration |
Courtyard by Marriott Marin Room |
| 6:00–8:00 PM |
Welcome Mixer |
Courtyard by Marriott Marin Room |
| 8:00–9:00 AM |
Breakfast |
Atrium |
| 8:30–9:00 AM |
Poster Setup |
Atrium |
| 9:00–10:00 AM |
Welcome and Keynote Address |
Drexler Auditorium |
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William C. Sessa, Pfizer
Advances in Vascular Biology and Application to Therapeutic Development |
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| 9:00–7:00 PM |
Poster Viewing |
Atrium |
| 10:00–12:00 PM |
Vascular Metabolism |
Drexler Auditorium |
| |
Zoltan Arany, University of Pennsylvania
Endothelial Metabolism in Health and Disease |
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Tara L. Haas, York University
Metabolic Signaling and the Regulation of Skeletal Muscle Angiogenesis |
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Eugene Chen, University of Michigan Medical Center
Adipose Tissue and Smooth Muscle Cell Cross-Talk in Atherosclerosis and Hypertension |
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Aaron J. Trask, Research Institute at Nationwide Children's Hospital
Short Talk: Short Talk: Spatial Transcriptomic Profiling of the Type 2 Diabetic Coronary Microcirculation Cell Types Varied by Regions of the Heart |
|
| 10:30–10:50 AM |
Coffee Break |
Atrium |
| 12:00–1:00 PM |
Lunch |
Atrium |
| 12:30–2:30 PM |
Poster Session 1 |
Drexler Auditorium |
| 2:30–4:30 PM |
Workshop |
Drexler Auditorium |
| |
Hisamichi Naito, Kanazawa University
Angiogenesis of Vasa Vasorum Precede the Onset of Aortic Dissection |
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Shashi Kant, Brigham Women's Hospital
PGC1α and Its Downstream Effectors of TERT-HMOX1 Signaling Regulate the Endothelial Response to Fluid Shear Stress |
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Erika Boerman, University of Missouri
NLRP3 Inflammasome Activation and Fibrosis Contribute to Perivascular Adipose Tissue Dysfunction in Inflammatory Bowel Disease |
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Youyang Zhao, Northwestern University-Lurie Children's Hospital of Chicago
Endothelium-targeted Nanoparticle Delivery of CRISPR/Cas9 Plasmid DNA Causes Robust Genome Editing of Endothelial HIF-2a in Adult Rats |
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Ana Paula Davel, University of Campinas (UNICAMP)
TUDCA Treatment Restores Anticontractile Function of Perivascular Adipose Tissue (PVAT) in Post-weaning Protein-restricted Mice |
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Fiene Daniel, University Hospital Halle (Saale)
Vascular Aging and Remodeling: The Role of miR-127-3p in Vascular Smooth Muscle Cells |
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Alexandra R. Lucas, Arizona State University
Virus-derived Serpin Targets Systemic Vascular Inflammation Improving Outcomes and Survival in Murine Models of SARS-CoV-2 and Ulcerative Colitis |
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Valentina Lo Sardo, University of Wisconsin-Madison
Stem Cell-based Functional Genomics Unravel Coronary Artery Disease Mechanisms Acting in the Vascular Wall |
|
| 4:30–5:00 PM |
Coffee Available |
Atrium |
| 5:00–7:00 PM |
Vascular Informatics |
Drexler Auditorium |
| |
Vivian de Waard, Amsterdam UMC
Shades of Vascular Smooth Muscle Cells, Revealed by Informatics |
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Elena Aikawa, Harvard Medical School, Brigham and Women’s Hospital
Multi-Omics in the Vasculature: Learning Layer by Layer |
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Nicholas Chavkin, University of Virginia
Single Cell Analysis in Vascular Biology |
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Wenduo Gu, Stanford University
Short Talk: Short Talk: Discrete Population of Rare SMC Progenitors Gives Rise Exclusively to the Fibrous Cap |
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Saivageethi Nuthikattu, University of California Davis
Short Talk: Short Talk: Single Nuclei Transcriptomics in Diabetic Mice Reveals Altered Brain Hippocampal Endothelial Cell Function, Permeability, and Behavior |
|
| 7:00–8:00 PM |
On Own for Dinner |
|
| 8:00–9:00 AM |
Breakfast |
Atrium |
| 8:30–9:00 AM |
Poster Setup |
Atrium |
| 9:00–12:00 PM |
Vascular Crosstalk and Mechanics |
Drexler Auditorium |
| |
Cynthia St. Hilaire, University of Pittsburgh
Calcification of the Vasculature: Mechanisms Driving Mineralization |
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Manu O. Platt, National Institutes of Health
Vascular Remodeling by Proteases in Sickle Cell Disease |
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Jennifer Pluznick, Johns Hopkins University School of Medicine
Does the Microbiome Influence Function of ALL Vascular Layers? |
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Sara Roccabianca, Michigan State University
Arterial Stiffness when Considering PVAT as a Vascular Layer |
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Gisele Bomfim, University of South Carolina
Short Talk: Short Talk: Is there a Difference in the Immune Function of Endothelial Cells among Different Vascular Beds |
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Ramani Ramchandran, Medical College of Wisconsin
Short Talk: Short Talk: Basolateral Brain Endothelial Cilia Location Suggests an Atypical Role in Promoting Vascular Stability |
|
| 9:00–6:00 PM |
Poster Viewing |
Atrium |
| 10:00–10:20 AM |
Coffee Break |
Atrium |
| 12:00–1:00 PM |
Lunch |
Atrium |
| 12:30–2:30 PM |
Poster Session 2 |
Atrium |
| 2:30–3:30 PM |
Career Roundtable |
Atrium |
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Rachel J. Roth Flach, Pfizer Inc.
Executive Director - Head of Cardiorenal Biology |
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Manu O. Platt, National Institutes of Health
Director, Center for Biomedical Engineering Technology Acceleration, NIBIB |
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| 3:30–4:00 PM |
Coffee Available |
Atrium |
| 4:00–5:45 PM |
Therapeutic Development in Vascular Biology |
Drexler Auditorium |
| |
Robert Menzies, AstraZeneca
Prioritising Molecular Mechanisms in the Vasculature to Deliver Therapeutic Success |
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Xiaojun Wang, Eli Lilly and Company
Discovery and Development of Long-Acting Relaxin to Treat Underlying Causes of Cardiorenal Diseases |
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William Jackson, Stanford University
Short Talk: Short Talk: Epigenetic and Phenotypic Modulation of Adventitial Fibroblasts in Atherosclerosis by Coronary Artery Risk Gene TCF21 |
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Jesus Maria Gomez Salinero, Weill Medical College of Cornell University
Short Talk: Short Talk: Development of a Vascularization Platform for Endothelial Cell Adaptability and Therapeutic Screening |
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| 5:45–6:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Drexler Auditorium |
| 6:00–7:00 PM |
On Own for Dinner |
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Wednesday, March 20, 2024
