Microproteins: from Discovery to Applications (T2)
February 6-8, 2025  | Wylie Center and Tupper Manor at Endicott College, Beverly, MA, United States
Thomas F. Martínez, Lena Ho and Anne-Ruxandra Carvunis
Scholarship Deadline: Nov. 14, 2024 | Abstract Deadline: Jan. 16, 2025 | Early Registration Deadline: Dec. 18, 2024
* Session Chair † Invited but not yet accepted | Program current as of August 23, 2025 4 AM | For the most up-to-date details, visit https://www.keystonesymposia.org
Thursday, February 6, 2025
4:00–8:00 PM Registration Conference Center Atrium
6:00–8:00 PM Welcome Mixer Conference Center Atrium
Friday, February 7, 2025
7:30–8:30 AM Breakfast Conference Center Atrium
8:00–8:30 AM Poster Setup Ipswich
8:00–5:00 PM Poster Viewing Ipswich
8:30–9:30 AM Welcome and Keynote Address Beverly Room
  * Thomas F. Martínez, University of California, Irvine
  
  Sarah Slavoff, Yale University
Microproteins and Chromatin Modifying-Proteins		  
9:30–12:00 PM Microprotein Annotation Across Species Beverly Room
  * Lin Chou, University of Pittsburgh
Session Chair		  
  Anne-Ruxandra Carvunis, University of Pittsburgh
Systems Approaches to Unravel Microprotein Biology in S. cerevisiae		  
  Kousuke Hanada, Kyushu Institute of Technology
Identification and Characterization of Microproteins in Arabidopsis		  
  Julie Aspden, University of Leeds
Discovery of Non-Canonical Peptides during Neuronal Differentiation		  
  Claudio Casola, Texas A&M University
Short Talk: Degradation Determinants are Abundant in Human Microproteins		  
10:00–10:20 AM Coffee Break Beverly Foyer
12:00–1:00 PM Lunch Newburyport
12:05–1:05 PM Women in Science Networking Event Hamilton
  * Lena Ho, Duke-NUS Medical School
Session Chair		  
  * Anne-Ruxandra Carvunis, University of Pittsburgh
Session Chair		  
12:45–3:00 PM Poster Session 1 Ipswich
3:00–3:30 PM Coffee Available Beverly Foyer
3:30–5:30 PM Disease-Regulating Microproteins Beverly Room
  * Miranda E Kelly, University of California, Irvine
  
  Thomas F. Martínez, University of California, Irvine
Investigation of Oncogenic KRAS-regulated Microproteins in Pancreatic Ductal Adenocarcinoma		  
  Erin E. Duffy, Harvard Medical School
Developmental Dynamics of Microprotein Translation in the Human Brain		  
  Catherine Makarewich, Cincinnati Children's Hospital Medical Center
Microproteins Implicated in Heart Failure		  
  Jin Chen, Altos Labs
Functional Genomics Strategies Reveal Microproteins Involved in Disease		  
5:30–9:30 PM On Own for Dinner
5:45–9:30 PM Transportation to Dinner Options
Saturday, February 8, 2025
7:30–8:30 AM Breakfast Conference Center Atrium
8:00–8:30 AM Poster Setup Ipswich
8:00–5:00 PM Poster Viewing Ipswich
8:30–11:30 AM Microprotein Interactions and Functions Beverly Room
  * Carly Houghton, University of Pittsburgh
Session Chair		  
  Lena Ho, Duke-NUS Medical School
EMBO Young Investigator Lecture: Microprotein Interactions with Mitochondrial Protein Complexes		  
  Christine Brun, TAGC Inserm-Univ. Mediterranee
Computational Predictions of Microprotein Interactions		  
  Ariel Alejandro Bazzini, Stowers Institute for Medical Research
Translation of Small Downstream Orfs (Dorf) Enhances Translation of Canonical Main Open Reading Frames		  
  Ryan L Boudreau, University of Iowa
Short Talk: A Misannotated LncRNA that is Dysregulated in Alzheimer’s Disease Encodes a Microprotein that Influences Amyloid Beta Processing and Learning and Memory in Mice		  
  Yiwen Chen, University of Texas MD Anderson Cancer Center
Short Talk: Large-Scale Approaches to Unravel the Functions of the “Dark” Proteome in Cancer Signaling Pathways		  
  Jasmyn Hoeger, University of Iowa
Short Talk: Discovery and Initial Characterization of a Diverse Family of Microproteins Derived from Alternative Open Reading Frames in SCN(NaV) Genes		  
9:30–9:50 AM Coffee Break Beverly Foyer
9:50–9:55 AM Award Recipient Acknowledgement Beverly Room
11:30–12:30 PM Lunch Newburyport
12:00–2:30 PM Poster Session 2 Ipswich
2:30–4:30 PM Symposia Spotlight: Late-breaking research presentations selected from abstract submissions Beverly Room
  * Lena Ho, Duke-NUS Medical School
  
  Anil Kumar, University of Saskatchewan
The Human Microproteins Encoded by Long Non-Coding Rnas LINC00888 and LINC00887 are Potent Restriction Factors for Enterovirus D68		  
  Mauro Siragusa, Goethe University
Identification and Functional Characterization of Endothelial Cell Microproteins Encoded by Non-Canonical Open Reading Frames.		  
  Vighnesh V Ghatpande, The University of Texas at Austin
Non-canonical Translation during Early Mouse Embryonic Development		  
  Beyza-Nur Güven, Goethe-University Frankfurt
The Inflammation-Induced Microprotein Mip-PSTPIP2 Modulates Intracellular Trafficking and Endothelial Cell Activation		  
  Fabricio Loayza-Puch, German Cancer Research Center
Upstream Open Reading Frame Translation Generates Microproteins and Enhances Immunogenic Peptide Presentation in Mitotically Arrested Cancer Cells		  
  Neelanjan Mukherjee, University of Colorado School of Medicine
Proteogenomic Discovery of Neoepitopes in Human Beta Cells		  
  Daniel Rebibo, Sanford Burnham Prebys
Characterizing the MYC-Regulated Microproteome in B-Cell Lymphoma		  
  Maria Abad, Altos Labs
Mining the Hidden Microproteome for Key Drivers of Cellular Plasticity		  
4:30–5:00 PM Coffee Available Beverly Foyer
5:00–6:45 PM The Functional Potential of Natural and Synthetic Microproteins Beverly Room
  * Anne-Ruxandra Carvunis, University of Pittsburgh
  
  Xuebing Wu, Columbia University
Noncoding Translation Mitigation		  
  Aaron Wacholder, University of Pittsburgh School of Medicine
Evolutionary Multi-Omics Strategies for Microprotein Characterization		  
  Alex S Holehouse, Washington University in St. Louis
Prediction of Microprotein Conformational Ensembles and Intermolecular Interactions from Sequence		  
6:45–7:00 PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Beverly Room
7:00–8:00 PM Dinner Tupper Manor Ballroom
Sunday, February 9, 2025
8:00–9:00 AM Departure