Cardiometabolic Diseases: The Role of Ethnic Diversity in Precision Medicine (X3)
February 4-7, 2024
| Fairmont Hotel Vancouver, Vancouver, BC, Canada
Paul W. Franks, Ewan Pearson and Karin Conde-Knape
Scholarship Deadline: Dec. 1, 2023 | Abstract Deadline: Dec. 6, 2023 | Early Registration Deadline: Dec. 6, 2023
| 4:00–8:00 PM |
Arrival and Registration |
British/Columbia Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
British/Columbia Foyer |
| 7:00–8:00 AM |
Breakfast |
Pacific Ballroom, Vancouver Island Room |
| 8:00–9:30 AM |
Welcome and Keynote Session (Joint) |
Columbia Ballroom |
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* Giles S.H. Yeo, University of Cambridge
Session Chair |
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* Ewan Pearson, University of Dundee
Session Chair |
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Stephen O'Rahilly, University of Cambridge
Leveraging Genetics to Understand Metabolic Disease |
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Jose C. Florez, Massachusetts General Hospital
Optimising Precision Medicine Across Diverse Ethnicities |
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| 9:30–9:50 AM |
Coffee Break |
British/Columbia Foyer |
| 9:50–11:15 AM |
Genetics of Obesity (Joint) |
Columbia Ballroom |
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* Andrea M. Haqq, University of Alberta
Session Chair |
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Kaja Wasik, Variant Bio
Metabolic Disease in the Context of Genetic Diversity |
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Peter R. Shepherd, University of Auckland
Population Specific Precision Medicine for Metabolic Disease |
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Kathrin Landgraf, Center for Pediatric Research, Hospital for Children and Adolescents, Medical Faculty, University of Leipzig
Short Talk: Short Talk: Ectopic ASIP Expression as a Monogenic cause of Childhood Obesity through Possible Interaction with the MC4R Pathway |
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Yana Hrytsenko, Beth Israel Deaconess Medical Center, Harvard Medical School
Short Talk: Short Talk: Obstructive Sleep Apnea is Associated with Increased Genetic Risk of Incident Diabetes Mellitus: the Hispanic Community Health Study/Study of Latinos |
|
| 11:15–1:00 PM |
Poster Setup |
Pacific Ballroom, Vancouver Island Room |
| 11:15–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Pacific Ballroom, Vancouver Island Room |
| 2:30–4:30 PM |
Workshop |
British Ballroom |
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* Karin Conde-Knape, Novo Nordisk A/S
Session Chair |
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Reka Nagy, Novo Nordisk Research Centre Oxford
Identification of South-Asian Ancestry-Specific Genetic Risk Factors for Cardiometabolic Disease |
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Claire Wang, University of Auckland
Understanding Genetic Impact on Metformin Efficacy to Guide Clinical Treatment in Diabetes |
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Arjana Begzati, University of California, San Diego
Racial Differences in Metabolite Predictors of Type 2 Diabetes Risk |
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Madeleine ME Hayman, University of Glasgow, University of Edinburgh
GLP1R locus: a Connection Between Mental Ill-Health and Cardiometabolic Disease? |
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Absalon Gutierrez, The University of Texas Health Science Center at Houston
Pharmacogenetics of the Response to GLP-1 in Mexican-Americans with Prediabetes: A Preliminary Analysis |
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Fannie Lajeunesse-Trempe, Université Laval
Adiposity Phenotypes and Associated Cardiometabolic Risk Profile Among the Inuit Population of Nunavik |
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Elizabeth Godschall, University of Virginia
Development of Humanized Glp-1 Receptor Mouse to Investigate the Small Molecule Agonist Mechanism of Action |
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| 4:30–5:00 PM |
Coffee Available |
British/Columbia Foyer |
| 5:00–7:00 PM |
Environmental Diversity Within and Between Populations |
British Ballroom |
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* Viswanathan Mohan, Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre
Session Chair |
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John Chambers, Nanyang Technological University
Epigenetic Drivers of CMD in South Asians |
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Karin Conde-Knape, Novo Nordisk A/S
How can we Ensure Precision Medicines are Efficacious and Safe Across Diverse Ethnicities? |
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Chirag J. Patel, Harvard Medical School
Assessing the Genetic Contribution of Behaviors and Exposures Associated with Longitudinal Type 2 Diabetes Highlights the Adiposity and the Brain-metabolic Axis |
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| 7:00–8:00 PM |
Social Hour with Lite Bites |
Pacific Ballroom, Vancouver Island Room |
| 7:30–10:00 PM |
Poster Session 1 |
Pacific Ballroom, Vancouver Island Room |
Tuesday, February 6, 2024
| 7:00–8:00 AM |
Breakfast |
Pacific Ballroom, Vancouver Island Room |
| 8:00–11:00 AM |
Diversity in Pathophysiological Drivers of CMD |
British Ballroom |
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* Moneeza Siddiqui, Queen Mary University of London
Session Chair |
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Paul W. Franks, Lund University and Novo Nordisk Foundation
Remote Presentation: Next-Generation Epidemiology, Ethnic Diversity and Cardiometabolic Disease |
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Shivani Misra, Imperial College London
Ethnic Diversity and Cardiometabolic Disease in Young People |
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Ewan Pearson, University of Dundee
Ethnicity, Phenotype and Precision Diabetes Care |
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Alan James Davidson, University of Auckland
Short Talk: Short Talk: A Gene Variant in CALCRL, Encoding a G-Protein Coupled Receptor, is Highly Enriched in Individuals with Māori and Pacific Ancestry and Associates with a Higher Risk of Kidney Failure in Diabetes |
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Andreas L Birkenfeld, Helmholtz Munich
Short Talk: Short Talk: Precision Remission of Prediabetes within High-Risk Prediabetes Clusters |
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| 9:00–9:20 AM |
Coffee Break |
British/Columbia Foyer |
| 11:00–1:00 PM |
Poster Setup |
Pacific Ballroom, Vancouver Island Room |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 11:30–1:00 PM |
Health Equity Forum (Joint) |
Columbia Ballroom |
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Kaja Wasik, Variant Bio
Panelist |
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Peter R. Shepherd, University of Auckland
Panelist |
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Moneeza Siddiqui, Queen Mary University of London
Panelist |
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Shivani Misra, Imperial College London
Panelist |
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Moffat Nyirenda, London School of Hygiene and Tropical Medicine
Panelist |
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| 1:00–10:00 PM |
Poster Viewing |
Pacific Ballroom, Vancouver Island Room |
| 4:30–5:00 PM |
Coffee Available |
British/Columbia Foyer |
| 5:00–7:00 PM |
Delivering Precision Medicine in Low-Middle Income Settings |
British Ballroom |
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* Ewan Pearson, University of Dundee
Session Chair |
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Moffat Nyirenda, London School of Hygiene and Tropical Medicine
Optimising the Prevention and Treatment of CMD when Infectious Disease is Highly Prevalent |
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John Dennis, University of Exeter Medical School
Parsimonious Strategies for Precision Medicine in Practice - Lessons from the TriMaster Trial |
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Viswanathan Mohan, Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre
Barriers and Possibilities when Delivering Precision Medicine in Resource Constrained Settings: Indian Experience |
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Kristina M Garske, Princeton University
Short Talk: Short Talk: Detecting Decoherent Gene Co-Expression Patterns Associated with a Rural-to-Urban Lifestyle Transition in Turkana |
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Alisa Manning, Massachusetts General Hospital
Short Talk: Short Talk: Proteins Associated with Self-Report Race/Ethnicity Partially Mediate the Association with Type 2 Diabetes. A Meta-Analysis of 2,339 Individuals From Two Multi-Ethnic Cohorts |
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William L. Holland, University of Utah
Short Talk: Short Talk: Identification and Characterization of a Novel Variant in Neutral Ceramidase Associated with Diabetes and Kidney Failure in Tongan and Samoan Patients |
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| 7:00–8:00 PM |
Social Hour with Lite Bites |
Pacific Ballroom, Vancouver Island Room |
| 7:30–10:00 PM |
Poster Session 2 |
Pacific Ballroom, Vancouver Island Room |
Wednesday, February 7, 2024
| 7:00–8:00 AM |
Breakfast |
Pacific Ballroom, Vancouver Island Room |
| 8:00–11:00 AM |
Precision Obesity Management (Joint) |
Columbia Ballroom |
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* Abd A Tahrani, Novo Nordisk
Session Chair |
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Karine Clément, INSERM / Sorbonne Universite
Precision Obesity Medicine in Practice |
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Daniel J. Drucker, Lunenfeld-Tanenbaum Research Institute
The GLP1/GIP System in Obesity Management |
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Moneeza Siddiqui, Queen Mary University of London
Insights From Genetic and Observational Studies in South Asian Populations |
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Sarah Berry, King's College London
Personalised Nutrition in Obesity Management |
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Jordan B. Wean, University of Michigan
Short Talk: Short Talk: GABAergic GIPR-expressing Neurons are Required for the Body Weight Reduction caused by Dual Incretin Agonists |
|
| 9:00–9:20 AM |
Coffee Break |
British/Columbia Foyer |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 3:00–4:30 PM |
Career Roundtable (Joint) |
British Ballroom |
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Jose C. Florez, Massachusetts General Hospital
Physician-in-Chief, Chair, and Professor |
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Leslie J. Baier, National Institutes of Health
Section Chief: Diabetes Molecular Genetics Section |
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Kyle Kai-How Farh, Illumina
VP & Distinguished Scientist |
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Sarah Berry, King's College London
Reader & Associate Professor |
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| 4:30–5:00 PM |
Coffee Available |
British/Columbia Foyer |
| 5:00–6:45 PM |
Genetic and Non-Genetic Biological Diversity Across Diverse Ethnicities |
British Ballroom |
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* John Chambers, Nanyang Technological University
Session Chair |
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Kyle Kai-How Farh, Illumina
Artificial Intelligence for Precision Medicine and Drug Target Discovery |
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Leslie J. Baier, National Institutes of Health
Understanding the Heritable basis of Obesity and Type 2 Diabetes Among Indigenous People Living in Southwestern United States |
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Megan P Leask, University of Alabama at Birmingham
Short Talk: Short Talk: GWAS And Beyond: Cardiometabolic Variant Discovery For Māori And Pacific People |
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| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
British Ballroom |
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Pacific Ballroom, Vancouver Island Room |
| 8:00–9:00 PM |
Cash Bar |
Pacific Ballroom, Vancouver Island Room |
Thursday, February 8, 2024
