Cachexia and Wasting Syndrome in Cancer and Chronic Diseases (T3)
May 5-7, 2024  | Buck Institute for Research on Aging, Novato, CA, United States
Bei B. Zhang and Teresa Zimmers
Scholarship Deadline: Feb. 14, 2024 | Abstract Deadline: Feb. 14, 2024 | Early Registration Deadline: Mar. 5, 2024
* Session Chair † Invited but not yet accepted | Program current as of August 23, 2025 4 AM | For the most up-to-date details, visit https://www.keystonesymposia.org
Sunday, May 5, 2024
4:00–8:00 PM Arrival and Registration Courtyard by Marriott Marin Room
6:00–8:00 PM Welcome Mixer Courtyard by Marriott Marin Room
Monday, May 6, 2024
7:45–8:30 AM Shuttle to Buck Institute Courtyard by Marriott Front Desk
8:00–9:00 AM Breakfast and Registration Atrium
8:30–9:00 AM Poster Setup Atrium
9:00–9:30 AM Welcome Address from the Organizers Drexler Auditorium
  Bei B. Zhang, Novo Nordisk
NovoNordisk
 
  Teresa Zimmers, Oregon Health and Science University Knight Cancer Institute
Oregon Health and Science University
 
9:00–7:00 PM Poster Viewing Atrium
9:30–12:15 PM Defining Cachexia as a Disease within a Disease Drexler Auditorium
  * Bette Caan, Kaiser Permanente
Session Chair
 
  * Denis C. Guttridge, Medical University of South Carolina
Session Chair
 
  Vickie Baracos, University of Alberta
Clinical Classification of Cancer Cachexia
 
  Stefan D. Anker, Charité Universitätsmedizin Berlin
Cardiac Dysfunction and Wasting at the Heart of Cachexia
 
  Mariam Jamal-Hanjani, University College London
Insights Into Lung Cancer-Associated Cachexia From the TRACERx Study
 
  Laure Bindels, Université Catholique de Louvain
Contribution and Therapeutic Prospects from the Gut Microbiome to Cancer Cachexia
 
10:30–10:50 AM Coffee Break Atrium
12:15–1:15 PM Lunch Atrium
1:00–3:00 PM Poster Session 1 Atrium
3:00–3:30 PM Coffee Available Atrium
3:30–5:30 PM Delineating Underlying Biological Pathways Drexler Auditorium
  * David J. Glass, Regeneron Pharmaceuticals, Inc.
Session Chair
 
  * Mariam Jamal-Hanjani, University College London
Session Chair
 
  Teresa Zimmers, Oregon Health and Science University Knight Cancer Institute
Organ Crosstalk in Cachexia
 
  Tony Tony Hui, Harvard T.H. Chan School of Public Health
Energy Metabolism in Cachexia - Quantitative Fluxomics
 
  Denis C. Guttridge, Medical University of South Carolina
Muscle Microenvironment in Cancer Cachexia
 
  Andrea Graziani, Università di Torino
Short Talk: Short Talk: Impaired cAMP/CREB1 Signaling Drives Mitochondrial Dysfunction in Skeletal Muscle During Cancer Cachexia
 
  Maria Rohm, Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt
Short Talk: Short Talk: Cancer Cachexia Causes Impaired CD8+ T Cell Activation and Lymphopenia that Contributes to Tissue Wasting
 
5:30–5:35 PM Introduction of the Cancer Cachexia Society Drexler Auditorium
  Andrea Bonetto, University of Colorado Anschutz Medical Campus
 
5:35–8:00 PM On Own for Dinner
8:00–9:00 PM Dessert Social Hour with Trivia Courtyard by Marriott Marin Room
Tuesday, May 7, 2024
7:45–8:30 AM Shuttle to Buck Institute Courtyard by Marriott Front Desk
8:00–9:00 AM Breakfast Atrium
8:30–9:00 AM Poster Setup Atrium
9:00–12:00 PM Cachexia in Chronic Illness Drexler Auditorium
  * Danna M. Breen, Pfizer Inc.
Session Chair
 
  * Laure Bindels, Université Catholique de Louvain
Session Chair
 
  Marcus D. Goncalves, Weill Cornell Medicine
Cachexia and Cancer
 
  Philip A. Efron, University of Florida
Persistent Inflammatory/Immunosuppressive Catabolic Syndrome (PICS) after Sepsis
 
  David J. Glass, Regeneron Pharmaceuticals, Inc.
Cachexia and COVID-19
 
  Marilia C Seelaender, University of São Paulo
Adipose Tissue Role in Acute COVID-19 and Long COVID Syndrome: A New Form of Cachexia?
 
  Shinpei Kawaoka, Tohoku University / Kyoto university
Short Talk: Short Talk: Systemic Metabolic and Immune Defects in Advanced Cancer Patients Prior to the Onset of Pre-Cachexia
 
  Aliesha Garrett, Terasaki Institute for Biomedical Innovation
Short Talk: Short Talk: Vagal Perturbation of the Liver-Brain Axis Deters Cancer-Associated Cachexia Independent of Tumor Burden
 
9:00–7:00 PM Poster Viewing Atrium
10:00–10:20 AM Coffee Break Atrium
12:00–1:00 PM Lunch Atrium
12:30–2:30 PM Poster Session 2 Atrium
2:30–4:30 PM Workshop Drexler Auditorium
  * Tony Tony Hui, Harvard T.H. Chan School of Public Health
Session Chair
 
  * Rodney Infante, University of Texas Southwestern Medical School
Session Chair
 
  Houda Cohen, University of Minnesota
Chronic Cardiac Wasting-Associated Cardiomyopathy in Post-Tumor-Mediated Cancer Cachexia
 
  Anja Karlstaedt, Cedars Sinai Medical Center
D2-HG Promotes IDH-Mutant Cancer-Associated Autophagic Proteolysis Skeletal Muscle
 
  Hassan Fakih, UMass Chan Medical School
Efficacious and Durable Myostatin Knockdown Using Chemically Optimized siRNAs
 
  Hong-Wen Tang, Duke-NUS Medical School
Deaf1 Regulates Muscle Regeneration through Autophagy
 
  Muhannad Abu-Remaileh, Dana Farber Cancer Institute
Roles of HIF2 and PTHLH in Kidney Cancer-Associated Cachexia: Treatment with a First-In-Class Agent
 
  Venise Jan Castillon, Memorial Sloan Kettering Cancer Center
Systemic Physiological Changes Indicative of Cancer Cachexia at Diagnosis
 
  Justin L Shahtout, University of Utah
Targeting Skeletal Muscle Lipid Hydroperoxides in Cancer Cachexia
 
  Paige Arneson-Wissink, OHSU
PDAC Recovery Associates with Impaired Hepatic metabolism, Delayed Muscle Recovery, and Decreased Activity Levels
 
4:30–5:00 PM Coffee Available Atrium
5:00–7:00 PM Approaches to Therapeutic Intervention Drexler Auditorium
  * Marcus D. Goncalves, Weill Cornell Medicine
Session Chair
 
  * Vickie Baracos, University of Alberta
Session Chair
 
  Steven Heymsfield, Pennington Biomedical Research Center
Digital Technology for Body Weight Phenotyping
 
  Rodney Infante, University of Texas Southwestern Medical School
Harnessing Cachexia Mechanisms to Elucidate Tumor-directed Therapies
 
  Danna M. Breen, Pfizer Inc.
GDF15/Ponsegromab: A Potential Treatment for Cachexia
 
  Kate Orlowsky, AVEO Oncology
Short Talk: Short Talk: A Phase 1b Dose Escalation Study of AV-380 in Combination with Standard of Care Chemotherapy in Metastatic Cancer Patients (pts) with Cachexia and Elevated GDF-15 Levels
 
  Andrei Turtoi, INSERM Cancer Research Institute of Montpellier, France
Short Talk: Short Talk: Nozomitumab: A Potential Treatment for Prevention of Cancer-Induced Cachexia via Reprogramming Macrophage Function in Adipose and Muscle Tissues
 
7:00–8:00 PM On Own for Dinner
7:45–9:30 PM Transportation to Novato for Dinner Courtyard by Marriott Front Desk