Stem Cell Models for Embryology (T4)
February 6-8, 2024
| Asilomar Hotel and Conference Grounds, Pacific Grove, CA, United States
Aryeh Warmflash and Magdalena D. Zernicka-Goetz
Scholarship Deadline: Nov. 2, 2023 | Abstract Deadline: Nov. 22, 2023 | Early Registration Deadline: Dec. 7, 2023
Tuesday, February 6, 2024
| 4:00–6:00 PM |
Arrival and Registration |
Kiln |
| 6:00–7:00 PM |
Dinner |
Crocker Dining Room |
| 7:00–8:00 PM |
Welcome Mixer and Registration |
Kiln |
Wednesday, February 7, 2024
| 7:30–8:30 AM |
Breakfast |
Crocker Dining Room |
| 8:00–8:30 AM |
Poster Setup |
Kiln |
| 8:30–9:30 AM |
Welcome and Keynote Address |
Fred Farr Forum |
| |
* Aryeh Warmflash, Rice University
Session Chair |
|
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* Magdalena D. Zernicka-Goetz, University of Cambridge
Session Chair |
|
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Janet Rossant, The Gairdner Foundation
Stem Cells, Embryos and Embryo Models |
|
| 8:30–9:00 PM |
Poster Viewing |
Kiln |
| 9:30–12:00 PM |
Blastocysts and Blastoids |
Fred Farr Forum |
| |
* Mijo Simunovic, Columbia University
Session Chair |
|
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Nicolas Rivron, Institute of Molecular Biotechnology
Mouse and Human Blastoids |
|
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Jun Wu, University of Texas Southwestern Medical Center
Integrated Stem Cell based Embryo Models for Early Human Development |
|
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Ge Guo, University of Exeter
Lineage Segregation in Blastoids |
|
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Samuel Ojosnegros, IBEC
Short Talk: Short Talk: Mechanotransduction of Human and Mouse Embryo Implantation |
|
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Zukai Liu, Jackson Labortary / UConn Health
Short Talk: Short Talk: A Trophoblast Origin of Extra-embryonic Mesenchyme in Human Early Development |
|
| 10:00–10:20 AM |
Coffee Break |
Fred Farr Forum |
| 12:00–1:00 PM |
Lunch |
Crocker Dining Room |
| 2:00–3:30 PM |
Workshop |
Fred Farr Forum |
| |
* Idse Heemskerk, University of Michigan
Session Chair |
|
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Harry McNamara, Princeton University
Recording Morphogen Signals Reveals Origins of Gastruloid Symmetry Breaking |
|
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Bohan Chen, University of Michigan
2D Gastruloids Develop Into Layered Structure With Spatially Patterned Mesoderm |
|
| |
Mijo Simunovic, Columbia University
Slingshot Through Time: A Stem Cell Approach to Modeling the First Cell Fate Decisions in Human Development |
|
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Luisa Rezende, Rice University
Role of Nodal Signaling Regulators in Nodal Dynamics and Cell Fate Decisions in a Stem Cell Model of Human Gastrulation |
|
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Blerta Stringa, Washington University in St. Louis
Exploring the Role of FGF17 in Human Gastrulation |
|
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Joshua Hislop, University of Pittsburgh School of Medicine
Modeling Post-Implantation Human Development to Yolk Sac Blood Emergence |
|
| 3:30–4:00 PM |
Coffee Available |
Fred Farr Forum |
| 4:00–6:00 PM |
Micropatterns and 2D Models |
Fred Farr Forum |
| |
* Mo Ebrahimkhani, University of Pittsburgh School of Medicine
Session Chair |
|
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Idse Heemskerk, University of Michigan
Germline Competence and BMP Signaling |
|
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Thorold Theunissen, Washington University in St. Louis
Regulation of Morphogenetic Cell Behaviors in Stem Cell Models of Human Gastrulation |
|
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Aryeh Warmflash, Rice University
Signaling Logic Underlying Germ Layer Differentiation |
|
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Mary Hynes, Stanford University
Short Talk: Short Talk: Distinct Roles for the Nanog 3’-Untranslated and Cognate Coding mRNA Components in Pluripotent Embryonic Stem Cell Patterning and Colony Formation |
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Gerrald Lodewijk, University of California Santa Cruz
Short Talk: Short Talk: Self-organization of Pluripotent Stem Cells Into Early Embryonic Developmental Patterns Through Minimal Epigenome Editing |
|
| 6:00–7:00 PM |
Dinner |
Crocker Dining Room |
| 7:00–9:00 PM |
Poster Session |
Kiln |
Thursday, February 8, 2024
| 7:30–8:30 AM |
Breakfast |
Crocker Dining Room |
| 8:30–11:30 AM |
Embryoids and 3D Models |
Fred Farr Forum |
| |
* Ge Guo, University of Exeter
Session Chair |
|
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Marta Shahbazi, MRC Laboratory of Molecular Biology
Remote Presentation: 3D Models of the Epiblast |
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Naomi Moris, Francis Crick Institute
Human Gastruloids |
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Magdalena D. Zernicka-Goetz, University of Cambridge
3D Whole Embryo Models |
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Kamyar Keshavarz Farajkhah, University of Pittsburgh School of Medicine
Short Talk: Short Talk: Building to Understand Multiorgan Function of Human Yolk Sac Tissue in vitro |
|
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Lizhong Liu, UT Southwestern
Short Talk: Short Talk: Stem-Cell-Based Modeling of Post-Implantation Human Development and Embryonic-Extraembryonic Interactions |
|
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Ikbal Choudhury, California Institute of Technology
Short Talk: Short Talk: Ex-Utero Human Embryo Implantation and Development in a 3D Vascular Niche |
|
| 9:30–9:50 AM |
Coffee Break |
Fred Farr Forum |
| 11:30–12:00 PM |
Presentation from CIRM |
Fred Farr Forum |
| |
Uta Grieshammer, CIRM
California Institute for Regenerative Medicine: Funding Programs and Resources |
|
| 12:00–1:00 PM |
Lunch |
Crocker Dining Room |
| 1:00–2:30 PM |
Group Walking Tour on History and Architecture of Asilomar State Park |
Social Hall |
| 3:00–4:00 PM |
Ethics Talk and Panel Discussion |
Fred Farr Forum |
| |
Insoo Hyun, Museum of Science
Ethics of Stem Cell Models of Embryos |
|
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Jun Wu, University of Texas Southwestern Medical Center
Panelist |
|
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Nicolas Rivron, Institute of Molecular Biotechnology
Panelist |
|
| |
Magdalena D. Zernicka-Goetz, University of Cambridge
Panelist |
|
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Janet Rossant, The Gairdner Foundation
Panelist |
|
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Thorold Theunissen, Washington University in St. Louis
Panelist |
|
| 4:00–4:30 PM |
Coffee Available |
Fred Farr Forum |
| 4:30–6:15 PM |
Models of Neural Tube and Somitogenesis |
Fred Farr Forum |
| |
* Naomi Moris, Francis Crick Institute
Session Chair |
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Olivier Pourquie, Harvard Medical School and Brigham and Women’s Hospital
Mechanisms of Somitogenesis in vivo and in vitro |
|
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Cantas Alev, Kyoto University
Modeling Development and Disease in Axioloids |
|
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Randolph Scott Ashton, University of Wisconsin
RosetteArrays™: Quantitative Highthrough-put Assessment of Human Neurodevelopmental Risk |
|
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Matthew Lefebvre, University of California Santa Barbara
Short Talk: Short Talk: Developmental Biology in Human Organoids: Studying the Effect of PCP Loss on in vitro Neural Tube Morphogenesis |
|
| 6:15–6:30 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Fred Farr Forum |
| 6:30–7:30 PM |
Dinner |
Crocker Dining Room |
| 7:30–9:00 PM |
Bonfire with S'mores and Trivia |
Crocker Fire Pit |
| 7:30–9:00 AM |
Breakfast |
Crocker Dining Room |
| 12:00–1:00 PM |
Lunch |
Crocker Dining Room |
