Metabolic and Nutritional Control of Development and Cell Fate (T5)
May 7-9, 2025  | Wylie Center and Tupper Manor at Endicott College, Beverly, MA, United States
Lydia Finley and Ralph J. DeBerardinis
Scholarship Deadline: Feb. 7, 2025 | Abstract Deadline: Apr. 17, 2025 | Early Registration Deadline: Mar. 21, 2025
* Session Chair † Invited but not yet accepted | Program current as of August 23, 2025 4 AM | For the most up-to-date details, visit https://www.keystonesymposia.org
Wednesday, May 7, 2025
4:00–8:00 PM Registration Conference Center Atrium
6:00–8:00 PM Welcome Mixer Conference Center Atrium
Thursday, May 8, 2025
7:30–8:30 AM Breakfast Beverly Foyer
8:00–8:30 AM Poster Setup Ipswich
8:15–3:30 PM Poster Viewing Ipswich
8:30–9:30 AM Welcome and Keynote Address Beverly Room
  * Lydia Finley, Memorial Sloan Kettering Cancer Center
 
  * Ralph J. DeBerardinis, University of Texas Southwestern Medical Center
 
  Navdeep S Chandel, Northwestern University
Mitochondrial Signals to Developmental Networks
 
9:30–11:30 AM Metabolic Control of Cell Fate Beverly Room
  * Ralph J. DeBerardinis, University of Texas Southwestern Medical Center
 
  Lydia Finley, Memorial Sloan Kettering Cancer Center
Identifying Mechanisms Linking Metabolites to Cell Fate Control
 
  Sean J. Morrison, University of Texas Southwestern Medical Center
Metabolic Regulation of Hematopoiesis
 
  Martin A Estermann, NIEHS
Short Talk: O-GlcNAcylation in the Testis: A Key Metabolic Mechanism for Male Fertility
 
  Juan Manuel Schvartzman, Columbia University
Short Talk: Polyamines Regulate Cell Fate by Altering the Accessibility of Histone Tails
 
10:00–10:20 AM Coffee Break Beverly Foyer
11:30–12:30 PM Lunch Newburyport
12:00–2:00 PM Poster Session 1 Ipswich
2:00–4:00 PM Symposia Spotlight: Redox Control of Developmental Pathways Beverly Room
  * Jan Zylicz, University of Copenhagen
 
  Zoe F Mann, King's College London
Full Talk: Metabolic 'Tuning' of Hair Cells Along the Tonotopic Axis of the Developing Cochlea
 
  Elaine Fuchs, Rockefeller University
Full Talk: Optimizing Tissue Fitness in the Face of Metabolic Stress
 
  Masayuki Yazawa, Icahn School of Medicine at Mount Sinai
Pyruvate and Lactate Imaging in Stem Cells
 
  Marc Amoyel, UCL
Somatic Glycolysis Sustains Germ Cell Survival Through Lactate Shuttling in The Drosophila Testis
 
  Nancy B De La Cruz, UT Southwestern Medical Center
Glucose 6-Phosphate Dehydrogenase Promotes Trophoblast Syncytialization
 
  Kristina S Stapornwongkul, EMBL Barcelona
Metabolic Control Of Germ Layer Proportions Through Regulation Of Nodal And Wnt Signalling
 
  Francesco Dalla Ricca, University of California, San Francisco
A Mitochondrial Redox Switch Licenses the Onset of Morphogenesis in Animals
 
  Jose A Soto, UCLA
Metabolic Atlas of Early Human Cortical Development
 
  Guido T Bommer, Universite Catholique de Louvain
Dolichol Synthesis: Novel Twists and Detours Involved in Human Disease
 
  Athena Jessica S Ong, Peter MacCallum Cancer Centre
NRF2 Induces Cell Plasticity During Liver Tumour Initiation
 
  Grigor Varuzhanyan, University of California Los Angeles
PGC-1α-Induced Mitochondrial Metabolism: Steering Lineage Fate in Small Cell Neuroendocrine Cancers
 
4:00–4:30 PM Coffee Available Beverly Foyer
4:30–6:30 PM Nutritional Influences on Development Beverly Room
  * Clifford D. L. Folmes, Mayo Clinic
 
  Alex P Gould, Francis Crick Institute
Cell-Type Specific Tagging and Tracing of Metabolites in vivo
 
  Vivian Gama, Vanderbilt University
The Coordination of Mitochondrial and Peroxisomal Fission is Essential During Neurogenesis
 
  Ömer H Yilmaz, Massachusetts Institute of Technology
Dietary Control of Stem Cells in Physiology and Disease
 
  Nick Burton, Van Andel Institute
Short Talk: Microbial Metabolism of Polyamines and Pyruvate Regulate Animal Development
 
  Ashish G Toshniwal, University of Utah
Short Talk: The Fate of Pyruvate: Metabolic regulation of Cell Growth
 
6:30–7:30 PM Dinner Newburyport
7:30–8:30 PM Trivia Beverly Room
Friday, May 9, 2025
7:30–8:30 AM Breakfast Beverly Foyer
8:00–8:30 AM Poster Setup Ipswich
8:15–2:30 PM Poster Viewing Ipswich
8:30–11:30 AM Metabolic Networks Defining Early Development Beverly Room
  * Ashley Solmonson, University of Texas Southwestern Medical Center
 
  Utpal Banerjee, UCLA
How Metabolism Drives Preimplantation Development
 
  Tristan A Rodriguez, Imperial College London
Nutrient Regulation of Cell Fitness and Patterning in the Early Mammalian Embryo
 
  Berna Sozen, Yale University
Glycolytic Gradients During Gastrulation
 
  Eleni Kafkia, Novo Nordisk Foundation Center for Stem Cell Medicine, Faculty of Health and Medical Sciences, University of Copenhagen
Short Talk: TCA Rewiring Underpins Implantation and Histone Acetylation Programming
 
  Alba Villaronga-Luque, Max Planck Institute of Molecular Cell Biology and Genetics
Short Talk: Metabolic Control of Cell Fate Specification And Morphogenesis In A Mammalian Embryo Model
 
  Tashbib Khan, BIDMC - Harvard Medical School
Short Talk: Glycogen Derived Glutamate Fuels TCA Cycle Function and Cellular Differentiation
 
  Patrick Steinmetz, University of Bergen
Short Talk: Nutritional Regulation of Cellular Quiescence Depth In A Population Of Stem-Like Cells In A Sea Anemone
 
9:30–9:50 AM Coffee Break Beverly Foyer
9:50–9:55 AM Award Recipient Acknowledgement Beverly Room
11:30–12:30 PM Lunch Newburyport
12:30–2:30 PM Poster Session 2 Ipswich
2:30–3:30 PM Panel Discussion: Identifying Shared Priorities and Standards in a New Field Beverly Room
  * Lydia Finley, Memorial Sloan Kettering Cancer Center
 
  * Ralph J. DeBerardinis, University of Texas Southwestern Medical Center
 
  Tristan A Rodriguez, Imperial College London
 
  Utpal Banerjee, UCLA
 
  Sean J. Morrison, University of Texas Southwestern Medical Center
 
  Alex P Gould, Francis Crick Institute
 
  Sally L. Dunwoodie, Victor Chang Cardiac Research Institute
 
3:30–4:00 PM Coffee Available Beverly Foyer
4:00–5:45 PM Gene-Environment Interactions in Development Beverly Room
  * Mary R. Loeken, Joslin Diabetes Center
 
  A.J. Marian Walhout, University of Massachusetts Medical School
REMOTE PRESENTER: Nutritional Regulatory Networks
 
  Sally L. Dunwoodie, Victor Chang Cardiac Research Institute
NAD Deficiency and Congenital Malformation
 
  Ralph J. DeBerardinis, University of Texas Southwestern Medical Center
Fixed Metabolic Defects and their Developmental Consequences
 
  Nuno Valente-Leal, Gulbenkian Institute for Molecular Medicine
Short Talk: The Sweet Path to Fertility: Transforming Sugars Into Viable Oocytes
 
5:45–6:00 PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Beverly Foyer
6:15–10:00 PM On Own for Dinner
6:30–10:00 PM Transportation to Town for Dinner Options
Saturday, May 10, 2025
8:00–9:00 AM Departure