Tuberculosis Across the Spectrum: from Pathogenesis to Prevention (T2)
January 1-5, 2028
| Location to be Determined
Thomas J Scriba, Bruno B. Andrade and Maha Farhat
Saturday, January 1, 2028
| 4:00–8:00 PM |
Registration |
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| 6:00–8:00 PM |
Welcome Mixer |
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| 8:00–8:10 AM |
Welcome Remarks |
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| 8:10–9:00 AM |
Keynote Address |
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Bruno B. Andrade, Fundação Oswaldo Cruz
Human Immunopathogenesis across the TB Spectrum, from Tissue Biology to Translational Biomarkers |
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| 9:00–11:15 AM |
Spectrum of Infection, Disease, and Transmission in Humans |
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Anna Kathleen Coussens †, University of Melbourne
Imaging and Biological Definition of Early and Asymptomatic Tuberculosis |
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Karen Rita Jacobson †, Boston University
Who Transmits TB and Why? |
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Julio Croda †, Oswaldo Cruz Foundation / Federal University of Mato Grosso do Sul / Yale School
Asymptomatic Tuberculosis and the Hidden Drivers of Transmission |
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Short Talk(s) Chosen from Abstracts
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| 9:30–9:50 AM |
Coffee Break |
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| 11:15–1:00 PM |
Poster Setup |
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| 11:15–5:00 PM |
On Own for Lunch |
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| 11:25–12:25 PM |
Panel Discussion 1 |
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| 1:00–10:00 PM |
Poster Viewing |
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| 2:30–4:30 PM |
Symposia Spotlight 1: Human Immunopathogenesis in Tissues and Correlates of Protection |
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Short Talks Chosen from Abstracts
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–7:00 PM |
Human Immunopathogenesis in Tissues and Correlates of Protection |
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Thomas J Scriba, University of Cape Town
The Human Spectrum of M. tuberculosis Infection and Disease |
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Rasmus Mortensen †, Statens Serum Institut
Next-Generation Antigen Design and Polyprotein Vaccine Strategies |
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Patricia A. Darrah †, NIAID, National Institutes of Health
Tissue-Level Immunity and Correlates of Protection across Infection and Vaccination |
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Short Talk(s) Chosen from Abstracts
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|
| 7:00–8:00 PM |
Social Hour with Dinner |
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| 8:00–11:00 AM |
M. tuberculosis Diversity, Evolution, and Virulence |
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Maha Farhat, Harvard Medical School
M. tuberculosis Evolution across Time Scales and Implications for Disease Control |
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Sébastien Gagneux †, Swiss Tropical and Public Health Institute
Bacterial Determinants of Transmissibility and Unfavorable Treatment Outcome |
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Ana M.S. Guimaraes †, University of Sao Paulo
Virulence Mechanisms across the M. tuberculosis Complex |
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Horia Todor †, University of California, San Francisco
Chemical Genetics and Emergent Phenotypes in Mycobacteria |
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Short Talk(s) Chosen from Abstracts
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|
| 9:00–9:20 AM |
Coffee Break |
|
| 11:00–1:00 PM |
Poster Setup |
|
| 11:00–5:00 PM |
On Own for Lunch |
|
| 11:10–12:10 PM |
Meet-the Editor |
|
| 1:00–10:00 PM |
Poster Viewing |
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| 3:00–4:30 PM |
Career Roundtable |
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–7:00 PM |
Biomarkers, Screening, and Diagnostics for Clinical Decision-Making |
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Simon C. Mendelsohn †, University of Cape Town
Community Screening and Detection of Asymptomatic TB using Imaging- and Biomarker-Informed Approaches |
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Yingda L Xie †, Rutgers New Jersey Medical School
A Streamlined CRISPR-based Test for Tuberculosis |
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David H. Persing †, Cepheid
Diagnostics that Bridge Discovery, Trials, and Real-World Clinical Use |
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Short Talk(s) Chosen from Abstracts
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| 7:00–8:00 PM |
Social Hour with Dinner |
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| 8:00–11:00 AM |
Vaccines, Innovative Therapeutics, and Clinical Trials |
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| 8:00–11:00 AM |
Panel Discussion 2: Translational Lessons Learned from TB Vaccine and Therapeutic Trials |
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Alemnew F. Dagnew †, Gates MRI
The M72:AS01E Phase 3 Efficacy Trial: Design, Implementation, and Translational Implications |
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Andréanne Lupien †, McGill University
Novel Therapeutic Strategies for Prevention and Treatment |
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Veronique Anne Dartois †, Hackensack Meridian Health and Rutgers University
Lesion Pharmacology, Drug Penetration, and Shortening Treatment |
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James C. Sacchettini †, Texas A & M University
Drug Design at the Speed of Artificial Intelligence |
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Short Talk(s) Chosen from Abstracts
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|
| 9:00–9:20 AM |
Coffee Break |
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| 11:00–5:00 PM |
On Own for Lunch |
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| 2:30–4:30 PM |
Symposia Spotlight 2: Systems Biology of Host-Pathogen Interactions across Scales |
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Short Talks Chosen from Abstracts
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|
| 4:30–5:00 PM |
Coffee Available |
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| 5:00–6:45 PM |
Systems Biology of Host-Pathogen Interactions across Scales |
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Lucas Boeck †, University of Basel
Antimicrobial Lethality and Drug Interactions at Single-Cell Resolution |
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David G. Russell †, Cornell University
Genetic Networks and Temporally Dependent Gene Essentiality during Intracellular Infection |
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Scarlet S. Shell †, Worcester Polytechnic Institute
Transcriptional Regulation and Bacterial Adaptation in M. tuberculosis |
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Short Talk(s) Chosen from Abstracts
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| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions |
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| 7:00–8:00 PM |
Social Hour with Dinner |
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| 8:00–11:00 PM |
Entertainment |
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Wednesday, January 5, 2028
