Precision Genome Engineering: From Laboratory to Clinic (X2)
January 1-4, 2027
| Location to be Determined
Erik J. Sontheimer
| 4:00–8:00 PM |
Registration |
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| 6:00–8:00 PM |
Welcome Mixer |
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Saturday, January 2, 2027
| 8:00–9:00 AM |
Welcome and Keynote Address (Joint) |
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Eric N. Olson †, University of Texas Southwestern Medical Center
Single-AAV base Editing Therapies for Duchenne Muscular Dystrophy |
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| 9:00–11:15 AM |
Viral Delivery of Genome Editors and Genetic Medicines (Joint) |
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| 9:00–11:15 AM |
Panel Discussion: Lessons Learned So Far: From Concept to Clinic |
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Beverly L. Davidson, Children’s Hospital of Philadelphia and University of Pennsylvania
AAV Capsid Engineering for Broad CNS Distribution |
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Sonia Vallabh †, Broad Institute
Development of Medicines to Treat Prion Diseases: A Personal Journey |
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Charles Gersbach †, Duke University
AAV-Delivered Epigenome Editors |
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Short Talk(s) Chosen from Abstracts
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| 9:30–9:50 AM |
Coffee Break |
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| 11:15–1:00 PM |
Poster Setup |
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| 11:15–5:00 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
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| 2:30–4:30 PM |
Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions |
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Short Talks Chosen from Abstracts
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–7:00 PM |
Next-Generation Editing Tools: Continuing Innovation to Push the Limits of Genome Engineering |
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Jennifer A. Doudna †, HHMI/University of California, Berkeley
CRISPR Genome Editing |
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Erik J. Sontheimer, University of Massachusetts Medical School
Next-Generation Genome Editing Platforms |
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Luigi M. Naldini †, San Raffaele Telethon Institute for Gene Therapy
Genome Editing in Hematopoietic Stem Cells |
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Short Talk(s) Chosen from Abstracts
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| 7:00–8:00 PM |
Social Hour with Dinner |
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| 8:00–9:00 AM |
Keynote Speaker (Joint) |
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David R. Liu †, Broad Institute, HHMI, and Harvard University
Development and Application of Virus-Like Particles for Genome Editing in vivo |
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| 9:00–9:20 AM |
Coffee Break |
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| 9:00–11:00 AM |
In vivo Genome Editing via Non-Viral Delivery (Joint) |
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Birgit C. Schultes †, IntelliaTherapeutics Inc.
Clinical Results from Liver Genome Editing in vivo |
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Rebecca Ahrens-Nicklas †, Children's Hospital of Philadelphia
Personalized Therapeutic Genome Editing for Hepatic Inborn Errors of Metabolism |
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Leah R. Sabin †, Regeneron Pharmaceuticals
Novel Delivery Strategies for Genetic Medicines |
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Short Talk(s) Chosen from Abstracts
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|
| 11:00–1:00 PM |
Poster Setup |
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| 11:00–5:00 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
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| 3:00–4:30 PM |
Career Roundtable |
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–7:00 PM |
Editing with Confidence: Evaluating Safety, Specificity, and Genomic Integrity |
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Maria Mirotsou, Scribe Therapeutics
Compact, Self-Inactivating CasX Editing in vivo |
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Shengdar Q. Tsai †, St. Jude Children's Research Hospital
Off-Target Profiling for Base and Prime Editing |
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Marcello Maresca †, AstraZeneca
Enhancing Prime Editing Platforms for in vivo Applications |
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Short Talk(s) Chosen from Abstracts
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| 7:00–8:00 PM |
Social Hour with Dinner |
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| 8:00–11:00 AM |
Redefining Editors: From CRISPR Biology to Recombination and Integration |
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Feng Zhang †, Broad Institute of MIT and Harvard University
Non-Canonical CRISPR Systems for Genome Editing |
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Sangsu Bae †, Seoul National University
Precise ADAR Base Editors and Prime Editor Enhancers |
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Kathleen Collins †, University of California, Berkeley
Transgene Insertion Editing with Engineered Retroelements |
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Hiroshi Nishimasu †, RCAST, The University of Tokyo
Engineering Programmable Transposases |
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Short Talk(s) Chosen from Abstracts
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| 9:00–9:20 AM |
Coffee Break |
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| 11:00–5:00 PM |
On Own for Lunch |
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| 2:30–4:30 PM |
Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions |
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| |
Short Talks Chosen from Abstracts
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| 4:30–5:00 PM |
Coffee Available |
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| 5:00–6:45 PM |
Machine-Learned Molecules: AI-Driven Design in Genome Engineering & Delivery |
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Silvana Konermann †, Stanford University School of Medicine
Protein Design and Genome Editor Enhancement |
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Peter Cameron †, Profluent Bio
Building Customized Editors via Large Language Model-Based Protein Design |
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Bruno Emanuel Correia †, École Polytechnique Fédérale de Lausanne
BindCraft, Protein Design, and Control over Genome Editing |
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Short Talk(s) Chosen from Abstracts
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| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
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| 7:00–8:00 PM |
Social Hour with Dinner |
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| 8:00–11:00 PM |
Entertainment |
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