MASH Pathogenesis and Therapeutic Approaches (X2)
February 23-26, 2025
| Fairmont Banff Springs, Banff, AB, Canada
Elizabeth K Speliotes, Rebecca A. Taub and Hannele Yki-Järvinen
Scholarship Deadline: Dec. 5, 2024 | Abstract Deadline: Jan. 31, 2025 | Early Registration Deadline: Jan. 9, 2025
Sunday, February 23, 2025
| 4:00–8:00 PM |
Registration |
Van Horne Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
Van Horne Foyer |
Monday, February 24, 2025
| 7:00–8:00 AM |
Breakfast |
President's Hall |
| 8:00–9:30 AM |
Welcome and Keynote Session (Joint) |
Van Horne A/B |
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* Paul Cohen, Rockefeller University
Session Chair |
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* Elizabeth K Speliotes, University of Michigan
Session Chair |
|
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Jeffrey M. Friedman, Rockefeller University
Obesity Causes and Treatment: The End of the Beginning |
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Anna Mae Diehl, Duke University
Morphogens, Metabolism and MASLD (Metabolic Dysfunction-Associated Steatotic Liver Disease) |
|
| 9:30–9:50 AM |
Coffee Break |
Van Horne Foyer |
| 9:50–9:55 AM |
Award Recipient Acknowledgement |
Van Horne A/B |
| 9:55–11:30 AM |
Genetic Insights into Body Fat Distribution and MASLD (Joint) |
Van Horne A/B |
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* Lucile Dollet, University of Copenhagen
Session Chair |
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Elizabeth K Speliotes, University of Michigan
Human Genetic Insights into MASLD |
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* Ruth J Loos, University of Copenhagen
Genetics of Obesity and Body Fat Distribution |
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Karen L. Mohlke, University of North Carolina at Chapel Hill
Genetics and Genomics of Obesity-Associated Diseases |
|
| 11:30–1:00 PM |
Poster Setup |
Van Horne C |
| 11:30–2:30 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Van Horne C |
| 2:30–4:30 PM |
Health Equity Forum (Joint) |
Van Horne A |
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* Joeva Barrow, Cornell University
Session Chair |
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* Keren I Hilgendorf, University of Utah
Lean Adipocytes Secrete an Oxylipin That Protects Against Obesity-Accelerated Breast Cancer |
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Lisa Lazarevski, University of Tübingen
Unraveling the Impact of White Adipose Tissue on Breast Cancer Metabolism And Therapy Resistance Using a Breast Cancer-On-Chip Model |
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Clarissa Strieder-Barboza, Texas Tech University
Single-Nuclei Analysis Reveals Depot- And Disease-Specific Cell Types In Adipose Tissue Of Women With Gestational Diabetes |
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Jennifer Below, Vanderbilt University Medical Center
Unmasking Early Cardiometabolic Risk In A High Risk Population |
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Elizabeth C Heintz, Pennington Biomedical Research Center
Deletion of Hepatocyte NRF2 Accelerates MASH Progression Through Similar Mechanisms in Male and Female Mice |
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Marijana Vujkovic, Philadelphia VA Medical Center / University of Pennsylvania
Genetic Variants Influence Chronic Liver Disease Progression through Distinct Pathways |
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Donna Conlon, University of Pennsylvania
The Role of FOG2S657G in Metabolic Dysfunction-Associated Steatohepatitis |
|
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Jashdeep Bhattacharjee, University of Southern California
The Role of MALRD1 on MASH Pathogenesis |
|
| 4:30–5:00 PM |
Coffee Available |
Van Horne Foyer |
| 5:00–7:00 PM |
Drivers of MASH |
Van Horne B |
| |
* Sami F Qadri, University of Helsinki
Session Chair |
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Hannele Yki-Järvinen, University of Helsinki
PNPLA3 Mechanisms and Beyond |
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* Xavier Revelo, University of Minnesota
Immune Mechanisms in MASH |
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Orian S Shirihai, David Geffen School of Medicine at UCLA
Mitochondrial Biology and MASH |
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Harmeet Malhi, Mayo Clinic
Extracellular Vesicles in MASH: Mediators of Injury, Inflammation, and Potential Therapeutic Targets |
|
| 7:00–8:00 PM |
Social Hour with Lite Bites |
President's Hall |
| 7:30–10:00 PM |
Poster Session 1 |
Van Horne C |
Tuesday, February 25, 2025
| 7:00–8:00 AM |
Breakfast |
President's Hall |
| 8:00–11:00 AM |
Cellular Stress, Fibrosis and MASLD |
Van Horne B |
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* Russell Goodman, Massachusetts General Hospital
Reductive Stress and Common Pathophysiology of Metabolic Disease |
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* Natalie J. Torok, Stanford University
Fibrosis in MASLD and Aging |
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Jin Ye, UT Southwestern
MASH: The Ferroptotic Diseases |
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Karthickeyan Chella Krishnan, University of Cincinnati
Short Talk: Role of Hepatic Mitochondrial Subpopulations in MASH Progression |
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Erin C Ciske, University of Minnesota
Short Talk: Pyruvate Metabolism Promotes B Cell Activation in Steatohepatitis |
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Yo Han Lee, Ulsan National Institute of Science and Technology
Short Talk: Hepatic miR-93 promotes the pathogenesis of metabolic dysfunction-associated steatotic liver disease by suppressing SIRT1 |
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Reddemma Sandireddy, Duke-NUS Medical School, National University of Singapore
Short Talk: Linking the Liver and Heart: MASH as a Key Driver of HFpEF in a Dietary Mouse Model of Liver Disease |
|
| 9:00–9:20 AM |
Coffee Break |
Van Horne Foyer |
| 11:00–1:00 PM |
Poster Setup |
Van Horne C |
| 11:00–3:15 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Van Horne C |
| 1:30–3:00 PM |
Career Roundtable (Joint) |
Van Horne B |
| |
Ricardo J. Samms, Eli Lilly and Company
Senior Director |
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Alexander Pfeifer, University of Bonn
Professor |
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Marie Guerraty, University of Pennsylvania
Assistant Professor |
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Henry H. Ruiz, New York Institute of Technology
Assistant Professor |
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Catherine Charneski, Science Translational Medicine
Senior Editor |
|
| 3:15–4:30 PM |
Meet the Editors (Joint) |
Van Horne B |
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Deniz Senyilmaz Tiebe, EMBO Press
*Session Chair, Senior Scientific Editor |
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Yevgeniya Nusinovich, AAAS/Science
Senior Editor |
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Revati Sumukh Dewal, Nature Metabolism
Associate Editor |
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Mari-Carmen Fernández-Agüera, Cell Metabolism, Cell Press
Scientific Editor |
|
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Rachel Sager, Med, Cell Press
Associate Scientific Editor |
|
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George Caputa, Nature
Senior Editor |
|
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Tatyana Kuznetsova, Cell Reports Medicine
Senior Scientific Editor |
|
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Catherine Charneski, Science Translational Medicine
Senior Editor |
|
| 4:30–5:00 PM |
Coffee Available |
Van Horne Foyer |
| 5:00–7:00 PM |
Challenges and Innovations in Preclinical Disease Modeling |
Van Horne B |
| |
* Michele Vacca, University of Bari & Roger Williams Institute of Liver Studies
An Unbiased Ranking of Murine Dietary Models based on their Proximity to Human Metabolic Dysfunction Associated Steatohepatitis |
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* Jacquelyn Maher, University of California, San Francisco
iPSC Modeling of Liver Disease |
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Carla Frau, BIH-Charite, MPIMG
Mechanisms controlling liver regeneration during MASH progression |
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Francisco Verdeguer, InSphero
Short Talk: Multiparametric Screening of MASH Clinical Candidates In Human Liver Spheroids Predicts Clinical Outcomes And Reveals Potential Novel Combinations For Anti-Steatotic And Anti-Fibrotic Therapies |
|
| 7:00–8:00 PM |
Social Hour with Lite Bites |
President's Hall |
| 7:30–10:00 PM |
Poster Session 2 |
Van Horne C |
Wednesday, February 26, 2025
| 7:00–8:00 AM |
Breakfast |
President's Hall |
| 8:00–11:00 AM |
The Biology of Therapeutics for Obesity and MASLD (Joint) |
Van Horne A/B |
| |
* Matthew Lynes, MaineHealth
Session Chair |
|
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* Luca Lotta, Regeneron Pharmaceuticals Inc.
CIEDB, GPR75, INHBE in Obesity and MASLD |
|
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Rebecca A. Taub, Madrigal Pharmaceuticals
Thyroid Agonist Biology and Human Effects |
|
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Ricardo J. Samms, Eli Lilly and Company
Dual Agonist Biology and Human Effects |
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Jacqueline Beaudry, University of Toronto
Short Talk: Clearance Of Postprandial Lipid Levels Into Adipose Tissue With The Help Of Glucose-Dependent Insulinotropic Peptide |
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Carla Hovarth, ETH Zürich
Short Talk: Adipose Tissue as A First Responder: Early Effects of Survodutide on Systemic Insulin Sensitivity |
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Joanne Hsieh, Gordian Biotechnology
Short Talk: Interrogating The Directionality And Mechanisms Of Genetic Associations As Part Of High-Throughput In Vivo Pooled Screening To Discover Novel Therapies For MASH |
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Prabhu Ponnandy, University of Michigan
Short Talk: CRISPR Whole Genome Knock-Out Screen Identifies Potential New Targets For Treatment of MASLD |
|
| 9:00–9:20 AM |
Coffee Break |
Van Horne Foyer |
| 11:00–1:00 PM |
Poster Setup |
Van Horne C |
| 11:00–2:30 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Van Horne C |
| 2:30–4:30 PM |
Symposia Spotlight: Emerging Mechanisms |
Van Horne B |
| |
John J. Lemasters, Medical University of South Carolina
Remote Presenter: Aldehydes Initiate the Shared Pathogenesis of Metabolic Dysfunction-Associated and Alcohol-Associated Steatohepatitis by Inducing Mitochondrial Depolarization, Mitophagy, and Release of Profibrotic and Proinflammatory Mitochondrial Damage-Associated Molecular Patterns |
|
| |
Eri Wada, Nagoya University
The Role of β2 Adrenergic Receptor in MASH |
|
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* Jesse Rose, University of Iowa
Fibroblast Growth Factor 21 Reverses MASH Through Coordinated Actions on the CNS and liver. |
|
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* Wen-Wei Tsai, Sagimet Biosciences
Denifanstat, a Fatty Acid Synthase Inhibitor, Increased Circulating Polyunsaturated Triglycerides and Decreased LDL-Cholesterol in MASH Patients with Advanced Fibrosis in a Post-Hoc Analysis of FASCINATE-2 Study |
|
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Benan Pelin Sermikli, Salk Institute for Biological Studies
Circadian FGF1 Signaling Orchestrates Nocturnal Hepatic Triglyceride Secretion via Non-Canonical IRE1a-XBP1 Pathway Activation |
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Rafael Mayoral Monibas, Corcept Therapautics
Metabolomic and Lipidomic Analysis of Patients with Presumed Metabolic Dysfunction-Associated Steatohepatitis (MASH) Treated with the Selective Glucocorticoid Receptor Modulator Miricorilant |
|
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Thomas Q de Aguiar Vallim, University of California, Los Angeles
Bile Acids Selectively Drive Fatty Acid Absorption To Regulate Systemic Lipid Metabolism |
|
| 4:30–5:00 PM |
Coffee Available |
Van Horne Foyer |
| 5:00–6:45 PM |
New Non-invasive Measures of MASH/Fibrosis |
Van Horne B |
| |
* Hannele Yki-Järvinen, University of Helsinki
Session Chair |
|
| |
* Quentin M. Anstee, Newcastle University
New Non-invasive Biomarkers for MASH Data from Litmus |
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Sami F Qadri, University of Helsinki
Surveillance of the Liver in Type 2 Diabetes: Important but Unfeasible? |
|
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Manal F. Abdelmalek, Mayo Clinic
Whole Genome Methylation Cell-Free DNA Signature and Methylome-Wide Association Study For Non-Invasive Diagnosis of At-Risk MASH |
|
| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Van Horne B |
| 7:00–8:00 PM |
Social Hour with Lite Bites |
President's Hall |
| 7:30–10:00 PM |
Poster Session 3 |
Van Horne C |
Thursday, February 27, 2025
