Spotlight on the Cancer Cell: From Early Detection to Intervention (V2)
January 1-5, 2028
| Location to be Determined
Jose Javier Bravo-Cordero
| 4:00–8:00 PM | Registration |
| 6:00–8:00 PM | Welcome Mixer |
| 12:45–2:00 PM | Poster Setup |
| 12:55–1:55 PM | Lunch |
| 7:30–8:30 AM | Breakfast |
| 8:30–8:40 AM | Welcome Remarks |
| 8:40–9:30 AM | Keynote Address (Joint) |
| Scott W. Lowe †, Memorial Sloan Kettering Cancer Center Tissue Interface: Epigenetic and Microenvironmental Triggers of Tumor Initiation |
| 9:30–11:45 AM | Co-Opting the Niche: Cancer Cell–Microenvironment Interactions from Tumor Initiation to Progression (Joint) |
| Eileen White †, Rutgers Cancer Institute Metabolic Plasticity and Autophagic Support at the Early Cell–Niche Interface |
| Peter Sorger †, Harvard Medical School High-Plex Spatial Mapping of Premalignant Architecture and Cellular Interactions |
| Helen Piwnica-Worms †, University of Texas MD Anderson Cancer Center Modeling Early Genomic and Niche Alterations in Patient-Derived Precancerous Models |
| Short Talk(s) Chosen from Abstracts |
| 10:00–10:20 AM | Coffee Break |
| 11:55–12:55 PM | Workshop: Spatial Multi-Omics and AI Foundation Models for Cell–Niche Mapping |
| 2:00–10:00 PM | Poster Viewing |
| 2:30–4:30 PM | Symposia Spotlight 1 |
| Short Talks Chosen from Abstracts |
| 4:30–5:00 PM | Coffee Available |
| 5:00–7:00 PM | Metabolic Rewiring and Genomic Triggers in Pre-Malignant Transitions |
| M. Celeste Simon †, University of Pennsylvania Nutrient Deprivation and Hypoxic Stress as Evolutionary Filters for Early Malignant Clones |
| Matthew G Vander Heiden †, Massachusetts Institute of Technology Cell-Intrinsic Metabolic Constraints Determining Carcinogenic Commitment |
| Ashok R. Venkitaraman, National University of Singapore & A*STAR IMCB Endogenous & Environmental Metabolic Stressors as Triggers of Cancer Genome Evolution |
| Short Talk(s) Chosen from Abstracts |
| 7:00–8:00 PM | Social Hour with Dinner |
| 7:30–10:00 PM | Posters |
| 12:30–2:00 PM | Poster Setup |
| 7:30–8:30 AM | Breakfast |
| 8:30–11:30 AM | Chromatin Dynamics, Lineage Infidelity, and Plasticity in Early Neoplasia |
| Yang Shi †, Ludwig Institute for Cancer Research, Oxford Branch Epigenetic Drivers of Reversible Cancer Cell States: Identifying Windows for Early Intervention |
| Susanne Schlisio †, Karolinska Institute Developmental De-differentiation and Lineage Plasticity in Pre-Malignant Transition |
| Duane Hassane †, AstraZeneca Translational Multi-Omic Profiling of Preleukemic Clones and Clonal Hematopoiesis of Indeterminate Potential (CHIP) |
| Daniel De Carvalho †, University Health Network Circulating Methylome Dynamics: Mapping Early Epigenetic Divergence for Non-Invasive Interception |
| Short Talk(s) Chosen from Abstracts |
| 9:30–9:50 AM | Coffee Break |
| 11:40–12:40 PM | Meet-the-Editors |
| 12:40–1:40 PM | Lunch |
| 2:00–10:00 PM | Poster Viewing |
| 3:00–4:30 PM | Career Roundtable |
| 4:30–5:00 PM | Coffee Available |
| 5:00–7:00 PM | Molecular Detection Frontiers: ctDNA, Epigenetic Signatures, and Pre- Invasive Interception |
| Rita Shaknovich, Agilent Technologies, Inc. Multi-Omic Liquid Biopsies: Translating High-Dimensional Molecular Signatures into Clinical Interception |
| Trevor Pugh †, University of Toronto Whole-Genome ctDNA Profiling for Longitudinal Trajectory Tracking and Interception |
| Liangliang Hao †, Boston University Engineered Nanomaterial Biomarkers and Precision Molecular Imaging of Occult Microlesions |
| Connie Trimble †, The Johns Hopkins University School of Medicine Molecular and Immune Interception in HPV-Driven High-Risk Precancerous Lesions |
| Short Talk(s) Chosen from Abstracts |
| 7:00–8:00 PM | Social Hour with Dinner |
| 7:30–10:00 PM | Posters |
| 12:40–1:40 PM | Lunch |
| 7:30–8:30 AM | Breakfast |
| 8:30–11:30 AM | Evolution Under Pressure: Tracking and Targeting Clones, Cell States, and Therapeutic Escape |
| Dan A. Landau †, Weill Cornell Medicine High-Resolution Single-Cell Multi-Omic Lineage Tracing of Clonal Fitness and Therapeutic Resistance |
| David R. Kelley †, Calico Life Sciences Generative AI Virtual Cell Platforms to Predict Cell-State Transitions and Therapeutic Vulnerabilities |
| Jan Smith †, Revolution Medicines Targeting the Active State: Drugging RAS(ON) and Overcoming Clonal Resistance Pathways |
| Short Talk(s) Chosen from Abstracts |
| 9:30–9:50 AM | Coffee Break |
| 11:40–12:40 PM | Roundtable Discussion: Translational & Regulatory Roundtable: Clinical Trial Design for Molecular Interception and MRD |
| 2:30–4:30 PM | Symposia Spotlight 2 |
| Short Talks Chosen from Abstracts |
| 4:30–5:00 PM | Coffee Available |
| 5:00–6:45 PM | The Latent Cell: Dissecting Dormancy, Niche Reactivation, and Late Intervention |
| Jose Javier Bravo-Cordero, Icahn School of Medicine at Mount Sinai Rewiring the Dormant Metastatic Niche: Vulnerabilities for Early Metastatic Interception |
| Judith Agudo †, Dana-Farber Cancer Institute Immune Privilege and Immune Evasion in Quiescent Residual Stem-Like Cancer Cells |
| Penelope Ottewell †, University of Sheffield Dissecting Bone-Niche Interactions and Preventing Late Skeletal Metastatic Outgrowth |
| Lewis A. Chodosh †, University of Pennsylvania School of Medicine Molecular Predictors of Dormant Cancer Cell Awakening and Sustained Recurrence Interception |
| Short Talk(s) Chosen from Abstracts |
| 6:45–7:00 PM | Meeting Wrap-Up: Outcomes and Future Directions |
| 7:00–8:00 PM | Social Hour with Dinner |
| 8:00–11:00 PM | Cash Bar |
| 8:00–11:00 PM | Entertainment |
| 12:00–11:59 PM | Departure |