Precision Genome Engineering: From Discovery to Cures (V5)
January 1-5, 2028  | Location to be Determined
Alexis C. Komor, Nicole Gaudelli and Gerald Schwank
* Session Chair † Invited but not yet accepted | Program current as of September 3, 2026 12 AM | For the most up-to-date details, visit https://www.keystonesymposia.org
Saturday, January 1, 2028
4:00–8:00 PM Registration
6:00–8:00 PM Welcome Mixer
Sunday, January 2, 2028
7:00–8:00 AM Breakfast
8:00–8:10 AM Welcome Remarks (Joint)
8:10–9:00 AM Keynote Address (Joint)
  David R. Liu †, Broad Institute, HHMI, and Harvard University
Advances in Programmable Genome Editing Technologies
 
9:00–11:15 AM Technological Frontiers of Precision Genome Engineering (Joint)
9:00–11:15 AM Meet the Editors (Joint)
  Prashant Mali †, University of California, San Diego
Genome and Cell Engineering with Circular RNAs
 
  James Dahlman †, Georgia Tech / Emory Medical School
Targeted in vivo Genome Engineering with Designer Nanoparticles
 
  Kristy Wood †, Intellia Therapeutics, Inc.
Development of in vivo CRISPR Medicines
 
  Short Talk(s) Chosen from Abstracts
 
9:30–9:50 AM Coffee Break
11:15–1:00 PM Poster Setup
11:15–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing
2:30–4:30 PM Symposia Spotlight 1: Emerging and Innovative Genome Editing Technologies
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available
5:00–7:00 PM Emerging Nucleic Acid–Modifying Systems
  Samuel H Sternberg †, Columbia University
Bacterial Immune Systems and Their Biotechnological Potential
 
  Rotem Sorek †, Weizmann Institute of Science
Large-Scale Discovery of Non-CRISPR Bacterial Defense Systems
 
  Elizabeth Kellogg †, St. Jude Children's Research Hospital
Structural Insights into New Nucleic Acid Modifying Systems
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM Social Hour with Dinner
7:30–10:00 PM Posters
Monday, January 3, 2028
7:00–8:00 AM Breakfast
8:00–11:00 AM Clinical Frontiers of Precision Genome Engineering (Joint)
  Kiran Musunuru †, University of Pennsylvania
Development of N=1 Clinical Trials
 
  Amy R. Simon †, Beam Therapeutics
Base Editing Clinical Trial
 
  Bill Lundberg †, CRISPR Therapeutics
Ex vivo/in vivo CRISPR-based Therapeutics
 
  Laura Sepp-Lorenzino †, Intellia Therapeutics
Perspectives on the Future of Genome Editing
 
  Short Talk(s) Chosen from Abstracts
 
9:00–9:20 AM Coffee Break
11:00–1:00 PM Poster Setup
11:00–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing
3:00–4:30 PM Career Roundtable
4:30–5:00 PM Coffee Available
5:00–7:00 PM Protein Engineering and Computational Impacts on Genome Engineering
  Alexis C. Komor, University of California, San Diego
Expanding the Capabilities of Base Editing
 
  Jin-Soo Kim †, Korea Advanced Institute for Science and Technology
Mitochondrial Genome Editing
 
  Britt Adamson †, Princeton University
Improving Genome Engineering Technologies using Mechanistic Insight
 
  Short Talk(s) Chosen from Abstracts
 
7:00–8:00 PM Social Hour with Dinner
7:30–10:00 PM Posters
Tuesday, January 4, 2028
7:00–8:00 AM Breakfast
8:00–11:00 AM Somatic and Germline Genome Engineering
  Speaker to be Announced
Genome Editing to Treat Cardiovascular Disease
 
  Tippi MacKenzie †, University of California, San Francisco
In utero Genome Editing
 
  Kathy K. Niakan †, University of Cambridge
Base Editing to Study Human Embryogenesis
 
  Manda Arbab †, Harvard University and Broad Institute
Development of Therapeutic Strategies to Treat Neurological Diseases
 
  Short Talk(s) Chosen from Abstracts
 
9:00–9:20 AM Coffee Break
11:10–12:10 PM Ethics Round Table Discussion: Responsible Translation of Precision Genome Editing
12:10–5:00 PM On Own for Lunch
2:30–4:30 PM Symposia Spotlight 2
  Short Talks Chosen from Abstracts
 
4:30–5:00 PM Coffee Available
5:00–6:15 PM Closing Session (Joint)
  Punit P. Seth, Alnylam Pharmaceuticals
Alnylam Update
 
  Gerald Schwank, University Zurich
Prime Editing for Inherited Metabolic Diseases
 
  Waseem Qasim †, University in London
Genome-Edited T Cell Therapies for Blood Cancer
 
  Short Talk(s) Chosen from Abstracts
 
6:15–7:00 PM Closing Keynote Address (Joint)
  John M. Maraganore †, City Therapeutics
Novel RNAi
 
7:00–7:15 PM Meeting Wrap-Up: Outcomes and Future Directions
7:15–8:15 PM Social Hour with Dinner
8:00–11:00 PM Entertainment
8:00–11:00 PM Cash Bar
Wednesday, January 5, 2028
12:00–11:59 PM Departure